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Patent # Description
US-9,737,544 Compounds
The invention relates to new pyridopyrazine and naphthyridine derivative compounds, to pharmaceutical compositions comprising said compounds, to processes for...
US-9,737,543 Treatment of erectile dysfunction and other indications
The present invention generally relates to the transdermal delivery of various compounds. In some aspects, transdermal delivery may be facilitated by the use of...
US-9,737,542 Pyrrolotriazine kinase inhibitors
The present disclosure is generally directed to compounds which can inhibit AAK1 (adaptor associated kinase 1), compositions comprising such compounds, and...
US-9,737,541 Substituted aminopurine compounds, compositions thereof, and methods of treatment therewith
Provided herein are Aminopurine Compounds having the following structures: ##STR00001## wherein R.sup.1, R.sup.2, and R.sup.3 are as defined herein,...
US-9,737,540 Combination treatment of cancer
The present invention relates to a combination comprising AZD5363, or a pharmaceutically acceptable salt thereof, and at least one androgen receptor signalling...
US-9,737,539 Salt of fused heterocyclic derivative and crystal thereof
The present invention provides 3-[2-fluoro-5-(2,3-difluoro-6-methoxybenzyloxy)-4-methoxyphenyl]-2,4-diox- ...
US-9,737,538 Solid dispersions of low-water solubility actives
Disclosed are compositions including a solid dispersion comprising a dispersion polymer, a basic low-water solubility active, and an anionic counterion, as well...
US-9,737,537 Heterocyclic receptor agonists for the treatment of diabetes and metabolic disorders
Compounds and methods are provided for the treatment of, inter alia, Type II diabetes and other diseases associated with poor glycemic control. The compounds of...
US-9,737,536 Pyrimidinyl-diazospiro compounds
The invention relates to spiro derivatives, to the use of said derivatives intreating diseases and conditions mediated by modulation of voltage-gated sodium...
US-9,737,535 Methods for treating cancer using TOR kinase inhibitor combination therapy comprising administering substituted...
Provided herein are methods for treating or preventing a cancer, comprising administering an effective amount of a TOR kinase inhibitor and an effective amount...
US-9,737,534 Oxazoline and isoxazoline derivatives as CRAC modulators
The present invention relates to compounds of Formula (I), ##STR00001## along with processes for their preparation that are useful for treating, preventing...
US-9,737,533 1,2,4-triazolo [4,3-A] pyridine derivatives and their use for the treatment of prevention of neurological and...
The present invention relates to methods of treating various central nervous system disorders using novel triazolo[4,3-a]pyridine derivatives of Formula (I) ...
US-9,737,532 Method of treating ischemia/reperfusion injury
An agent for treating ischemia/reperfusion injury, including a therapeutically effective amount of a p53 agonist compound including a cis-imidazoline structure.
US-9,737,531 Composition and method for treatment of depression and psychosis in humans
Compositions and methods tor the treatment of depression and psychoses in humans are disclosed. More particularly, the invention is directed to formulations...
US-9,737,530 Process of making stable abuse-deterrent oral formulations
The present disclosure relates to cured pharmaceutical compositions designed to reduce the potential for improper administration of drugs that are subject to...
US-9,737,529 Pharmaceutical formulation containing opioid agonist, opioid antagonist and irritant agent
Disclosed in certain embodiments is an oral dosage form comprising: a therapeutically effective amount of an opioid analgesic; an opioid antagonist; and an...
US-9,737,528 Liposomes useful for drug delivery to the brain
The present invention provides liposome compositions containing substituted ammonium and/or polyanion, and optionally with a desired therapeutic or imaging...
US-9,737,527 Biopolymer drug loading method
A method of producing a drug-loaded Poly (Glycerol Sebacate) (PGS) comprising providing PGS; dissolving at least one drug in a solvent; incubating the PGS in...
US-9,737,525 Small molecule activators of NRF2 pathway
This disclosure relates to compounds that act as activators of the NRF2/KEAP1/ARE pathway. Specifically, the compounds provided herein can act as high affinity...
US-9,737,524 Prophylactic and/or therapeutic agent for mild cognitive impairment
Provided is a prophylactic and/or therapeutic drug for mild cognitive impairment, which can improve interstitial flow in cerebral blood vessel and the like to...
US-9,737,523 Anti-fibrogenic compounds, methods and uses thereof
Presented herein are methods for treatment of diseases or conditions related to fibrosis. Compounds, or pharmaceutically acceptable salts thereof or...
US-9,737,522 NMDA receptor modulators and uses related thereto
This disclosure relates to NMDA modulators and used related thereto such as for treatment of central nervous system disorders. In certain embodiments, compounds...
US-9,737,521 Pharmaceutical compositions containing a PDE4 inhibitor and a PI3 delta or dual PI3 delta-gamma kinase inhibitor
This present invention relates to a method of treating a autoimmune, respiratory and/or inflammatory disease or condition (e.g., psoriasis, rheumatoid...
US-9,737,520 Aclidinium for use in improving the quality of sleep in respiratory patients
The present disclosure provides aclidinium or any of its stereoisomers or mixture of stereoisomers, or a pharmaceutically acceptable salt or solvate thereof,...
US-9,737,519 Compositions and methods for enhancing brain function
Compositions and methods are provided that enhance cognition in a human to which the composition is orally administered. Remarkably, clinical studies have...
