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Patent # Description
US-9,932,330 Piperazine derivatives for treating disorders
Anti-angiogenic treatments, treatments of hyperpermeability disorders, treatments of neuropathic and neurodegenerative disorders, pain treatments, methods of...
US-9,932,329 Benzimidazole derivatives as RLK and ITK inhibitors
The present disclosure is directed to certain inhibitors of RLK and ITK of formula (I), pharmaceutical compositions comprising such compounds, and method of...
US-9,932,328 3-(6-alkoxy-5-chlorobenzo[d]isoxazol-3-yl)propanoic acid useful as kynurenine monooxygenase inhibitors
Compound of formula (I) ##STR00001## wherein: R.sup.1 is heteroaryl either unsubstituted or substituted by methyl, ethyl, halo or .dbd.O; and R.sup.2 is H,...
US-9,932,327 Rohitukine analogs as cyclin-dependent kinase inhibitors and a process for the preparation thereof
The present invention relates to the rohitukine (5,7-dihydroxy-8-(3-hydroxy-1-methyl-piperidin-4-yl)-4H-chromen-4-ones) analogs of formula A and...
US-9,932,326 Potent and selective inhibitors of hepatitis C virus
The present invention is directed to compounds, compositions and methods for treating or preventing hepatitis C virus (HCV) infection in human subjects or other...
US-9,932,325 Compounds, compositions, and methods
The present disclosure relates generally to LRRK2 inhibitors, or a pharmaceutically acceptable salt, deuterated analog, prodrug, tautomer, stereoisomer, or...
US-9,932,324 Substituted benzimidazolium compounds useful in the treatment of respiratory diseases
The present invention relates to compounds of formula (I), or the tautomers or pharmacologically acceptable acid addition salts thereof, wherein R.sup.1,...
US-9,932,323 Therapeutic hydroxypyridinones, hydroxypyrimidinones and hydroxypyridazinones
The invention provides compounds of formula I: ##STR00001## and salts and prodrugs thereof wherein R.sub.4, X.sup.1 and X.sup.2 have any of the meanings...
US-9,932,322 Method for producing sulfonyl chloride compound
An object of the present invention is to provide a production method of an intermediate used in the production method of a sulfonylpyrrole compound useful as a...
US-9,932,321 Process for the preparation of piperidine compounds
The present invention relates to a process for the preparation of efinaconazole.
US-9,932,320 Quinoline-based kinase inhibitors
The present disclosure is generally directed to compounds of formula (I) which can inhibit AAKI (adaptor associated kinase 1), compositions comprising such...
US-9,932,319 Antioxidant humic acid derivatives and methods of preparation and use
Disclosed are antioxidative, natural compounds, their salts, chelates and cleavage derivatives that exhibit a superior combination of properties. The compounds...
US-9,932,318 Catalyst performance in propylene epoxidation
The present disclosure relates to a method of epoxidizing an olefin to form an epoxide, the method comprising contacting an alkene.sub.(C.ltoreq.12) or...
US-9,932,317 Quinazoline compounds and their use in therapy
This invention relates to quinazoline compounds of Formula (I) which are inhibitors of the histone lysine methyltransferase (HKMTase) EZH2, and to uses of such...
US-9,932,316 Imidazolium salts having liquid crystal characteristics, useful as electrolytes
Novel imidazolium salts of formula (I) are described in which R is a C.sub.1-C.sub.14 alkyl group, optionally substituted by one or more fluorine atoms, or a...
US-9,932,315 Persistent carbene adducts and related methods
Persistent carbene adducts and methods of forming the same are generally described, as well as compositions comprising the persistent carbene adduct. In some...
US-9,932,314 Pyrazole compounds and their use as T-type calcium channel blockers
The invention relates to compounds of formula (I) ##STR00001## wherein X, Y, R.sup.1, R.sup.2, (R.sup.4).sub.n, and (R.sup.5).sub.m are as defined in the...
US-9,932,313 Pyrazolyl guanidine F.sub.1F.sub.0-ATPase inhibitors and therapeutic uses thereof
The invention provides pyrazolyl guanidine compounds that inhibit F.sub.1F.sub.o-ATPase, and methods of using pyrazolyl guanidine compounds as therapeutic...
US-9,932,312 Process for preparing 5-fluoro-1-methyl-3-difluoromethyl-1H-pyrazole-4-carbaldehyde
The present invention relates to a novel process for preparing 5-fluoro-1-methyl-3-difluoromethyl-1H-pyrazole-4-carbaldehyde, a useful intermediate in the...
US-9,932,311 Antidiabetic tricyclic compounds
Novel compounds of the structural formula (I), and the pharmaceutically acceptable salts thereof, are agonists of G-protein coupled receptor 40 (GPR40) and may...
US-9,932,310 DNA2 inhibitors for cancer treatment
Disclosed herein, inter alia, are compositions and methods for inhibiting DNA2.
US-9,932,309 2-oxo-3,4-dihydropyridine-5-carboxylates and their use
The present invention is directed to novel compounds of Formula (I), pharmaceutically acceptable salts or solvates thereof, and their use. ##STR00001##
US-9,932,308 Method for producing indoline compound
Provided is a salt including a compound represented by a formula (4) and a compound represented by a formula (5). A method for producing the salt includes...
US-9,932,307 Process for annealing amorphous atorvastatin
Processes for annealing amorphous atorvastatin is described. Pharmaceutical compositions and formulations containing annealed amorphous atorvastatin are also...
US-9,932,306 Isothiocyanate functional surfactant and associated method of use
A method for treating phytophotodermatitis including the steps of applying an isothiocyanate functional surfactant to an area affected by phytophotodermatitis,...
