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Patent # Description
US-9,862,739 Metal complexes, comprising carbene ligands having an O-substituted non-cyclometalated aryl group and their use...
Cyclometallated Ir complex comprising three N,N diaryl substituted carbene ligands, bearing substituents in the 2 position of the non-cyclometallated aryl ring;...
US-9,862,738 Heterocyclic selenophosphites and method for the preparation thereof
Novel heterocyclic selenophosphites, method for preparation thereof and use thereof as ligand unit for preparing ligands for use in complexes.
US-9,862,737 Salts, prodrugs and polymorphs of fab I inhibitors
In part, the present invention is directed to antibacterial compounds and salts thereof.
US-9,862,736 Bimetallic complex comprising cyclopentadienyl and amidine ligands
The present invention relates to a new bimetallic complex of the formula (1) wherein: M is a group 4-6 metal R.sup.1 means is a substituent comprising a...
US-9,862,735 Organosilicon compound having diphenylethyl and methoxysilyl and making method
An organosilicon compound having diphenylethyl and methoxysilyl groups is more readily hydrolyzable than ethoxysilyl-containing organosilicon compounds and...
US-9,862,734 Metal-ligand complex, olefin polymerization catalyst derived therefrom, and olefin polymerization method...
A metal-ligand complex has formula (I): wherein J, L, M, R.sup.1, R.sup.2, R.sup.3, R.sup.4, X, p, q, and r are defined herein. The metal-ligand complex is...
US-9,862,733 Apparatus and methods for the automated synthesis of small molecules
Provided are methods for purifying N-methyliminodiacetic acid (MIDA) boronates from solution. Also provided are methods for deprotection of boronic acids from...
US-9,862,732 Regioselective 1,2-dearomatization of functionalized azines by organolanthanide catalysts
A 1,2-regioselective organolanthanide-catalyzed azine dearomatization process using pinacolborane is disclosed.
US-9,862,731 Difluoroboron dipyrromethene fluorescent probe, production method and application thereof
The present invention provides a difluoroboron dipyrromethene fluorescent probe having a structure represented by the following general formula I, and a...
US-9,862,730 Imidazothiadiazole derivatives as protease activated receptor 4 (PAR4) inhibitors for treating platelet aggregation
The present invention provides imidazothiadiazole compounds of Formula (I) wherein A, B, D, R.sup.x, R.sup.1, R.sup.2, R.sup.3, X.sub.1, X.sub.2 and s are as...
US-9,862,729 Broad spectrum beta-lactamase inhibitors
Broad spectrum beta-lactamase inhibitors. Certain inhibitors also exhibit potent antibiotic activity in addition to beta-lactamase inhibition. Compounds of the...
US-9,862,728 Crystalline forms of an antiviral compound
Crystalline forms of the anti-HCV compound (1aR,5S,8S,9S,10R,22aR)-5-tert-butyl-N-[(1R,2R)-2-(difluoromethyl)-1-{[(1- ...
US-9,862,727 Process for controlling malodors using oxazolidines
The invention describes a method for degrading off-odors by employing a special 1-aza-3,7-dioxabicyclo[3.3.0]octane compound. Degradation of off-odors to the...
US-9,862,726 Opioid receptor modulating oxabicyclo[2.2.2]octane morphinans
The application is directed to compounds of Formula (I) and pharmaceutically acceptable salts and solvates thereof, wherein R.sup.1, R.sup.2, Y, Z, and G are...
US-9,862,725 Process for preparing chiral dipeptidyl peptidase-IV inhibitors
A process for preparing a compound of structural Formula Ia: comprising Boc deprotection with TFA of, reductive amination of: ##STR00001##
US-9,862,724 Pyrazolo[1,5-a]pyrimidine-based compounds, compositions comprising them, and methods of their use
Pyrazolo[1,5-a]pyrimidine-based compounds of the formula: ##STR00001## are disclosed, wherein R.sub.1, R.sub.2 and R.sub.3 are defined herein. Compositions...
