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Patent # Description
US-9,771,356 Inhibitors of beta-hydroxylase for treatment of cancer
The present invention relates to compounds which modulate (e.g., inhibit) the activity of beta-hydroxylase (e.g., Asparatyl (asparaginyl) .beta.-hydroxylase...
US-9,771,355 Compositions and methods for the treatment of epilepsy and neurological disorders
The invention relates to the compounds of formula I and formula Ia or its pharmaceutical acceptable polymorphs, solvates, enantiomers, stereoisomers and...
US-9,771,354 Pyrazole p38 map kinase inhibitors
There are provided inter alia compounds of formula (I) ##STR00001## wherein R.sup.1, R.sup.2a, R.sup.2b, R.sup.3, R.sup.4, L, X, R.sup.5 and R.sup.6 are as...
US-9,771,353 Kinase inhibitors based upon N-alkyl pyrazoles
Compounds are of formula (I): ##STR00001## The compounds have antiinflammatory activity (e.g., through inhibition of one or more of members of: the family of...
US-9,771,352 Hydroxyalkyl-substituted phenyltriazole derivatives and uses thereof
The present invention relates to novel 5-(hydroxyalkyl)-1-phenyl-1,2,4-triazole derivatives, to processes for the preparation of such compounds, to...
US-9,771,351 Wnt signaling inhibitor
A Wnt signaling inhibitor which comprises, as an active ingredient, a fused-ring heterocyclic compound represented by the following formula (IA) or a...
US-9,771,350 Diamide compounds having muscarinic receptor antagonist and .beta..sub.2 adrenergic receptor agonist activity
This invention relates to a compound of formula I: ##STR00001## or a pharmaceutically acceptable salt thereof. Such compounds possess both muscarinic...
US-9,771,349 Pyridinyl quinolinone derivatives as mutant-isocitrate dehydrogenase inhibitors
The invention relates to inhibitors of mutant isocitrate dehydrogenase (mt-IDH) proteins with neomorphic activity useful in the treatment of cell-proliferation...
US-9,771,348 Method for preparing benzamide derivative, novel intermediate used in preparation of benzamide, and method for...
The present invention relates to a method for preparing N-[[1-{3-(1,2,3-triazol-1-yl)propyl}piperidin-4-yl]methyl]-4-amino-5-chlo- ro-2-methoxybenzamide, which...
US-9,771,347 Process for making compounds for use in the treatment of cancer
Disclosed herein is a process of making a compound of formula I ##STR00001## The compound of formula I is an inhibitor of MEK and thus can be used to treat...
US-9,771,346 Salt, acid generator, resist composition and method for producing resist pattern
A salt represented by formula (I): ##STR00001## wherein R.sup.1 and R.sup.2 independently represent a hydrogen atom, a hydroxy group or a C.sub.1 to C.sub.12...
US-9,771,345 Coferons and methods of making and using them
The present invention is directed to a monomer useful in preparing therapeutic compounds. The monomer includes one or more pharmacophores which potentially...
US-9,771,344 Peloruside analogs
The present invention provides new therapeutic compounds for treatment of diseases caused or influenced by microtubule stability, such as proliferative...
US-9,771,343 2-alkyl-or-aryl-substituted tanshinone derivatives, and preparation method and application thereof
The present invention belongs to the field of natural medicine and pharmaceutical chemistry, and specifically relates to novel 2-alkyl- or ...
US-9,771,342 Monascuspurpurones, preparation process thereof, and uses of the monascuspurpurones
The present invention relates to a novel monascuspurpurone compound of formula (I): ##STR00001## or a pharmaceutically acceptable derivative thereof as...
US-9,771,341 Piperazine carbamates and methods of making and using same
Provided herein are piperazine carbamates and pharmaceutical compositions comprising said compounds. The subject compounds and compositions are useful as...
US-9,771,340 2-aminothiazole derivatives and methods of preparing and using the same
2-aminothiazole derivatives represented by formula (I), where R.sub.1 and R.sub.2 represent cycloalkyls, respectively; or R.sub.1 represents a substituted...
US-9,771,339 Cystathionine-.gamma.-lyase (CSE) inhibitors
Described herein are compounds and pharmaceutical compositions containing such compounds which inhibit cystathionine-.gamma.-lyase (CSE). Also described herein...
US-9,771,338 1,2,4-oxadiazole derivatives as immunomodulators
The present invention relates to 1,2,4-oxadiazole and 1,2,4-thiadiazole compounds as therapeutic agents capable of inhibiting the programmed cell death 1 (PD1)...
US-9,771,337 Neprilysin inhibitors
In one aspect, the invention relates to compounds having the formula: ##STR00001## where R.sup.1, R.sup.2, R.sup.3, X, R.sup.4, R.sup.5, and R.sup.6 are as...
US-9,771,336 Tetrazole based corrosion inhibitors
Disclosed are corrosion inhibitor compounds and compositions useful for preventing or inhibiting corrosion of surfaces found in cooling water applications. In...
US-9,771,335 Derivatives of rufinamide and their use in inhibtion of the activation of human voltage-gated sodium channels
The present invention provides compounds of formula I which are capable of inhibition of the activation of hNav1.1 or hNav1.6 sodium channels in neurons....
US-9,771,334 Triketone compound and preparation method and use thereof
Disclosed in the present invention is a triketone compound which has a structure shown in Formula (I). Also disclosed in the present invention is a method for...
US-9,771,333 Quinazoline derivatives as TAM family kinase inhibitors
Disclosed are compounds, compositions and methods for treating diseases, syndromes, conditions and disorders that are affected by the modulation of the activity...
