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Patent # Description
US-9,944,992 Methods and compositions related to T-cell activity
Embodiments concern methods and composition related to anergic T-cells in patients, such as cancer patients. T cell anergy is a hyporesponsive state induced by...
US-9,944,991 Compositions and methods for diagnosis, prognosis and treatment of hematological malignancies
This invention is based, at least in part, on the finding that certain microRNAs (miRNAs) are expressed at higher or lower levels in circulating exosonies or...
US-9,944,990 Gene expression markers for breast cancer prognosis
The present invention provides gene sets the expression of which is important in the diagnosis and/or prognosis of breast cancer.
US-9,944,989 Micrornas as new therapeutic targets for the prevention and/or treatment of retinopathy
Methods and compositions are disclosed to identify plasma and vitreous microRNA (miRNA) signatures of diabetic retinopathy (DR), and then as diagnostic...
US-9,944,988 Modulation of NLGn4 expression, NK cell activity in non-alcoholic fatty liver disease (NAFLD)
The present invention provides a method of diagnosing and/or monitoring a liver disorder in a subject. The method calls for isolating an immune cell population...
US-9,944,987 Assessment of risk of aneuploidy
The present disclosure relates generally to methods and materials for use in detecting abnormalities of the number of whole chromosomes or chromosome regions...
US-9,944,986 Therapeutic targets for Alzheimer's disease
The present invention relates to novel methods for the prevention, treatment and diagnosis of Alzheimer's disease. In addition, the invention relates to methods...
US-9,944,985 Personalized pain management and anesthesia: preemptive risk identification and therapeutic decision support
Methods and compositions disclosed herein generally relate to methods of improving clinical and economic outcomes to address adverse effects related to...
US-9,944,984 High density DNA array
A high density DNA array comprising a patterned surface, said surface comprising a pattern of small DNA binding regions separated by a non-DNA binding surface,...
US-9,944,983 Method of screening a plurality of single secreting cells for functional activity
This invention generally relates to methods, devices and kits for screening a plurality of single secreting cells for functional activity of the secreted...
US-9,944,982 Surface chemistry and deposition techniques
Surface chemistries for the visualization of labeled single molecules (analytes) with improved signal-to-noise properties are provided. To be observed, analyte...
US-9,944,981 Methods and apparatus for measuring analytes
Methods and apparatus relating to FET arrays for monitoring chemical and/or biological reactions such as nucleic acid sequencing-by-synthesis reactions. Some...
US-9,944,980 Articles having localized molecules disposed thereon and methods of producing same
Methods of producing substrates having selected active chemical regions by employing elements of the substrates in assisting the localization of active chemical...
US-9,944,979 Inhibition method of nucleic acid amplification by photoirradiation and method of selective nucleic acid...
Provided is a method for rapidly and easily detecting a mutated nucleic acid, which is contained in a small amount in a nucleic acid sample together with...
US-9,944,978 Multiplex quantitative PCR
Disclosed are methods and compositions for determining the average length or abundance of a first target nucleic by calculating the abundance of a first target...
US-9,944,977 Distinguishing rare variations in a nucleic acid sequence from a sample
The invention generally relates to methods for distinguishing a rare genetic variation in a nucleic acid sequence.
US-9,944,976 Method for stirring solution
A method of stirring a test substance-containing solution injected into an analysis chip, wherein said analysis chip includes a recess to which said test...
US-9,944,975 Hybridization buffers
Disclosed herein are hybridization buffer compositions and hybridization compositions, methods of making the compositions, and methods of using the...
US-9,944,974 Method for the specific isolation of nucleic acids of interest
A method and diagnostic kit for selective isolation of microorganisms of interest and/or nucleic acids of interest including: a) bringing a liquid biological...
US-9,944,973 Methods for standardized sequencing of nucleic acids and uses thereof
Methods for standardized sequencing of nucleic acids and uses thereof are described. The identification of genetic information is becoming a key piece of...
US-9,944,972 High-throughput and highly multiplexed imaging with programmable nucleic acid probes
The present invention provides, inter alia, methods and compositions for imaging, at high spatial resolution, targets of interest.
US-9,944,971 Determination of direct thrombin inhibitors in fluids like serum or urine
The present invention relates to a method for detecting at least one direct thrombin inhibitor in a sample other than citrate plasma, comprising the step of...
US-9,944,970 Glycated hexapeptide oxidase and use thereof
The present invention provides a protein comprising an amino acid sequence in which arginine at position 61 of a protein comprising the amino acid sequence...
US-9,944,969 Devices, systems and methods for detecting viable infectious agents in a fluid sample
Various devices, systems and methods for detecting a susceptibility of an infectious agent to an anti-infective are described herein. A method comprises...
US-9,944,968 Control of protein glycosylation by culture medium supplementation and cell culture process parameters
The present invention pertains to a cell culture medium comprising media supplements that are shown to control recombinant protein glycosylation and/or cell...
US-9,944,967 Methods for the site-selective introduction of halogen into natural products
Organohalides (e.g., organofluorides) represent a rapidly expanding proportion of molecules used in pharmaceuticals, diagnostics, agrochemicals, and materials....
