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Patent # Description
US-9,951,142 Anti-presepsin antibody
The present invention provides methods and compositions for determining sepsis in an individual. Specifically, the present invention provides for antibodies of...
US-9,951,141 Antibody-drug conjugates, their preparation and their therapeutic use
The present disclosure relates to conjugates comprising biologically active molecules linked to a multimeric antigen-binding compound or a multimeric...
US-9,951,140 Antibodies against human CSF-1R and uses thereof
The present invention relates to antibodies against human CSF-1R (CSF-1R antibody), methods for their production, pharmaceutical compositions containing said...
US-9,951,139 Antibodies against human CSF-1R and uses thereof
The present invention relates to antibodies against human CSF-1R (CSF-1R antibody), methods for their production, pharmaceutical compositions containing said...
US-9,951,138 Antigen binding proteins that bind CCR2
There is disclosed compositions and methods relating to or derived from anti-CCR2 antibodies. More specifically, there is disclosed fully human antibodies that...
US-9,951,137 ST2L antagonists and methods of use
The present invention relates to ST2L antagonists, polynucleotides encoding the antagonists or fragments thereof, and methods of making and using the foregoing.
US-9,951,136 Anti-IL-6 receptor antibodies and methods of use
The present invention provides anti-IL-6R monoclonal antibodies and related compositions, which may be used in any of a variety of therapeutic methods for the...
US-9,951,135 Monoclonal antibodies against the DEC-205 receptor of chicken dendritic cells
The invention relates to the production and the characterization of new murine monoclonal antibodies that recognize the domain CTDL-2 (SEQ ID NO: 1) of the cell...
US-9,951,134 Modified J-chain
The present invention concerns modified recombinant J-chain polypeptides, binding molecules, such as antibodies, comprising the same, and their uses.
US-9,951,133 Anti-CD33 antibodies and immunoconjugates
The invention provides anti-CD33 antibodies and immunoconjugates and methods of using the same.
US-9,951,132 Anti-prokineticin receptor (PROKR) antibodies and uses thereof
The present invention provides antibodies that bind to prokineticin receptors (PROKRs) and methods of using same. According to certain embodiments of the...
US-9,951,131 Antibodies that recognize IAPP
The invention provides monoclonal antibody 3H6 and related antibodies. The 3H6 antibody binds to an epitope within residues 28-36 of IAPP. The antibodies of the...
US-9,951,130 IL-6 antagonists and uses thereof
Interleukin 6 (IL-6) antagonists are provided that are specific for binding to site II of IL-6. Methods of using such inhibitors to treat IL-6 related diseases,...
US-9,951,129 Human IL-23 antigen binding proteins
Antigen binding proteins that bind to human IL-23 protein are provided. Nucleic acids encoding the antigen binding protein, vectors, and cells encoding the same...
US-9,951,128 Caninized anti-NGF antibodies and methods thereof
The present disclosure describes novel caninized anti-NGF antibodies, antigen binding proteins and polynucleotides encoding the same. The disclosure further...
US-9,951,127 Anti-ANGPTL3 antibodies and uses thereof
A fully human antibody or antigen-binding fragment of a human antibody that specifically binds and inhibits or interferes with at least one activity of human...
US-9,951,126 Antibodies directed against nerve growth factor (NGF)
The invention relates to an isolated immunoglobulin heavy chain polypeptide and an isolated immunoglobulin light chain polypeptide that binds to Nerve Growth...
US-9,951,125 A.beta. conformer selective anti-A.beta. globulomer monoclonal antibodies
The subject invention relates to monoclonal antibodies that may be used in the treatment and diagnosis of Alzheimer's Disease. In particular, the present...
US-9,951,124 Antibody producing non-human mammals
Described are transgenic, non-human animals comprising a nucleic acid encoding an immunoglobulin light chain, whereby the immunoglobulin light chain is human,...
US-9,951,123 Anti-LPS O11 antibody
The purpose of the present invention is to provide a substance having superior antibacterial activity against Pseudomonas aeruginosa, and a pharmaceutical...
US-9,951,122 Antibodies against influenza virus and methods of use thereof
The invention provides human scFv antibodies and monoclonal antibodies that neutralize influenza virus. Also provided are methods of treating and/or preventing...
US-9,951,121 Phage displaying system expressing single chain antibody
Disclosed are nucleic acid libraries for identifying a signal peptide that facilitates production of disulfide-stabilized single chain antibody, and for...
US-9,951,120 Method of treating diabetes using non-glycosylated apolipoprotein A-IV
Methods for treating type two diabetes mellitus in a subject in need thereof and pharmaceutical compositions for the treatment of type two diabetes mellitus are...
US-9,951,119 Peptides and combination of peptides for use in immunotherapy against various tumors
A method of treating a patient who has hepatocellular carcinoma (HCC), colorectal carcinoma (CRC), glioblastoma (GB), gastric cancer (GC), esophageal cancer,...
US-9,951,117 Vesicular stomatitis viruses
This document provides methods and materials related to vesicular stomatitis viruses. For example, vesicular stomatitis viruses, nucleic acid molecules encoding...