US-9,932,305 Process for the asymmetric oxidation of organic compounds with peroxides in the presence of a chiral acid catalyst
The present invention relates to a process for the asymmetric oxidation of nucleophilic organic compounds, particularly metal-free, with peroxide compounds in...
US-9,932,304 Thromboxane receptor antagonists
The invention relates to novel chemical entities that act as thromboxane (TX) A.sub.2 receptor, or T prostanoid receptor (TP), antagonists and to their use in...
US-9,932,303 N-hydroxymethanesulfonamide nitroxyl donors
The disclosed subject matter provides N-hydroxymethanesulfonamide compounds, pharmaceutical compositions and kits comprising such compounds, and methods of...
US-9,932,302 N-phenyl and N-benzyl enaminones and methods for using same
The present disclosure provides compounds, compositions, and methods for use of the compounds. The compounds are N-phenyl or N-benzyl enaminones. The...
US-9,932,301 Polyacrylate allophanate
The invention relates to a modified allophanate compound bearing acrylate functions, resulting from the reaction of a particular allophanate with an ester from...
US-9,932,300 N,N'-diarylurea compounds and N,N'-diarylthiourea compounds as inhibitors of translation initiation
Compositions and methods for inhibiting translation initiation are provided. Compositions, methods and kits for treating (1) cellular proliferative disorders,...
US-9,932,299 Process for separating an isocyanate prepared by phosgenation of a primary amine in the gas phase from the...
The present invention relates to a process for separating an isocyanate prepared by reaction of a primary amine with an excess of phosgene in the gas phase from...
US-9,932,298 Process for producing pentenenitriles
The invention provides methods useful in the industrial scale process for hydrocyanation of butadiene to adiponitrile for recycle of unwanted byproduct...
US-9,932,297 Alkynes and methods of reacting alkynes with 1,3-dipole-functional compounds
1,3-Dipole-functional compounds (e.g., azide functional compounds) can be reacted with certain alkynes in a cyclization reaction to form heterocyclic compounds....
US-9,932,296 Method of producing cycloalkanone oxime
A method of producing a cycloalkanone oxime by a photochemical reaction of a cycloalkane with a photo nitrosating agent in a liquid by light irradiation...
US-9,932,295 Process for preparation of levothyroxine and salts thereof
The present invention relates to a process for the preparation of Levothyroxine and salts thereof. The process described in the present invention provides...
US-9,932,294 Compositions and methods for the treatment of multiple sclerosis
The invention relates to the compounds of formula I and formula II or its pharmaceutical acceptable salts, as well as polymorphs, solvates, enantiomers,...
US-9,932,293 Etheramines based on alkoxylated glycerine or trimethylolpropane
This invention relates to an etheramine of formula (I) based on glycerine or trimethylolpropane and its manufacturing process, ##STR00001## wherein R=H or...
US-9,932,292 Process for workup of a crude ester comprising esterification catalyst hydrolysis product in suspended...
In a process for workup of a crude ester comprising esterification catalyst hydrolysis product in suspended particulate form, a) the crude ester is admixed in...
US-9,932,291 Reduced fouling process for the production of methyl methacrylate
Fouling of an MMA process is reduced by acidifying a stream comprising recycled components.
US-9,932,290 Process for producing ethyl esters of polyunsaturated fatty acids
The present invention relates to a process for producing ethyl esters of polyunsaturated fatty acids, comprising transesterifying triacylglycerols in extracted...
US-9,932,289 Process for producing ethyl esters of polyunsaturated fatty acids
The present invention relates to a process for producing ethyl esters of polyunsaturated fatty acids, comprising transesterifying triacylglycerols in extracted...
US-9,932,288 Chemical compound for inhibition of SHP2 function and for use as an anti-cancer agent
This invention provides a compound that is 4,4'-(4'-Carboxy)-4-nonyloxy-[1,1'-biphenyl]-3,5-diyl)dibutanoic acid (CNBDA), derivative compounds of CNBDA, and...
US-9,932,287 Process for oxidation of alkyl aromatic compound to aromatic carboxylic acid
The present disclosure provides a process for oxidation of p-xylene to terephthalic acid. Recovery of fluid medium and valuable chemicals in carried out using...
US-9,932,286 Side-chain variants of redox-active therapeutics for treatment of mitochondrial diseases and other conditions...
Methods of treating or suppressing mitochondrial diseases, such as Friedreich's ataxia (FRDA), Leber's Hereditary Optic Neuropathy (LHON), mitochondrial...
US-9,932,285 Phenolic resin precursors via supercritical water
A method for transforming selected plant or plant-derived materials, and optionally selected waste plastics, into a plurality of phenolic reaction products...
US-9,932,284 Process for the separation of 1,4-butanediol and co-products
The present invention provides a process for the recovery of 1,4-butanediol and at least one co-product selected from .gamma.-butyrolactone, n-butanol and...
US-9,932,283 Cross coupling of 2-bromo-1-phenyl indenes with phenyl acetylenes and other substituted acetylenes in water
The cross-coupling reaction of 2-bromo-1-phenyl indenes with phenyl acetylenes or propargyl alcohol is disclosed. The cross-coupling reaction uses a palladium...
US-9,932,281 Process and plant for the production of olefins
The present invention relates to a process for the production of olefins from oxygenates, comprising the following steps: (i) heterogeneously catalyzed...
US-9,932,280 Synthesis of olefins from oxygen-free direct conversion of methane and catalysts thereof
Provided is a method for the preparation of a metal lattice-doping catalyst in an amorphous molten state, and the process of catalyzing methane to make olefins,...
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