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Patent # Description
US-9,758,523 Triazolopyridines and triazolopyrazines as LSD1 inhibitors
The present invention is directed to [1,2,4]triazolo[4,3-a]pyridine and [1,2,4]triazolo[4,3-a]pyrazine derivatives which are LSD1 inhibitors useful in the...
US-9,758,522 Hydrophobically tagged small molecules as inducers of protein degradation
Provided are bifunctional small molecules of Formula (I): or pharmaceutically acceptable salts thereof, wherein M represents a small organic molecule which...
US-9,758,521 Kinase inhibitors
Compounds of formulae (I), (II), and (III), defined herein, are p38 MAPK inhibitors and are useful as anti-inflammatory agents in the treatment of, inter alia,...
US-9,758,520 Substituted fused heterocycles as GPR119 modulators for the treatment of diabetes, obesity, dyslipidemia and...
The present invention relates to substituted fused heterocyclic compounds. The substituted fused heterocyclic compounds are GPR119 modulators and useful for the...
US-9,758,518 Compositions, uses and methods for making them
Generally, the present invention provides novel quinoline compounds and pharmaceutical composition thereof which may inhibit cell proliferation and/or induce...
US-9,758,517 Histone demethylase inhibitors
The present invention relates generally to compositions and methods for treating cancer and neoplastic disease. Provided herein are substituted pyrrolopyridine...
US-9,758,516 Crystalline form of an anxiolytic compound
A crystalline Form B of compound 1 can be used in pharmaceutically compositions. The pharmaceutical compositions can be used in methods of treating a disease...
US-9,758,515 Substituted polycyclic carbamoyl pyridone derivative prodrug
The present invention provides a compound having antiviral effects, particularly having growth inhibitory activity on influenza viruses, a preferred example of...
US-9,758,514 Modulators of calcium release-activated calcium channel
Disclosed are novel calcium release-activated calcium (CRAC) channel inhibitors, methods for preparing them, pharmaceutical compositions containing them, and...
US-9,758,512 Substituted anilines as CCR(4) antagonists
Aniline compounds are provided which bind to CCR(4) and are useful for the treatment of diseases such as allergic diseases, autoimmune diseases, graft rejection...
US-9,758,511 NAMPT inhibitors
Disclosed are compounds which inhibit the activity of NAMPT, compositions containing the compounds and methods of treating diseases during which NAMPT is...
US-9,758,510 Modulators of ATP-binding cassette transporters
Compounds of the present invention and pharmaceutically acceptable compositions thereof, are useful as modulators of ATP-Binding Cassette ("ABC") transporters...
US-9,758,509 Substituted 3-(5-membered unsaturated heterocyclyl-1, 3-dihydro-indol-2-one's and derivatives thereof as kinase...
The present invention relates to organic molecules capable of modulating tyrosine kinase signal transduction in order to regulate, modulate and/or inhibit...
US-9,758,508 2,3-dihydro-isoindole-1-on derivative as BTK kinase suppressant, and pharmaceutical composition including same
The present invention provides a compound selected from the group consisting of a compound of formula (I), pharmaceutically acceptable salts, esters, prodrugs,...
US-9,758,507 Chiral synthesis of pyrrolidine core compounds en route to neuronal nitric oxide synthase inhibitors
A chiral synthesis of pyrrolidine compounds en route to selective neuronal nitric oxide synthase inhibitors, and representative inhibitor compounds heretofore...
US-9,758,506 Muscarinic agonists
This invention relates to compounds that are agonists of the muscarinic M.sub.1 receptor and/or M.sub.4 receptor and which are useful in the treatment of...
US-9,758,505 3-(indol-3-yl)-pyridine derivatives, pharmaceutical compositions and methods for use
The present invention relates to compound of Formula I ##STR00001## or pharmaceutically acceptable enantiomers, salts or solvates thereof. The invention...
US-9,758,504 Method for producing 2,3,5-trimethyl benzoquinone by oxidation of 2,3,6-trimethylphenol
The invention relates to a method for producing 2,3,5-trimethyl benzoquinone or a compound containing 2,3,5-trimethyl benzoquinone, the method comprising the...
US-9,758,503 Coumarin-gossypol derivatives with antitumor activities and a method of preparing the same
A compound with antitumor activities is represented by formula A ##STR00001## or formula B ##STR00002## R.sub.1, R.sub.2, R.sub.3, and R.sub.4 are...
US-9,758,502 Dihydropyrone compounds and herbicides comprising the same
The present invention provides a compound having an excellent efficacy for controlling weeds. A dihydropyrone compound of formula (I): wherein m is 1, 2 or 3; n...
US-9,758,501 Fluorophore 3-hydroxyflavone
The present invention discloses the syntheses of new 3-hydroxyflavone salts with defined structures, which are suitable for sensor applications for sensing...
US-9,758,500 Process for the preparation of (3E, 7E)-homofarnesol
The present invention relates to new types of processes for the improved preparation of homofarnesol, in particular of (3E,7E)-homofarnesol and homofarnesol...
US-9,758,499 Stereo controlled synthesis of (E,Z)-dienals via tandem Rh(I) catalyzed propargyl claisen rearrangement
A novel Rh(I)-catalyzed approach to synthesizing functionalized (E,Z) dienal compounds has been developed via tandem transformation where a stereoselective...
US-9,758,498 Carrier treatment to improve catalytic performance of an ethylene oxide catalyst
A method for lowering the sodium content of different carriers which may have different physical properties as well as varying degrees of sodium is provided....
US-9,758,497 Antibacterial compounds
The present invention relates to the following compounds for use in the treatment of a bacterial infection ##STR00001## wherein the integers are as defined in...
