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Patent # Description
US-9,938,271 Inhibitors of human immunodeficiency virus replication
The disclosure generally relates to compounds of formula I, including compositions and methods for treating human immunodeficiency virus (HIV) infection. The...
US-9,938,270 Mono-phosphate salt of 6-fluoro-2-[4-(pyridin-2-yl)but-3-yn-1-yl]imidazo[1,2A]pyridine (dipraglurant) and...
The present invention relates to crystalline and amorphous forms of 6-fluoro-2-[4-(pyridin-2-yl)but-3-yn-1-yl]imidazo[1,2-a]pyridine mono-phosphate salt and...
US-9,938,269 Inhibitor compounds of phosphodiesterase type 10A
The present invention relates to novel carboxamide compounds, pharmaceutical compositions containing them, and their use in therapy. The compounds possess...
US-9,938,268 C-ring modified tricyclic benzonaphthiridinone protein kinase inhibitors and use thereof
Disclosed are C-ring modified tricyclic benzonaphthiridinone compounds and analogs thereof, pharmaceutical compositions comprising such compounds and processes...
US-9,938,267 Heterocyclic inhibitors of glutaminase
The invention relates to novel heterocyclic compounds and pharmaceutical preparations thereof. The invention further relates to methods of treatment using the...
US-9,938,266 Selective BACE1 inhibitors
The present invention provides a compound of Formula I: or a pharmaceutically acceptable salt thereof. ##STR00001##
US-9,938,265 1,3,4-thiadiazole compounds and their use in treating cancer
A compound of Formula (I): ##STR00001## or a pharmaceutically acceptable salt thereof, where: Q can be 5-methylpyridazin-3-yl,5-chloropyridazin-3-yl,...
US-9,938,264 Proteolysis targeting chimera compounds and methods of preparing and using same
The present invention includes novel compounds and methods for preventing or treating diseases associated with and/or caused by overexpression and/or...
US-9,938,263 Gamma-secretase modulators
There are provided, inner alia, compounds and methods for lowering total AB peptide production by inhibiting the catalytic activity of gamma-secretase. Since...
US-9,938,262 Benzamides
Novel benzamide derivatives of formula (I) ##STR00001## wherein W.sup.1, W.sup.2, R.sup.1 to R.sup.7, R.sup.6, X and Y have the meaning according to the...
US-9,938,261 Heterocyclic compounds and methods of use thereof
Provided herein are heterocyclic compounds for treatment of CSF1R, FLT3, KIT, and/or PDGFR.beta. kinase mediated diseases. Also provided are pharmaceutical...
US-9,938,260 Soluble guanylate cyclase activators and their use
The invention relates to activators of soluble guanylate cyclase and their use in pharmaceutical compositions, primarily topically administered ophthalmic...
US-9,938,259 Therapeutic compositions and related methods of use
Compositions comprising compounds that modulate pyruvate kinase M2 (PKM2) are described herein. Also described herein are methods of using the compounds that...
US-9,938,258 Substituted 2,3-dihydrobenzofuranyl compounds and uses thereof
The invention generally relates to substituted 2,3-dihydrobenzofuranyl compounds, and more particularly to a compound represented by Structural Formula I: ...
US-9,938,257 Substituted heteroaryl compounds and methods of use
The present invention provides novel heteroaryl compounds, pharmaceutical acceptable salts and formulations thereof. They are useful in preventing, managing,...
US-9,938,256 Annelated benzamides
The present invention relates to compounds of formula (I) ##STR00001## wherein R.sup.1, R.sup.2, and Z.sup.- have one of the meanings as indicated in the...
US-9,938,255 Metalloenzyme inhibitor compounds
The instant invention describes compounds having metalloenzyme modulating activity, and methods of treating diseases, disorders or symptoms thereof mediated by...
US-9,938,254 Antiproliferative compounds, and their pharmaceutical compositions and uses
Compounds of formula A-I and B-I, compositions comprising the compounds, methods of making the compounds and methods of their uses are disclosed.
US-9,938,252 Kynurenine-3-monooxygenase inhibitors, pharmaceutical compositions, and methods of use thereof
Certain compounds, or pharmaceutically acceptable salts or prodrugs thereof, are provided herein. Also provided are pharmaceutical compositions comprising at...
US-9,938,251 Cyclic ketone peroxide composition
A composition comprising at least two trimeric cyclic ketone peroxides: a trimeric cyclic methyl ethyl ketone peroxide (3MEK-cp) of formula (I) and at least one...
US-9,938,250 Antifibrotic effects of oxetanyl sulfoxides
A compound, or a pharmaceutically acceptable salt thereof, having a structure of ##STR00001## wherein Z is aryl or substituted aryl, heteroaryl, or...
US-9,938,249 Anti-amyloid compounds containing benzofurazan
In general, among other things, compounds of Formula I are provided: ##STR00001## in which R.sub.11 is e.g., 4-(pyrrolidin-1-yl)piperidin-1-yl, ...
US-9,938,248 Method for preparing 3-trifluoromethyl chalcones
Disclosed is a method for preparing a compound of Formula 1 wherein Q and Z are as defined in the disclosure comprising distilling water from a mixture...
US-9,938,247 Combined reactor for high-pressure synthesis of melamine
A reactor and associated process for the high-pressure synthesis of melamine from urea, comprising a primary step of conversion of the urea into crude melamine...
US-9,938,246 Disubstituted triazole analogs
The present invention relates to disubstituted triazoles, their synthesis, and their use as anti-cancer compounds. In particular, compounds of Formula (I) are...
