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Patent # Description
US-9,861,624 Method of treating cancer
This invention is directed to the treatment of cancer, particularly castration-resistant prostate cancer and osteolytic bone metastases, with a dual inhibitor...
US-9,861,623 Combination treatment of RAS-positive diseases with PDE-.delta. inhibitor and direct autophagy inhibitor
The present invention provides methods for treatment of a RAS-positive disease, in particular KRAS-positive non-small cell lung cancer as well as a method for...
US-9,861,622 Methods for treating disorders or diseases associated with hyperlipidemia and hypercholesterolemia while...
The present invention provides methods and compositions for treating hyperlipidemia and/or hypercholesterolemia comprising administering to the subject an...
US-9,861,621 LPT-723 and immune checkpoint inhibitor combinations and methods of treatment
The present invention provides, inter alia, a composition containing a compound of formula (I): ##STR00001## or a pharmaceutically acceptable salt thereof,...
US-9,861,620 Substituted quinolizine derivatives useful as HIV integrase inhibitors
The present invention relates to Substituted Quinolizine Derivatives of Formula (I): and pharmaceutically acceptable salts or prodrug thereof, wherein X, Y,...
US-9,861,619 Antibiotic methods and compositions for bacteria infections
Compositions and methods are provided for treating or inhibiting a bacterial infection involving at least one antibiotic and a compound that potentiates the...
US-9,861,618 Thiazoles as modulators of ROR.gamma.t
The present invention comprises compounds of Formula I ##STR00001## wherein: R.sup.1, R.sup.2, R.sup.3, R.sup.4, R.sup.5, R.sup.7, R.sup.8, and ##STR00002## ...
US-9,861,617 Compositions of 1,2,4-oxadiazole benzoic acid compounds and methods for their use
Novel 1,2,4-oxadiazole benzoic acid compounds, methods of using and pharmaceutical compositions comprising an 1,2,4-oxadiazole benzoic acid derivative are...
US-9,861,616 Methods for treating respiratory diseases and formulations therefor
Compounds of formula (I), compositions comprising them, and methods and uses thereof are described herein for the treatment of respiratory diseases, including...
US-9,861,615 Methods and pharmaceutical compositions for the treatment of beta-thalassemias
The present invention relates to methods and pharmaceutical compositions for the treatment of beta-thalassemias. In particular, the present invention relates to...
US-9,861,614 Nuclear transport modulators and uses thereof
The present invention relates to compounds of formula I: ##STR00001## and pharmaceutically acceptable salts thereof, pharmaceutical compositions comprising the...
US-9,861,613 GPR142 agonist compounds
The present invention provides compounds of the Formula (Ia) wherein R is selected from the group consisting of CH.sub.3, CH(CH.sub.3).sub.2, CH.sub.2CN,...
US-9,861,612 Indolyl-containing ROR.gamma.t inhibitors
The invention relates to compounds of formula (I), wherein R.sup.1 and R.sup.2 are as defined herein. The compounds of the invention are inhibitors of...
US-9,861,611 Formulations of water-soluble derivatives of vitamin E and soft gel compositions, concentrates and powders...
Provided herein are compositions that contain water-soluble vitamin E derivative mixtures (compositions), such as tocopheryl polyethylene glycol succinate...
US-9,861,610 Process for selective extraction of bioactive and bioavailable cinnamon polyphenols and procyanidin oligomers...
The present invention relates to a process for selective extraction of bioactive and bioavailable cinnamon polyphenols and procyanidin oligomers of the type A...
US-9,861,609 Chemical engineering processes and apparatus for the synthesis of compounds
The present invention provides methods for producing cannabinoids and cannabinoid analogs as well as a system for producing these compounds. The inventive...
US-9,861,608 Methods for delivering cromolyn
Methods of delivering cromolyn to a patient in need thereof, methods of treating amyloid-associated conditions and inflammatory or allergic lung diseases, and...
US-9,861,607 Methods of using low-dose doxepin for the improvement of sleep
Methods of preventing early awakenings, and improving sleep efficiency in hours 7 and 8 of a period of sleep, by administration of low doses of doxepin (e.g.,...
US-9,861,606 Therapeutic for treating inflammatory lung disorders
A calcium/cation-sensing receptor (CaSR) antagonist to treat an inflammatory lung disorder is described. Methods of treatment including the antagonist,...
US-9,861,605 Enriched injectable emulsion containing selected fatty acid triglycerides
A composition including a triglyceride containing glycerol which is esterified with three fatty acids, wherein the three fatty acids include at least one fatty...
US-9,861,604 Coriolus versicolor extracts, methods of isolating biologically-active compounds, and uses thereof
The subject invention provides efficient and convenient methods of isolating 9-oxo-10E, 12E-octadecadienoic acid methyl ester (9-KODE methyl ester) from C....
US-9,861,603 Therapeutic compositions
Ingenol angelate is a potent anticancer agent, and can be stabilized by dissolving it in an aprotic solvent in the presence of an acidic buffer.
US-9,861,602 Compositions and methods comprising C16:1n7-palmitoleate
One embodiment described herein is related to methods and compositions, such as nutraceutical formulations and dietary supplements, comprising ...
US-9,861,601 Treatment of pulmonary arterial hypertension with leukotriene inhibitors
Pulmonary arterial hypertension (PAH) can be prevented in persons susceptible to the diseases and PAH patients can be treated by administering an effective dose...