US-9,758,496 Method of using a cyclic carbodiimide
A method of sealing an end of a polymer with a carbodiimide compound without liberating an isocyanate compound. A compound including a cyclic structure having...
US-9,758,495 Heteroaryl acid morpholinone compounds as MDM2 inhibitors for the treatment of cancer
The present invention provides MDM2 inhibitor compounds of Formula (I), or the pharmaceutically acceptable salts thereof, wherein the variables are defined...
US-9,758,494 N-(oxazol-2-yl)-aryl-carboxylic acid amides and use thereof as herbicides
N-(Oxazol-2-yl)-aryl-carboxylic acid amides and use thereof as herbicides N-(Isoxazol-3-yl)arylcarboxamides and their use as herbicides are described. ...
US-9,758,493 Phosphoric acid loaded covalent organic framework and a process for the preparation thereof
The present invention is directed to a process for the preparation of phosphoric acid loaded covalent organic framework (PA@Tp-Azo and PA@Tp-Stb) with high...
US-9,758,492 IDO inhibitors
There are disclosed compounds that modulate or inhibit the enzymatic activity of indoleamine 2,3-dioxygenase (IDO), pharmaceutical compositions containing said...
US-9,758,491 Molecules having pesticidal utility, and intermediates, compositions, and processes, related thereto
This disclosure relates to the field of molecules having pesticidal utility against pests in Phyla Arthropoda, Mollusca, and Nematoda, processes to produce such...
US-9,758,490 Antifungal compounds of (arylalkyl) azole derivatives in the structure of oxime ester
This invention is related to the antifungal compounds having azole structure in Formula (1), and hydrates, solvates, pharmaceutically acceptable salts or...
US-9,758,489 Azepane derivatives and methods of treating hepatitis B infections
Provided herein are compounds useful for the treatment of HBV infection in a subject in need thereof, pharmaceutical compositions thereof, and methods of...
US-9,758,488 Method for preparing phenyloxymethyl-nitro-imidazole derivatives and use of same
Fexinidazole is prepared according to a method which comprises the following steps: a) reacting 1-methyl-2-hydroxymethyl-5-nitro-imidazole with methanesulfonyl...
US-9,758,487 Hepatitis C virus inhibitors
The present disclosure relates to compounds, compositions and methods for the treatment of hepatitis C virus (HCV) infection. Also disclosed are pharmaceutical...
US-9,758,486 Edaravone-gossypol derivatives with antitumor activities and a method of preparing the same
A compound with antitumor activities represented by formula I: ##STR00001## In formula I, R.sub.1 is alkyl, alkoxy, or ethenyl; and R.sub.2 is alkyl, alkoxy,...
US-9,758,485 Compounds for controlling arthropods
The invention relates inter alia to compounds of the general formula (I) ##STR00001## in which the A.sub.1-A.sub.4, T, n, W, Q, R.sup.1 and B.sub.1-B.sub.4...
US-9,758,484 Base addition salts of nitroxoline and uses thereof
Novel base addition salts of nitroxoline with improved solubility and increased urine secretion under physiological conditions are described. Pharmaceutical...
US-9,758,483 Pyridone amides as modulators of sodium channels
The invention relates to pyridone amide compounds of formula I and I' or pharmaceutically acceptable salts thereof, useful as inhibitors of sodium channels: ...
US-9,758,481 Targeting of EWS-FLI1 as anti-tumor therapy
Peptides and compounds are provided that function as EWS-FLI1 protein inhibitors. The peptides and compounds have utility in the treatment of Ewing's sarcoma...
US-9,758,480 1-(cycloalkyl-carbonyl)proline derivative
A compound represented by formula (1) (in the formula: ring-D represents a three- to eight-membered hydrocarbon ring; R.sup.a represents an optionally...
US-9,758,479 Method for preparing organic peroxides
A method for preparing peroxide, including a step of treating, in a reaction medium, a component having at least one tertiary alcohol grouping with a compound...
US-9,758,478 Allyl disulfide-containing addition-fragmentation oligomers
A Addition-fragmentation oligomers containing allylic disulfide groups are described. The oligomers may be added to polymerizable compositions to provide labile...
US-9,758,477 Sulfamoylbenzamide derivatives as antiviral agents against HBV infection
The present invention provides sulfamoylbenzamide derivatives, and pharmaceutical compositions thereof. In certain embodiments, the compounds and pharmaceutical...
US-9,758,476 Ortho-alkynyl anilines and process for preparation thereof
The present invention relates to novel ortho alkynyl anilines of formula (I) which are useful in synthesis of drug intermediates and natural products and...
US-9,758,475 Perfume compositions containing isomeric alkadienenitriles
A perfume composition comprising an effective amount of at least one alkadienenitrile selected from 4,8-undecadienenitrile and isomers thereof,...
US-9,758,474 Immunomodulator and anti-inflammatory compounds
The present invention provides dihydroorotate dehydrogenase inhibitors, methods of preparing them, pharmaceutical compositions containing them and methods of...
US-9,758,473 Inhibitors of lysine gingipain
The present invention relates generally to therapeutics targeting the bacterium Porphyromonas gingivalis, including its protease Lysine gingipain (Kgp), and...
US-9,758,472 Non-lactone carbocyclic and heterocyclic antagonists and agonists of bacterial quorum sensing
Non-lactone carbocyclic and heterocyclic antagonists and agonists of bacterial quorum sensing. Pharmaceutical composition containing antagonists. Methods...
US-9,758,471 Process for the preparation of 4-dimethylaminocrotonic acid
The present invention provides a process for the preparation of 4-dimethylaminocrotonic acid of Formula (II) or its salts, which is used as an intermediate for...
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