US-9,944,966 Method for production of single-stranded macronucleotides
The invention relates to a method for production of single-stranded macronucleotides by amplifying and ligating an extended monomeric single-stranded target...
US-9,944,965 Biosynthesis of oligosaccharides
The present invention relates to methods for production of 2'Fucosyllactose by a microbial system comprising a .alpha.-1,2 fucosyltransferase (FucT2)...
US-9,944,964 Processes for increasing bioalcohol yield from biomass
A process for increasing alcohol yield from biomass (the form or agro- or forest residue, grains, hops, etc.), involving multiple hydrodynamic cavitation...
US-9,944,963 Transaminase biocatalysts
The present disclosure relates to polypeptides having transaminase activity, polynucleotides encoding the polypeptides, and methods of using the polypeptides.
US-9,944,962 Clone of xiamenmycin biosynthesis gene cluster and heterologous expression thereof
The present invention involves the application of a gene cluster, and bacterial strains that used in the biosynthesis of Xiamenmycin. The nucleotide sequence of...
US-9,944,961 Process for removing sulphide from an aqueous solution
A process for removing sulphide from an aqueous solution comprising sulphide is disclosed, in which the aqueous solution is subjected to sulphide-oxidizing...
US-9,944,960 Process for microbial production of dihydrolipoic acid and extraction of dihydrolipoic acid with edible oils
A process for production and extraction of dihydrolipoic acid (DHLA) relates to the biotransformation of R-lipoic acid to dihydrolipoic acid. The process...
US-9,944,959 Production of fatty acids esters
A microbial cell is used for producing at least one fatty acid ester, wherein the cell is genetically modified to contain (i) at least one first genetic...
US-9,944,958 Method for preparing triacylglycerol high-productivity algae
The purpose of the present invention is to effectively accumulate triacylglycerol in algae cells, the present invention providing a method for introducing a...
US-9,944,957 Recombinant Escherichia coli for producing D-lactate and use thereof
Provided is recombinant Escherichia coli comprising a mutated ldhA gene. Disclosed are use of the recombinant Escherichia coli in the preparation of D-lactate,...
US-9,944,956 Methods and microbial cultures for improved conversion of lignocellulosic biomass
The present technology pertains to methods and microbial co-cultures for converting lignocellulosic biomass to biofuels and/or other carbon-based chemicals....
US-9,944,954 Glycerol 3-phosphate dehydrogenase for butanol production
Provided herein are glycerol-3-phosphate dehydrogenase (GPD) enzymes with increased K.sub.M for NADH and GPD enzymes with substantially the same affinity for...
US-9,944,953 Method of expressing goldfish gfTP1 tranposase protein
An expression method of active goldfish gfTP1 transposase protein comprises: constructing an expression vector comprising a gfTP1 transposase reading frame of a...
US-9,944,952 Replication-defective arenavirus vectors
The invention relates to an infectious arenavirus particle that is engineered to contain a genome with the ability to amplify and express its genetic...
US-9,944,951 Chromosome 3p21.3 genes are tumor suppressors
Tumor suppressor genes play a major role in the pathogenesis of human lung cancer and other cancers. Cytogenetic and allelotyping studies of fresh tumor and...
US-9,944,950 Methods and compositions for producing induced airway tissue progenitor cells
A method of generating an induced progenitor population (iPP) of cells and/or induced population of cells from somatic cells, comprising the steps: a)...
US-9,944,949 Compositions and methods conferring resistance of maize to corn rootworm 1
Methods and compositions for increasing a plant's resistance to an insect pest such as the corn rootworm are provided. Methods are provided for overexpression...
US-9,944,948 Down-regulating gene expression in insect pests
The present invention relates to the prevention and/or control of infestation by insect pest species. In particular, the invention relates to down-regulation of...
US-9,944,947 Methods and compositions for selecting soybean plants resistant to phytophthora root rot
The present invention relates to the field of plant breeding and disease resistance. More specifically, the invention includes a method for breeding soybean...
US-9,944,946 Fungal resistant plants expressing HCP4
The present invention relates to a method of increasing resistance against fungal pathogens of the order Pucciniales, preferably the family Phacopsoraceae, in...
US-9,944,945 Soybean event MON89788 and methods for detection thereof
The present invention provides for soybean plant and seed comprising transformation event MON89788 and DNA molecules unique to these events. The invention also...
US-9,944,944 AAD-12 event 416, related transgenic soybean lines, and event-specific identification thereof
This invention includes a novel aad-12 transformation event for herbicide tolerance in soybean plants--referred to herein as pDAB4468-0416. This invention...
US-9,944,943 Method of producing stress tolerant plants overexpressing CaSUN1
The present disclosure relates to a method of producing transgenic plants that over-express the chickpea protein, CaSUN1, expression of which enhances the...
US-9,944,942 Methods and compositions for enhanced resistance to abiotic stress in plants
The present invention provides transgenic plants having increased tolerance to abiotic stress comprising a recombinant nucleic acid molecule, said recombinant...
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