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Patent # Description
US-9,856,298 Modified antibiotic peptides having variable systemic release
The invention relates to modified antibiotic peptides, in particular derivatives of apidaecin and oncocin, preferably having increased stability, reduced...
US-9,856,297 Plant transcriptional regulators
The invention relates to plant transcription factor polypeptides, polynucleotides that encode them, homologs from a variety of plant species, and methods of...
US-9,856,296 Hypoallergen
The present invention provides mutant polypeptides useful as hypoallergens. More specifically the present invention provides mutant Bet v 1 proteins and the use...
US-9,856,295 Recombinant feline leukemia virus vaccine containing optimized feline leukemia virus envelope gene
The present invention provides vectors that contain and express in vivo or in vitro FeLV antigens that elicit an immune response in animal or human against...
US-9,856,294 Cyclodecapeptide compounds for use as drugs
The invention relates to novel cyclodecapeptide compounds having formula (I) for use as drugs and, more specifically, for use in the diagnosis, prevention...
US-9,856,293 Methods for inducing nestin expression of astrocytes by nestin-inducing synthetic peptides derived from the...
A synthetic peptide having nestin expression inducing ability which allows induction of expression of nestin in astrocytes; an agent for inducing nestin...
US-9,856,292 Immunomodulators
The present disclosure provides compounds which are immunomodulators and thus are useful for the amelioration of various diseases, including cancer and...
US-9,856,291 Cancer stem cell targeting peptide and use thereof
A synthetic peptide that targets cancer stem cells is provided. The peptide consists of the amino acid sequence of anyone of SEQ ID NO: 1 to SEQ ID NO: 15. Also...
US-9,856,290 Glycopeptide compositions and uses thereof
The present disclosure provides glycosylated oligopeptides having the sequence Palmitoyl-X1-Lys-X2-X3-Lys-X4-OH, where: X1 is: absent, Ser having a glycosylated...
US-9,856,289 Peptides capable of reactivating p53 mutants
The invention provides peptides that can reactivate p53 mutants efficiently and specifically, as well as methods that allow the identification, selection and...
US-9,856,288 Tripeptide epoxyketone compound constructed by heterocycle and preparation method and use thereof
Disclosed are a tripeptide epoxyketone compound, a preparation method thereof, and a use thereof in the preparation of anti-tumor drugs.
US-9,856,287 Refolding proteins using a chemically controlled redox state
A method of refolding proteins expressed in non-mammalian cells present in concentrations of 2.0 g/L or higher is disclosed. The method comprises identifying...
US-9,856,286 2,2-difluoropropionamide derivatives of bardoxolone methyl, polymorphic forms and methods of use thereof
The present invention relates generally to the compound: N-((4aS,6aR,6bS,8aR,12aS,14aR,14bS)-11-cyano-2,2,6a,6b,9,9,12a-heptamethy- ...
US-9,856,285 Reagents for universal site-specific labeling and modifications of nucleic acids
The present invention discloses a method of harnessing versatile phosphoramidation reactions to regioselectively link a group of alkynyl-/azido-containing...
US-9,856,284 Solid forms of a thiophosphoramidate nucleotide prodrug
The present application relates to solid state forms, for example, crystalline forms of ...
US-9,856,283 Thiosaccharide mucolytic agents
There are provided, inter alia, methods for decreasing mucus elasticity or decreasing mucus viscosity in a subject in need thereof, the methods including...
US-9,856,282 Dehydrogenation catalyst, and carbonyl compound and hydrogen production method using said catalyst
Objects of the present invention are to provide a novel dehydrogenation reaction catalyst, to provide a method that can produce a ketone, an aldehyde, and a...
US-9,856,281 Solid-state materials formed of molecular clusters and method of forming same
A solid-state material comprising a solid-state compound is provided. The solid-state compound has the formula: [Cluster1][Cluster2].sub.n, where Cluster1 can...
US-9,856,280 Method for producing aqueous preparations of complexes of platinum group metals
The invention relates to a method for producing aqueous preparations of complexes of platinum group metals (PGM) Pt, Pd, Rh and Ir having the general formula ...
US-9,856,279 Therapeutically active compositions and their methods of use
Provided are piperazine compounds of Formula I useful for treating cancer and methods of treating cancer comprising administering to a subject in need thereof a...
US-9,856,278 Lysophosphatidylserine derivative
An object of the present invention is to provide a lysophosphatidylserine derivative or a salt thereof. The present invention provides a lysophosphatidylserine...
US-9,856,277 Method for the purification of lecithin
The present invention relates to a method for the purification of lecithin, comprising the steps of (a) mixing lecithin with active carbon to form a dispersion;...
US-9,856,276 Compounds useful in the synthesis of halichondrin B analogs
In general, the invention features compounds useful for the synthesis of analogs of halichondrin B, such as eribulin or pharmaceutically acceptable salts...
US-9,856,275 Synthesis and use of fluorinated compounds
The invention is directed to the preparation of fluorinated compounds and their use in organic synthesis. In particular, the invention is directed to methods of...
US-9,856,274 Substituted pyrazolo[1,5-a]pyridines as PDE-10 inhibitors
Provided herein are substituted pyrazolopyridine compounds, and pharmaceutical compositions thereof, useful for the treatment of, for example, central nervous...
US-9,856,273 ETP derivatives
Provided herein, inter alia, is the synthesis of ETP derivatives. The uses of the ETP derivatives described herein include treatment of cancer.
