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Patent # Description
US-9,890,394 Gene therapy for amyotrophic lateral sclerosis and other spinal cord disorders
This disclosure provides methods and compositions for treating disorders or injuries that affect motor function and control in a subject. In one aspect, the...
US-9,890,393 Methods for engineering T cells for immunotherapy by using RNA-guided CAS nuclease system
The present invention relates to methods of developing genetically engineered, preferably non-alloreactive T-cells for immunotherapy. This method involves the...
US-9,890,392 Method for preparing specific cells of human-derived cells
A method for preparing neoplastically transformed cells from human-derived cells, including the step of introducing human telomerase catalytic subunit (hTERT)...
US-9,890,391 RNA vector with an open reading frame, an albumin 3'-UTR, and a histone stem loop
The invention relates to an artificial nucleic acid molecule comprising at least one open reading frame and at least one 3'UTR element comprising a nucleic acid...
US-9,890,390 CRY1D for controlling corn earworm
The subject invention relates in part to the surprising discovery that Cry1Da is active against corn earworm (CEW), Helicoverpa zea (Boddie). Methods for using...
US-9,890,388 GRF3 mutants, methods and plants
The present disclosure provides a novel modified gene, rGRF3, or an ortholog thereof, which is shown to be decoupled from control by miR396, particularly in the...
US-9,890,387 Modification of fructan biosynthesis, increasing plant biomass, and enhancing productivity of biochemical...
The present invention relates to the modification of fructan biosynthesis in plants and, more particularly, to methods of manipulating fructan biosynthesis in...
US-9,890,386 Soybean transcription terminators and use in expression of transgenic genes in plants
Five novel plant transcription terminators MYB2, KTI1, PIP1, EF1A2, and MTH1 are isolated from soybean and their functions in the regulation of RNA...
US-9,890,385 Type II restriction modification system methylation subunit of Alicyclobacillus acidocaldarius
Isolated and/or purified polypeptides and nucleic acid sequences encoding polypeptides from Alicyclobacillus acidocaldarius are provided. Further provided are...
US-9,890,384 Recombinant microorganisms and uses therefor
Carboxydotrophic acetogenic microorganisms do not produce MEK and/or 2-butanol. They lack the biosynthesis pathways to make these products. In addition, they...
US-9,890,383 Antisense design
A novel class of pharmaceuticals which comprises a Locked Nucleic Acid (LNA) which can be used in antisense therapy. These novel oligonucleotides have improved...
US-9,890,382 Nucleic acid compositions related to MIR-138-1-3P and uses thereof
Described herein are polynucleotides associated with prostate and lung cancer. The polynucleotides are miRNAs and miRNA precursors. Related methods and...
US-9,890,381 Antisense nucleic acids
The present invention provides a pharmaceutical agent which causes skipping of the 55th, 45th, 50th or 44th exon in the human dystrophin gene with a high...
US-9,890,379 Treatment of genetic disorders associated with DNA repeat instability
The current invention provides for methods and medicaments that apply oligonucleotide molecules complementary only to a repetitive sequence in a human gene...
US-9,890,378 Surface anchored light chain bait antibody display system
The present invention provides, in part, an antibody display system that simultaneously uses a secretion and a display mode. Embodiments of the invention...
US-9,890,377 Antigen-binding molecule capable of binding to two or more antigen molecules repeatedly
The present inventors discovered that antibodies having weaker antigen-binding activity at the early endosomal pH in comparison with that at the pH of plasma...
US-9,890,376 Chromatographic purification of polynucleotides with negatively charged particles
A method of purifying a sample that includes a polynucleotide includes the steps of (i) providing a packed chromatographic column having negatively charged...
US-9,890,375 Isolated oligonucleotide and use thereof in nucleic acid sequencing
Provided are an isolated oligonucleotide and a use thereof in nucleic acid sequencing, wherein the isolated oligonucleotide comprises a first strand, wherein...
US-9,890,374 Thermostable carbonic anhydrases and methods of use thereof
The present compositions and methods relate to a thermostable carbonic anhydrases, polynucleotides encoding the carbonic anhydrase, and methods of make and/or...
US-9,890,373 Modified isoprene synthase
The present application relates to a modified isoprene synthase that has an isoprene synthetic activity and has at least one mutation of an amino acid residue...
US-9,890,372 Aspartic proteases
Methods and composition, thereof, relate to aspartic proteases, and particularly to aspartic proteases for plants. Disclosed are modified plant aspartic...
US-9,890,371 Thermophilic ethanol-resistant .beta.-glucosidase and encoding gene and application thereof
The present invention discloses thermophilic ethanol-resistant .beta.-glucosidase and an encoding gene and application thereof. The amino acid sequence of the...
US-9,890,370 Hyperthermostable endoglucanase
A hyperthermostable endoglucanase, having an endoglucanase catalytic domain including: (A) a polypeptide including an amino acid sequence represented by SEQ ID...
US-9,890,369 Cytolethal distending toxin subunit B conjugated or fused to Bacillus anthracis toxin lethal factor
Disclosed is a protein comprising a cytolethal distending toxin subunit B (CdtB) conjugated or fused to a Bacillus anthracis toxin lethal factor (LF) or a...
