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Patent # Description
US-9,765,087 Benzimidazole derivatives
The present invention discloses compounds of Formula (I), or pharmaceutically acceptable salts, esters, or prodrugs thereof: ##STR00001## which inhibit...
US-9,765,085 SHIP1 modulators and methods related thereto
Compounds of formula (II): wherein A, R.sup.1, R.sup.2, R.sup.5 and R.sup.13 are described herein, or a stereoisomer, enantiomer or tautomer thereof or mixtures...
US-9,765,084 Recovery and refining of dianhydrosugars
A process for the production of a refined dianhydrosugar-containing product is disclosed. The process includes controlled continuous crystallization of the...
US-9,765,083 Method for the synthesis of irinotecan
The present invention relates to a method for the synthesis of 7-ethyl-10-[4-(1-piperidino)-1-piperidino]carbonyloxycamptothecin (i.e. iriniotecan), comprising:...
US-9,765,082 Crystalline form of tiotropium bromide with lactose
A cocrystal of tiotropium bromide and lactose monohydrate is herein disclosed. In the cocrystal the components tiotropium bromide and lactose are preferably...
US-9,765,081 Pharmaceutical compositions comprising perillyl alcohol derivatives
A pharmaceutical composition is provided which includes perillyl alcohol conjugated with a therapeutic agent and further includes and a hydrolyzable acylated...
US-9,765,080 Triazolo[4,5-D] pyramidine derivatives and their use as purine receptor antagonists
Compounds of formula (I) that are capable of acting as purine receptor antagonists, pharmaceutical compositions including the compounds, and methods of making...
US-9,765,079 Crystalline forms of pemetrexed diacid and manufacturing processes therefor
Crystalline forms of pemetrexed diacid are provided (Forms 1 and 2) which are readily produced for either laboratory-scale or industrial scale. Processes for...
US-9,765,078 Compounds and methods for inhibiting mitotic progression
This invention relates to compounds and methods for the treatment of cancer. In particular, the invention provides compounds that inhibit Aurora kinase,...
US-9,765,077 Synthesis of duocarmycin analogues
A novel Fmoc protected duocarmycin subunit and utilization as a reagent in solid phase protein synthesis methodology. Also provided is a novel method of solid...
US-9,765,076 Aurora kinase inhibitors for inhibiting mitotic progression
The present invention relates to compounds and methods for the treatment of cancer. In particular, the invention provides potent inhibitors of Aurora A kinase,...
US-9,765,075 Substituted bridged urea analogs as sirtuin modulators
Provided herein are novel substituted bridged urea and related analogs and methods of use thereof. The sirtuin-modulating compounds may be used for increasing...
US-9,765,074 Inhibitors of the renal outer medullary potassium channel
The present invention provides compounds of Formula I ##STR00001## and the pharmaceutically acceptable salts thereof, which are inhibitors of the ROMK...
US-9,765,073 Cyclopropabenzofuranyl pyridopyrazinediones
Compounds and pharmaceutically acceptable salts of the compounds are disclosed, wherein the compounds have the structure of Formula I ##STR00001## wherein X,...
US-9,765,072 1H-1,8-naphthyridin-2ones as anti proliferative compounds
The present invention relates to novel antiproliferative 1H-1, 8-naphthyridin-2-ones of the general formula (I) or pharmaceutically acceptable salts thereof: In...
US-9,765,071 Substituted imidazo ring systems and methods
Imidazo ring systems substituted at the 1-position, pharmaceutical compositions containing the compounds, intermediates, methods of making the compounds, and...
US-9,765,070 Substituted oxopyridine derivatives
The invention relates to substituted oxopyridine derivatives and to processes for their preparation, and also to their use for preparing medicaments for the...
US-9,765,069 Antimicrobial compounds
The present invention relates to certain tetramic acid derivatives that are suitable for use in the preparation and development of antimicrobial (e.g....
US-9,765,068 PRMT5 inhibitors and uses thereof
Described herein are compounds of Formula (I), pharmaceutically acceptable salts thereof, and pharmaceutical compositions thereof. Compounds of the present...
US-9,765,067 Thiophen-2-yl-pyridin-2-yl-1H-pyrazole-4-carboxylic acid derivatives and the use thereof as soluble guanylate...
The present invention provides a compound of formula (I) or a pharmaceutically acceptable salt thereof; a method for manufacturing the compounds of the...
US-9,765,066 Selective HDAC1 and HDAC2 inhibitors
Provided herein are compounds, pharmaceutical compositions comprising such compounds and methods of using such compounds to treat or prevent diseases or...
US-9,765,065 Therapeutic substituted cyclopentanes
Disclosed herein are compounds having formula (I) wherein a dashed line represents the presence or adsence of a bond; Y is an organic acid functional group, or...
US-9,765,064 Alpha-hydroxy-beta-azido-tetrazoles
Alpha-hydroxy-beta-azido tetrazole compounds of formula (I): ##STR00001## a process for manufacturing alpha-hydroxy-beta-azido tetrazoles of formula (I), and...
US-9,765,063 Amido compounds as ROR.gamma.t modulators and uses thereof
Amido compounds are disclosed that have a formula represented by the following: ##STR00001## and wherein Cy.sup.1, Cy.sup.2, n1, n2, R.sup.1a, R.sup.1b,...
US-9,765,062 Method for producing silymarin
The present invention relates to a method for producing silymarin. The method comprises: pressing silybum marianum seeds to obtain silymarin powder, and soaking...