US-9,856,272 [1-3]-thiazine-fulleropyrrolo derivatives of C60 and C70 as HIV-inhibitor agents
Certain embodiments useful as HIV-inhibitor agents are directed to fullerene derivatives tetrahydro-1H--C.sub.60-fulleropyrrolo[1,2-c][1,3]thiazine salts...
US-9,856,271 Process for the preparation of dolutegravir and pharmaceutically acceptable salts thereof
The present invention relates to a novel process for the preparation of dolutegravir and pharmaceutically acceptable salts thereof using novel intermediates.
US-9,856,270 Dolutegravir salts
Dolutegravir potassium salt and solid state forms thereof are provided, as well as methods of making and interconverting these forms. The Dolutegravir potassium...
US-9,856,269 Method for producing pyromellitic dianhydride, pyromellitic dianhydride produced by the method, and apparatus...
A method for producing a highly pure PMDA comprises at least the following steps: (1) a step of preparing a raw material solution by dissolving a raw material...
US-9,856,268 Lactam kinase inhibitors
Compounds useful as kinase inhibitors are provided herein, as well as salts, pharmaceutical compositions, methods of medical treatment and methods of synthesis...
US-9,856,267 CARM1 inhibitors and uses thereof
Provided herein are compounds of Formula (I): ##STR00001## and pharmaceutically acceptable salts thereof, and pharmaceutical compositions thereof; wherein X,...
US-9,856,266 IRE-1alpha inhibitors
The invention provides compounds which directly inhibit IRE-1.alpha. activity in vitro, prodrugs, and pharmaceutically acceptable salts thereof. Such compounds...
US-9,856,265 Macrocyclic inhibitors of hepatitis C virus
Inhibitors of HCV replication of formula (I) ##STR00001## and the N-oxides, salts, and stereoisomers, wherein each dashed line represents an optional double...
US-9,856,264 Isoquinolinesulfonyl derivative as RHO kinase inhibitor
The present invention discloses a class of isoquinolinesulfonyl derivatives as RHO kinase inhibitors, and pharmaceutical compositions thereof, and relates to...
US-9,856,263 Heteroaromatic compounds and their use as dopamine D1 ligands
The present invention provides, in part, compounds of Formula (I): and pharmaceutically acceptable salts thereof; processes for the preparation of;...
US-9,856,262 Analogues of 4H-pyrazolo[1,5-a] benzimidazole compound as PARP inhibitors
Disclosed is a series of analogs of 4H-pyrazolo[1,5-.alpha.]benzimidazole compound as PARP inhibitors. In particular, disclosed in the invention is a compound...
US-9,856,261 Piperidine inhibitors of Janus kinase 3
The present invention relates to new piperidine inhibitors of Janus kinase 3 activity, pharmaceutical compositions thereof, and methods of use thereof. ...
US-9,856,260 Compounds useful for inhibiting metastasis from cancer and methods using same
The present invention includes compositions that are useful in preventing or treating metastasis in a subject diagnosed with cancer. The present invention also...
US-9,856,259 Heterocyclic compounds and uses thereof
Heterocyclic compounds of formula (I), pharmaceutical compositions containing such a compound and their therapeutic uses.
US-9,856,258 (5,6-dihydro)pyrimido[4,5-E]indolizines
A compound of Formula I: ##STR00001## wherein, R.sup.1 and R.sup.2 independently are selected from the group consisting of optionally substituted (6-10C)aryl...
US-9,856,257 Pyrazolonaphthyridinone derivatives as MetAP2 inhibitors (methionine aminopeptidase type-2)
The invention related to pyrazolonaphthyridinone derivatives of formula (I) to their preparation and to their therapeutic use as selective inhibitors of type 2...
US-9,856,256 Pyridino[1,2-A]pyrimidone analogue used as P13K inhibitor
The present invention relates to novel pyridino[1,2-.alpha.]pyrimidone compounds represented by formula (I) or pharmaceutically acceptable salts thereof; and a...
US-9,856,255 Imidazo[4,5-c]quinolin-2-one compounds and their use in treating cancer
The specification generally relates to compounds of Formula (I): ##STR00001## and pharmaceutically acceptable salts thereof, where R.sup.1, R.sup.2, R.sup.3,...
US-9,856,254 Alkoxy substituted imidazoquinolines
Imidazoquinoline compounds with an alkoxy substituent at the 6, 7, 8, or 9-position, pharmaceutical compositions containing the compounds, intermediates,...
US-9,856,253 Tricyclic modulators of TNF signaling
The invention provides tricyclic heterocyclic compounds, pharmaceutically acceptable salts, pro-drugs, biologically active metabolites, stereoisomers and...
US-9,856,252 2-(hetero)aryl-benzimidazole and imidazopyridine derivatives as inhibitors of asparagime emethyl transferase
Substituted benzimidazole and 3H-imidazo[4,5-b]pyridines or formula I: where X and Y respectively are selected from: (i) N and N; and (ii) N and CR.sup.4;...
US-9,856,251 Substituted berbines and processes for their synthesis
The present invention provides processes for the synthesis of substituted berbine compounds. Also provided are intermediates used in the synthesis of...
US-9,856,250 Substituted tropane derivatives
Provided is a compound which is useful as a prophylactic or therapeutic agent for various diseases in which T-type calcium channels are involved, such as...
US-9,856,249 Inhibitors of leukotriene A4 hydrolase
The present invention is directed to compounds encompassed by the Formula (I), pharmaceutical compositions thereof, methods for inhibiting LTA-4 hydrolase, and...
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