US-9,938,245 Carbonyl erastin analogs and their use
The present invention provides, inter alia, compounds having the structure of formula (I): Compositions containing such compounds are also provided. Methods for...
US-9,938,244 Process for manufacturing pyrimidine sulfamide derivatives
The invention relates to a process for manufacturing the compound of formula I ##STR00001## wherein R is H, (C.sub.1-C.sub.6)alkyl or benzyl, or a salt...
US-9,938,243 Compounds for affinity chromatography and for extending the half-life of a therapeutic agent
Compounds useful for affinity chromatography as presented, more particularly for use in affinity chromatography to purify serum albumin, especially human serum...
US-9,938,242 Methods for producing optically active valeric acid derivatives
A method for producing a compound (3), which comprises allowing a compound (1) to react with hydrogen gas in an inert solvent, in the presence of a specific...
US-9,938,241 Diazirine compounds and compositions derived therefrom
A series of diazirine compounds of formula (I) having utility as photocrosslinkers are disclosed. ##STR00001## Where, A, L, z, Ar.sub.x and R.sub.y are as...
US-9,938,240 Fluorinated derivatives of 3-hydroxypyridin-4-ones
Provided are compounds of Formula I which are derivatives of 3-Hydroxypyridin-4-ones. The compounds may be used in treatment of a medical condition related to a...
US-9,938,239 Method for preparing silodosin
The present invention relates to a process for preparing silodosin with high optical purity up to 99.9% enantiomeric excess (e.e.) or above. The process makes...
US-9,938,238 Anti-auxin compounds
Provided herein are methods and compositions for controlling auxin responses in plants.
US-9,938,237 Mixed decyl mercaptans compositions and methods of making same
Compositions comprising branched C.sub.10 mercaptans selected from the group consisting of 5-methyl-1-mercapto-nonane, 3-propyl-1-mercapto-heptane,...
US-9,938,236 Antiviral agents against HBV infection
The present invention provides novel compounds of formula (I) and methods of use thereof. In certain embodiments, the compounds of the invention are useful as...
US-9,938,235 Compounds with neural protective effect, and preparation and use thereof
The invention generally relates to compounds of formula (I) with neural protective effect, and preparation and uses thereof. ##STR00001## The compounds have...
US-9,938,234 PPAR agonists
Provided herein are compounds and compositions useful in increasing PPAR.delta. activity. The compounds and compositions provided herein are useful for the...
US-9,938,233 Purification of X-ray contrast agents
The present invention relates to a process for purification of iodinated X-ray contrast agents and in particular to purification of crude dimeric contrast...
US-9,938,232 LED photoinitiators
Amine derivatives of benzoylbenzoic acid, benzoylbenzoic acid esters and salts were prepared, which are suitable as photo initiators for UV & LED curable...
US-9,938,231 Liquid arylbenzoyl benzoic acid ester derivatives for energy curable compositions
4-Arylbenzoyl benzoic acid esters, such as the ethylhexyl esters and amyl esters of 4-phenylbenzoyl benzoic acid, are described, which are liquid and show...
US-9,938,230 Esters or salts of 2-hydroxy-4-propylcyclohepta-2,4,6-trienone and application thereof in preparation of animal...
Esters or salts of 2-hydroxy-4-propyleyclohepta-2,4,6-trienone, and applications thereof in preparation of animal antibacterial agents and growth promoters used...
US-9,938,229 Polymerisable compounds and the use thereof in liquid-crystal displays
The present invention relates to polymerizable compounds, to processes and intermediates for the preparation thereof, to liquid-crystal (LC) media comprising...
US-9,938,228 Process for the preparation of spiro[2.5]octane-5,7-dione and spiro[3.5]nonane-6,8-dione
This invention relates to methods for the synthesis of spiro[2.5]octane-5,7-dione and spiro[3.5]nonane-6,8-dione which are useful as intermediates in the...
US-9,938,227 Method for preparing methyl formate and coproducing dimethyl ether
Method for preparing methyl formate and coproducing dimethyl ether by reacting a formaldehyde and methanol raw material (molar ratio range of 1:4 to 1:0.05) in...
US-9,938,226 Gas phase production of alkyl alkanoate
Alkyl alkanoates, e.g., methyl propionate, are made by a gas phase process comprising the step of contacting under carbonylation conditions an alkene (e.g.,...
US-9,938,225 Biomass-derived methyl methacrylate and corresponding manufacturing method, uses and polymers
The invention relates to methyl methacrylate characterized in that at least one portion of the carbons thereof is biologically sourced and, more specifically,...
US-9,938,224 Methods for producing alkyl hydroxyalkanoates
Methods and systems for producing alkyl hydroxyalkanoate from hydroxy carboxylic acid recovery bottoms. The methods generally comprise the steps of obtaining a...
US-9,938,223 Catalytic transesterification of ester compounds with groups reactive under transesterification conditions
Disclosed are methods for the catalytic transesterification of compounds having one or more ester groups and groups reactive under transesterification...
US-9,938,222 Cyclopropanecarboxylic acid GPR120 modulators
The present invention provides compounds of Formula (I): ##STR00001## or a stereoisomer, or a pharmaceutically acceptable salt thereof, wherein all of the...
US-9,938,221 Substituted aromatic compounds and pharmaceutical uses thereof
The present invention relates to substituted aromatic compounds of Formula I and their pharmaceutical uses. Particular aspects of the invention relate to the...
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