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Patent # Description
US-9,943,620 Chlorine dioxide decontamination system and methods
A scalable, portable and modular chlorine dioxide fumigant decontamination system having an activating area and a neutralizing area which may be housed...
US-9,943,619 Sanitizing machine
A sanitizing machine comprising a supporting structure which includes two compartments or chambers (A, B), wherein, when the machine is in stand-by, a first...
US-9,943,618 Ultraviolet light source and methods
A UV illumination method includes moving a UV peripheral separate from a smart device to location associated with a plurality of target surfaces, selecting a UV...
US-9,943,617 Inline intravenous fluid sterilizer
An inline intravenous (IV) fluid sterilization system can be located within directly upstream of the patient's access point, downstream of any breach points, so...
US-9,943,616 Removal of microorganisms from fluid samples using nanofiber filtration media
A method for removing microorganisms from liquid samples and a nanofiber containing liquid filtration medium that simultaneously exhibits high liquid...
US-9,943,615 Nanoparticles and method for manufacturing the same
Disclosed herein are nanoparticles and method for manufacturing the same. The nanoparticle is essentially composed of albumin and polyethylene glycol, wherein...
US-9,943,614 Cationic steroid antimicrobial diagnostic, detection, screening and imaging methods
The invention relates to diagnostic, detection, screening and imaging methods. In various embodiments, methods of diagnosis, detection, screening and imaging...
US-9,943,613 DAB-4 linked nitroxide citrate, useful as MRI contrast agent
A method of imaging a joint of a subject comprises administering to the subject an amount of a salt of DAB-4 linked nitroxide citrate effective to enhance an...
US-9,943,612 Long poly(A) plasmids and methods for introduction of long poly(A) sequences into the plasmid
Disclosed herein are polynucleotides having a plurality of thymine nucleotides and an endonuclease recognition site inserted therein, methods of engineering the...
US-9,943,611 Reversible gene expression
According to some embodiments herein, expression systems and methods for reversible gene expression are provided. In some embodiments, adeno-associated viral...
US-9,943,610 Hydrophilic self-immolative linkers and conjugates thereof
The present disclosure provides compounds with a hydrophilic self-immolative linker, which is cleavable under appropriate conditions and incorporates a...
US-9,943,609 Protein-polymer-drug conjugates
Auristatin compounds and conjugates thereof are provided herein. The conjugate comprises a protein based recognition-molecule (PBRM) and a polymeric carrier...
US-9,943,608 Multi-arm biodegradable polymers for nucleic acid delivery
In some embodiments, the present disclosure pertains to compositions for nucleic acid delivery into cells. In some embodiments, the composition comprises: (1) a...
US-9,943,607 Beta-glucan compounds, compositions, and methods
Described herein are beta-glucan compounds, compositions, and methods. Generally, the methods exploit the observation that beta-glucan compounds can bind to B...
US-9,943,606 Dendritic polypeptide-based nanocarriers for the delivery of therapeutic agents
Dendritic polypeptides useful for the delivery of therapeutic agents into cells are disclosed, together with their methods of preparation. These dendritic...
US-9,943,605 Polymer-semaxanib moiety conjugates
The invention relates to (among other things) polymer-semaxanib moiety conjugates and related compounds. A compound of the invention, when administered by any...
US-9,943,604 Targeted therapeutic nucleosides and their use
Provided herein are compounds comprising one or more therapeutic nucleosides and one or more targeting groups. In certain embodiments, the compounds further...
US-9,943,603 Coferons and methods of making and using them
The present invention is directed to a monomer useful in preparing therapeutic compounds. The monomer includes a diversity element which potentially binds to a...
US-9,943,602 Orally bioavailable lipid-based constructs
The present invention is embodied by a composition capable inducing weight loss in a patient in need thereof.
US-9,943,601 Etanercept formulations stabilized with combinations of sugars and polyols
The invention provides stabilized aqueous pharmaceutical etanercept compositions suitable for long-term storage of etanercept, methods of manufacture of these...
US-9,943,600 Stabilizing agent for pharmaceutical proteins
A method for stabilising a human blood protein or human blood plasma protein with a molecular weight of >10 KDa by adding melezitose to a solution comprising...
US-9,943,599 Therapeutic applications of calcium electroporation to effectively induce tumor necrosis
The present inventors have shown that electroporation with calcium ions are efficient on cutaneous and subcutaneous nodules. In particular the present inventors...
US-9,943,598 Nanoparticles with attached DNA repair inhibitors and nuclear localisation signal elements
A radio- or chemo-sensitizing compound is described herein. The compound comprises a nanoparticle and attached to the nanoparticle; (i) a DNA repair...
US-9,943,597 Anti-LPS enriched immunoglobulin preparation for use in treatment and/or prophylaxis of a pathologic disorder
Methods and compositions for treating conditions including liver dysfunction, e.g., associated with fatty liver; glucose intolerance; and others, by...
US-9,943,596 Combination therapy using dual inhibitor of c-MET and EGFR and IGF-1R inhibitor
A method of preventing and/or treating a cancer, the method including co-administering a dual inhibitor of c-Met and EGFR (hereinafter, `c-Met/EGFR dual...
