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Patent # Description
US-9,738,707 Heterodimeric Fc regions, binding molecules comprising same, and methods relating thereto
The present invention features inter alia polypeptides comprising heterodimeric Fc regions. In addition, the instant invention provides methods for treating or...
US-9,738,706 Inflammatory disease diagnosis and methods of treatment using lipopolysaccharides-responsive beige-like anchor
Anti-cytokine therapy has revolutionized immunological disease treatment, but is not always effective and subject to treatment resistance as the cytokine...
US-9,738,705 Monoclonal antibodies specific for Cry1Ca and related detection methods
Described herein are murine monoclonal antibodies and methods useful for determining and quantitating the presence of Cry1Ca delta endotoxin. The claimed...
US-9,738,704 Binding molecules against Chikungunya virus and uses thereof
The invention relates to binding molecules against Chikungunya virus, which are able of neutralizing Chikungunya virus infectivity, and which can be used with...
US-9,738,703 Neutralizing antibodies to HIV-1 and their use
Monoclonal neutralizing antibodies are disclosed that specifically bind to the CD4 binding site of HIV-1 gp120. Monoclonal neutralizing antibodies also are...
US-9,738,702 Antibodies with improved half-life in ferrets
The antibodies, immunoglobulin constructs, or immunoglobulin fusion proteins whose in vivo half-life is increased in ferrets by a modified ferret IgG Fc region...
US-9,738,701 Method for selecting a single cell expressing a heterogeneous combination of antibodies
The present invention provides combinations of specific binding proteins, such as immunoglobulins, that are designed to be true combinations, essentially all...
US-9,738,700 ZCYTOR17 heterodimeric cytokine receptor
Novel polypeptide combinations, polynucleotides encoding the polypeptides, and related compositions and methods are disclosed for zcytor17-containing multimeric...
US-9,738,699 Recombinant fusion proteins and libraries from immune cell repertoires
Disclosed herein are methods and compositions for generating a repertoire of recombinant fusion polypeptides from immune cells, and uses thereof.
US-9,738,698 Peptide analogs of alpha-melanocyte stimulating hormone
Provided herein are stable peptide analogs of the native alpha-melanocyte stimulating hormone (.alpha.-MSH) having selectivity for the melanocortin 1 receptor...
US-9,738,697 Alpha/beta-polypeptide analogs of glucagon-like peptide-1
Described herein are peptide analogs of glucagon-like peptide 1 (GLP-1) that retain agonist activity, but are more resistant to proteolytic degradation than...
US-9,738,696 Superkines and synthekines: repurposed cytokines with new and enhanced signaling activities
Disclosed herein are IL-4 cytokine compositions with enhanced biological activity having increased selectivity for IL-4 cytokine receptors, and methods for...
US-9,738,695 Compositions and methods of using islet neogenesis peptides and analogs thereof
The invention provides peptides and analogs of INGAP and HIP peptides. The peptides and analogs can be used in methods for treating various diseases and...
US-9,738,694 Gene of porcine alpha-s1 casein, a promoter of the same and use thereof
The present invention relates to a porcine alpha-S1-casein gene, a porcine alpha-S1-casein gene promoter, an expression comprising the same promoter, and a...
US-9,738,693 Nucleic acids and proteins from streptococcus groups A and B
The invention provides proteins from group B streptococcus (Streptococcus agalactiae) and group A streptococcus (Streptococcus pyogenes), including amino acid...
US-9,738,692 Process for production of recombinant proteins as a soluble form
A target protein is prepared as soluble protein using a recombinant protein expression system. An expression vector is used that includes (1) an...
US-9,738,691 Truncated L1 protein of human papillomavirus type 58
Provided are an N-terminal truncated L1 protein of the Human Papillomavirus Type 58, a coding sequence and preparation method thereof, and a virus-like particle...
US-9,738,690 Polyoma virus JC peptides and proteins in vaccination and diagnostic applications
The present invention relates to the field of vaccination or immunization, in particular therapeutic vaccination, and diagnosis. Pharmaceutical compositions and...
US-9,738,689 Prefusion RSV F proteins and their use
Disclosed are immunogens including a recombinant RSV F protein stabilized in a prefusion conformation. Also disclosed are nucleic acids encoding the immunogens...
US-9,738,688 HIV-1 envelope glycoprotein
The present application relates to novel HIV-1 envelope glycoproteins, which may be utilized as HIV-1 vaccine immunogens, and antigens for crystallization,...
US-9,738,687 Polypeptide-based shuttle agents for improving the transduction efficiency of polypeptide cargos to the cytosol...
The present description relates to synthetic peptides useful for increasing the transduction efficiency of polypeptide cargos to the cytosol of target...
US-9,738,686 Electron spin labeled ice binding compounds used for carrying paramagnetic centers for dynamic nuclear polarization
Spin labeled ice binding compounds (IBCs) including ice binding proteins (IBPs), also called antifreeze proteins (AFPs) and their analogs are exploited to carry...
US-9,738,685 Use of ruthenium complexes for preparing amides, polypeptides and cyclic dipeptides
A process for preparing amides by reacting a primary amine and a primary alcohol in the presence of a Ruthenium complex to generate the amide and molecular...
US-9,738,684 N-terminally modified linear and branched polyamine conjugated peptidomimetics as antimicrobials agents
N-terminally modified linear and branched polyamine conjugated peptidomimetics as antimicrobials agents. The invention relates to therapeutically viable...
US-9,738,683 Enhanced functionality and delivery of a protein from a porous substrate
Compositions, methods, articles of manufacture, and kits are provided for storage and delivery of proteins.
