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Patent # Description
US-9,926,591 Fluid identification system and production and use thereof
A fluid identification system comprising a plurality of particles, each particle encapsulating therein at least one tracer material having an identifiable DNA,...
US-9,926,590 Devices and compositions for preservation of cell-free nucleic acids
Devices including a composition for preserving and processing cell-free nucleic acids located within a blood sample and methods of using the same are disclosed,...
US-9,926,589 Identification and quantification of multiple nucleic acid targets in complex mixtures
A complex mixture is analyzed for multiple nucleic acid sequences (e.g., DNA or RNA sequences) simultaneously by target specific multiplex amplification...
US-9,926,588 Method for testing and screening P38 MAP kinase modifiers
This invention provides methods for treating diseases associated with elevated p38 mitogen-activated protein kinase activity. Moreover, the invention provides...
US-9,926,587 Cosmetic use of chitinase-type proteins
The present invention relates to the use, notably cosmetic and/or therapeutic, of the YKL-40 protein belonging to the family of chitinase-type proteins, of...
US-9,926,586 Rapid method for detection of Salmonella live vaccine strains
The present specification discloses methods of detecting a pathogen of interest, components useful in carrying out these methods, including a pre-enrichment...
US-9,926,585 Method for producing a minor ginsenoside using a ginsenoside glycosidase
Provided are a method of producing minor ginsenosides using a ginsenoside glycosidase protein derived from a Microbacterium sp. (Microbacterium testaceum)...
US-9,926,584 Expression of natively secreted polypeptides without signal peptide
The present invention relates to methods of recombinantly producing a natively secreted polypeptide, the method comprising the steps of providing a...
US-9,926,583 Methods of cell culture
Polypeptide preparations having target levels of glycans, and methods of producing such polypeptide preparations using DMSO, are described.
US-9,926,582 Method for the production of polypeptides in the periplasm of prokaryotic cells
Herein is reported a method for producing a polypeptide comprising the step of incubating (resuspended) prokaryotic cells in a solution comprising about 10 mM...
US-9,926,581 Fagopyritol synthase genes and uses thereof
The present invention relates to an isolated DNA molecule encoding a fagopyritol synthase. A method for producing a fagopyritol, an insulin mediator, an insulin...
US-9,926,580 Process for producing coenzyme Q10
A process for producing on an industrial scale the oxidized coenzyme Q.sub.10, includes culturing a reduced coenzyme Q.sub.10-producing microorganism selected...
US-9,926,579 Synthesis of long-chain polyunsaturated fatty acids by recombinant cell
The present invention relates to methods of synthesizing long-chain polyunsaturated fatty acids, especially eicosapentaenoic acid, docosapentaenoic acid and...
US-9,926,578 Process for manufacturing butanediol
A process for the preparation of butanediol includes providing an aqueous medium comprising magnesium succinate by fermentation of a carbohydrate source, in the...
US-9,926,577 Yeast organism producing isobutanol at a high yield
The present invention provides recombinant microorganisms comprising an isobutanol producing metabolic pathway and methods of using said recombinant...
US-9,926,576 Prevention of bacterial growth in fermentation processes
A fermentation process for the production of ethanol from natural sources, such as corn, comprising introducing a fermentable sugar, an inoculant, and a...
US-9,926,575 Method for operating a bioreactor that methanizes biomass
The invention relates to a bioreactor for methanizing biomass, a biogas plant having a plurality of such bioreactors, and a method for operating such a...
US-9,926,574 Widespread gene delivery to motor neurons using peripheral injection of AAV vectors
The present invention relates to compositions and methods, in particular to methods based on systemic injection of rAAV, for delivering genes to cells of the...
US-9,926,573 Glyphosate-tolerant gene and use thereof
Disclosed is a glyphosate-tolerant gene. The nucleotide sequence of the gene is SEQ ID NO: 1, SEQ ID NO: 3 or SEQ ID NO: 5, and a mutant form of the gene that...
US-9,926,572 Reversible genic male sterility in compositae
The present invention relates to plants of the Compositae family exhibiting a reversible genic male sterility trait, characterized in that the genic male...
US-9,926,571 Methods and compositions for targeted polynucleotide modification
A variety of methods and compostions are provided, including methods and compositions for targeted modification of a specific target site in a cell or organism,...
US-9,926,570 Host cells and methods of use
The present invention relates to genetically modified host cells, in particular yeast cells, comprising at least one isolated polynucleotide encoding a Killer...
US-9,926,569 Promoter and use thereof
The invention discloses a promoter which can be induced to express in acidic conditions, and relates to the field of bioengineering technology. The promoters of...
US-9,926,568 Compositions and methods for clostridial transformation
The invention provides compositions and methods for clostridial bacteria that have been engineered to produce and/or to improve efficiency of production of...
US-9,926,567 Promoter
The current invention reports a promoter having the nucleic acid sequence of SEQ ID NO: 02, or SEQ ID NO: 03, or SEQ ID NO: 04, or SEQ ID NO: 06, which is a 5'...
US-9,926,566 Multiaptamer target detection
Described herein are compositions comprising a first aptamer, second aptamer and a target that are capable of forming a ternary complex, and wherein the first...
