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Patent # Description
US-9,951,091 Process for preparing tris[3-(alkoxysilyl)propyl] isocyanurates
A tris[3-(alkoxysilyl)propyl] isocyanurate from the group of tris[3-(trialkoxysilyl)propyl] isocyanurate, tris[3-(alkyldialkoxysilyl)propyl] isocyanurate and ...
US-9,951,090 Mono-functional branched organosiloxane compound and method for producing the same
The present invention is a mono-functional branched organosiloxane compound that is liquid and shown by the following general formula (1) ...
US-9,951,089 Methods of treating a fatty acid amide hydrolase-mediated condition
The present invention provides fatty acid amide hydrolase inhibitors, solid forms thereof, compositions thereof, and methods of making and using the same.
US-9,951,088 D2 receptor modulators and methods of use thereof in the treatment of diseases and disorders
Provided herein are heteroaryl compounds, methods of their synthesis, pharmaceutical compositions comprising the compounds, and methods of their use. In one...
US-9,951,087 Fused ring analogues of anti-fibrotic agents
The present invention relates to arylcarbonyl and heteroarylcarbonyl anthranilate compounds that may be useful as anti-fibrotic agents. The present invention...
US-9,951,086 Indazolecarboxamides, processes for their preparation, pharmaceutical preparations comprising them and their...
The present application relates to novel 6-substituted indazoles having a carboxamide side chain, to processes for their preparation, to their use alone or in...
US-9,951,085 Labeled chemically reactive and biologically active comjugates, and methods and compositions thereof
The invention generally relates to novel fluorophore-labeled, bi- or multi-functional, chemically reactive and/or biologically active conjugates, and related...
US-9,951,084 Spiro-cyclic amine derivatives as S1P modulators
The present invention relates spiro-cyclic amine derivatives of the formula (1) wherein R1; R2; R3; Q; --W-T-; R5; Z; and A have the definitions provided in the...
US-9,951,083 Cyclopamine analogs
The invention provides derivatives of cyclopamine having the following formula: ##STR00001##
US-9,951,082 Crystal of 6,7-unsaturated-7-carbamoyl morphinan derivative and method for producing the same
Stable crystalline forms of a compound represented by the formula (IA): ##STR00001## an acid addition salt, and/or a solvate thereof are provided by the...
US-9,951,081 Chlorin e6 derivative and pharmaceutically acceptable salt thereof and process for preparing and use of the same
The present application relates to a new chlorin e6 derivatives and pharmaceutically acceptable salt thereof, as well as preparation and use thereof, which...
US-9,951,080 Processes for the preparation of (3S,4R)-3-ethyl-4-(3H-imidazo[1,2-alpha]pyrrolo[2,3-e]-pyrazin-8-yl)-N-(2- ...
The present disclosure relates to processes for preparing (3S,4R)-3-ethyl-4-(3H-imidazo[1,2-a]pyrrolo[2,3-e]pyrazin-8-yl)-N-(2,2,2-- ...
US-9,951,079 Fused tricyclic heterocyclic compounds as HIV integrase inhibitors
The present invention relates to Fused Tricyclic Heterocycle Derivatives of Formula (I): (I) and pharmaceutically acceptable salts thereof, wherein A, X, Y, m,...
US-9,951,078 Inhibitors of ERK and methods of use
The present invention provides chemical entities or compounds and pharmaceutical compositions thereof that are capable of modulating certain protein kinases...
US-9,951,077 Aminopyridazinone compounds as protein kinase inhibitors
The present disclosure provides a compound of formula (I) and the use thereof for the therapeutic treatment of human cancers including B-cell lymphoma and...
US-9,951,076 Deuterated pentylenetetrazoles for improving cognitive function
Provided are compounds having formula I: ##STR00001## wherein R.sup.1, R.sup.2, R.sup.3, R.sup.4, R.sup.5, R.sup.6, R.sup.7, R.sup.8, R.sup.9, and R.sup.10...
