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Patent # Description
US-9,938,576 Materials and methods for determining metabolizer status in humans
The present invention provides methods and materials useful for determining metabolizer status. Embodiments of the present invention provide an approach using a...
US-9,938,575 Compositions and methods for high-throughput nucleic acid analysis and quality control
Methods for improved quality control of nucleic acid containing biological samples utilized in high-throughput situations such as biorepositories engaged in the...
US-9,938,574 Method and kit for detecting a wild-type and/or a mutated target DNA sequence
The present invention relates to a method for detecting a first and/or a second target DNA sequence from a DNA library, differing in that a mutation...
US-9,938,573 Methods and kits for nucleic acid sequencing
Various embodiments of the present disclosure generally relate to molecular biological protocols, equipment and reagents for the sequencing of target nucleic...
US-9,938,572 System and method for forming an emulsion
Systems and methods are provided for forming emulsions from an aqueous fluid and oil. The aqueous fluid-in-oil emulsions are useful for numerous molecular...
US-9,938,571 Compositions and methods for dehydrated storage of on-board reagents in microfluidic devices
Manufacturing methods and compositions are described for production of self-contained microfluidic cartridge devices with on-board reagents for molecular...
US-9,938,570 Methods and compositions for universal detection of nucleic acids
Provided are methods and compositions for detecting the presence or amount of one or more target nucleic acids in a sample. Methods of the present invention...
US-9,938,569 Compensation for spectral crosstalk in multiplex nucleic acid amplification
A method includes performing a nucleic acid amplification of a nucleic acid sample using a detection probe, wherein the nucleic acid amplification occurs over...
US-9,938,568 Ligase-assisted nucleic acid circularization and amplification
Provided herein are methods for generation and amplification of a single-stranded DNA circle in a single reaction vessel from a linear DNA without any...
US-9,938,567 High-throughput RNA interaction assay
The present invention is directed to a method for detecting an interaction between a ribonucleic acid (RNA) molecule and a second molecule. This method involves...
US-9,938,565 Compositions for RNA-chromatin interaction analysis and uses thereof
The invention described herein provides reagents (e.g., kits), compositions, and methods for carrying out an unbiased genome-wide strategy to identify the...
US-9,938,564 Substituted imidazo[1,2-a]pyrazines for use in bioluminogenic methods
The present invention provides, among other things, imidazo[1,2-.alpha.]pyrazine derivatives including ##STR00001## The derivatives are useful in any method...
US-9,938,563 Method for determining the spatiotemporal distribution of activity of a proteolytic enzyme in a heterogeneous...
The invention relates to the field of biotechnology. The method for determining the spatial and temporal distribution of the activity of a proteolytic enzyme in...
US-9,938,562 Naphthalene derived chromogenic enzyme substrates
Conjugates of 2,3-dihydroxynaphthalene and its derivatives with enzyme cleavable groups are chromogenic substrates that form colored compounds when complexed...
US-9,938,561 Method for diagnosing cancer through detection of deglycosylation of glycoprotein
Provided is a method for diagnosing cancer through a difference with a control group in view of the ratio of a deglycosylated peptide fragment and a...
US-9,938,560 Methods for identifying modulators of Ras using nonlinear techniques
Provided herein are compositions and methods for identifying and detecting modulators of Ras protein conformational states through the use of second harmonic...
US-9,938,559 Bismuth-containing concentration agents for microorganisms
A bismuth-containing concentration agent for microorganisms is provided. Additionally, articles that include the concentration agent and methods of...
US-9,938,558 Methods, apparatuses, and systems for analyzing microorganism strains from complex heterogeneous communities,...
Methods, apparatuses, and systems for screening, analyzing and selecting microorganisms from complex heterogeneous communities, predicting and identifying...
US-9,938,557 Red blood cell dynamics for administering treatment for iron-deficiency anemia
Methods for identifying patients with anemia, distinguishing thalassemia-trait anemia from iron-deficiency anemia, and identifying pre-anemic patients several...
US-9,938,556 Reagent composition for biosensor and biosensor having the same
This invention discloses a reagent composition for a biosensor having high sensitivity which is capable of improving analysis linearity of an analyte such as...
US-9,938,555 Determination of hydrogen peroxide concentrations
For amperometric determination of the hydrogen peroxide concentration in a fluid sample, different electrical voltage steps are applied to the electrodes. In...
US-9,938,554 Co-cultivation of propionibacterium and yeast
The invention provides a fungal cell, such as a yeast cell, capable of growing in co-cultivation with Propionibacterium. Also provided are methods of producing...
US-9,938,553 Methods and devices for nucleic acid synthesis
Disclosed are devices and methods to synthesize polynucleotides and libraries of polynucleotides such as libraries of oligonucleotides. In exemplary...
US-9,938,552 Methods of saccharifying and fermenting a cellulosic material
The invention relates to methods of saccharifying a cellulosic material comprising subjecting the cellulosic material to a catalase and a cellulolytic enzyme...
US-9,938,551 Variants of cellobiohydrolases
Disclosed are a number of homologs and variants of Hypocrea jecorina Ce17A (formerly Trichoderma reesei cellobiohydrolase I or CBH1), nucleic acids encoding the...
US-9,938,550 Aureobasidium pullulans, culturing medium and method for producing .beta.-glucan, a culture of Aureobasidium...