US-9,890,368 Polypeptide fragments comprising endonuclease activity and their use
The present invention relates to polypeptide fragments comprising an amino-terminal fragment of the PA subunit of a viral RNA-dependent RNA polymerase or...
US-9,890,367 Bifunctional lipase mutant and methods of using same
The present invention provides a novel dual-function lipase variant and its application in processing of flour products. The amino acid sequence of the lipase...
US-9,890,366 DNA polymerases with improved activity
Disclosed are DNA polymerases having increased reverse transcriptase efficiency relative to a corresponding, unmodified polymerase. The polymerases are useful...
US-9,890,365 Compositions useful in treatment of ornithine transcarbamylase (OTC) deficiency
Non-viral delivery systems comprising engineered hOTC DNA and RNA sequences are provided which when delivered to a subject in need thereof are useful for...
US-9,890,364 TAL-Tet1 fusion proteins and methods of use thereof
Fusion proteins comprising a DNA binding domain, e.g., a TAL effector repeat array or zinc finger, and a catalytic domain comprising a sequence that catalyzes...
US-9,890,363 Influenza virus replication for vaccine development
The invention provides a composition useful to prepare high titer influenza viruses, e.g., in the absence of helper virus, which includes internal genes from an...
US-9,890,362 Compositions, methods and uses for inducing viral growth
Embodiments herein report methods, compositions and uses for inducing and/or accelerating viral growth. In certain embodiments, methods, compositions and uses...
US-9,890,361 Methods for increasing the infectivity of viruses utilizing alkyne-modified fatty acids
Methods of using viruses labeled with alkyne-modified biomolecules, such as fatty acids, carbohydrates and lipids, to treat a plant, an insect or an animal...
US-9,890,360 Method for producing induced pluripotent stem cells
A method that includes bringing a nuclear reprogramming substance (DLX4 gene, OCT3/4 gene, and SOX2 gene) into contact with a cell and thereby producing iPS cells.
US-9,890,359 Culture medium for proliferating stem cell, which contains sulfated compound
A medium which comprises a fibroblast growth factor (FGF), and a sulfated compound or a pharmaceutically acceptable salt thereof at a concentration which...
US-9,890,358 Latent neural stem cell population
The present invention relates to a latent neural stem cell population which is capable of activation by membrane depolarization of a neural cell population,...
US-9,890,357 Method for inducing differentiation of human pluripotent stem cells into intermediate mesoderm cells
The present invention provides a method for inducing differentiation of a human pluripotent stem cell into an intermediate mesoderm cell without the use of a...
US-9,890,356 Use of G-CSF in in vitro embryo culture
An in vitro culture medium for embryos consisting of IVF culture medium additionally containing G-CSF at a concentration of at least 0.5 ng/ml, preferably...
US-9,890,355 Electroporation systems having a plurality of hollow members
An electroporation apparatus comprising an elongated hollow member in order to provide a uniform electric field during electroporation, wherein specifically,...
US-9,890,354 Biochemical reactor with a lower divider support structure
This disclosure describes a biochemical reactor with a lower divider support structure. The biochemical reactor may include a tank configured to house...
US-9,890,353 Media suction devices and methods
Devices and methods are provided for removing media from a culture vessel that decreases disruption of the interface between the cellular material and media...
US-9,890,352 Injectable tissue engineered cartilage in vitro construction apparatus
An injectable tissue engineered cartilage in vitro construction apparatus, comprising an incubator (1), a centrifugal device arranged in the incubator (1), and...
US-9,890,351 Encapsulates
The present application relates to encapsulates, compositions, products comprising such encapsulates, and processes for making and using such encapsulates. Such...
US-9,890,350 Methods of using a soil release polymer in a neutral or low alkaline prewash
The invention provides methods of cleaning including the use of a soil release polymer. In some embodiments, the soil release polymer can be included in a...
US-9,890,349 Process and system for producing liquid biofuel from bio-based oils and/or fats
A process for utilizing bio-based oils and/or fats for producing biofuels includes the steps of: mixing alcohol with a raw material for forming a reaction...
US-9,890,348 Natural oil metathesis compositions and methods
A metathesized natural oil composition comprising (i) a mixture olefins and/or esters, or (ii) a metathesized natural oil, is disclosed. The metathesized...
US-9,890,347 Ashless or reduced ash quaternary detergents
A composition of an oil-soluble ionic detergent that does not contribute metal ions to the composition, and which comprises a quaternary non-metallic pnictogen...
US-9,890,346 Selective alkylation method for producing p, p'-di-alkylated diphenylamine antioxidants
Liquid diphenylamine compositions comprising predominately p,p'-di-alkylated diphenylamines and low amounts of mono-alkylated diphenylamines are prepared by...
US-9,890,345 Superlubricating graphene and graphene oxide films
A system and method for forming at least one of graphene and graphene oxide on a substrate and an opposed wear member. The system includes graphene and graphene...
US-9,890,344 Apparatus for dust reduction and dispersion supply of input coal in system for drying coal using reheat steam
The present invention relates to a coal supply device for reducing dust of coal input for dry and supplying dispersing and supplying the coal in a system for...
US-9,890,343 Process and biofilter system for H2S removal from a H2S contaminated energy production gas stream containing...
The invention relates to a process and a biofilter system (10) for removing H.sub.2S from a H.sub.2S contaminated energy production gas stream containing...
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