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Patent # Description
US-9,777,027 Method for the synthesis of ethane-1-hydroxy-1,1-diphosphonic acid
The present invention is related to a method for the synthesis of ethane-1-hydroxy-1,1-diphosphonic acid or its salt which includes the steps of reacting...
US-9,777,026 Branched oligoarylsilanes and method for producing same
Novel branched oligoarylsilanes of general formula (I) ##STR00001## A method of preparation of branched oligoarylsilanes is that a compound of general formula...
US-9,777,025 Si-containing film forming precursors and methods of using the same
Mono-substituted TSA precursor Si-containing film forming compositions are disclosed. The precursors have the formula: (SiH.sub.3).sub.2N--SiH.sub.2--X, wherein...
US-9,777,024 Heteroaryl inhibitors of PDE4
The present invention relates to compounds and methods useful as inhibitors of phosphodiesterase 4 (PDE4) for the treatment or prevention of disease.
US-9,777,023 Dinuclear indium catalysts and their use for (Co)polymerization of cyclic esters
Provided are novel dinuclear indium catalysts of formula (A) that are capable of living and immortal ring opening polymerization and copolymerization of cyclic...
US-9,777,022 Process for the preparation of macrocyclic polyazacarboxylate ligands and chelates
The present disclosure relates generally to a process for the synthesis of 1,4,7,10-tetraazacyclododecane ligands, chelates, and derivatives thereof. In...
US-9,777,021 Lubricant additives
Lubricant additives useful as friction reducing additives are disclosed herein that have a structure according to general formula I, where M is metal such as...
US-9,777,020 Furo-3-carboxamide derivatives and methods of use
Compounds of formula (I) ##STR00001## and pharmaceutically acceptable salts, esters, amides, or radiolabelled forms thereof, wherein R.sup.1, Z.sup.1,...
US-9,777,019 Amino-oxazine and amino-dihydrothiazine compounds as beta-secretase modulators and methods of use
The present invention comprises a new class of compounds useful for the modulation of Beta-secretase enzyme activity and for the treatment of Beta-secretase...
US-9,777,018 Compounds as modulators of GPR-119
The present invention relates to novel compounds of formula (A) and (B) as modulators of GPR-119, methods of preparing them, pharmaceutical compositions...
US-9,777,017 Tricyclic fused thiophene derivatives as JAK inhibitors
The present invention provides tricyclic fused thiophene derivatives, as well as their compositions and methods of use, that modulate the activity of Janus...
US-9,777,016 Isoergoline compounds and uses thereof
Provided herein are isoergoline compounds and pharmaceutical compositions thereof. In other embodiments, provided herein are methods of treatment, prevention,...
US-9,777,015 Useful thiophene derivatives in the treatment of diabetes
The present invention relates to a thiophene derivative of the following general formula I ##STR00001## or an enantiomer, diastereoisomer, hydrate, solvate,...
US-9,777,014 Tetrahydro-2H-pyrano[3,2-C]isochromene-6-ones and analogs for the treatment of inflammatory disorders
The present invention relates to 2,3,4,4a-tetrahydro-3,4,8,10-tetrahydroxy-2-(hydroxymethyl)-9-methoxypyra- no[3,2-c]isochromen-6(10bH)-one analogs of the...
US-9,777,013 Derivatives of uncialamycin, methods of synthesis and their use as antitumor agents
In one aspect, the present disclosure provides new analogs of uncialamycin of formulae (I) and (II). The present disclosure also provides novel synthetic...
US-9,777,012 Substituted furo[2,3-d]pyrimidines as multi-targeted receptor tyrosine kinase inhibitors and microtubule...
Compounds of Formula I: ##STR00001## and compounds of Formula II: ##STR00002## are provided. Pharmaceutical compositions comprising either the compound of...
US-9,777,011 Process for preparing oxycodone compositions
In certain embodiments the invention is directed to a process for preparing an oxycodone hydrochloride composition having less than 25 ppm of 14-hydroxycodeinone.
US-9,777,010 Substituted 4-phenylpiperidines, their preparation and use
The present invention provides a compound having the structure: ##STR00001## wherein R.sub.1, R.sub.2, R.sub.3, R.sub.4, and R.sub.5 are each independently...
US-9,777,009 Deuterated ibrutinib
The present invention in one embodiment provides a compound of Formula I: ##STR00001## or a pharmaceutically acceptable salt thereof, wherein the variables...
US-9,777,008 PRMT5 inhibitors and uses thereof
Described herein are compounds of Formula (I), pharmaceutically acceptable salts thereof, and pharmaceutical compositions thereof. Compounds of the present...
US-9,777,007 Short-acting benzodiazepine salts and their polymorphic forms
The invention relates to besylate salts of the compound of formula (I): ##STR00001## Methods of preparing the salts, and their use as medicaments, in...
US-9,777,006 Inhibitors of leukotriene A4 hydrolase
The present invention is directed to compounds encompassed by the Formula (I): ##STR00001## pharmaceutical compositions thereof, methods for inhibiting LTA-4...
US-9,777,005 Bicyclic heterocyclic compound containing a substituted pyrrole ring
Provided is a compound having a cholinergic muscarinic M1 receptor positive allosteric modulator activity, and useful as a prophylactic or therapeutic drug for...
US-9,777,004 Amino-substituted imidazopyridazines
The present invention relates to amino-substituted imidazopyridazine compounds of general formula (I), in which A, R1, R2, R3, R4, R5 and n are as defined in...
US-9,777,003 Tricyclic heterocycles as bet protein inhibitors
The present invention relates to tricyclic heterocycles which are inhibitors of BET proteins such as BRD2, BRD3, BRD4, and BRD-t and are useful in the treatment...