US-9,862,723 Stable polymorph of the salt of (2R)-4-oxo-4-[3-(trifluoromethyl)-5,6-dihydro[1,2,4]triazolo[4,3-.alpha.]- ...
A stable polymorph (Form Z1) of the salt of (2R)-4-oxo-4-[3-(trifluoromethyl)-5,6-dihydro ...
US-9,862,722 Inhibitors of Bruton's tyrosine kinase
Described herein are kinase inhibitor compounds, methods for synthesizing such inhibitors, and methods for using such inhibitors in the treatment of diseases....
US-9,862,721 Tetrahydrocarboline derivative
An object of the present invention is to provide a drug having the inhibitory activity on ENPP2 which is a different target from that of the existing drug, as a...
US-9,862,720 Inhibitors of the renal outer medullary potassium channel
The present invention provides compounds of Formula I and the pharmaceutically acceptable salts thereof, which are inhibitors of the ROMK (Kir1.1) channel. The...
US-9,862,719 Process or preparing spirocyclic cyclohexane compounds, compositions containing such compounds and method of...
Spirocyclic cyclohexane compounds corresponding to formula I ##STR00001## a method for producing them, pharmaceutical compositions containing them, and methods...
US-9,862,718 Sodium salt of (2S, 5R)-6-benzyloxy-7-oxo-1,6-diaza-bicyclo [3.2.1] octane-2-carboxylic acid and its preparation
Sodium salt of (2S,5R)-6-benzyloxy-7-oxo-1,6-diaza-bicyclo[3.2.1]octane-2-carboxylic acid and a process for its preparation is disclosed.
US-9,862,717 Indazoles
The invention provides novel substituted indazole compounds according to Formula (I), their manufacture and use for the treatment of hyperproliferative diseases...
US-9,862,716 TRKA kinase inhibitors, compositions and methods thereof
The present invention is directed to a bicyclic heteroaryl benzamide compounds of formula (I) which are tropomyosin-related kinase (Trk) family protein kinase...
US-9,862,715 Thiazolyl- or thiadiazolyl-substituted pyridyl compounds useful as kinase inhibitors
Compounds having the following formula: ##STR00001## or an enantiomer, diastereomer or a pharmaceutically-acceptable salt thereof, wherein X is N or...
US-9,862,714 Methods and compositions useful in treating cancer and reducing Wnt mediated effects in a cell
Provided herein are novel compounds, pharmaceutical compositions for use, inter alia, in methods of reducing Wnt-mediated effects and treating cancer.
US-9,862,713 Substituted bicyclic heteroaryl compounds as RXR agonists
The present invention relates to certain substituted bicyclic compounds that are agonists of RXR and which are therefore useful in the treatment of certain...
US-9,862,712 Benzimidazole based EGFR inhibitors
The present invention disclosed a novel EGFR inhibitor compound of formula (I), process for preparation thereof and methods of treating abnormal cell growth in...
US-9,862,711 Pyrazine derivatives as phosphatidylinositol 3-kinase inhibitors
The present invention provides compounds of formula (I) which inhibit the activity of PI 3-kinase gamma isoform, which are useful for the treatment of diseases...
US-9,862,710 1,2,4-oxadiazol compounds active against gram-positive pathogens
The present invention relates to novel oxazolidinone compounds of general formula (I) having antibiotic activity also against multiresistant bacterial strains. ...
US-9,862,709 Processes for making compounds useful as inhibitors of ATR kinase
The present invention relates to processes and intermediates for preparing compounds useful as inhibitors of ATR kinase, such as aminopyrazine-isoxazole...
US-9,862,708 Pyrazolone compounds and uses thereof
The invention disclosed herein is directed to compounds of Formula I [Formula should be entered here] and pharmaceutically acceptable salts thereof, which are...
