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Patent # Description
US-9,938,322 .beta.-hairpin peptidomimetics
Beta-hairpin peptidomimetics of the general formula (I), cyclo[P.sup.1-p.sup.2-p.sup.3-p.sup.4-p.sup.5-p.sup.6-p.sup.7-p.sup.8-p.s- ...
US-9,938,321 Cyclic peptoid oligomers, pharmaceutical compositions and methods of using the same
Novel peptoid oligomers are disclosed that have a formula represented by the following formula I: ##STR00001## wherein R.sup.1 and n are as described herein....
US-9,938,320 Peptides for promoting angiogenesis and use thereof
The present invention relates to a peptide promoting angiogenesis and novel use thereof. More particularly, the invention relates to peptides promoting...
US-9,938,319 Egg white processing
This disclosure relates to inexpensive and efficient methods of preparing egg white (e.g., obtained from eggs laid by transgenic chickens) for bulk ...
US-9,938,318 Process for production of fibrinogen
The present invention relates to a method or process for the manufacture of a virus and prion save native fibrinogen concentrate of high purity and low amounts...
US-9,938,317 Enhanced purification of antibodies and antibody fragments by apatite chromatography
Methods are disclosed for use of apatite chromatography, particularly without reliance upon phosphate gradients, for purification or separation of at least one...
US-9,938,316 Selective inhibitors of .alpha.2 isoform of Na,K-ATPase and use thereof for reduction of intra-ocular pressure...
The present invention relates to digoxin and digitoxin derivatives that are selective inhibitors of the .alpha.2 isoform of Na,K-ATPase, and that reduce...
US-9,938,315 Chemical compounds and use thereof for improving muscular quality
Chemical compounds and the therapeutic use thereof, in particular for improving muscular quality in mammals. More particularly, a method of improving muscular...
US-9,938,314 Cytidine-5-carboxamide modified nucleotide compositions and methods related thereto
Described herein are 5-position modified cytosine nucleotides and nucleosides as well as phosphoramidites and triphosphates derivatives thereof. Further...
US-9,938,313 Rectangular parallelepipedal maltitol
The invention concerns maltitol crystals, characterized in that they have a rectangular parallelepipedal shape and have a length to width dimensional ratio in...
US-9,938,312 Compounds and methods for chemical and chemo-enzymatic synthesis of complex glycans
The present invention provides chemical and chemo-enzymatic methods for the synthesis of a wide array of complex asymmetric multi-antennary glycans.
US-9,938,311 Process for producing a particulate composition comprising crystalline alpha, alpha-trehalose di-hydrate
A process for enabling the production of a particulate composition containing crystalline trehalose dihydrate is provided. Including allowing an...
US-9,938,310 1, 1'-bis(phosphino)ferrocene ligands for alkoxycarbonylation
Diastereomer mixture comprising diastereomers of the formulae (I.1) and (I.2) ##STR00001## where R.sup.2, R.sup.4 are each independently selected from...
US-9,938,309 Organometallic complex, light-emitting element, light-emitting device, electronic device, and lighting device
A novel light-emitting material is provided. A novel orgnometallic complex is provided. An orgnometallic complex having a high carrier-transport property is...
US-9,938,308 Coordination compounds having redox non-innocent ligands and flow batteries containing the same
Electrolyte solutions for flow batteries and other electrochemical systems can contain an active material capable of transferring more than one electron per...
US-9,938,307 Polyfluoroalkylated alkenes and silane compounds prepared therefrom
Novel polyfluoroalkylated alkenes and silane compounds prepared therefrom are described.
US-9,938,306 Fluoroalkylsilanes and coatings therefrom
Novel fluoroalkysilanes of the following formula are described; R.sub.f--O--CHFCF.sub.2--O--(CH.sub.2).sub.n--Si(R).sub.xX.sub.3-x, wherein R.sub.f is a...
US-9,938,305 Aminosilyl-substituted diarylethene compounds for anionic polymerisation
The invention related to novel compounds useful as modifying monomers and precursors for polymerization initiators. The invention further relates to a method of...
US-9,938,304 Catalysts with a silylene ligand
A metal complex including at least one metal atom chosen from the metals of Groups 8, 9 and 10 of the Periodic Table of the Elements and one or more ligands,...
US-9,938,303 Organosilane precursors for ALD/CVD silicon-containing film applications
Disclosed are Si-containing thin film forming precursors, methods of synthesizing the same, and methods of using the same to deposit silicon-containing films...
US-9,938,302 Chimeric compounds targeting proteins, compositions, methods, and uses thereof
The present invention provides chimeric compounds that modulate protein function, to restore protein homeostasis, including cytokine, aiolos, and/or ikaros...
US-9,938,301 Dihydropyrimido fused ring derivative as HBV inhibitor
Disclosed is a dihydropyrimido fused ring derivative as a HBV inhibitor, and in particular relates to a compound shown as formula (I) or a pharmaceutically...
US-9,938,300 Isothiazolopyrimidinones, pyrazolopyrimidinones, and pyrrolopyrimidinones as ubiquitin-specific protease 7...
The disclosure relates to inhibitors of USP7 inhibitors useful in the treatment of cancers, neurodegenerative diseases, immunological disorders, inflammatory...
US-9,938,299 Glycosidase inhibitors and uses thereof
The invention provides compounds with enhanced permeability for selectively inhibiting glycosidases, prodrugs of the compounds, and pharmaceutical compositions...
US-9,938,298 Solvated crystal form of rifaximin, production, compositions and uses thereof
The present invention describes a new crystalline form of rifaximin, characterized in that it is a solvated form of rifaximin called rifaximin .tau.. The...