US-9,777,002 Inhibitors of the renal outer medullary potassium channel
The present invention provides compounds of Formula I ##STR00001## and the pharmaceutically acceptable salts thereof, which are inhibitors of the ROMK...
US-9,777,001 Macrocycles with aromatic P2' groups as factor xia inhibitors
The present invention provides compounds of Formula (I): or stereoisomers, tautomers, or pharmaceutically acceptable salts thereof, wherein all the variables...
US-9,777,000 Pyrazole derivative
It has been desired to develop a pharmaceutical composition, which is used in agents for preventing and/or treating various diseases related to PDE10 (e.g....
US-9,776,999 Antiparisitic dihydroazole compounds and compositions comprising same
The present invention relates to novel dihydroazole of formula (I) and salts thereof: ##STR00001## Wherein R.sub.1, A.sub.1, A.sub.2, G, X and Y are as...
US-9,776,998 Synthesis of heterocyclic compounds
Provided herein are intermediates and processes useful for facile synthesis of compounds of formula (I): ##STR00001## or a pharmaceutically acceptable salt, a...
US-9,776,997 3-aryl-substituted imidazo[1,2-A]pyridines and their use
The present application relates to novel 3-aryl-substituted imidazo[1,2-a]pyridines, to processes for preparation thereof, to the use thereof, alone or in...
US-9,776,996 Substituted 6,5-fused bicyclic heteroaryl compounds
The present invention relates to azole bicyclic heteroaryl compounds. The present invention also relates to pharmaceutical compositions containing these...
US-9,776,995 Bicyclic sulfonamide compounds as sodium channel inhibitors
The present invention provides compounds of Formula I or pharmaceutically acceptable salts thereof, that are inhibitors of voltage-gated sodium channels, in...
US-9,776,994 Pyrazoline derivatives as insecticidal compounds
The present invention relates to compounds of formula (I) wherein P is selected from P1 and P2, or P and R.sup.5 together are P3 or P is a heterocycle H,...
US-9,776,993 Nitrogen-containing heterocyclic compounds for plant disease control
The present invention relates to novel isoxazoline carboxamide derivatives, to processes for preparing these compounds, to compositions comprising these...
US-9,776,992 1-oxo-1,2-dihydroisoquinolin-7-yl-(5-substituted-thiophen-2-yl)-sulfonamid- e compounds, formulations containing...
1-Oxo-1,2-dihydroisoquinolin-7-yl-(5-substituted-thiophen-2-yl)-sulfonami- de compounds, formulations containing those compounds, and their use as AICARFT...
US-9,776,991 Thienomethylpiperazine derivatives as inhibitors of soluble epoxide hydrolase
The present invention relates to compounds of the formula (I), wherein R1, R2, R3, R4 and X have the meanings indicated in the claims. The compounds of formula...
US-9,776,990 Isoindolone derivatives
The present invention provides for compounds of formula (I) ##STR00001## wherein A, Y, J, R.sup.1, R.sup.2, and R.sup.3 have any of the values defined...
US-9,776,989 Chromone alkaloid dysoline for the treatment of cancer and inflammatory disorders
The present invention relates to novel chromone alkaloid of formula 1 isolated from the plant Dysoxylum binectariferum. The compound ...
US-9,776,988 Pyrazolylbenzo[d]imidazole derivatives
A compound represented by the general Formula (I), wherein hydrogen atoms shown as attached to pyrazole and benzimidazole rings are attached to one of nitrogen...
US-9,776,987 Amide derivatives for GPR119 agonist
The present invention relates to novel amide derivatives, stereoisomers thereof or pharmaceutically acceptable salts thereof; methods for preparing the...
US-9,776,986 Parasiticidal compositions comprising indole derivatives, methods and uses thereof
The invention relates to oral, topical or injectable compositions for combating liver fluke parasites in mammals, comprising at least one indole derivative...
US-9,776,985 Process for preparation of alogliptin
Provided is a novel process for the preparation of alogliptin.
US-9,776,984 Compounds containing a pentalene unit and process for their preparation
Compound containing a pentalene unit having general formula (I) wherein R.sub.1 and R.sub.2, equal to or different from each other, are selected from: linear or...
US-9,776,983 Method for manufacturing fluoropolymers
The invention pertains to a method for making a fluoropolymer comprising an aqueous emulsion polymerization of one or more fluorinated monomers wherein said...
US-9,776,982 Treprostinil derivative compounds and methods of using same
Compounds represented by formulae I, II, III, and IV including pro-drugs for treprostinil and prostacyclin analogs. Uses include treatment of pulmonary...
US-9,776,981 Hepatitis C virus inhibitors
The present disclosure relates to compounds, compositions and methods for the treatment of Hepatitis C virus (HCV) infection. Also disclosed are pharmaceutical...
US-9,776,980 Process for making HMF from sugars with reduced byproduct formation, and improved stability HMF compositions
Disclosed is a process for making HMF or a derivative of HMF by dehydrating one or more hexose sugars in a reduced oxygen environment. In another, related...
US-9,776,979 EBI2 modulators
Provided herein are small molecule Epstein-Barr virus-induced G-protein coupled receptor 2 (EBI2) modulator compounds, compositions comprising the compounds,...
US-9,776,978 1,3,4-oxadiazole and 1,3,4-thiadiazole derivatives as immunomodulators
The present invention relates to 1,3,4-oxadiazole and 1,3,4-thiadiazole compounds as therapeutic agents capable of inhibiting the programmed cell death 1 (PD1)...
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