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Patent # Description
US-9,765,137 Early marker of proteinuria in patients treated with an anti-VEGF treatment
This document provides methods and materials related to determining whether or not a human receiving a therapy (e.g., an anti-VEGF therapy such as a bevacizumab...
US-9,765,136 Modulators and methods of use
Novel modulators, including antibodies and derivatives thereof, and methods of such modulators to treat hyperproliferative disorders are provided.
US-9,765,135 Anti-C5 antibodies
An objective of the invention is to provide anti-C5 antibodies and methods of using the same. The invention provides anti-C5 antibodies and methods of using the...
US-9,765,134 MZB1, a novel B cell factor, and uses thereof
The marginal zone (MZ) and B1 subsets of B cells, which differ from conventional follicular (FO) B cells both developmentally and functionally, are involved in...
US-9,765,133 Antibody producing non-human mammals
Described are transgenic, non-human animals comprising a nucleic acid encoding an immunoglobulin light chain, whereby the immunoglobulin light chain is human,...
US-9,765,132 Fibronectin binding domains with reduced immunogenicity
Fibronectin type III (.sup.10Fn3) binding domains having novel designs that are associated with reduced immunogenicity are provided. The application describes...
US-9,765,131 Oxyntomodulin derivatives and pharmaceutical composition for treating obesity comprising the same
The present invention relates to a novel peptide showing more excellent activities on a glucagon like peptide-1 receptor and a glucagon receptor than native...
US-9,765,130 Glucagon/GLP-1 agonists for the treatment of obesity
This disclosure provides GLP-1/glue agon agonist peptides for the treatment of metabolic diseases, e.g., obesity.
US-9,765,129 Treatment of obesity
The present invention relates generally to a method of increasing lipid oxidation in a mammal and to agents useful for same. More particularly, the present...
US-9,765,128 Erythropoietin-derived short peptide and its mimics as immuno/inflammatory modulators
The present invention provides isolated stabilized EPO-derived peptides and their mimics that protect against tissue damage in subjects having diverse forms of...
US-9,765,127 Compositions and methods of use for recombinant human secretoglobins
Methods of synthetically producing, formulating and using secretoglobins SCGB1A1, SCGB3A2, and SCGB3A1 are provided. Methods of using secretoglobins SCGB1A1,...
US-9,765,126 Compositions and methods for modulating biomass productivity
The disclosure generally relates to methods and materials for modulating cell productivity. In particular, the present disclosure provides polynucleotides...
US-9,765,125 Fused antigen vaccines and compositions against Streptococcus pneumoniae
Streptococcus pneumoniae is a major health concern, especially in very young, elderly, or immunocompromised patients. The present disclosure provides, inter...
US-9,765,124 RhtB protein variants and the method of producing O-phosphoserine using the same
The present invention relates to an RhtB (homoserine/homoserine lactone export transporter) protein variant having an enhanced ability to export O-phosphoserine...
US-9,765,123 Pseudomonas exotoxin a with less immunogenic T cell and/or B cell epitopes
The invention provides a Pseudomonas exotoxin A (PE) comprising an amino acid sequence having a substitution of one or more B-cell and/or T-cell epitopes. The...
US-9,765,122 Theragnostic particles
The present invention provides viral-based nanoparticles for therapeutic and diagnostic use, and methods for making and using the nanoparticles. Specifically,...
US-9,765,121 De novo structural protein design for manufacturing high strength materials
Provided is a supramolecular polypeptide comprising alternating repeats of crystallite-forming subsequences and amorphous subsequences. The crystallite-forming...
US-9,765,120 Cobalamin acquisition protein and use thereof
The present invention relates to a cobalamin acquisition protein, compositions containing the cobalamin acquisition protein, and the use of such compositions.
US-9,765,119 Cyclosporine analogue mixtures and their use as immunomodulating agents
The invention is directed to isomeric mixtures of cyclosporine analogs that are structurally similar to cyclosporine A. The mixtures possess enhanced efficacy...
US-9,765,118 Pharmaceutical composition for cancer prevention and treatment containing peptide originated from C12orf59...
As explained hereinbefore, the C12orf59 gene of the present invention suppresses cancer cell invasion and inhibits cancer cell survivability, and the over...
US-9,765,117 Peptides for treating cancer
Provided are novel peptides having a human minute binding protein-2 (HDM-2) targeting sequence that target the human minute binding protein-2. Also provided are...
US-9,765,116 Inhibitors of the Eph-A receptor and uses thereof
Eph A receptor inhibitor peptides, and particularly Eph A4 receptor inhibitor peptides, are provided. The peptides comprise a sequence derived from the G-H loop...
US-9,765,115 Inhibitors of metastasis, methods of generating such inhibitors and their therapeutic applications
The chain of events that explains calcitonin receptor (CTR)-stimulated invasion and metastasis of prostate cancer cells was identified. The CTR-stimulated...
US-9,765,114 Method for cancer immunotherapy
A novel compound of the formula (1): ##STR00001## wherein X is a tyrosine residue or a methionine residue; Y and Z each are a single bond or the like;...
US-9,765,113 Methods and agents for the treatment of cancer
There are disclosed methods for prophylaxis or treatment of cancer in a mammal. The methods comprise administering an effective amount of an agent to the...
US-9,765,112 Method and system for processing of aquatic species
The present disclosure relates, according to some embodiments, to methods for recovering multiple products from industrial-scale production of a biomass of an...