US-9,938,297 Process for the synthesis of everolimus and intermediates thereof
The present invention relates to a novel process for the synthesis of everolimus of formula (I): ##STR00001## and intermediates thereof.
US-9,938,296 Process for preparing (4R,12aS)-N-(2,4-difluorobenzyl)-7-hydroxy-4-methyl-6,8-dioxo-3,4,6,8,12,- ...
The present invention relates to the preparation of carbamoylpyridone derivatives such as the compound of formula (VIIIa): ##STR00001##
US-9,938,295 N-azaspirocycloalkane substituted N-heteroaryl compounds and compositions for inhibiting the activity of SHP2
The present invention relates to compounds of formula I: ##STR00001## in which p, q, Y.sub.1, Y.sub.2, R.sub.1, R.sub.2a, R.sub.2b, R.sub.3a, R.sub.3b,...
US-9,938,294 Tricyclic heterocycles as BET protein inhibitors
The present invention relates to tricyclic heterocycles of Formula (I): ##STR00001## which are inhibitors of BET proteins such as BRD2, BRD3, BRD4, and BRD-t...
US-9,938,292 Quinoline derivatives as SMO inhibitors
Disclosed are quinoline derivatives as hedgehog pathway inhibitors, especially as SMO inhibitors. Compounds of the present invention can be used in treating...
US-9,938,291 N-alkyl-2-phenoxyethanamines, their preparation and use
The present invention provides a compound having the structure: (structurally represented) wherein R1, R2, R3, R4, and R5 are each independently H, halogen, CF3...
US-9,938,290 Tricyclic heterocyclic compounds as phosphoinositide 3-kinase inhibitors
Compounds of formula (I) or a pharmaceutically acceptable salt thereof, wherein: W is O, N--H, N--(C.sub.1-C.sub.10 alkyl) or S; each X is independently CH or...
US-9,938,289 Therapeutic pyrazolyl thienopyridines
The present invention provides for compounds of Formula I, and pharmaceutically acceptable salts thereof, ##STR00001## wherein R.sup.1, R.sup.2, R.sup.3,...
US-9,938,288 Macrocyclic compound and uses thereof
The present invention provides novel Compound (1) having tumor vascular remodeling effect and/or anti-CAF (Cancer Associated Fibroblasts) activity, or a...
US-9,938,287 Blue fluorescence dopant compound and organic electroluminescent device using the same
A blue fluorescence dopant is characterized by the following structural formula: ##STR00001## in which R.sub.1, R.sub.2, R.sub.3, R.sub.4, R.sub.5 and...
US-9,938,286 Nalmefene salts as medicaments for reducing alcohol consumption or for preventing excessive alcohol consumption
The present invention relates to new nalmefene salts which salts fall within at least one of the two following categories: non-hydrate forming salts and...
US-9,938,285 Process for improved oxymorphone synthesis
Processes for preparing oxymorphone are provided. Said processes encompass a step which is a hydrogenation of an 14-hydroxymorphinone salt in the presence of...
US-9,938,284 Organic compounds
The invention relates to novel inhibitors of phosphodiesterase 1 (PDE1), useful for the treatment of diseases or disorders characterized by disruption of or...
US-9,938,283 Crystalline form of baricitinib
The present invention provides a crystalline form of baricitinib characterized by an XRPD pattern substantially as depicted in FIG. 1, a process for its...
US-9,938,282 Expedient synthesis of sitagliptin
Novel intermediates are disclosed as intermediates for preparation of a Sitagliptin. A novel synthetic method to prepare Sitagliptin using the said...
US-9,938,281 Purine inhibitors of human phosphatidylinositol 3-kinase delta
The instant invention provides compounds of formula I which are PI3K-delta inhibitors, and as such are useful for the treatment of PI3K-delta-mediated diseases...
US-9,938,280 Compositions comprising folic acid derivatives, their preparations and methods of use
Described herein are methods for making folic acid derivatives, intermediates, pharmaceutical compositions and uses thereof.
US-9,938,279 Method for treating disease or condition susceptible to amelioration by AMPK activators and compounds of...
The present invention relates to a method for treating disease or condition susceptible to amelioration by AMPK activators and compounds of formula which are...
US-9,938,278 FXR (NR1H4) modulating compounds
The present invention relates to compounds which bind to the NR1H4 receptor (FXR) and act as agonists of FXR. The invention further relates to the use of the...
US-9,938,277 Ergoline compounds and uses thereof
Provided herein are ergoline compounds and pharmaceutical compositions thereof. In some embodiments, provided herein are methods of treatment, prevention, or...
US-9,938,276 6,5-bicyclic octahydropyrrolopyridine orexin receptor antagonists
The present invention is directed to 6,5-bicyclic octahydropyrrolopyridine compounds which are antagonists of orexin receptors. The present invention is also...
US-9,938,275 Substituted imidazoquinolines, imidazopyridines, and imidazonaphthyridines
Imidazo-quinoline, -pyridine, and -naphthyridine ring systems (particularly quinolines, tetrahydroquinolines, pyridines, [1,5]naphthyridines,...
US-9,938,274 Naphthyridine compounds, medical combinations and use thereof
This invention involves the field of biomedicine, and reveals naphthyridine compounds, medical combinations and use thereof. The naphthyridine compounds has the...
US-9,938,273 Compounds and methods for kinase modulation, and indications therefor
Disclosed are compounds of Formula I: ##STR00001## or a pharmaceutically acceptable salt, a solvate, a tautomer, an isomer or a deuterated analog thereof,...
US-9,938,272 Hydrazine compound as blood coagulation factor Xa inhibitor
Provided is a compound of formula (I) or a pharmaceutically acceptable salt thereof, wherein X is selected from a 3-9 membered carbon ring or a ring which is...
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