US-9,926,565 Aptamer-RNAi therapeutic compositions
A recombinant nucleic acid comprising an aptamer that binds CD4 and an RNAi sequence that silences the expression of ROR.gamma.2 is described herein....
US-9,926,564 Aptamers, multimeric aptamers and uses thereof
Monomeric and multimeric aptamers are provided. Also provided are pharmaceutical compositions which comprise same and methods of using same.
US-9,926,563 Modified TGF-beta oligonucleotides
The invention refers to an oligonucleotide consisting of 10 to 20 nucleotides of selected regions of the TGF-beta1, TGF-beta2 or TGF-beta3 nucleic acid...
US-9,926,562 Methods for preventing and treating chronic kidney disease (CKD)
The present invention relates to methods for preventing and treating chronic kidney disease (CKD).
US-9,926,561 Composition for regenerating normal tissue from fibrotic tissue
The present invention relates to a pharmaceutical composition and a method for regenerating normal tissue from fibrotic tissue, the pharmaceutical composition...
US-9,926,560 Lipid encapsulating interfering RNA
Rich tooling is provided for REST application development that integrates the exploration of a REST API, modeling of data types and the REST API, and the...
US-9,926,559 Compositions and methods for modulation of SMN2 splicing in a subject
Disclosed herein are compounds, compositions and methods for modulating splicing of SMN2 mRNA in a subject. Also provided are uses of disclosed compounds and...
US-9,926,558 Culicinae mosquito Tra-2 RNA interference technique to genetically produce maleness population
The present invention develops a novel method for controlling mosquito populations. Culicinae mosquitoes carrying one or more loci of transformant Tra-2 RNAi...
US-9,926,557 Methods and means for efficient skipping of exon 45 in Duchenne muscular dystrophy pre-mRNA
The invention relates to a method for inducing or promoting skipping of exon 45 of DMD pre-mRNA in a Duchenne Muscular Dystrophy patient, preferably in an...
US-9,926,556 Linkage modified oligomeric compounds
The present invention provides oligomeric compounds comprising at least one neutral methoxypropyl phosphonate modified internucleoside linkage. Such oligomeric...
US-9,926,555 Recombinant fusion proteins and libraries from immune cell repertoires
Disclosed herein are methods and compositions for generating a repertoire of recombinant fusion polypeptides from immune cells, and uses thereof.
US-9,926,554 Recombinant fusion proteins and libraries from immune cell repertoires
Disclosed herein are methods and compositions for generating a repertoire of recombinant fusion polypeptides from immune cells, and uses thereof.
US-9,926,553 Sample extraction and preparation device
A fluid sample extraction device is disclosed comprising a housing defining an internal fluid passage having a distal open end and a proximal open end and a...
US-9,926,552 Microfluidic device for extracting, isolating, and analyzing DNA from cells
The present invention relates to a microfluidic device for extracting and isolating DNA from cells. The device includes a support having an inlet port for...
US-9,926,551 Encapsulating device and encapsulating method for encapsulating a sample in a polymer capsule
The invention relates to an encapsulating device (100), which is designed to encapsulate a sample (1, 2) in a polymer capsule, comprising a drop generator (10),...
US-9,926,550 Protease variants and polynucleotides encoding same
The present invention relates to protease variants and methods for obtaining protease variants. The present invention also relates to polynucleotides encoding...
US-9,926,549 Medium composition for preparing botulinum toxin
The present invention relates to a medium composition for production of botulinum toxin and, more particularly, to a medium composition for culture of...
US-9,926,548 Nucleic acid constructs and host cells for producing neurospora endoglucanases
Polypeptides having endoglucanase activity, catalytic domains, and polynucleotides encoding the polypeptides or catalytic domains. Nucleic acid constructs,...
US-9,926,547 Polypeptides having endoglucanase activity and polynucleotides encoding same
The present invention relates to isolated polypeptides having endoglucanase activity, catalytic domains, cellulose binding domains and polynucleotides encoding...
US-9,926,546 Engineered CRISPR-Cas9 nucleases
Engineered CRISPR-Cas9 nucleases with improved specificity and their use in genomic engineering, epigenomic engineering, genome targeting, and genome editing.
US-9,926,545 Engineered CRISPR-CAS9 nucleases with altered PAM specificity
Engineered CRISPR-Cas9 nucleases with altered and improved PAM specificities and their use in genomic engineering, epigenomic engineering, and genome targeting.
US-9,926,544 Chimeric alkaline phosphatase-like proteins
The invention relates to improved alkaline phosphatases, pharmaceutical compositions comprising improved alkaline phosphatases and the use of improved alkaline...
US-9,926,543 Pyrophosphorolysis-activated polymerization (PAP) using ribonucleic acid (RNA) template
A new method of RNA-PAP was developed that can directly amplify RNA template without additional treatment. RNA-PAP brings in a new mechanism for amplification...
US-9,926,542 Practical method for enzymatically synthesizing cyclic di-GMP
A practical method for enzymatically synthesizing c-di-GMP with excellent productivity is provided. A diguanylate cyclase having physical and chemical...
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