US-9,951,075 Pteridines useful as HCV inhibitors and methods for the preparation thereof
The present invention relates to the use of pteridines as inhibitors of HCV replication as well as their use in pharmaceutical compositions aimed to treat or...
US-9,951,074 Dihydropteridinone derivatives and uses thereof
The present disclosure provides compounds of Formula (I), and pharmaceutically compositions thereof. Compounds of Formula (I) have been found to bind...
US-9,951,073 Compounds and compositions for treating chemical warfare agent-induced injuries
Compounds and compositions for treating injuries caused by exposure to chemical warfare agents are described herein.
US-9,951,072 Compositions and methods for inhibiting beta-lactamase
Substituted dihydroisoxazole derivatives useful as inhibitors of .beta.-lactamases are provided. The invention further provides medical uses of substituted...
US-9,951,071 Dihydropyridone P1 as factor XIa inhibitors
The present invention provides compounds of Formula (V): ##STR00001## or stereoisomers, tautomers, or pharmaceutically acceptable salts thereof, wherein all...
US-9,951,070 Ergoline compounds and uses thereof
Provided herein are ergoline compounds and pharmaceutical compositions thereof. In some embodiments, provided herein are methods of treatment, prevention, or...
US-9,951,069 Bicyclic inhibitors of histone deacetylase
Provided herein are compounds and pharmaceutically acceptable salts thereof, and pharmaceutical compositions thereof, which are useful in the treatment of...
US-9,951,068 Imidazo[4,5-C]pyridine and pyrrolo[2,3-C]pyridine derivatives as SSAO inhibitors
The compounds of formula (I) are inhibitors of SSAO activity ##STR00001## wherein V, W, X, Y, Z, R.sup.1 and R.sup.2 are as defined in the claims.
US-9,951,067 Optically active .alpha.-trifluoromethyl-.beta.-amino acid derivative production method
A method for producing an optically active .alpha.-trifluoromethyl-.beta.-amino acid derivative, the method including: allowing a compound represented by the...
US-9,951,066 Compositions, uses and methods for making them
Generally, the present invention provides novel quinolone compounds and pharmaceutical composition thereof which may inhibit cell proliferation and/or induce...
US-9,951,065 Benzimidazole and imadazopyridine carboximidamide compounds
The present disclosure provides indoleamine 2,3-dioxygenase 1 (IDO1) inhibitors of Formula I: ##STR00001## or pharmaceutically acceptable salts thereof, in...
US-9,951,064 Azaindazole compounds as inhibitors of T790M containing EGFR mutants
This invention relates to novel compounds which are inhibitors of T790M containing EGFR mutants, to pharmaceutical compositions containing them, to processes...
US-9,951,063 8-(piperazin-1-yl)-1,2,3,4-tetrahydro-isoquinoline derivatives
The invention relates to compounds of Formula (I) wherein R.sup.1, R.sup.2, R.sup.3, R.sup.4 and R.sup.5 are as described in the description; to...
US-9,951,062 Substituted 1 H-pyrrolo [2, 3-b] pyridine and 1 H-pyrazolo [3, 4-b] pyridine derivatives as salt inducible...
Compounds according to Formulas I, IA or IB: ##STR00001## to pharmaceutically acceptable composition, salts thereof, their synthesis and their use as SIK2...
US-9,951,061 CaMKII inhibitors and uses thereof
The present invention provides compounds useful as inhibitors of Ca.sup.2+/calmodulin-dependent protein kinase (CaMKII), compositions thereof, and methods of...
US-9,951,060 2-acylaminothiazole derivative or salt thereof
[Problem] To provide a compound which is useful as an active ingredient for a pharmaceutical composition for preventing or treating urine storage dysfunction,...
US-9,951,059 Dual mechanism inhibitors for the treatment of disease
Provided are compounds that are inhibitors of both rho kinase and of a monoamine transporter (MAT) act to improve the disease state or condition. Further...