US-9,943,595 Messenger RNA therapy for treatment of articular disease
The present invention provides, among other things, a method of intra-articular delivery of messenger RNA (mRNA), comprising administering into a joint of a...
US-9,943,594 Methods for the treatment of rheumatoid arthritis
The present invention provides compositions and methods of treating and improving the symptoms of rheumatoid arthritis using an antibody or antigen-binding...
US-9,943,593 Modified matrix proteins of vesicular stomatitis virus
The present invention relates to vesicular stomatitis virus (VSV) matrix (M) protein mutants. One mutant M protein includes a glycine changed to a glutamic acid...
US-9,943,592 Vaccine adjuvants from self-assembling peptides
Pharmaceutical or veterinary compositions, vaccine systems, methods, and kits for treating or protecting a subject from a condition using peptide-based...
US-9,943,591 Compositions and methods for the treatment or prevention of hepatitis B virus infection
Disclosed are yeast-based immunotherapeutic compositions, hepatitis B virus (HBV) antigens, and fusion proteins for the treatment and/or prevention of HBV...
US-9,943,590 Use of Listeria vaccine vectors to reverse vaccine unresponsiveness in parasitically infected individuals
This invention relates to methods of using a Listeria vaccine vector to induce a Th1 immune response in subjects having persistent Th2 immune response profiles.
US-9,943,589 Immunopotentiator-linked oligomeric influenza immunogenic compositions
Disclosed herein are immunogenic compositions for preventing infection with influenza viruses wherein the immunogenic compositions comprises an immunogen such...
US-9,943,588 Influenza vaccine
The present invention relates to monovalent influenza vaccine formulations and vaccination regimes for immunising against influenza disease, their use in...
US-9,943,587 Prevention and treatment of sub-clinical PCVD
The present invention relates to the use of an immunogenic composition comprising a porcine circovirus type 2 (PCV2) antigen for the prevention and treatment of...
US-9,943,586 Truncated L1 protein of human papillomavirus type 11
The invention relates to a truncated L1 protein of the Human Papillomavirus Type 11, a virus-like particle consisting of the protein, a vaccine comprising said...
US-9,943,585 Methods and compositions related to reorganization of arenavirus genome for development of novel arenavirus...
Disclosed are compositions and methods related to recombinant arenaviruses and their use in vaccines for the treatment or prevention of an arenavirus infection.
US-9,943,584 Non-typeable haemophilus influenzae vaccines and their uses
Provided are non-typeable Haemophilus influenzae vaccines useful for the treatment of chronic obstructive pulmonary disease and asthma in a patient. In certain...
US-9,943,583 Proline-rich peptides protective against S. pneumoniae
The invention relates to lipopeptides consisting of a peptide chain comprising a parallel coiled-coil domain, a proline-rich peptide antigen, and a lipid...
US-9,943,582 Cholera toxin chimera and its use as a staph vaccine
The present invention relates to chimeric protein vaccines and methods of use thereof in the treatment of Staphylococcus aureus. One embodiment of the present...
US-9,943,581 Compositions produced using enteric pathogens and methods of use
The present invention provides compositions including polypeptides having the characteristics of polypeptides expressed by a reference microbe such E. coli or...
US-9,943,580 Malaria vaccine
Embodiments are directed to malaria vaccines comprising a bacteriophage VLP displaying a heterologous peptide identified by affinity selection as an...
US-9,943,579 Immunotherapy against several tumors, such as lung cancer, including NSCLC
A method of treating a patient who has non-small cell lung carcinoma (NSCLC), lung cancer, gastric cancer, and/or glioblastoma includes administering to said...
US-9,943,578 Standardized ex vivo platforms for the antigen-specific expansion of CD4+ T cell populations
The invention relates to methods, peptides, nucleic acids and cells for use in isolating and expanding human T cell populations in an antigen-specific manner...
US-9,943,577 Aminoacyl tRNA synthetases for modulating inflammation
Inflammatory and other cellular response-modulating compositions are provided comprising aminoacyl-tRNA synthetase polypeptides, including active fragments...
US-9,943,576 Formulations of biologics for intravesical instillation
Pharmaceutical formulations comprising a clostridial derivative and a permeabilizing agent for intravesical instillation are disclosed.
US-9,943,575 Pharmaceutical compositions of tenecteplase
Pharmaceutical compositions of tenecteplase that are safe and effective in the treatment of acute ischemic stroke compared with the known compositions are...
US-9,943,574 Combination for treating an inflammatory disorder
The invention provides a combination of a source of a CD39 and of a source of a CD73.
US-9,943,573 Treatment of ocular neovascularization using anti-VEGF proteins
The present disclosure provides compositions and methods for the prevention or treatment of ocular neovascularization, such as AMD, in a human subject, by...
US-9,943,572 Synergistic glycocalyx treatment compositions and methods
Compositions and methods for treating endothelial glycocalyx include glucosamine, hyaluronan and/or fucoidan, and one or more antioxidants, such as superoxide...
US-9,943,571 Use of ultrarapid acting insulin
Disclosed herein are improved methods of treating hyperglycemia with a combination of an ultrarapid acting insulin and insulin glargine comprising prandial...
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