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| Patent # | Description |
|---|---|
| US-9,765,087 |
Benzimidazole derivatives The present invention discloses compounds of Formula (I), or pharmaceutically acceptable salts, esters, or prodrugs thereof: ##STR00001## which inhibit... |
| US-9,765,085 |
SHIP1 modulators and methods related thereto Compounds of formula (II): wherein A, R.sup.1, R.sup.2, R.sup.5 and R.sup.13 are described herein, or a stereoisomer, enantiomer or tautomer thereof or mixtures... |
| US-9,765,084 |
Recovery and refining of dianhydrosugars A process for the production of a refined dianhydrosugar-containing product is disclosed. The process includes controlled continuous crystallization of the... |
| US-9,765,083 |
Method for the synthesis of irinotecan The present invention relates to a method for the synthesis of 7-ethyl-10-[4-(1-piperidino)-1-piperidino]carbonyloxycamptothecin (i.e. iriniotecan), comprising:... |
| US-9,765,082 |
Crystalline form of tiotropium bromide with lactose A cocrystal of tiotropium bromide and lactose monohydrate is herein disclosed. In the cocrystal the components tiotropium bromide and lactose are preferably... |
| US-9,765,081 |
Pharmaceutical compositions comprising perillyl alcohol derivatives A pharmaceutical composition is provided which includes perillyl alcohol conjugated with a therapeutic agent and further includes and a hydrolyzable acylated... |
| US-9,765,080 |
Triazolo[4,5-D] pyramidine derivatives and their use as purine receptor
antagonists Compounds of formula (I) that are capable of acting as purine receptor antagonists, pharmaceutical compositions including the compounds, and methods of making... |
| US-9,765,079 |
Crystalline forms of pemetrexed diacid and manufacturing processes
therefor Crystalline forms of pemetrexed diacid are provided (Forms 1 and 2) which are readily produced for either laboratory-scale or industrial scale. Processes for... |
| US-9,765,078 |
Compounds and methods for inhibiting mitotic progression This invention relates to compounds and methods for the treatment of cancer. In particular, the invention provides compounds that inhibit Aurora kinase,... |
| US-9,765,077 |
Synthesis of duocarmycin analogues A novel Fmoc protected duocarmycin subunit and utilization as a reagent in solid phase protein synthesis methodology. Also provided is a novel method of solid... |
| US-9,765,076 |
Aurora kinase inhibitors for inhibiting mitotic progression The present invention relates to compounds and methods for the treatment of cancer. In particular, the invention provides potent inhibitors of Aurora A kinase,... |
| US-9,765,075 |
Substituted bridged urea analogs as sirtuin modulators Provided herein are novel substituted bridged urea and related analogs and methods of use thereof. The sirtuin-modulating compounds may be used for increasing... |
| US-9,765,074 |
Inhibitors of the renal outer medullary potassium channel The present invention provides compounds of Formula I ##STR00001## and the pharmaceutically acceptable salts thereof, which are inhibitors of the ROMK... |
| US-9,765,073 |
Cyclopropabenzofuranyl pyridopyrazinediones Compounds and pharmaceutically acceptable salts of the compounds are disclosed, wherein the compounds have the structure of Formula I ##STR00001## wherein X,... |
| US-9,765,072 |
1H-1,8-naphthyridin-2ones as anti proliferative compounds The present invention relates to novel antiproliferative 1H-1, 8-naphthyridin-2-ones of the general formula (I) or pharmaceutically acceptable salts thereof: In... |
| US-9,765,071 |
Substituted imidazo ring systems and methods Imidazo ring systems substituted at the 1-position, pharmaceutical compositions containing the compounds, intermediates, methods of making the compounds, and... |
| US-9,765,070 |
Substituted oxopyridine derivatives The invention relates to substituted oxopyridine derivatives and to processes for their preparation, and also to their use for preparing medicaments for the... |
| US-9,765,069 |
Antimicrobial compounds The present invention relates to certain tetramic acid derivatives that are suitable for use in the preparation and development of antimicrobial (e.g.... |
| US-9,765,068 |
PRMT5 inhibitors and uses thereof Described herein are compounds of Formula (I), pharmaceutically acceptable salts thereof, and pharmaceutical compositions thereof. Compounds of the present... |
| US-9,765,067 |
Thiophen-2-yl-pyridin-2-yl-1H-pyrazole-4-carboxylic acid derivatives and
the use thereof as soluble guanylate... The present invention provides a compound of formula (I) or a pharmaceutically acceptable salt thereof; a method for manufacturing the compounds of the... |
| US-9,765,066 |
Selective HDAC1 and HDAC2 inhibitors Provided herein are compounds, pharmaceutical compositions comprising such compounds and methods of using such compounds to treat or prevent diseases or... |
| US-9,765,065 |
Therapeutic substituted cyclopentanes Disclosed herein are compounds having formula (I) wherein a dashed line represents the presence or adsence of a bond; Y is an organic acid functional group, or... |
| US-9,765,064 |
Alpha-hydroxy-beta-azido-tetrazoles Alpha-hydroxy-beta-azido tetrazole compounds of formula (I): ##STR00001## a process for manufacturing alpha-hydroxy-beta-azido tetrazoles of formula (I), and... |
| US-9,765,063 |
Amido compounds as ROR.gamma.t modulators and uses thereof Amido compounds are disclosed that have a formula represented by the following: ##STR00001## and wherein Cy.sup.1, Cy.sup.2, n1, n2, R.sup.1a, R.sup.1b,... |
| US-9,765,062 |
Method for producing silymarin The present invention relates to a method for producing silymarin. The method comprises: pressing silybum marianum seeds to obtain silymarin powder, and soaking... |
| US-9,765,061 |
