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Patent # Description
US-9,738,657 Highly efficient polarizing agents for dynamic nuclear polarization
The invention relates to compounds of general formula (I) wherein X is C.dbd.O or SO.sub.2, M is NR.sup.2 or O, and Q.sup.1 and Q.sup.2 are nitroxide-containing...
US-9,738,656 Pyranodipyridine compound
Compounds represented by formulae (I) to (XXII) or pharmaceutically acceptable salts thereof: ##STR00001## ##STR00002## ##STR00003## ##STR00004## ##STR00005##
US-9,738,655 Tetrahydroisoquinolines containing substituted azoles as factor XIa inhibitors
The present invention provides compounds of Formula (I): ##STR00001## or stereoisomers, tautomers, or pharmaceutically acceptable salts thereof, wherein all...
US-9,738,654 Method for producing nitrogen-containing heterocyclic N-oxide compound
The problem of the present invention is to provide a production method for safely synthesizing a nitrogen-containing heterocyclic N-oxide compound in high...
US-9,738,653 Fused furans for the treatment of hepatitis C
The disclosure provides compounds of formula I or II, including their salts, as well as compositions and methods of using the compounds. The compounds have...
US-9,738,652 Spiro urea compounds as RSV antiviral compounds
The invention concerns novel substituted spiro urea azetidinyl or piperidinyl compounds of formula (I) having antiviral activity, in particular, having an...
US-9,738,651 CARM1 inhibitors and uses thereof
Provided herein are compounds of Formula (I) and pharmaceutically acceptable salts thereof, and pharmaceutical compositions thereof; wherein X, R.sup.1,...
US-9,738,650 Spiro-lactam NMDA receptor modulators and uses thereof
Disclosed are compounds having enhanced potency in the modulation of NMDA receptor activity. Such compounds are contemplated for use in the treatment of...
US-9,738,649 Tetrahydro-pyrimidoazepines as modulators of TRPV1
Certain tetrahydro-pyrimidoazepine compounds are described, which are useful as TRPV1 modulators. Such compounds may be used in pharmaceutical compositions and...
US-9,738,648 Pyridines, pyrimidines, and pyrazines, as BTK inhibitors and uses thereof
The present invention relates to pyridine, pyrimidine, and pyrazine compounds, and pharmaceutically acceptable compositions thereof, useful as BTK inhibitors.
US-9,738,647 Methods for the synthesis of polycyclic guanidine compounds
The present invention provides methods for the synthesis of polycyclic guanidine compounds. In certain embodiments, provided methods include the step of...
US-9,738,646 Solid forms of a toll-like receptor modulator
The present invention provides crystalline forms, solvates and hydrates of 4-amino-2-butoxy-8-(3-(pyrrolidin-1-ylmethyl)benzyl)-7,8-dihydropterid- in-6(5H)-one,...
US-9,738,644 Chemical compounds, compositions and methods for kinase modulation
Substituted isoquinolinone compounds and pharmaceutical compositions that modulate kinase activity, including PI3 kinase activity, and compounds, pharmaceutical...
US-9,738,643 Substituted indazoles for targeting Hsp90
Described herein are substituted indazoles that may selectively bind to Hsp90, methods of using the compounds, and kits including the compounds. The compounds...
US-9,738,642 Triazolopyridine ether derivatives and their use in neurological and pyschiatric disorders
The disclosure generally relates to compounds of formula I, including their salts, as well as compositions and methods of using the compounds. The compounds...
US-9,738,641 Bicyclic inhibitors
The present invention provides compounds of formula (I): compositions comprising such compounds; the use of such compounds in therapy (for example in the...
US-9,738,640 Substituted benzamide derivatives as in vitro MAO-B inhibitors
The invention relates to the use of substituted benzamide derivatives of Formula I: Wherein: A.sup.1 and A.sup.2 are --N or --CH, so that if A.sup.1 is --N,...
US-9,738,639 Pyrroloquinoline quinone lithium salt crystal and preparation method and application thereof
The present invention provides pyrroloquinoline quinone lithium salt crystal and a preparation method and application thereof. Characteristic absorption peaks...
US-9,738,638 2-(1H-indazol-3-yl)-3H-imidazo[4,5-B]pyridine and therapeutic uses thereof
Indazole compounds for treating various diseases and pathologies are disclosed. More particularly, the present invention concerns the use of an indazole...
US-9,738,637 Histone demethylase inhibitors
The present invention relates generally to compositions and methods for treating cancer and neoplastic disease. Provided herein are substituted pyrrolopyridine...
US-9,738,636 Fused heterocyclic compounds as selective BMP inhibitors
The present invention provides small molecule inhibitors of BMP signaling. These compounds may be used to modulate cell growth, differentiation, proliferation,...
US-9,738,635 Heteroaryl amides as inhibitors of protein aggregation
The present invention relates to certain heteroaryl amide compounds, pharmaceutical compositions containing them, and methods of using them, including methods...
US-9,738,634 Heterocyclic amide compound and herbicide
Provided are: a heterocyclic amide compound represented by formula (1); and a herbicide containing the heterocyclic amide compound. In the formula, G represents...
US-9,738,633 Cognition enhancing compounds and compositions, methods of making, and methods of treating
The invention relates generally to muscarinic agonists, which are useful for stimulating muscarine receptors, and treating cognitive disorders. Included among...
US-9,738,632 Phenyl and benzodioxinyl substituted indazoles derivatives
A compound of formula Ia: ##STR00001## The present invention relates to novel indazolyl derivatives, to pharmaceutical compositions comprising such...