US-9,771,332 2-thiopyrimidinones
Myeloperoxidase inhibitor, pharmaceutical compositions containing the inhibitor and the use of the inhibitor to treat, for example, cardiovascular conditions.
US-9,771,331 Methods of identifying neuroprotective compounds for retinal ganglion cells
Neuroprotective compounds for treating optic neuropathies and screening methods for identifying neuroprotective compounds.
US-9,771,330 Pyrimidine compounds for the treatment of cancer
Compounds of Formula I or II: ##STR00001## are described, along with pharmaceutical compositions containing the same and methods of using such compounds for...
US-9,771,329 Inhibitors of lysine specific demethylase-1
The present invention relates generally to compositions and methods for treating cancer and neoplastic disease. Provided herein are substituted heterocyclic...
US-9,771,328 Processes for preparing ASK1 inhibitors
The present disclosure provides processes for the preparation of a compound of formula: ##STR00001## which exhibits apoptosis signal-regulating kinase...
US-9,771,327 Compounds and methods for the treatment of cystic fibrosis
The invention relates to a compound of Formula I and methods of treating CFTR (cystic fibrosis transmembrane conductance regulator) mediated diseases, in...
US-9,771,326 S1P and/or ATX modulating agents
Compounds of formula (I), and pharmaceutically acceptable salts thereof, can modulate the activity of one or more SIP receptors and/or the activity of autotaxin...
US-9,771,325 Tricyclic compounds and preparation thereof
The present invention provides novel tricyclic compound of Formula I or its stereoisomer or ester or pharmaceutically acceptable salts and preparation thereof...
US-9,771,324 Chemical film on substrate, method of forming the same, and method of forming N-hydroxysuccinimide...
The present invention provides a method of forming N-hydroxysuccinimide ester-functionalized paracyclophane. The present method is carried out by adding...
US-9,771,323 Beta-cryptoxanthin from plant source and a process for its preparation
The present invention provides beta-cryptoxanthin crystals from plant source and a process for its preparation. The present invention particularly relates to a...
US-9,771,322 Isothiocyanate functional surfactant and associated method of use
A method for treating phytophotodermatitis including the steps of applying an isothiocyanate functional surfactant to an area affected by phytophotodermatitis,...
US-9,771,321 Small molecules that covalently modify transthyretin
A family of covalent kinetic stabilizer compounds that selectively and covalently react with the prominent plasma protein transthyretin in preference to more...
US-9,771,320 Carbocyclic sulfone ROR.gamma. modulators
Described are ROR.gamma. modulators of the formula (I), or stereoisomers, tautomers, pharmaceutically acceptable salts, solvates, or prodrugs thereof, wherein...
US-9,771,319 Cross-linker for the preparation of a new family of single ion conduction polymers for electrochemical devices...
A specific cross-linker, an alkaline metal bis(styrenesulfonyl)imide monomer, is used in the synthesis of single ionic conductive copolymers that are...
US-9,771,318 Ethoxylate isocyanate compound and its use as a emulsifier
Provided is a composition comprising one or more compound having the structure of formula II: ##STR00001## wherein A is a residue of a polyisocyanate, L is...
US-9,771,317 Process for preparing lacosamide and related compounds
There is provided a process for the preparation of Lacosamide in a particular polymorphic form, which process involves the isolation of a salt of formula I:...
US-9,771,316 Phenoxyalkylamine compound
The invention provides a compound having a selective inhibitory activity against highly-expressed LAT-1 in tumor cell. The compound is represented by the...
US-9,771,315 Phenyl (meth)acrylate production method and phenyl (meth)acrylate composition
Provided is a method that can produce phenyl(meth)acrylate inexpensively and at high yields. The phenyl(meth)acrylate production method of the present invention...
US-9,771,314 Process for preparing acrylic acid from formaldehyde and acetic acid
The invention relates to a process for preparing acrylic acid from formaldehyde and acetic acid, comprising (i) providing a gaseous stream S1 comprising...
US-9,771,313 Cyclohexanol, method for producing cyclohexanol, and method for producing adipic acid
A purified cyclohexanol of the present invention has a methylcyclopentanol concentration of 10 to 1000 ppm by weight and a cyclohexylcyclohexene isomer...
US-9,771,312 Process for the co-production of acetic acid and dimethyl ether
Process for the co-production of acetic acid and dimethyl ether with reduced formic acid content by distilling a mixture containing dimethyl ether, methanol and...
US-9,771,311 Coupling a phenol and an arene using selenium dioxide
Method for coupling a phenol and an arene using selenium dioxide, and also novel phenol-arene derivatives.
US-9,771,310 Styrenated phenol useful as curing agent or plasticizing agent for epoxy resin
The present invention relates to styrenated phenol useful as a curing agent or a plasticizing agent for an epoxy resin. More particularly, it relates to use of...
US-9,771,309 Chromia based fluorination catalyst
A chromia-based fluorination catalyst comprising at least one additional metal selected from zinc, nickel, aluminum and magnesium in which from 0.1 to 8.0% by...
US-9,771,308 Production of 1,3-butadiene
Olefins and diolefins, such as 1,3-butiadiene, may be produced by a method utilizing a series of bromination and dehydrobromination reactions. Bromine may be...
US-9,771,307 Process for obtaining modified molecular sieves
A process may include contacting an oxygen-containing, halogenide-containing or sulphur-containing organic feedstock in an XTO reactor with a catalyst composite...
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