US-9,765,061 Trail enhancers for the selective killing of cancer cells
The invention is directed to methods of inducing apoptosis, arresting cell cycle, or inhibiting cellular proliferation, or any combination thereof, in a tumor...
US-9,765,060 Phosphatidylinositol 3-kinase inhibitors
The present disclosure provides phosphatidylinositol 3-kinase (PI3K) inhibitors of formula (J), ##STR00001## or pharmaceutically acceptable salts thereof, in...
US-9,765,059 5-(Pyridin-2-yl-amino)-pyrazine-2-carbonitrile compounds and their therapeutic use
The present invention pertains generally to the field of therapeutic compounds. More specifically the present invention pertains to certain ...
US-9,765,058 Substituted benzylpyrazoles
Compounds of formula (I), and their use as pharmaceuticals. ##STR00001##
US-9,765,057 3-ester-4 substituted orexin receptor antagonists
The present invention is directed to 3-ester-4-substituted compounds which are antagonists of orexin receptors. The present invention is also directed to uses...
US-9,765,056 Indole and pyrrole compounds, a process for their preparation and pharmaceutical compositions containing them
Compounds of formula (I): ##STR00001## wherein R.sub.a, R.sub.b, R.sub.c, R.sub.d, R.sub.3, R.sub.4, R.sub.5, A.sub.1, A.sub.2, T and W are as defined in the...
US-9,765,055 Intramolecular hydrogen-bonded nitric oxide synthase inhibitors
Compounds and related compositions and methods as can be used to selectively inhibit neuronal nitric oxide synthase and as can be employed in the treatment of...
US-9,765,054 Histone deacetylase inhibitors and compositions and methods of use thereof
Provided are certain histone deacetylase (HDAC) inhibitors of Formula I, compositions thereof, and methods of their use. ##STR00001##
US-9,765,053 Methods of treatment using selective 5-HT2A inverse agonists
Compounds and methods are provided for the treatment of disease conditions in which modification of serotonergic receptor activity has a beneficial effect. In...
US-9,765,052 Anthranilamide compounds, their mixtures and the use thereof as pesticides
Compounds of formula (I) ##STR00001## wherein R.sup.1, R.sup.2, R.sup.3, R.sup.4, R.sup.5, R.sup.6a and R.sup.6b are as defined in the description; or a...
US-9,765,051 Compositions, apparatus, systems, and methods for resolving electronic excited states
The present disclosure relates, according to some embodiments, to molecules, including conjugated fused polycyclic molecules, that may receive excited state...
US-9,765,050 Pyridyl reverse sulfonamides for HBV treatment
The present invention includes a method of inhibiting, suppressing or preventing HBV infection in an individual in need thereof, comprising administering to the...
US-9,765,049 N-cycloalkyl-N-[(fusedphenyl)methylene]-(thio)carboxamide derivatives
The present invention relates to fungicidal N-cycloalkyl-N-[(fusedphenyl)methylene] carboxamide derivatives, for example, compounds of formula (I), and their...
US-9,765,048 Organocatalytic process for asymmetric synthesis of decanolides
The present invention discloses organocatalytic process for asymmetric synthesis of highly enantioselective decanolide compounds in high yield with >99% ee....
US-9,765,047 Process for making beraprost
A method is described for making single isomers of synthetic beraprost diol, a key intermediate for making 314-d isomer of beraprost. The method requires fewer...
US-9,765,046 Process for preparing phthalic anhydride
The present invention relates to a process for preparing phthalic anhydride by gas phase oxidation of aromatic hydrocarbons, in which a gas stream comprising at...
US-9,765,045 Esterification of 2,5-furan-dicarboxylic acid
A method of making a furan dicarboxylate by means of reacting 2,5-furan dicarboxylic acid (FDCA) with an alcohol or mixture of alcohols in a ...
US-9,765,044 Synthesis of novel ionic liquids from lignin-derived compounds
Methods and compositions are provided for synthesizing ionic liquids from lignin derived compounds comprising: contacting a starting material comprising lignin...
US-9,765,043 Salts of potassium ATP channel openers and uses thereof
Provided are immediate or prolonged administration of certain salts of K.sub.ATP channel openers such as diazoxide to a subject to achieve novel ...
US-9,765,042 Methods of chemical synthesis of diaminophenothiazinium compounds including methylthioninium chloride (MTC)
Methods of synthesizing and purifying certain 3,7-diamino-phenothiazin-5-ium compounds (referred to herein as "diaminophenothiazinium compounds") including...
US-9,765,041 Integrated process for urea and melamine production
In an integrated process for urea and melamine production, urea is produced in a urea plant (10) comprising a high pressure urea synthesis section (11) from...
US-9,765,040 Therapeutic agent for pain
[Problem] Provided is a pharmaceutical, in particular, a pharmaceutical composition which is useful for the treatment of pain. [Means for Solution] The present...
US-9,765,039 Biaryl derivatives as bromodomain inhibitors
The present disclosure relates to compounds, which are useful for inhibition of BET protein function by binding to bromodomains, and their use in therapy.
US-9,765,038 Heteroaryl compounds and uses thereof
The present invention provides compounds, pharmaceutically acceptable compositions thereof, and methods of using the same.
US-9,765,037 Compositions and methods for treating toxoplasmosis, cryptosporidiosis, and other apicomplexan protozoan...
Compositions and methods for the treatment of toxoplasmosis, caused by the infectious eukaryotic parasite Toxoplasma gondii (T. gondii) and for the treatment of...
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