US-9,951,058 Compound, pharmaceutically acceptable salt or optical isomer thereof, method for preparing the same, and...
The present invention relates to a novel compound, to a pharmaceutically acceptable salt or optical isomer thereof, to a method for preparing same, and to a...
US-9,951,057 COMT inhibiting methods and compositions
The present inventions include a method of inhibiting COMT enzyme in a subject as well as compounds of formula I, or a pharmaceutically acceptable salt thereof,...
US-9,951,056 Substituted nicotinamide inhibitors of BTK and their preparation and use in the treatment of cancer,...
Compounds of Formula I, as shown below and defined herein: ##STR00001## and pharmaceutically acceptable salts, syntheses, intermediates, formulations, and...
US-9,951,055 Thiazole-based inhibitors of scavenger receptor BI
This application describes compounds and methods that can inhibit Scavenger receptor class B, type I (SR-BI) activity, which compounds and methods can used, for...
US-9,951,054 CMP porous pad with particles in a polymeric matrix
The invention provides a chemical-mechanical polishing pad comprising a polymeric matrix and 0.1-15 wt. % of metal oxide particles. The polymeric matrix has...
US-9,951,053 .gamma.-diketones as Wnt/.beta.-catenin signaling pathway activators
The present disclosure provides .gamma.-diketones or analogs thereof, that activate Wnt/.beta.-catenin signaling and thus treat or prevent diseases related to...
US-9,951,052 Inhibitors of the renal outer medullary potassium channel
The present invention provides compounds of Formula I ##STR00001## and the pharmaceutically acceptable salts thereof, which are inhibitors of the ROMK...
US-9,951,051 Process for producing alkynylketone derivative
The present invention relates to a Sonogashira-Carbonylation reaction using two types of gas, as well as novel crystals which can control a heat of the said...
US-9,951,050 Method of inhibiting DYRK1B
The present invention relates to a DYRK1B inhibitor for use in the treatment of cancer, wherein in said cancer and/or in cells of said cancer the hedgehog...
US-9,951,049 Pyrazole linked benzimidazole conjugates and a process for preparation thereof
Pyrazole linked benzimidazole conjugates and a method for synthesis of one or more compounds having a pyrazole linked benzimidazole conjugate, particularly...
US-9,951,048 Isoquinolin-3-yl carboxamides and preparation and use thereof
Isoquinoline compounds for treating various diseases and pathologies are disclosed. More particularly, the present invention concerns the use of an isoquinoline...
US-9,951,047 Salt of monocyclic pyridine derivative and crystal thereof
The present invention provides salts consisting of an organocarboxylic acid selected from the group consisting of succinic acid and maleic acid and a compound...
US-9,951,046 TRPA1 modulators
This disclosure relates to polycyclic heteroaromatic compounds useful as TRPA1 modulators, as well as compositions and methods of treating pain that include the...
US-9,951,045 Indazole compounds as 5-HT.sub.4 receptor agonists
The present invention relates to novel indazole compounds of the Formula (I), wherein, R.sub.1 is alkyl or cycloalkyl; (Formula II) including their...
US-9,951,044 Quinazoline derivatives and their use as DNA methyltransferase inhibitors
The present invention relates to compounds of the following formula (I): and pharmaceutically acceptable salts and solvates thereof, their methods of...
US-9,951,043 Therapeutic compounds
Compounds of formula (I) or salts thereof are disclosed. Also disclosed are pharmaceutical compositions comprising a compound of formula I, processes for...
US-9,951,042 Polymorphic form of [5-fluoro-3-({2-[(4-fluorobenzene) sulfonyl] ...
The invention relates to a polymorphic form of [5-fluoro-3-({2-[(4-fluorobenzene)sulfonyl]pyridin-3-yl}methyl)-2-methyli- ndol-1-yl]-acetic acid which has higher...
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