The present application provides a culture medium for producing .beta.-glucan. The culture medium comprises: a carbon source, a nitrogen source and an ascorbic...
US-9,938,549 Process for producing monosaccharides
The present invention relates to a process for producing a monosaccharide using a microorganism. The microorganism possesses a glycosyltransferase and a...
US-9,938,548 Process for preparing (meth)acrylic esters of functionalized furyl alcohols
The invention relates to a process for preparing a compound of the formula (I), ##STR00001## in which R is H or C.sub.1-C.sub.6 alkyl, by reaction of at least...
US-9,938,547 Process for the preparation of 2,5-furandicarboxylic acid
The invention is directed to a process for the preparation of 2,5-furandicarboxylic acid (FDCA) by fermentation comprising fermenting a suitable starting...
US-9,938,546 Method for producing L-lysine using microorganisms having ability to produce L-lysine
The present invention relates to a modified polynucleotide encoding aspartate kinase (EC:2.7.2.4; hereinafter, referred to as LysC), transketolase (EC:2.2.1.1;...
US-9,938,545 Modified algae strain and method of triacylglycerol accumulation using said strain
The present invention relates to a genetically engineered algae strain in which the expression of the CGI-58 gene or homologous gene thereof is silenced. The...
US-9,938,544 Biological methods for preparing a fatty dicarboxylic acid
The technology relates in part to biological methods for producing a fatty dicarboxylic acid and engineered microorganisms capable of such production.
US-9,938,543 Methods, reagents and cells for biosynthesizing glutarate methyl ester
This document describes biochemical pathways for producing 2,4-pentadienoyl-CoA by forming one or two terminal functional groups, comprised of carboxyl or...
US-9,938,542 Mixotrophic fermentation method for making acetone, isopropanol, butyric acid and other bioproducts, and...
Mixotrophic fermentation method performed to make one or more bioproducts such as alcohols, organic acids of less than 7 carbons, acetone, 2,3-butanediol and...
US-9,938,541 AAV variant
The invention provides an AAV particle containing an adeno-associated viral (AAV) capsid protein having an amino acid sequence selected from the group...
US-9,938,540 Gene vector for inducing transgene-specific immune tolerance
A gene vector adapted for transient expression of a transgene in a peripheral organ cell comprising a regulatory sequence operably linked to a transgene wherein...
US-9,938,539 Method for synthetic genes
The present invention provides a method of designing an optimized gene which comprises altering a nucleotide sequence of a target protein gene, so that only...
US-9,938,538 Fertility gene and use thereof
The present disclosure relates to a fertility gene and the use thereof, and relates to the biotechnology field, particularly to a method of plant hybrid...
US-9,938,537 Compositions and methods conferring resistance of maize to corn rootworm II
Methods and compositions for increasing a plant's resistance to an insect pest such as the corn rootworm are provided. Methods are provided for overexpression...
US-9,938,536 Transgenic plants having increased tolerance to aluminum
Methods and materials for modulating aluminum tolerance in plants are disclosed. For example, nucleic acids encoding aluminum tolerance-modulating polypeptides...
US-9,938,535 Medicago truncatula gene-regulatory elements and uses thereof
Recombinant DNA molecules and constructs useful for modulating gene expression in plants, including molecules derived from Medicago truncatula sequences, are...
US-9,938,534 Medicago truncatula gene-regulatory elements and uses thereof
Recombinant DNA molecules and constructs useful for modulating gene expression in plants, including molecules derived from Medicago truncatula sequences, are...
US-9,938,533 DNA aptamers specific to CD200R1 and their therapeutic uses
Disclosed are short DNA aptamers that selectively recognize CD200R1, a protein expressed on the surface of myeloid and lymphoid cells that delivers immune...
US-9,938,532 Molecules inhibiting the human immunodeficiency virus type 1 (HIV-1), method for the production thereof and...
The invention relates to an aptamer, the structure thereof comprising at least one nucleotide sequence 5'-GGCA(A/G)GGA-3', that can specifically bind to the...
US-9,938,531 Compositions and methods for inhibiting expression of RRM2 genes
The invention relates to a double-stranded ribonucleic acid (dsRNA) for inhibiting the expression of a RRM2 gene. The invention also relates to a pharmaceutical...
US-9,938,530 RNA interference in skin indications
The present invention relates to RNAi constructs with improved tissue and cellular uptake characteristics and methods of use of these compounds in dermal...
US-9,938,529 Double-stranded and single-stranded RNA molecules with 5' triphosphates and their use for inducing interferon
Double-stranded and single-stranded RNA molecules, and their use in methods for inducing interferon are provided. The interferon induction provides anti-viral...
US-9,938,528 Methods and pharmaceutical compositions for treating human immunodeficiency virus type 1 (HIV-1) infections
The present invention provides methods and pharmaceutical compositions for treating human immunodeficiency virus type 1 (HIV-1) infections. In particular, the...
US-9,938,527 Potent LNA oligonucleotides for the inhibition of HIF-1A expression
The present disclosure relates to an LNA oligonucleotide consisting of a sequence selected from the group consisting of ...
US-9,938,526 Manganese ion coated nanoparticles for delivery of compositions into the central nervous system by nasal...
The compositions and methods of the disclosure particularly target the divalent metal transporter expressed on olfactory nerve terminals to transport divalent...
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