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Patent # Description
US-9,732,110 Nucleoside and nucleotide derivatives
The present invention discloses compounds of formula (I), or a pharmaceutically acceptable salt thereof: ##STR00001## which inhibit, preventing or treating...
US-9,732,109 Pesticidal compositions
The invention disclosed in this document is related to the field of pesticides and their use in controlling pests. A compound having the following structure is...
US-9,732,108 Halogenated di- and trisaccharides, pharmaceutical formulations, diagnostic kits and methods of treatment
The present invention relates to a novel family of alkylated halogenated di- and trisaccharides which exhibit pharmaceutical efficacy in the areas of permeation...
US-9,732,107 Method for producing beta-hematin crystal comprising step of heating
This invention provides a method of preparing a .beta.-hematin crystal comprising a step of heating, the .beta.-hematin crystal obtained by such method, and a...
US-9,732,106 Phosphinyl amidine compounds, metal complexes, catalyst systems, and their use to oligomerize or polymerize olefins
N.sup.2-phosphinyl amidine compounds, N.sup.2-phosphinyl amidinates, N.sup.2-phosphinyl amidine metal salt complexes, N.sup.2-phosphinyl amidinate metal salt...
US-9,732,105 Targeted nitroxide agents
A compound having a structure of: ##STR00001##
US-9,732,104 Ether compounds for treatment of complement mediated disorders
Compounds, methods of use, and processes for making inhibitors of complement factor D comprising Formula I, or a pharmaceutically acceptable salt or composition...
US-9,732,103 Carbamate, ester, and ketone compounds for treatment of complement mediated disorders
Compounds, methods of use, and processes for making inhibitors of complement factor D comprising Formula I, or a pharmaceutically acceptable salt or composition...
US-9,732,102 System for controlling the reactivity of boronic acids
A protected organoboronic acid includes a boron having an sp.sup.3 hybridization, a conformationally rigid protecting group bonded to the boron, and an organic...
US-9,732,101 Bioreversible boronates for delivery of molecules into cells
Methods for enhancing cellular uptake of cargo molecules by boronating the cargo molecule, particularly with one or more phenylboronic acid groups. Boronation...
US-9,732,100 Preparation of alkaline earth metal-complexed metal bisamides from metal monoamides
The present invention relates to a process for preparing alkaline earth metal-complexed metal bisamides of the formula (I) from metal monoamides of the formula...
US-9,732,099 Organic electroluminescent compounds and organic electroluminescent devices comprising the same
The present invention relates to an organic electroluminescent compound and an organic electroluminescent device comprising the same. By using the organic...
US-9,732,098 5,6-dihydro-4H-benzo[b]thieno-[2,3-d]azepine derivative
There is provided a 5,6-dihydro-4H-benzo[b]thieno-[2,3-d]azepine derivative which is useful in the treatment of respiratory syncytial virus (RSV) infection and...
US-9,732,097 Process for the synthesis of a phosphoinositide 3-kinase inhibitor
The present application is directed to processes and intermediates for making (S)-7-(1-((9H-purin-6-yl)amino)ethyl)-6-(3-fluorophenyl)-3-methyl-- ...
US-9,732,096 Buprenorphine dimer and its use in treatment of gastrointestinal disorders
The present invention provides a buprenorphine dimer compound, wherein the two buprenorphine portions are linked via an ethylene spacer, wherein the spacer is...
US-9,732,095 Bicyclic heterocyclyl derivatives as IRAK4 inhibitors
The present invention provides bicyclic heterocyclyl kinase enzyme inhibitor compounds of formula (I), which are therapeutically useful as kinase inhibitors,...
US-9,732,094 Arylquinazolines
The invention relates to novel compounds of the formula (I) which can be used for the inhibition of serine-threonine protein kinases and for the sensitization...
US-9,732,093 FLAP modulators
The present invention relates to compounds of Formula (I), or a form thereof, wherein ring A, R.sub.1, L and R.sub.2 are as defined herein, useful as FLAP...
US-9,732,092 Substituted 2,3,4,5,7,9,13,13a-octahydropyrido[1',2':4,5]pyrazino[2,1-b][1,3]OXAZEPIN- ES and methods for...
Compounds for use in the treatment of human immunodeficiency virus (HIV) infection are disclosed. The compounds have the following Formula (I): ##STR00001## ...
US-9,732,091 Tryptophanol-derived oxazoloisoindolinones: small-molecule P53 activators
The present application discloses novel family of Tryptophanol-Derived Oxazoloisoindolinones for use in the treatment of p53 associated conditions, such as...
US-9,732,090 Bicyclic and tricyclic pyrimidine tyrosine kinase inhibitors with antitubulin activity and methods of treating...
Bicyclic and tricyclic pyrimidine tyrosine kinase inhibitors with antitubulin activity are provided in the present invention. The compositions of the present...
US-9,732,089 Substituted pyrazolo[1,5-a]pyrimidines and their use in the treatment of medical disorders
The invention provides substituted pyrazolo[1,5-a]pyrimidine and related organic compounds, compositions containing such compounds, medical kits, and methods...
US-9,732,088 C2-carbocyclic iminothiazine dioxides as BACE inhibitors, compositions, and their use
In its many embodiments, the present invention provides certain C2-carbocyclic iminothiazine dioxide compounds, including compounds Formula (I); or a tautomers...
US-9,732,087 Diamino-pyridine, pyrimidine, and pyridazine modulators of the histamine H.sub.4 receptor
Diamino-pyridine, pyrimidine and pyridazine compounds which may be used as H.sub.4 receptor modulators, and in pharmaceutical compositions and methods for the...