US-9,861,600 Methods and compositions for treating and identifying compounds to treat age-related macular degeneration treatment
The present invention provides methods for treating or limiting development of age-related macular degeneration, as well as methods for identifying compound...
US-9,861,599 Beta-substituted beta-amino acids and analogs as chemotherapeutic agents
.beta.-Substituted .beta.-amino acids, .beta.-substituted .beta.-amino acid derivatives, and .beta.-substituted .beta.-amino acid analogs and (bio)isosteres and...
US-9,861,598 Ketoprofen lysine salt-containing aqueous patch
A ketoprofen-containing aqueous patch is provided in which not only operational efficiency in producing is improved, but also the aqueous patch has excellent...
US-9,861,597 Gluconate-based compositions as a neonate anticonvulsant
The present invention is drawn to the treatment of neonatal patients exhibiting convulsion comprising administering a composition comprising a gluconate...
US-9,861,596 Compositions and methods for treating neurological diseases or injury
Provided are compounds for the treatment of neurological diseases or injuries, including neurodegenerative diseases, stroke, trauma, epilepsy, acute and chronic...
US-9,861,595 Compositions and methods for increasing the metabolic lifetime of dextromethorphan and related pharmacodynamic...
This disclosure relates to methods administering various compounds in conjunction with dextromethorphan to a human being. Dosage forms, drug delivery systems,...
US-9,861,594 Treatments for attention and cognitive disorders, and for dementia associated with a neurodegenerative disorder
The present invention provides a method of treating or preventing an attention and/or cognitive disorder in a subject in need thereof, comprising administering...
US-9,861,593 Method for treating or preventing dry eye disorders using alkylamino-polyhydroxyalkanes
Method for the treatment or prophylaxis of dry eye disorders by the administration of alkylamino-polyhydroxyalkanes and compositions thereof.
US-9,861,592 Methods and compositions for treating neurodegenerative diseases
The present invention provides methods and compositions for treating neurodegenerative diseases by cyclohexenone compounds.
US-9,861,591 Nitric oxide-releasing wound treatment film and preparation method therefor
Provided is a nitric oxide-releasing wound treatment film containing S-nitroglutathione, which is a nitric oxide donor to be spontaneously formed in the human...
US-9,861,590 Self-supporting films for delivery of therapeutic agents
The present disclosure relates to self-supporting films for delivery of a therapeutic agent containing at least one hydrophobic polymer and at least one...
US-9,861,589 Diester and triester based low molecular weight, biodegradeable cationic lipids for oligonucleotide delivery
The instant invention provides for novel cationic lipids of Formula A that can be used in combination with other lipid components such as cholesterol and...
US-9,861,588 Nanoparticulate systems prepared from sorbitan esters
The invention relates to systems comprising homogenous nanoparticles having an average size of less than 1 micrometer and containing at least a sorbitan ester,...
US-9,861,587 Composition and method for treating ketosis in cows
A method for prophylactic treatment of ketosis in a calving cow, the method including orally administering to the cow within a time period of about 12 hours...
US-9,861,586 Chewable soft capsules
A matrix formulation for a soft chewable capsule is provided which includes a gel-forming composition, a plasticizer, a polymer modifier, and water. The polymer...
US-9,861,585 Osmotic floating tablets
The present invention relates to an osmotic floating tablet comprising: (i) an inner core comprising a drug, one or more low density polymers, and one or more...
US-9,861,584 Tamper resistant controlled release dosage forms
In certain embodiments, the present invention is directed to a solid controlled release dosage form comprising: a core comprising a first portion of an opioid...
US-9,861,583 Pharmaceutical formulation containing gelling agent
Disclosed in certain embodiments is a controlled release oral dosage form comprising a therapeutically effective amount of a drug susceptible to abuse together...
US-9,861,582 Pharmaceutical formulation containing gelling agent
Disclosed in certain embodiments is a controlled release oral dosage form comprising a therapeutically effective amount of a drug susceptible to abuse together...
US-9,861,581 Granulate for the formulation of orodispersible tablets
This invention relates to a granulate comprising mannitol and sorbitol in a weight ratio of between 70:30 and 97:3. This invention also relates to the use of a...
US-9,861,580 Method of making a dry powder pharmaceutical composition
A method of making active pharmaceutical ingredient particles with surface-modified nanoparticles deposited on the particles' surfaces, the method comprising:...
US-9,861,579 Foamable formulation
The present invention provides DMSO-containing foamable formulations, methods for preparation, and methods of treatment. The formulations can provide good...
US-9,861,578 Sublingual dosimetric drip caged ball valve device
A device for self-administration of fractional amounts of a total volume dose of liquid medicament supplied from a capsule over a period of time for delivery to...
US-9,861,577 Orally disintegrating tablet
It is an object of the present invention to provide an orally disintegrating tablet that has desirable oral disintegrability and excellent tablet hardness, a...
US-9,861,576 Biodegradable alpha-2 agonist polymeric implants and therapeutic uses thereof
Biocompatible intraocular implants include an alpha-2 adrenergic receptor agonist and a polymer associated with the alpha-2 adrenergic receptor agonist to...
US-9,861,575 Vitamin-containing nutrition infusion for administration through peripheral vein
A nutrition infusion is provided for administration through a peripheral vein that contains a vitamin B group and vitamin C stably and includes two solutions of...
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