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Patent # Description
US-9,932,381 Exendin-4 derivatives as selective glucagon receptor agonists
The present invention relates to glucagon receptor agonists and their medical use, for example in the treatment of severe hypoglycemia.
US-9,932,380 Interleukin-2 muteins for the expansion of T-regulatory cells
Provided herein are IL-2 muteins and IL-2 mutein Fc-fusion molecules that preferentially expand and activate T regulatory cells and are amenable to large scale...
US-9,932,379 Isolated nucleotide sequences encoding GDF traps
In certain aspects, the present invention provides compositions and methods for increasing red blood cell and/or hemoglobin levels in vertebrates, including...
US-9,932,378 Regulators of NFAT
Disclosed are methods of identifying an agent that modulates an NFAT regulator protein. One such method comprises contacting at least one test agent with a...
US-9,932,377 Mitochondrial targeting and therapeutic use thereof
The present invention provides, among other things, compositions and methods for treatment of Friedrich's Ataxia based on effective targeting of a therapeutic...
US-9,932,376 Analogues of temporin-SHa and uses thereof
The present invention relates to novel antimicrobial peptides, pharmaceutical compositions comprising said peptides, and the uses thereof, in particular as...
US-9,932,375 Targeting of chondroitin sulfate glycans
The present invention relates to functional binding fragments comprising the minimal binding fragments of VAR2CSA, to antibodies against such binding fragments...
US-9,932,374 Clostridium difficile polypeptides as vaccine
The invention provides methods, proteins, nucleic acids and antibodies for preventing or treating a C. difficile infection in a mammal.
US-9,932,372 Designer peptide-based PCV2 vaccine
Porcine circovirus (PCV2) vaccine compositions comprising a peptide antigen derived from a PCV2 capsid protein are described. In various embodiments, the...
US-9,932,371 Promiscuous HPV16-derived T helper epitopes for immunotherapy
The present invention relates to novel amino acid sequences of peptides derived from HPV16 that are able to bind to MHC complexes of class II, and elicit an...
US-9,932,370 Stabilized mosaic human immunodeficiency virus type 1 (HIV-1) GP140 envelope (ENV) trimers
The invention features isolated human immunodeficiency virus (HIV) envelope (Env) trimers, in which the amino acid sequence of the Env polypeptides is optimized...
US-9,932,369 Thermosensitive, bioactive biopolymer and associated method of cell harvesting
The present invention relates to a biopolymer and a cell-harvesting scaffold comprising same, as well as the associated cell-harvesting method that allows said...
US-9,932,368 Peptides for the stimulation of collagen formation
The present invention relates to a compound of formula (I) (R.sub.1-Arg-Gly-Asp-Gly-Ala-Asn-Pro-Asn-Ala-Ala-Gly-R.sub.2), formula II ...
US-9,932,367 Modification of polypeptides
The invention provides a method for conjugating a peptide displayed on a genetic display system to a molecular scaffold performed on an ion exchange resin.
US-9,932,366 Method for using nanoparticles as nucleation agents for the crystallization of proteins
The present invention relates to a method for the crystallization of protein using nanoparticles as nucleation agents. Precisely, the inventors performed the...
US-9,932,365 Protein labeling with cyanobenzothiazole conjugates
The invention provides compounds and methods for site-specifically labeling proteins with cyanobenzothiazole derivatives of formula I. For example, the...
US-9,932,364 Antisense-based small RNA agents targeting the Gag open reading frame of HIV-1 RNA
Antisense nucleic acid molecules, such as ribozymes, shRNA and siRNA, targeting the Gag region of HIV-1 open reading frame, and uses thereof for inhibiting...
US-9,932,363 Substituted nucleosides, nucleotides and analogs thereof
Disclosed herein are nucleosides, nucleotides and analogs thereof, pharmaceutical compositions that include one or more of nucleosides, nucleotides and analogs...
US-9,932,362 Processes for the preparation of ruthenium or osmium complexes comprising P and N donor ligands
An improved processes for the preparation of ruthenium or osmium complexes including P and N donor ligands, in particular, ruthenium complexes.
US-9,932,361 Convenient process for the preparation of statins
Object of the present invention is an improved process for the preparation of key intermediates for the synthesis of statins.
US-9,932,360 Qualitative and quantitative point-of-care assays
Disclosed herein are "equipment-free" flow-through assay devices based on patterned porous media, methods of making same, and methods of using same. The porous,...
US-9,932,359 Organic electroluminescent materials and devices
A compound having a structure according to ##STR00001## wherein Y is a carbene moeity coordinated to a trivalent copper atom Cu is disclosed. In Formula I,...
US-9,932,358 Energy storage molecular material, crystal dielectric layer and capacitor
The present disclosure provides an energy storage molecular material, crystal dielectric layer and capacitor which may solve a problem of the further increase...
US-9,932,357 Synthetic method of fused heteroaromatic compound and fused heteroaromatic compound and intermediate therefor
A synthetic method of a fused heteroaromatic compound includes preparing a first intermediate represented by Chemical Formula 1, obtaining a second intermediate...
US-9,932,356 Pyrazolopyrimidine macrocycles as inhibitors of human immunodeficiency virus replication
The disclosure generally relates to compounds of formula I, including compositions and methods for treating human immunodeficiency virus (HIV) infection. The...
US-9,932,355 2,5,6,7-tetrasubstituted thiazolo[4,5-b]pyridine derivatives and use thereof
Provided are a pharmaceutical composition containing a 2,5,6,7-tetrasubstituted thiazolo[4,5-b]pyridine derivative represented by Formula 1 as an active...