US-9,737,518 Tiotropium dry powders
The present invention relates to respirable dry powder comprising respirable dry particles that comprise sodium chloride, leucine, and tiotropium bromide,...
US-9,737,517 Pharmaceutical use of hexahydro-dibenzo[a,g]quinolizine compounds
Use of hexahydro-dibenzo[a,g]quinolizine compounds as shown in formula(I) in preparing a medicine for treating and/or preventing benign prostate hyperplasia...
US-9,737,516 Bicyclic heterocycles as bet protein inhibitors
The present invention relates to bicyclic heterocycles which are inhibitors of BET proteins such as BRD2, BRD3, BRD4, and BRD-t and are useful in the treatment...
US-9,737,515 Compositions and methods for inhibiting tumor growth
The present invention relates to compositions and methods for preventing and treating cell proliferation in cancer. More specifically, the present invention...
US-9,737,514 Methods and compositions for the treatment of proliferative vascular disorders
The technology described herein is directed to methods and compositions for the treatment of proliferative vascular disorders, e.g. hemangioma. In some aspects,...
US-9,737,513 Methods for dosing an orally active 1,2,4-oxadiazole for nonsense mutation suppression therapy
The present invention relates to specific doses of and dosing regimens for using a 1,2,4-oxadiazole benzoic acid compound in treating or preventing diseases...
US-9,737,512 Methods and compositions for treating chronic pain
Certain embodiments are directed to methods of treating pain, e.g., chronic or neuropathic pain, comprising administering an effective amount of an EPAC inhibitor.
US-9,737,511 Method of treating or preventing pathologic effects of acute increases in hyperglycemia and/or acute increases...
One aspect of the present invention relates to a method of treating or preventing pathologic effects of hyperglycemia and/or increased fatty acid flux in a...
US-9,737,510 Indazole compounds and a process for the preparation thereof
The patent discloses novel indazole compounds of general formula 1 and analogues thereof, use thereof for the treatment of diabetes, diabetic complications,...
US-9,737,509 Antimicrobial compositions, methods of use, and methods of treatment of infections
The present disclosure provides compositions including a compound (e.g., compounds A-D), pharmaceutical compositions including the compound, methods of...
US-9,737,508 Use of NK-1 receptor antagonists in pruritus
The invention relates to methods for treating pruritus with NK-1 receptor antagonists such as serlopitant. The invention further relates to pharmaceutical...
US-9,737,507 Use of NK-1 receptor antagonist serlopitant in pruritus
The invention relates to methods for treating pruritus with NK-1 receptor antagonists such as serlopitant. The invention further relates to pharmaceutical...
US-9,737,506 1-aryl-3-azabicyclo[3.1.0]hexanes: preparation and use to treat neuropsychiatric disorders
The invention provides novel, multiply-substituted 1-aryl-3-azabicyclo[3.1.0]hexanes, and related processes and intermediates for preparing these compounds, as...
US-9,737,505 Prodrug of 1,1'-(1,6-dioxo-1,6-hexanediyl)bis-D-proline
The compound (2R,2'R)-bis(((((tetrahydro-2H-pyran-4-yl)oxy)carbonyl)oxy)methyl) 1,1'-adipoylbis(pyrrolidine-2-carboxylate) possesses physicochemical ...
US-9,737,504 Dihydroorotic and acid dehydrogenase inhibitor
The present invention provides a novel dihydroorotic acid dehydrogenase inhibitor which is applicable to various diseases. When used as an active ingredient, a...
US-9,737,503 Short acting phenylalkylamine calcium channel blockers and uses thereof
The present invention relates to the use of a pharmaceutically effective amount of an short-acting calcium channel blocking compound to treat ischemic heart...
US-9,737,502 Calebin A for hepatic steatosis
The present invention discloses the potential of Calebin A in attenuating high fat diet (HFD) induced hepatic steatosis in mammals.
US-9,737,501 Compositions, method, and kits for treating pulmonary conditions
Compositions, methods, and kits useful for treating pulmonary conditions are provided herein. Such compositions can contain synergizing amounts of a...
US-9,737,500 Compositions and methods for treating severe pain
The present specification discloses pharmaceutical compositions, methods of preparing such pharmaceutical compositions, and methods and uses of treating a...
US-9,737,499 Methods of modulation of branched chain acids and uses thereof
A method of modulating plasma levels of branched chain amino acids and branched chain alpha-keto acids is disclosed, wherein an ammonia scavenger compound or a...
US-9,737,498 Method for treating an inflammation or lesion caused by a virus
A method for treating an inflammation or lesion caused by herpes virus, comprising topically applying to said inflammation or lesion a composition comprising or...
US-9,737,497 Electrostatically charged nasal application method and product for micro-filtration
A method of microfiltration of inhaled air for nasal application and product for reducing the risk of inhalation of fine and ultra-fine (i.e., microscopic and...
US-9,737,496 Alkoxy compounds for disease treatment
The present invention relates generally to compositions and methods for treating neurodegenerative diseases and disorders, particularly ophthalmic diseases and...
US-9,737,495 Process for obtaining purified pterostilbene and methods of use thereof
The present invention relates to a process of extraction and purification of a stilbenoid, pterostilbene, from botanical sources. The process involves obtaining...
US-9,737,494 Method of regulating circadian rhythm, and method of preparing circadian rhythm regulatory agent
Disclosed are a method of preparation and method of application of a circadian rhythm regulatory agent having as an active ingredient an alkylresorcinol...
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