US-9,862,707 TrkA kinase inhibitors, compositions and methods thereof
The present invention is directed to a bicyclic heteroaryl benzamide compounds of formula (I) which are tropomyosin-related kinase (Trk) family protein kinase...
US-9,862,706 Compounds
Imidazolone and pyrazolone derivatives of formula (I) described herein exhibit human neutrophil elastase inhibitory properties and are useful for the therapy of...
US-9,862,705 Salts of a pim kinase inhibitor
The present invention relates to salt forms of the Pim kinase inhibitor N-{(7R)-4-[(3R,4R,5S)-3-amino-4-hydroxy-5-methylpiperidin-1-yl]-7-hydroxy- ...
US-9,862,704 Oxindole derivatives carrying an amine-substituted piperidyl-acetidinyl substituent and use thereof for...
The present invention relates to novel substituted oxindole derivatives of formula (I) wherein the variables are as defined in the claims and description; to...
US-9,862,703 Heterocyclic compounds and use thereof
Heterocyclic compounds of Formula (I) shown herein. Also disclosed are pharmaceutical compositions containing the heterocyclic compounds and methods of using...
US-9,862,702 Processes for the preparation of pesticidal compounds
The present application provides processes for making pesticidal compounds and compounds useful both as pesticides and in the making of pesticidal compounds.
US-9,862,701 Inhibitors of KRAS G12C mutant proteins
Compounds having activity as inhibitors of G12C mutant KRAS protein are provided. The compounds have the following structure (I): ##STR00001## or a...
US-9,862,699 Meldrum's acid, barbituric acid and pyrazolone derivatives substituted with hydroxylamine as HNO donors
The disclosed subject matter provides certain N-substituted hydroxylamine derivative compounds, pharmaceutical compositions and kits comprising such compounds,...
US-9,862,698 Indenyl compounds, pharmaceutical compositions, and medical uses thereof
Disclosed are compounds, for example, compounds of formula I, ##STR00001## wherein R, R.sub.0, R.sub.1-R.sub.8, n, X, Y, Y', and E are as described herein,...
US-9,862,697 pH-sensitive fluorescent sensors for biological amines
The invention is directed to dual-analyte fluorescent chemosensors for the direct detection and visualization (imaging) of neurotransmitters released upon...
US-9,862,696 Synthetic route to anhydroryanodol, ryanodol and structural analogues
This disclosure is related to methods for producing anhydroryanodol, ryanodol, or analogs thereof and novel compounds prepared thereby.
US-9,862,695 Monomer having N-acyl carbamoyl group and lactone skeleton, and polymeric compound
Disclosed is a monomer containing an N-acylcarbamoyl group and a lactone skeleton. The monomer is exemplified by Formula (1): ##STR00001## where R.sup.a is...
US-9,862,694 Method for the synthesis and purification of ethers
Methods of synthesizing and purifying ethers are described. The synthesis and purification are achieved using an etherification technique followed by one or two...
US-9,862,693 Compounds and methods of treating cancer
Presented herein inter alia are novel compounds and methods of using the same for the treatment of cancers.
US-9,862,692 Highly selective anti-cancer agents targeting non-small cell lung cancer and other forms of cancer
Described herein are analogs of 2-methyl-3-(2-ethynylthiazol-4-yl)cyclopent-2-enol and the corresponding ketone...
US-9,862,691 Cyclic triazo and diazo sodium channel blockers
A method of treating a disorder. The method includes administering to a subject in need thereof a compound of general formula (I): ##STR00001## Each of A, N*,...
US-9,862,690 Treatment of pulmonary and other conditions
Disclosed is a compound, or a pharmaceutically acceptable salt or ester thereof, having a structure of: X.sup.1-L-X.sup.2 wherein L is a linking moiety...
US-9,862,689 Processes for the preparation of pyrimidinylcyclopentane compounds
The present invention relates to a process for the preparation of a compound of formula (I), wherein R.sup.1 is as defined herein, which is useful as an...
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