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Patent # Description
US-9,908,916 Peptide for suppressing osteoclast differentiation and use thereof
The peptide of the present invention performs a function, which is the same as or similar to that of natural interleukin (IL)-3, and has superior skin...
US-9,908,915 Cell-penetrating compositions and methods using same
An isolated transport peptide, which crosses the cell membrane of a cell and/or binds to a target cell, is described. The transport peptide can be incorporated...
US-9,908,914 Methods of preparing substituted nucleoside analogs
Disclosed herein are methods of preparing a nucleoside analog (I) by a reaction that includes an intermediate (GG): ##STR00001## Nucleoside analog (I) is...
US-9,908,913 Non-caloric sweeteners and methods for synthesizing
Disclosed are steviol glycosides referred to as rebaudioside V and rebaudioside W. Also disclosed are methods for producing rebaudioside M (Reb M), rebausoside...
US-9,908,912 Triclosan derivatives and uses thereof
A selective agent comprising a triclosan derivative for use in selective inhibition of non-target cells in a mixed population of target and non-target cells....
US-9,908,910 Bidentate diphosphoramidites with a piperazine group as ligands for hydroformylation
The invention relates to Rh, Ru, Co and Ir complexes comprising bidentate diphosphoramidites as ligands and to the use thereof as catalysts for the ...
US-9,908,909 Crystal of cyclic phosphonic acid sodium salt and method for manufacturing same
An object of the present invention is to provide a crystal of a cyclic phosphonic acid sodium salt (2ccPA) with high purity and excellent storage stability and...
US-9,908,908 Tenofovir prodrug and pharmaceutical uses thereof
The invention relates to a tenofovir prodrug and pharmaceutical uses thereof. In particular, the invention relates to a compound as shown in general formula...
US-9,908,907 Substituted piperaziniums for the treatment of emesis
Disclosed are compounds, compositions and methods for the prevention and/or treatment of diseases which are pathophysiologically mediated by the neurokinin...
US-9,908,906 Luminescent metal halide perovskites and methods
Nanoscale metal halide perovskites are provided. The nanoscale metal halide perovskites may have a 2D structure, a quasi-2D structure, or a 3D structure....
US-9,908,905 Aluminum-modified polysilazanes for polymer-derived ceramic nanocomposites
Methods for synthesizing aluminum-modified silazanes, their use as polymer-derived ceramic precursors, and polymer-derived ceramics and carbon nanotube...
US-9,908,904 Triorganoborane-amino functionalized nanoparticles, compositions, and methods
Surface-modified nanoparticles wherein each nanoparticle includes an inorganic core and surface modifying groups, wherein the surface modifying groups include...
US-9,908,903 Method of producing organohalosilanes
A method for producing an organohalosilane, the method comprising: reacting an organic compound comprising a halogen-substituted or unsubstituted aromatic...
US-9,908,902 Flame retardant filler
A flame retardant filler having brominated silica particles, for example, imparts flame retardancy to manufactured articles such as printed circuit boards...
US-9,908,901 Articles and methods comprising persistent carbenes and related compositions
Articles and methods comprising persistent carbenes are provided, as well as related compositions. In some embodiments, a persistent carbene may be associated...
US-9,908,900 Methods for forming protected organoboronic acids
Described are methods of forming protected boronic acids that provide in a manner that is straightforward, scalable, and cost-effective a wide variety of...
US-9,908,899 Histone deacetylase inhibitors
The compounds provided herein are phenyl analine amides and are useful for inhibiting histone deacteylase ("HDAC") enzymes, such as HDAC1, HDAC2, and HDAC3.
US-9,908,898 Fused imidazobenzothiazole compounds
The present invention relates to novel fused Imidazobenzothiazole derivatives, their pharmaceutically acceptable salts, and their isomers, steroisomers,...
US-9,908,897 Spirocyclic derivatives
The present invention provides compounds of formula (I): compositions comprising such compounds; the use of such compounds in therapy (for example in the...
US-9,908,896 P38 and JNK MAPK inhibitors for the treatment and prophylaxis of degenerative diseases of the nervous system
p38 and JNK mitogen activated protein (MAP) kinase al losteric inhibitors are useful for treatment and/or prophylaxis of degenerative diseases of the nervous...
US-9,908,895 Tricyclic fused thiophene derivatives as JAK inhibitors
The present invention provides tricyclic fused thiophene derivatives, as well as their compositions and methods of use, that modulate the activity of Janus...
US-9,908,894 Methods for the preparation of 1,3-benzodioxole heterocyclic compounds
The present invention relates to novel methods for the preparation of 1,3-benzodioxole heterocyclic compounds and intermediates for the same. The compounds are...
US-9,908,893 Thieno [2,3-b] pyridines as multidrug resistance modulators
The thieno[2,3-b]pyridines of general formula (I), ##STR00001## wherein R.sup.1 is Me, C.sub.6H.sub.5, 3,4,5-(OMe).sub.3C.sub.6H.sub.2, NH.sub.2; R.sup.2 is...
US-9,908,892 Melampomagnolide B derivatives
The present disclosure provides derivatives of melampomagnolide B (MMB), including carbonates, carbamates, and thiocarbamates. The derivatives may be...
US-9,908,891 Process for the preparation of morphinan-6-one compounds
The present invention provides processes for preparing morphinan-6-one compounds, in particular oxymorphone and salts thereof, having improved impurity profiles.