US-9,738,682 Compounds with a combined antioxidant activity against free radicals together with an anti-inflammatory action,...
The invention relates to 2,4,6-octatrienoic acid derivative compounds having general formula (I) (CH.sub.3--CH.dbd.CH--CH.dbd.CH--CH.dbd.CH--CO--O--).sub.n--R...
US-9,738,681 Intermediate for production of nucleoside analog and method for producing the same
A compound represented by the general formula (III) which serves as an intermediate of an oligonucleotide analog having stable and excellent antisense or...
US-9,738,680 5' triphosphate oligonucleotide with blunt end and uses thereof
The present invention provides an oligonucleotide which is capable of activating RIG-I and inducing an anti-viral, in particular, an IFN, response in cells...
US-9,738,679 Methods of synthesizing substituted purine compounds
The present invention provides an efficient process for the synthesis of (2R,3R,4S,5R)-2-(6-amino-9H-purin-9-yl)-5-((((1r,3S)-3-(2-(5-(tert-butyl)- ...
US-9,738,678 Substituted nucleoside derivatives with antiviral and antimicrobial properties
The present invention relates to fatty acid and fatty alcohol substituted nucleoside derivatives and nucleoside and nucleoside derivatives substituted on...
US-9,738,677 Amphotericin B derivative with reduced toxicity
Disclosed is a derivative of amphotericin B (AmB), denoted C2'epiAmB, with an improved therapeutic index over amphotericin B, pharmaceutical compositions...
US-9,738,676 Selected macrolides with PDE4-inhibiting activity
The application relates to the macrolide compound of the formula (I): wherein * indicates a stereocentre which is in (R) or (S) configuration, or a...
US-9,738,675 Water-soluble photochromic compound
A diarylethene compound represented by formula (I) ##STR00001## wherein, Sg is a monovalent sugar residue formed by removing one hydroxyl group from a sugar...
US-9,738,674 Process for producing a particulate composition comprising crystalline trehalose dihydrate
A process for enabling the production of a particulate composition containing crystalline trehalose dihydrate is provided. Including allowing an...
US-9,738,673 Ferrocene derivative, preparation method and use thereof
The present invention relates to the ferrocene derivative represented by formula (IA) or formula (IB), or to the pharmaceutically acceptable salt or solvate...
US-9,738,672 Compounds, compositions, and methods for the treatment of cancers
The present teachings relate to compounds and compositions for treatment of cancers. In some embodiments, the composition comprises a platinum (IV) complex...
US-9,738,671 Cyclic bent allene metal complexes
The present invention provides stable, cyclic bent allene metal complexes and methods of conducting chemical processes, preferably olefin hydrogenation,...
US-9,738,670 Pentaaza macrocyclic ring complexes possessing oral bioavailability
Aspects of the present disclosure relate to compounds which have enhanced oral bioavailability. A transition metal complex includes a transition metal...
US-9,738,669 Pentaaza macrocyclic ring complexes possessing oral bioavailability
Aspects of the present disclosure relate to compounds which have enhanced oral bioavailability. A transition metal complex includes a transition metal...
US-9,738,668 Phosphonate derivatives and methods of use thereof in the treatment of Alzheimer's disease
Benzothiazole phosphonate analogs and methods of using the same to inhibit the activity of Amyloid Binding Alcohol Dehydrogenase and in the amelioration or...
US-9,738,667 Phosphorus-containing compound and curing epoxy resin composition containing same
Provided is a novel phosphorus-containing compound represented by general formula (I). The compound has reactivity with a glycidyl group and is therefore...
US-9,738,666 Electrolyte salt and electrolyte for electricity storage device, and electricity storage device
Provided is an electrolyte salt comprising a quaternary ammonium cation indicated by formula (1) and a trimethylsilyl alkanesulfonate anion indicated by formula...
US-9,738,665 Metallated metal-organic frameworks
Porous metal-organic frameworks (MOFs) and metallated porous MOFs are provided. Also provided are methods of metallating porous MOFs using atomic layer...
US-9,738,664 Boronic acid inhibitors of HIV protease
Protease inhibitors, particularly aspartyl protease inhibitors, and more particularly HIV protease inhibitors which are boronated to enhance activity or to...
US-9,738,663 Process for the preparation of aminoaryl- and aminoheteroaryl boronic acids and esters
The present invention relates to a process for the preparation of aminoaryl- and aminoheteroaryl boronic acids and esters thereof of formula (I) in high yield....
US-9,738,662 Process for producing tetrakis(.sup.F aryl)borate salts
This invention provides processes for forming halomagnesium tetrakis(.sup.Faryl)borates, which processes comprise bringing together, in an anhydrous liquid...
US-9,738,661 HCV NS3 protease inhibitors
The present invention relates to macrocyclic compounds of formula (I) that are useful as inhibitors of the hepatitis C virus (HCV) NS3 protease, their...
US-9,738,660 Selective inhibitors for protein kinases and pharmaceutical composition and use thereof
The present invention provides a compound of formula (I) or the salt thereof: ##STR00001## wherein R is at least one selected from the group consisting of...
US-9,738,659 Compositions of protein receptor tyrosine kinase inhibitors
The present invention relates to novel synthetic substituted heterocyclic compounds and pharmaceutical compositions containing the same that are capable of...
US-9,738,658 Compounds as diacylglycerol acyltransferase inhibitors
This invention relates to novel compounds which are inhibitors of acyl coenzyme A: diacylglycerol acyltransferase 1 (DGAT-1), to pharmaceutical compositions...
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