US-9,738,631 Compositions and methods for the treatment of neurological disorders
The invention relates to the compounds of formula I and formula IA or its pharmaceutical acceptable salts, as well as polymorphs, solvates, enantiomers,...
US-9,738,630 Inhibitors of lysine methyl transferase
There are disclosed compounds that are inhibitors of EZH2, pharmaceutical compositions containing said compounds and methods of treating hyperproliferative,...
US-9,738,629 Bridged ring compounds as Hepatitis C virus inhibitors, pharmaceutical compositions and uses thereof
Provided herein is a bridged bring compound of formula (I) or a stereoisomer, a tautomer, an N-oxide, a hydrate, a solvate, a metabolite, a pharmaceutically...
US-9,738,628 Substituted 1H-indazol-1-OL analogs as inhibitors of beta catenin/Tcf protein-protein interactions
In one aspect, the invention relates to substituted 1H-benzo[d][1,2,3]triazol-1-ol analgoues, derivatives thereof, and related compound; synthetic methods for...
US-9,738,627 Method for synthesizing 2,6-bis[3'-(N-carbazolyl)phenyl]pyridine compound
The present invention relates to "a method for synthesizing 2,6-bis[3'-(N-carbazolyl)phenyl]pyridine compound", and belongs to the field of chemical synthesis....
US-9,738,626 Antagonists of prostaglandin EP3 receptor
Provided herein are antagonists of prostaglandin EP3 receptor, processes to make said antagonists, and methods comprising administering said antagonists to a...
US-9,738,625 Therapeutically active compounds and their methods of use
Provided are isocitrate dehydrogenase 2 (IDH2) inhibitor compounds useful for treating cancer and methods of treating cancer, comprising administering to a...
US-9,738,624 Nuclear transport modulators and uses thereof
The present invention relates to compounds of formula (I): and pharmaceutically acceptable salts thereof, pharmaceutical compositions comprising the compounds...
US-9,738,623 Curcumin analogs
Provided herein are curcumin analogues that are able to interact with amyloid .beta. (A.beta.) and to attenuate the copper-induced crosslinking of A.beta.. Also...
US-9,738,622 Nicotine salts, co-crystals, and salt co-crystal complexes
The invention provides certain nicotine salts, co-crystals, and salt co-crystals and provides novel polymorphic forms of certain nicotine salts. In particular,...
US-9,738,621 Multifunctional materials and composites
Forming multifunctional materials and composites thereof includes contacting a first material having a plurality of oxygen-containing functional groups with a...
US-9,738,620 Trientine prodrugs, pharmaceutical compositions thereof, and methods of use
Trientine prodrugs, pharmaceutical compositions comprising the trientine prodrugs, and methods of using trientine prodrugs and pharmaceutical compositions...
US-9,738,619 2,5-furan dicarboxylic acid production method
The present invention relates to a process for producing 2,5-furan dicarboxylic acid by subjecting 5-hydroxymethylfurfural to oxidation reaction in the presence...
US-9,738,618 Malienated derivatives
This invention relates to malienated derivatives made from maleic anhydride, functionalized monomers, and one or more additional reagents, e.g., an...
US-9,738,617 Methods for producing fuels, gasoline additives, and lubricants
The present disclosure generally relates to the production of fuels, gasoline additives, and/or lubricants, and precursors thereof. The compounds used to...
US-9,738,616 Process for preparing propylene oxide
A continuous process for the preparation of propylene oxide, comprising (i) providing a liquid feed stream comprising propene, hydrogen peroxide, acetonitrile,...
US-9,738,614 Malignant and non-malignant disease treatment with Ras antagonists
The present disclosure describes new inhibitors or antagonists of Ras useful for the treatment of conditions resulting from Ras-induced or mediated cellular...
US-9,738,613 Substituted 1,2,3-triazoles as antitumor agents
Compounds represented by Formula I: ##STR00001## and/or a pharmaceutically acceptable salts, a prodrug, a solvate and a combination thereof, a pharmaceutical...
US-9,738,612 Methylacryloyl benzimidazolone derivative and anti-tumour use thereof
Disclosed are a use of a methylacryloyl benzimidazolone derivative, an optical isomer or a pharmaceutically acceptable salt or prodrug thereof in the...
US-9,738,611 Dithiolene metal complex colorless IR absorbers
The invention relates to the use of compounds of formulae (I) and/or (II) as colorless IR absorbers wherein M is Ni, Pd, Pt, Au, Ir, Fe, Zn, W, Cu, Mo, In, Mn,...
US-9,738,610 Indazole derivatives and uses thereof
The present invention provides novel compounds (e.g., compounds of Formula (I)), and pharmaceutically acceptable salts, solvates, hydrates, polymorphs,...
US-9,738,609 Electrically conducting oligo(pyrazoles)
An electrically conducting organic oligomer comprising 3-amino-1H-pyrazole-4-carbonitrile, 3-amino-1H-pyrazole-4-carboxylic acid, 3-amino-4-nitro-1H-pyrazole,...
US-9,738,608 Synthesis of lactam based ionic liquid
Lactamium based ionic liquids are described. They comprise at least one of: the reaction product of a lactam compound having a formula (IV) ##STR00001## ...
US-9,738,607 Scalable process for the preparation of Sorafenib tosylate ethanol solvate and Sorafenib tosylate form III
The present invention refers to an improved process for the preparation of Sorafenib tosylate ethanol solvate and Sorafenib tosylate form III.
US-9,738,606 Substituted diarylamines and use of same as antioxidants
A compound of Formula I, Formula IA, Formula IB, or Formula II, or an acid or base addition salt thereof, and use of these compounds as antioxidants. In one...
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