US-9,932,354 Imidazo-oxadiazole and imidazo-thiadiazole derivatives
The present invention provides compounds of Formula (I) used as Amyloid beta lowering agent for the treatment of neurodegenerative diseases. ##STR00001##
US-9,932,353 Imidazopyrimidine macrocycles as inhibitors of human immunodeficiency virus replication
The disclosure generally relates to compounds of formula I, including compositions and methods for treating human immunodeficiency virus (HIV) infection. The...
US-9,932,352 Compounds for the treatment of ischemia-reperfusion-related diseases
The present invention relates to compounds of formula (I) useful in the treatment of ischemia-reperfusion-related pathologies.
US-9,932,351 Thienopyrimidinones as ubiquitin-specific protease 7 inhibitors
The disclosure relates to inhibitors of USP7 inhibitors useful in the treatment of cancers, neurodegenerative diseases, immunological disorders, inflammatory...
US-9,932,350 Inhibitors of IRAK4 activity
The present invention relates to inhibitors of IRAK4 of Formula I and provides compositions comprising such inhibitors, as well as methods therewith for...
US-9,932,349 8-carboxamido-2,6-methano-3-benzazocines
8-Substituted-2,6-methano-3-benzazocines of general structure I in which A is --CH.sub.2--OH, --CH.sub.2NH.sub.2, --NHSO.sub.2CH.sub.3, ##STR00001## and Y is...
US-9,932,348 Process for improved oxycodone synthesis
Processes for preparing oxycodone are provided. Said processes encompass a step which is a hydrogenation of an 14-hydroxycodeinone salt in the presence of...
US-9,932,347 Spiro-lactam NMDA receptor modulators and uses thereof
Disclosed are compounds having enhanced potency in the modulation of NMDA receptor activity. Such compounds can be used in the treatment of conditions such as...
US-9,932,346 Pyrrolopyrimidines for use in influenza virus infection
The invention relates to compounds having the structure of formula (I) which can be used for the treatment of or against influenza infections. ##STR00001##
US-9,932,345 Substituted [1,2,4]triazolo[1,5-A]pyrimidin-7-yl compounds as PDE2 inhibitors
The invention provides a chemical entity of Formula (I) wherein R.sup.1, R.sup.2, X, Y and Z have any of the values described herein, and compositions...
US-9,932,344 Pyrazolo[1,5-A]pyrimidine-5,7-diamine compounds as CDK inhibitors and their therapeutic use
Certain pyrazolo[1,5-a]pyrimidine-5,7-diamine compounds that inhibit cycline dependent kinase (CDK) (e.g., CDK1, CDK2, CDK4, CDK5, CDK6, CDK7, CDK8, CDK9,...
US-9,932,343 Fused tricyclic benzimidazoles derivatives as modulators of TNF activity
A series of tricyclic benzimidazole derivatives, in particular dihydro-1H-imidazo [1,2-a]benzimidazole, dihydro-1H-pyrrolo [1,2-a]benzimidazole,...
US-9,932,342 Imidazopyrimidine derivatives as modulators of TNF activity
A series of substituted imidazo[1,2-a]pyrimidine derivatives of formula (I), being potent modulators of human TNFa activity, are accordingly of benefit in the...
US-9,932,341 Use of pyrazolopyrimidine derivatives for the treatment of PI3K-delta related disorders
The present application provides methods of treating PI3K.delta. related disorders using compounds of Formula I: ##STR00001## or pharmaceutically acceptable...
US-9,932,340 Substituted indoles
The invention provides for compounds of formula (I) ##STR00001## wherein R.sup.1, R.sup.2, R.sup.3, R.sup.4, R.sup.5, and R.sup.6 have any of the values...
US-9,932,339 Helquats with heteroaromatic substituents, preparation thereof, and use thereof as G-quadruplex stabilizers
Helquat derivatives of general formula I, in which substituents R.sup.1 and R.sup.2 are independently selected from a group comprising H and C.sub.1 to C.sub.4...
US-9,932,338 Compounds having muscarinic receptor antagonist and BETA2 adrenergic receptor agonist activity
Compounds of formula (I), defined herein, act both as muscarinic receptor antagonists and beta2 adrenergic receptor agonists and are useful for the prevention...
US-9,932,337 Method for the production of Praziquantel and precursors thereof
The present invention relates to methods for the production of enantiopure or enantioenriched Praziquantel precursors and to methods for the production of...
US-9,932,336 Process for the preparation of apixaban and intermediates thereof
The present invention relates to an improved process for the preparation of Apixaban and intermediates thereof. Further the present invention also relates to...
US-9,932,335 Pyrrolopyridine or pyrazolopyridine derivatives
The present invention relates to compounds of formula ##STR00001## wherein R.sup.1, Y.sup.1, Y.sup.2, X, R and n are as defined herein.
US-9,932,334 Tetrahydroimidazopyridine derivatives as modulators of TNF activity
A series of substituted 4,5,6,7-tetrahydro-1H-imidazo[4,5-c]pyridine derivatives, being potent treatment and/or prevention of various human ailments, including...
US-9,932,333 Benzothiazole compound and medicine containing same
It is intended to provide: a compound useful as an amyloid oxidation catalyst which is applicable in vivo and is applicable not only to A.beta. peptides but to...
US-9,932,332 FXR (NR1H4) modulating compounds
The present disclosure relates generally to compounds which bind to the NR1H4 receptor (FXR) and act as agonists of FXR. The disclosure further relates to the...
US-9,932,331 Phenyl tetrahydroisoquinoline compound substituted with heteroaryl
The present invention provides a compound represented by the following formula [1] or a pharmaceutically acceptable salt thereof which has an excellent NHE3...
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