US-9,732,086 Bicyclic heterocyclic compound containing a substituted pyrrole ring
Provided is a compound having a cholinergic muscarinic M1 receptor positive allosteric modulator activity, and useful as a prophylactic or therapeutic drug for...
US-9,732,085 Pyridinone and pyrimidinone derivatives as factor Xia
The present invention provides compounds of the general formula (I), their salts and N-oxides, and solvates and prodrugs thereof (wherein the characters are as...
US-9,732,084 Pyrrolobenzodiazepines used to treat proliferative diseases
Pyrrolobenzodiazepine dimers having a C2-C3 double bond and an aryl group at the C2 position on one monomer unit, and a C2-C3 double bond and either a...
US-9,732,083 Tricyclic gyrase inhibitors
Disclosed herein are compounds having the structure of Formula I and pharmaceutically suitable salts, esters, and prodrugs thereof that are useful as...
US-9,732,082 Purinone derivative
Compounds represented by general formula (I) (all of the symbols in the formula conform to the definitions in the Description) are compounds that, in addition...
US-9,732,081 1,6-diazabicyclo [3,2,1] octan-7-one derivatives and their use in the treatment of bacterial infections
Compounds of Formula (I), their preparation and use in preventing or treating bacterial infections are disclosed. ##STR00001##
US-9,732,079 Yellow reduced pyrroloquinoline quinone crystal and method of producing the same, and food, pharmaceutical,...
A yellow reduced pyrroloquinoline quinone crystal having a solubility in water of 0.040 to 0.20 (mg/mL).
US-9,732,078 Therapeutic use of imidazopyridine derivatives
The invention relates to the use of compounds corresponding to formula (I) in which R.sub.2 and R.sub.3 together form, with the carbon atoms of the phenyl...
US-9,732,077 Diazepane orexin receptor antagonists
The present invention is directed to diazepane compounds which are antagonists of orexin receptors. The present invention is also directed to uses of the...
US-9,732,076 Solid oral dosage formulation of HCV inhibitor in the amorphous state
Described herein are solid oral dosage forms containing Compound (1) or a pharmaceutically acceptable salt thereof (Formula 1), wherein Compound (1) is in the...
US-9,732,075 Benzimidazole-proline derivatives
The present invention relates to compounds of the formula (I) ##STR00001## wherein Ar.sup.1, R.sup.1, R.sup.2, R.sup.3, R.sup.4a, R.sup.4b and (R.sup.5).sub.n...
US-9,732,074 Methods, compounds, and compositions for the treatment of angiotensin-related diseases
Disclosed are small molecule non-peptidic compounds, as well as methods and compositions for the treatment of angiotensin-related diseases and disorders,...
US-9,732,073 Compositions and methods for inhibition of the JAK pathway
The invention encompasses compounds having formula I-V and the compositions and methods using these compounds in the treatment of conditions in which modulation...
US-9,732,072 PRMT5 inhibitors and uses thereof
Described herein are compounds of Formula (I), pharmaceutically acceptable salts thereof, and pharmaceutical compositions thereof. Compounds of the present...
US-9,732,071 Compounds useful as modulators of TRPM8
The present disclosure relates to compounds which are useful as cooling sensation compounds.
US-9,732,070 Protein kinase C inhibitors and uses thereof
This disclosure concerns compounds which are useful as inhibitors of protein kinase C (PKC) and are thus useful for treating a variety of diseases and disorders...
US-9,732,069 Carbazole compound and organic light emitting device including the same
A carbazole compound represented by Formula 1 ##STR00001## wherein, in Formula 1, X.sub.1, L.sub.1 to L.sub.5, R.sub.1 to R.sub.4, R.sub.11, R.sub.12, a1 to...
US-9,732,068 System for crystalizing chemical compounds and methodologies for utilizing the same
A system including a fluid receiver defined by a crystallization chamber, three or more fluid input conduits, wherein each fluid input conduit is configured to...
US-9,732,067 Compounds and methods for activating the apoptotic arm of the unfolded protein response
N-substituted sulfonylphenyl-5-mitrofuranyl-2-carboxamide derived compounds, which selectively activate the apoptotic, but not the adaptive arm, of the Unfolded...
US-9,732,066 Heterocyclic derivative and pharmaceutical drug
The present invention provides a novel heterocyclic derivative or a pharmaceutically acceptable salt thereof. For example, the present invention provides a...
US-9,732,065 Cyclic aminomethyl pyrimidine derivative
The present invention provides a cyclic aminomethyl pyrimidine derivative and a pharmaceutically acceptable salt thereof with high selectivity for dopamine...
US-9,732,064 5-substituted quinazolinone derivatives and compositions comprising and methods of using the same
Provided are 5-substituted quinazolinone compounds, for example, of formula (I), and pharmaceutically acceptable salts, solvates, clathrates, stereoisomers, and...
US-9,732,063 Kinase inhibitors
In compounds of formula I: ##STR00001## R.sup.1 to R.sup.5, Ar and X.sup.1 to X.sup.3 have defined meanings. The compounds have anti-inflammatory activity...
US-9,732,062 Therapeutically active compounds and their methods of use
Provided are compounds useful for treating cancer and methods of treating cancer comprising administering to a subject in need thereof a compound described herein.
US-9,732,061 Cinnoline derivatives useful as CB-1 receptor inverse agonists
The present invention is directed to cinnoline derivatives pharmaceutical compositions containing them and their use in the treatment of disorders and...
US-9,732,060 Aminotriazine derivative and pharmaceutical composition comprising the same
The present invention provides novel compounds having a P2X.sub.3 and/or P2X.sub.2/3 receptor antagonistic activity. A compound of Formula (I): ##STR00001## ...
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