US-9,951,116 Alpha- and gamma-MSH analogues
The present invention provides peptide analogs of .alpha.-MSH and .gamma.-MSH, comprising the amino acid sequence of human .alpha.-MSH or .gamma.-MSH, or...
US-9,951,115 CGRP agonist peptides
The embodiments provide a calcitonin gene-related peptide (CGRP) agonist peptide or pharmaceutically acceptable salt thereof, including pharmaceutical...
US-9,951,114 Recombinant cancer therapeutic cytokine
Recombinant therapeutic cytokines ("therakines") for the treatment of cancer are provided. The recombinant therakines include a truncated region of MDA-7/TL-24...
US-9,951,113 Lectin compositions and methods for modulating an immune response to an antigen
The present invention provides a fusion polypeptide which can bind to a cell surface binding moiety (e.g., a carbohydrate) and serve as a ligand for a cell...
US-9,951,112 BMP-4 peptides and methods of use
The invention relates to truncated BMP-4 growth factors and variants thereof. The invention also relates to methods of making and using the truncated BMP-4...
US-9,951,111 Type I interferon mimetics as therapeutics for cancer, viral infections, and multiple sclerosis
The subject invention pertains to agonist peptides of type I interferons and methods of using the peptides. These peptides are based on the amino acid sequence...
US-9,951,110 Neuropeptides useful as insecticides
The invention provides short peptides derived from an insect neuropeptide for controlling insects, particularly peptides or their analogs derived from PBAN...
US-9,951,109 Composition for preventing Mycoplasma spp. infection
The present invention provides proteins that are suitable to be used as the active ingredient in subunit vaccine against Mycoplasma spp. The present invention...
US-9,951,108 Protein isolation
A general method and strains of bacteria are described by means where the endogenous DNAK protein or homolog of the DNAK protein is tagged with a recognizable...
US-9,951,107 Vault complexes
The invention relates to compositions of vault complexes containing recombinant membrane lytic proteins, such as an adenovirus protein VI lytic domain, and...
US-9,951,106 Recombinant fusion protein comprising HIV gp120 linked to an enhancing CD4 binding site mAb
Fusion proteins comprising a portion of the HIV-1 Env protein (gp120 and gp140) and single-chain fragment V regions (ScFv) of an enhancing antibody that...
US-9,951,105 Methods of developing selective peptide antagonists
Methods and compositions related to the selective, specific disruption of multiple ligand-receptor signaling interactions, such as ligand-receptor interactions...
US-9,951,104 Peptides and methods of using same
We describe peptides and their uses for the treatment of autoimmune, inflammatory and metabolic diseases.
US-9,951,103 Beta sheet tapes ribbons in tissue engineering
There is described a material comprising tapes, ribbons, fibrils or fibers characterized in that each of the ribbons, fibrils or fibers have an antiparallel...
US-9,951,102 Peptide inhibitor of Nox1 NADPH oxidase
An isolated peptide or fusion having the peptide useful to interfere with the phosphorylation of Nox1, block or inhibit binding of NoxA1 activation domain (AD)...
US-9,951,101 Protein separations using an acrylamide containing filter
Novel compositions for removing impurities such as, protein aggregates, from a sample containing a protein of interest, e.g., an antibody. Such compositions can...
US-9,951,100 Method for isolating and purifying recombinant human serum albumin from transgenic rice grain
A method for separating and purifying recombinant human serum albumin (rHSA) from transgenic rice grain, sequentially comprising the steps of: 1) subjecting...
US-9,951,099 Stabilized compounds having secondary structure motifs
The present invention provides novel stabilized crosslinked compounds having secondary structure motifs, libraries of these novel compounds, and methods for the...
US-9,951,098 Synthesis of 5-azacytidine
Provided herein are processes for the preparation of 5-azacytidine, useful for treating, preventing, and/or managing diseases or conditions including cancer,...
US-9,951,097 Antibacterial compounds targeting isoprenoid biosynthesis
With the rise in resistance to antibiotics such as methicillin, there is a need for new drugs. The invention provides small molecules that inhibit cellular drug...
US-9,951,096 Catalysts and methods for polymer synthesis
The present invention provides unimolecular metal complexes having increased activity in the copolymerization of carbon dioxide and epoxides. Also provided are...
US-9,951,095 Chromium metal organic frameworks and synthesis of metal organic frameworks
The present invention relates to monocrystalline metal organic frameworks comprising chromium ions and carboxylate ligands and the use of the same, for example...
US-9,951,094 Phosphole compound and fluorescent dye containing the same
The following formula is an example of a phosphole compound of the present invention. The phosphole compound of the present invention has the characteristic of...
US-9,951,093 Chiral compounds substituted with phosphonic acid ester functions or phosphonic acid functions
The present invention relates to novel compounds that contain PNA units substituted with phosphonic acid ester functions or phosphonic acid functions, and have...
US-9,951,092 Methods, compositions, devices, and kits for performing phospholipid separation
Methods, kits and devices for separating phospholipids and proteins from small molecules in biochemical samples can feature an apparatus having a wetting...
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