US-9,765,111 Separation processes for soy protein
The invention provides a process for the separation of soy protein. The process begins with an aqueous extract or solution of soy protein, which is passed...
US-9,765,110 Neuroactive 19-alkoxy-17(20)-Z-vinylcyano-substituted steroids, prodrugs thereof, and methods of treatment...
The present disclosure is generally directed to neuroactive 19-alkoxy-17(20)-Z-vinylcyano-substituted steroids as referenced herein, and pharmaceutically...
US-9,765,109 2'-arabino-fluorooligonucleotide N3'.fwdarw.P5' phosphoramidates: their synthesis and use
Oligonucleotides with a novel sugar-phosphate backbone containing at least one 2'-arabino-fluoronucleoside and an internucleoside 3'-NH--P(--O)(OR)--O-5'...
US-9,765,108 Formulation of 5-azacytidine
The present invention relates to polymorphic forms of 5-Azacytidine and the process for preparation thereof. The present invention further relates to...
US-9,765,107 Cyclic phosphonate substituted nucleoside derivatives and methods of use thereof for the treatment of viral...
The present invention relates to Cyclic Phosphonate Substituted Nucleoside Derivatives of Formula (I): (structure) and pharmaceutically acceptable salts...
US-9,765,106 Neisseria gonorrhoeae therapeutic based on CMP-nonulosonate sugars
N. gonorrhoeae has become resistant to almost every conventional antibiotic. Described herein is the use of CMP-nonulosonate analogs to counter gonococcal...
US-9,765,105 Macrolide compound
The present disclosure relates to a macrolide compound as shown by formula I and pharmaceutically acceptable salt thereof. The compound of the present...
US-9,765,104 Non-caloric sweetener
Disclosed is a steviol glycoside referred to as rebaudioside D3. Rebaudioside D3 has five .beta.-D-glucosyl units connected to the aglycone steviol. Also...
US-9,765,103 Cleavable conjugates of functionalized platinum-acridine and platinum-benzacridine agents and methods thereof
The present invention relates to using a versatile synthetic approach to generate a new class of ester, amido, or carbamate prodrugs of highly potent, but...
US-9,765,102 ONO pincer ligands and ONO pincer ligand comprising metal complexes
Embodiments of the invention are directed to ONO pincer ligands that can be in a trianionic, protonated or protonated equivalent form. The ONO pincer ligand can...
US-9,765,101 Organo-arsenoxide compounds and use thereof
The present invention relates to organo-arsenoxide compounds and to methods for their synthesis. The invention also relates to pharmaceutical compositions...
US-9,765,100 Nucleoside phosphonate salts
The present invention relates to compounds and methods for treating viral diseases. Some compounds of the invention are described by Formula I: ##STR00001## ...
US-9,765,099 STAT6 inhibitors
The present disclosure provides compounds that are useful for inhibiting the STAT6 pathway. Also provided are related pharmaceutical compositions and methods of...
US-9,765,098 Preparation method of 3,7,11-trimethyldodec-2,4,6,10-tetraene-1-yl-phosphonic salt
Provided in the present invention is a preparation method for a phosphonic salt, comprising the step of: reacting 3,7,11-trimethyldodec-1,4,6,10-tetraene-3-ol...
US-9,765,097 Method for producing silane compound having sulfonyl bond
A method of producing a silane compound having a Formula (1) sulfonyl bond includes reacting a Formula (I) chlorosulfonyl compound with sodium sulfite in water...
US-9,765,096 Organohalosilane and use thereof in electrolytes of non-aqueous lithium ion batteries
A method for preparation of an organohalosilane represented by formula I is disclosed. The method comprises: contacting an alcohol with metal sodium to yield a...
US-9,765,095 Easily synthesizable, spontaneously water-soluble, essentially voc-free, environmentally friendly...
The invention relates to a composition and to a process for producing the composition comprising essentially water-soluble (meth)acrylamido-functional...
US-9,765,094 Ultrastable silver nanoparticles
Ultrastable silver nanoparticles, methods of making the same, and methods of using the same, are disclosed.
US-9,765,093 Aza-benzimidazole inhibitors of PAD4
The present invention provides compounds useful as inhibitors of PAD4, compositions thereof, and methods of treating PAD4-related disorders.
US-9,765,092 Tricyclic piperidine compounds
The present invention relates to compounds of the formula (I) ##STR00001## wherein R, R.sup.1a, R.sup.1b, R.sup.2, R.sup.3, and X are as described in the...
US-9,765,091 Tetrahydropyrazolo [3,4-b] azepine derivatives and their use as allosteric modulators of metabotropic glutamate...
The present invention relates to novel compounds of Formula (I), wherein M, A and Y are defined as in Formula (I); invention compounds are modulators of...
US-9,765,090 Epidithiodioxopiperazine compound or its derivatives, and the use thereof
The present invention relates to an epidithiodioxopiperazine derivative represented by the following Chemical Formula 1 or its reduced derivative; a method for...
US-9,765,089 ACC inhibitors and uses thereof
The present invention provides compounds useful as inhibitors of Acetyl CoA Carboxylase (ACC), compositions thereof, and methods of using the same.
US-9,765,088 Process for the preparation of rifamycin derivatives
The present invention relates to an improved and industrially advantageous process for the preparation of Rifaximin with high purity and yield. Particularly,...
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