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Patent # Description
US-9,944,634 Pyrazolopyridine derivatives as TTX-S blockers
The present invention relates to pyrazolopyridine derivatives which have blocking activities of voltage gated sodium channels as the TTX-S channels, and which...
US-9,944,633 Compounds and methods for the treatment of isocitrate dehydrogenase related diseases
The invention relates to compounds of Formula I or a pharmaceutically acceptable salt, ester or prodrug thereof: ##STR00001##
US-9,944,632 Compounds having estrogen receptor alpha degradation activity and uses thereof
The present disclosure relates to novel compounds, pharmaceutical compositions containing such compounds, and their use in prevention and treatment of...
US-9,944,631 Modulators of calcium release-activated calcium channel
Disclosed are novel calcium release-activated calcium (CRAC) channel inhibitors, methods for preparing them, pharmaceutical compositions containing them, and...
US-9,944,630 Dithiolane carbonate monomers and polymers thereof
1,2-Diothiolane monomers are disclosed, as are polymers and hydrogels comprising the polymers. Processes for preparing the monomers, polymers and compositions...
US-9,944,629 Material for organic electroluminescent element, organic electroluminescent element, illumination device, and...
A material for an organic electroluminescent element contains a compound represented by Formula (1): ##STR00001## where R.sub.1 to R.sub.3 independently...
US-9,944,628 Inhibitors of cellular necrosis and related methods
A compound having the following structure (I): ##STR00001## or a pharmaceutically acceptable salt, prodrug, stereoisomer or tautomer thereof, is provided....
US-9,944,627 Spiroacridine-triazine hybrids and applications for electroluminescent devices
The present invention relates to compounds of the formula (1), to the use thereof in electroluminescent devices, and particularly organic electroluminescence...
US-9,944,626 6-(5-hydroxy-1H-pyrazol-1-YL)nicotinamide inhibitors of PHD
The present invention provides compounds of the formula: ##STR00001## which are useful as inhibitors of PHD, pharmaceutical compositions thereof, methods for...
US-9,944,625 Substituted tetrahydroisoquinoline compounds as factor XIa inhibitors
The present invention provides compounds of Formula (I): ##STR00001## or stereoisomers, pharmaceutically acceptable salts thereof, wherein all of the variables...
US-9,944,624 Substituted amino triazoles useful as human chitinase inhibitors
Disclosed are amino triazole compounds substituted with a piperidinyl ring that is itself substituted with a heterocyclic ring. These compounds are inhibitors...
US-9,944,623 Sterically hindered amine stabilizer
The present invention relates to oxygen-substituted sterically hindered amines of the formulae I or II: (II), wherein, for example, F.sub.2, R.sub.3, R.sub.5,...
US-9,944,622 Pyrimidinyl tyrosine kinase inhibitors
The present invention provides compounds and compositions thereof which are useful as inhibitors of Bruton's tyrosine kinase and which exhibit desirable...
US-9,944,621 Substituted piperidinyl tetrahydroquinolines
The present application relates to novel substituted piperidinyltetrahydroquinolines, to processes for their preparation, to their use for the treatment and/or...
US-9,944,620 Indolizine compounds, a process for their preparation and pharmaceutical compositions containing them
Compounds of formula (I) wherein Ra, Rb, Rc, Rd, T, R3, R4, R5, X, Y and Het are as defined in the description. ##STR00001## Medicinal products containing the...
US-9,944,619 Compounds for the treatment of HIV
The invention provides compounds of formula (I): or a salt thereof as described herein. The invention also provides pharmaceutical compositions comprising a...
US-9,944,618 Inhibiting neurotransmitter reuptake
This document relates to compounds as well as methods and materials involved in modulating neurotransmitter reuptake. For example, compounds, methods for...
US-9,944,617 Selective aerobic oxidations using carbon nitride nanotubes
The present invention discloses an improved oxidation process using carbon nitride nanotubes as metal free catalyst and molecular O2 as the oxidant to obtain...
US-9,944,616 Processes for the preparation of Tasimelteon and intermediates thereof
The present invention provides processes for the preparation of Tasimelteon (1), as well as processes for the preparation of intermediates of Formulas (2), (3)...
US-9,944,615 Purifying crude furan 2,5-dicarboxylic acid by hydrogenation and a purge zone
A process for purifying a crude furan 2,5-dicarboxylic acid composition (cFDCA) by hydrogenation of a FDCA composition dissolved in a hydrogenation solvent such...
US-9,944,614 Production of furfural from xylose
Described is a method for producing furfural from one or more substances selected from the group consisting of xylose, oligosaccharides comprising xylose units...
US-9,944,613 Fumagillol spirocyclic compounds and fused bicyclic compounds and methods of making and using same
Disclosed herein, in part, are fumagillol compounds and methods of use in treating medical disorders, such as obesity. Pharmaceutical compositions and methods...
US-9,944,612 1-phenyl-2-pyridinyl alkyl alcohol derivatives as phosphodiesterase inhibitors
Compounds of formula (I) described herein are inhibitors of the phosphodiesterase 4 (PDE4) enzyme and are useful for the prevention and/or treatment of an...
US-9,944,611 Polymerizable resins containing a 1,3,5-hexahydro-1,3,5-triazine moiety, methods of making, and dental...
Disclosed herein are methods of making polymerizable resins containing a 1,3,5-hexahydro-1,3,5-triazine moiety and dental compositions comprising such novel...
US-9,944,610 Preparation and method for use in the treatment of respiratory diseases
The present disclosure relates to a novel active compound having the formula Ia: ##STR00001## solid preparations, uses and methods for the treatment or...