US-9,908,890 Selective inhibitors of constitutive androstane receptor
The compounds of the invention are antagonists of CAR, with specificity for CAR over other proteins including PXR. The disclosed compounds are useful in...
US-9,908,888 Processes for preparing pyrazolyl-substituted pyrrolo[2,3-d]pyrimidines
The present invention is related to processes for preparing chiral substituted pyrazolyl pyrrolo[2,3-d]pyrimidines of Formula III, and related synthetic...
US-9,908,887 PRMT5 inhibitors and uses thereof
Described herein are compounds of Formula (A), pharmaceutically acceptable salts thereof, and pharmaceutical compositions thereof. Compounds of the present...
US-9,908,886 Bicyclic heterocyclic derivatives as MNK1 and MNK2 modulators and uses thereof
The present invention relates to certain compounds (e.g., imidazopyrazine, imidazopyridine, imidazopyridazine and imidazpyrimidine compounds) that act as...
US-9,908,885 Bromodomain inhibitors
The present invention relates to substituted heterocyclic derivative compounds, compositions comprising said compounds, and the use of said compounds and...
US-9,908,884 EGFR inhibitors and methods of treating disorders
The present invention relates to novel pyrimidine, pyrrolo-pyrimidine, pyrrolo-pyridine, pyridine, purine and triazine compounds which are able to modulate...
US-9,908,883 N1-pyrazolospiroketone acetyl-CoA carboxylase inhibitors
The invention provides a compound of Formula (I) ##STR00001## or a pharmaceutically acceptable salt of the compound, wherein R.sup.1, R.sup.2, R.sup.3, Z,...
US-9,908,882 Process for preparing halogenated azaindole compounds using boroxine
A process for preparing halogenated azaindole compounds makes use of stable reagents including a brominating reagent, a boroxine and a sulfonic anhydride to...
US-9,908,881 Process for the preparation of apixaban and intermediates thereof
The present invention refers to novel process for the preparation of Apixaban. Further, the invention also related to a process for the preparation of...
US-9,908,880 Substituted imidazoquinolines
Imidazoquinolines of formula I that contain substituted amine or amide functionality at 1-position and that are effective as Toll like Receptor 7 activators are...
US-9,908,879 P2X3 and/or P2X2/3 compounds and methods
The present application provides novel compounds and methods for preparing and using these compounds. In one embodiment, the compounds are of the structure of...
US-9,908,878 Inhibitors of influenza viruses replication
Methods of inhibiting the replication of influenza viruses in a biological sample or patient, of reducing the amount of influenza viruses in a biological sample...
US-9,908,877 Imidazo[1,5-a]pyridinium ion fluorophores, and methods of making and using the same
A fluorophore and methods of detecting cations and hydrophobic environments using the fluorophore are disclosed. The fluorophore includes an...
US-9,908,876 Imidazo [1,2-a]pyridine compounds, synthesis thereof, and methods of using same
Embodiments relate to the field of chemistry and biochemistry, and, more specifically, to imidazopyridine compounds, synthesis thereof, and methods of using...
US-9,908,875 Apoptosis signal-regulating kinase inhibitors
The present application relates to compounds having the inhibitory activity to apoptosis signal-regulating kinase (ASK1), thus are thus useful in treating...
US-9,908,874 Separation method for active pharmaceutical ingredients (apis) from excipients in pharmaceutical formulations
The present invention provides a method for physically separating the active pharmaceutical ingredient (API) from the excipients in a pharmaceutical formulation...
US-9,908,873 GPR40 agonists for the treatment of type II diabetes
Disclosed are compounds, compositions and methods for treating of disorders that are affected by the modulation of the GPR40 receptor. Such compounds are...
US-9,908,872 Methods to treat lymphoplasmacytic lymphoma
The present invention provides compounds of any one of Formulae (I) to (V) (e.g., compounds of any one of Formulae (I-1) to (I-9)), and methods for treating...
US-9,908,871 Monomers and polymers for functional polycarbonates and poly(ester-carbonates) and PEG-co-polycarbonate hydrogels
The invention generally relates to functional polymers and hydrogels. More particularly, the invention provides versatile monomers and polymers with...
US-9,908,870 Crystalline form of a benzimidazole derivative and a preparation method thereof
The present invention relates to a novel crystalline form of a benzimidazole derivative and a preparation method thereof. The novel crystalline form according...
US-9,908,869 Compounds useful for treating aids
A compound having the following formula or a pharmaceutically acceptable salt thereof: ##STR00001## where: R'' is a hydrogen atom or a ...
US-9,908,868 Isoindolinone compounds as GPR119 modulators for the treatment of diabetes, obesity, dyslipidemia and related...
The present invention relates to isoindolinone compounds. The isoindolinone compounds are GPR119 modulators and useful for the prevention and/or treatment of...
US-9,908,867 3-(benzoimidazol-2-yl)-indazole inhibitors of the Wnt signaling pathway and therapeutic uses thereof
Indazole compounds for treating various diseases and pathologies are disclosed. More particularly, the present disclosure concerns the use of an indazole...
US-9,908,866 Certain chemical entities, compositions, and methods
Chemical entities that are quinoxaline kinase inhibitors, pharmaceutical compositions and methods of treatment of cancer are described.
US-9,908,865 Histone demethylase inhibitors
Provided herein are substituted pyrazolylpyridine, pyrazolylpyridazine, and pyrazolylpyrimidine derivative compounds and pharmaceutical compositions comprising...
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