Trail enhancers for the selective killing of cancer cells The invention is directed to methods of inducing apoptosis, arresting cell cycle, or inhibiting cellular proliferation, or any combination thereof, in a tumor... |
| US-9,765,060 |
Phosphatidylinositol 3-kinase inhibitors The present disclosure provides phosphatidylinositol 3-kinase (PI3K) inhibitors of formula (J), ##STR00001## or pharmaceutically acceptable salts thereof, in... |
| US-9,765,059 |
5-(Pyridin-2-yl-amino)-pyrazine-2-carbonitrile compounds and their
therapeutic use The present invention pertains generally to the field of therapeutic compounds. More specifically the present invention pertains to certain ... |
| US-9,765,058 |
Substituted benzylpyrazoles Compounds of formula (I), and their use as pharmaceuticals. ##STR00001## |
| US-9,765,057 |
3-ester-4 substituted orexin receptor antagonists The present invention is directed to 3-ester-4-substituted compounds which are antagonists of orexin receptors. The present invention is also directed to uses... |
| US-9,765,056 |
Indole and pyrrole compounds, a process for their preparation and
pharmaceutical compositions containing them Compounds of formula (I): ##STR00001## wherein R.sub.a, R.sub.b, R.sub.c, R.sub.d, R.sub.3, R.sub.4, R.sub.5, A.sub.1, A.sub.2, T and W are as defined in the... |
| US-9,765,055 |
Intramolecular hydrogen-bonded nitric oxide synthase inhibitors Compounds and related compositions and methods as can be used to selectively inhibit neuronal nitric oxide synthase and as can be employed in the treatment of... |
| US-9,765,054 |
Histone deacetylase inhibitors and compositions and methods of use thereof Provided are certain histone deacetylase (HDAC) inhibitors of Formula I, compositions thereof, and methods of their use. ##STR00001## |
| US-9,765,053 |
Methods of treatment using selective 5-HT2A inverse agonists Compounds and methods are provided for the treatment of disease conditions in which modification of serotonergic receptor activity has a beneficial effect. In... |
| US-9,765,052 |
Anthranilamide compounds, their mixtures and the use thereof as pesticides Compounds of formula (I) ##STR00001## wherein R.sup.1, R.sup.2, R.sup.3, R.sup.4, R.sup.5, R.sup.6a and R.sup.6b are as defined in the description; or a... |
| US-9,765,051 |
Compositions, apparatus, systems, and methods for resolving electronic
excited states The present disclosure relates, according to some embodiments, to molecules, including conjugated fused polycyclic molecules, that may receive excited state... |
| US-9,765,050 |
Pyridyl reverse sulfonamides for HBV treatment The present invention includes a method of inhibiting, suppressing or preventing HBV infection in an individual in need thereof, comprising administering to the... |
| US-9,765,049 |
N-cycloalkyl-N-[(fusedphenyl)methylene]-(thio)carboxamide derivatives The present invention relates to fungicidal N-cycloalkyl-N-[(fusedphenyl)methylene] carboxamide derivatives, for example, compounds of formula (I), and their... |
| US-9,765,048 |
Organocatalytic process for asymmetric synthesis of decanolides The present invention discloses organocatalytic process for asymmetric synthesis of highly enantioselective decanolide compounds in high yield with >99% ee.... |
| US-9,765,047 |
Process for making beraprost A method is described for making single isomers of synthetic beraprost diol, a key intermediate for making 314-d isomer of beraprost. The method requires fewer... |
| US-9,765,046 |
Process for preparing phthalic anhydride The present invention relates to a process for preparing phthalic anhydride by gas phase oxidation of aromatic hydrocarbons, in which a gas stream comprising at... |
| US-9,765,045 |
Esterification of 2,5-furan-dicarboxylic acid A method of making a furan dicarboxylate by means of reacting 2,5-furan dicarboxylic acid (FDCA) with an alcohol or mixture of alcohols in a ... |
| US-9,765,044 |
Synthesis of novel ionic liquids from lignin-derived compounds Methods and compositions are provided for synthesizing ionic liquids from lignin derived compounds comprising: contacting a starting material comprising lignin... |
| US-9,765,043 |
Salts of potassium ATP channel openers and uses thereof Provided are immediate or prolonged administration of certain salts of K.sub.ATP channel openers such as diazoxide to a subject to achieve novel ... |
| US-9,765,042 |
Methods of chemical synthesis of diaminophenothiazinium compounds
including methylthioninium chloride (MTC) Methods of synthesizing and purifying certain 3,7-diamino-phenothiazin-5-ium compounds (referred to herein as "diaminophenothiazinium compounds") including... |
| US-9,765,041 |
Integrated process for urea and melamine production In an integrated process for urea and melamine production, urea is produced in a urea plant (10) comprising a high pressure urea synthesis section (11) from... |
| US-9,765,040 |
Therapeutic agent for pain [Problem] Provided is a pharmaceutical, in particular, a pharmaceutical composition which is useful for the treatment of pain. [Means for Solution] The present... |
| US-9,765,039 |
Biaryl derivatives as bromodomain inhibitors The present disclosure relates to compounds, which are useful for inhibition of BET protein function by binding to bromodomains, and their use in therapy. |
| US-9,765,038 |
Heteroaryl compounds and uses thereof The present invention provides compounds, pharmaceutically acceptable compositions thereof, and methods of using the same. |
| US-9,765,037 |
Compositions and methods for treating toxoplasmosis, cryptosporidiosis,
and other apicomplexan protozoan... Compositions and methods for the treatment of toxoplasmosis, caused by the infectious eukaryotic parasite Toxoplasma gondii (T. gondii) and for the treatment of... |
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