US-9,944,609 Formation of N-protected bis-3,6-(4-aminobutyl)-2, 5-diketopiperazine through a cyclic alpha-N-protected amino...
A method for the synthesis of N-protected 3,6-aminoalkyl-2,5-diketopiperazines is provided. The method includes obtaining a cyclic .alpha.-N protected active...
US-9,944,608 Herbicidal pyridazinone derivatives
The present invention relates to herbicidal benzyloxy-substituted phenyl-diones and benzyloxy substituted phenyl-dioxo-thiazinone derivatives of formula (I), as...
US-9,944,607 Thiohydantoin derivatives and uses thereof
The present invention provides novel compounds (e.g., compounds of Formula (I)), and pharmaceutically acceptable salts, solvates, hydrate, polymorphs,...
US-9,944,606 Cannabinoid receptor modulators
The present invention relates to certain compounds of Formula Ia and pharmaceutical compositions thereof that modulate the activity of the cannabinoid CB2...
US-9,944,605 Farnesoid X receptor antagonists
Provided herein are Farnesoid X receptor (FXR) antagonists having the structure of formula (I), and pharmaceutical compositions comprising the compound of...
US-9,944,604 Aminobenzamide derivatives as useful agents for controlling animal parasites
The invention relates to a composition comprising at least one aminobenzamide compound or a salt thereof for controlling animal parasites, veterinary...
US-9,944,603 Compounds and methods for the treatment of cystic fibrosis
The invention relates to a compound of Formula I and methods of treating cystic fibrosis comprising the step of administering a therapeutically effective amount...
US-9,944,602 Piperidinone herbicides
Disclosed are compounds of Formula 1, including all stereoisomers, N-oxides, and salts thereof: ##STR00001## wherein R.sup.1, R.sup.2, R.sup.3, R.sup.2A,...
US-9,944,601 (Hetero)aryl cyclopropylamine compounds as LSD1 inhibitors
The invention relates to (hetero)aryl cyclopropylamine compounds, including particularly the compounds of formula I as described and defined herein, and their...
US-9,944,600 Piperidine derivatives for GPR119 agonist
The present invention relates to novel piperidine derivatives, stereoisomers thereof or pharmaceutically acceptable salts thereof; methods for preparing the...
US-9,944,599 Processes for the preparation of beta-aminosulfone compounds
The present invention relates to processes for preparing .beta.-aminosulfone compounds. The provided compounds are useful intermediates in the preparation of...
US-9,944,598 Mono- or di-substituted indole derivatives as dengue viral replication inhibitors
The present invention concerns mono- or di-substituted indole derivatives (I) which are useful to prevent or treat dengue viral infections and also relates to...
US-9,944,597 Polysubstituted pyrroles having microtubule-disrupting, cytotoxic and antitumor activities and methods of use...
The present invention provides polysubstituted pyrrole compounds, pharmaceutically effective salts, prodrugs, solvates and hydrates thereof, having antimitotic,...
US-9,944,596 Heterocyclic compound
Provided is a heterocyclic compound having a superior RBP4-lowering action and useful as a medicament for the prophylaxis or treatment of a disease or symptom...
US-9,944,595 Process for producing perfluoropolyoxyalkylene peroxide compound
The present invention provides a process for producing a perfluoropolyoxyalkylene peroxide compound comprising a step of reacting a perfluoroalkene with oxygen,...
US-9,944,594 Catalyst for the synthesis of methyl mercaptan and process for producing methyl mercaptan from synthesis gas...
The invention relates to a catalyst comprising an active component based on molybdenum and on potassium and a support based on hydroxyapatite, and also to a...
US-9,944,593 Process for the synthesis of fluoralkyl sulfonate salts
A process for the preparation of the fluoroalkyl sulfonate salt of a nitrogen-based organic base said process comprising the step of reacting a fluoroalkyl...
US-9,944,592 Acyloxyalkyl carbamate prodrugs, methods of synthesis and use
The disclosures herein relate generally to acyloxyalkyl carbamate prodrugs of (.+-.)-4-amino-3-(4-chlorophenyl)butanoic acid and analogs thereof, pharmaceutical...
US-9,944,591 Active compound and related composition for dermatological use in the pharmaceutical or cosmetic field
The invention relates to the 4-((2E,4E,6E)-octa-2,6,4-trienamid)butanoic acid; its use in the therapeutic and cosmetic field for topical application to the skin...
US-9,944,590 Crystalline solid forms of the acetate salt of ...
The present invention is generally directed to novel crystalline forms of the acetate salt of ...
US-9,944,589 Cycloproplyamine derivatives useful as inhibitors of histone demethylases KDM1A
The present invention relates to cyclopropyl derivatives of general formula (I), wherein A, R.sup.1, and R.sup.2 are as defined in the specification. The...
US-9,944,588 Method for preparing methyl formate
A method for preparing methyl formate in which a raw material containing formaldehyde, methanol and/or dimethyl ether is introduced into a first reaction zone...
US-9,944,587 Process for vapor-phase methanol carbonylation to methyl formate, a catalyst used in the process and a method...
A process for vapor-phase carbonylation of methanol to methyl formate, whereby a feed gas containing methanol, carbon monoxide, hydrogen and oxygen is passed...
US-9,944,586 Methods for producing alkyl hydroxyalkanoates
Methods and systems for producing alkyl hydroxyalkanoate from hydroxy carboxylic acid recovery bottoms. The methods generally comprise the steps of obtaining a...
US-9,944,585 Flavor and fragrance formulation (V)
The present invention relates to the use of a specific organic compound as flavor and fragrance material. Furthermore the invention relates to flavor and...
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