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Patent # Description
US-9,957,532 Fermentation process for the production of organic acids
This invention relates to improvements in the fermentation process used in the production of organic acids from biological feedstock using bacterial catalysts....
US-9,957,531 Genetically engineered bacterium for the production of 3-hydroxybutyrate
The invention relates to a genetically engineered bacterium having an enzyme that converts acetyl-CoA to acetoacetyl-CoA, an enzyme that converts...
US-9,957,530 Production of propanols, alcohols, and polyols in consolidated bioprocessing organisms
The present invention provides for novel metabolic pathways leading to propanol, alcohol or polyol formation in a consolidated bioprocessing system (CBP), where...
US-9,957,529 Recombinant microorganism with improved butanol production ability and method for producing butanol by using...
The present invention relates to a recombinant microorganism with improved butanol production ability which has an acetyl-CoA synthesis pathway and a...
US-9,957,528 Process for enzymatic hydrolysis of lignocellulosic material and fermentation of sugars
The invention relates to a process for the preparation of a sugar product from ligno-cellulosic material, comprising the following steps: a) optionally...
US-9,957,527 Microbial engineering for the production of chemical and pharmaceutical products from the isoprenoid pathway
The invention relates to the production of one or more terpenoids through microbial engineering, and relates to the manufacture of products comprising terpenoids.
US-9,957,526 Delivery methods and compositions for nuclease-mediated genome engineering
The present disclosure is in the field of genome engineering, particularly targeted modification of the genome of a cell.
US-9,957,525 Recombinant protein expression using a hybrid CHEF1 promoter
The invention provides expression vectors and host cells for high-level expression of recombinant proteins. The expression vectors comprise Chinese hamster...
US-9,957,524 Pesticidal toxin proteins active against coleopteran insects
The invention generally relates to the field of insect inhibitory toxin proteins. A novel class of proteins exhibiting insect inhibitory activity against...
US-9,957,523 Transgenic plant-based methods for plant pests using RNAI
The present invention relates to methods for controlling pest infestation using double stranded RNA molecules. The invention provides methods for making...
US-9,957,522 Fungal resistant plants expressing CASAR
The present invention relates to a method of increasing resistance against fungal pathogens of the family Phacopsoraceae in plants and/or plant cells. This is...
US-9,957,521 Nucleotide sequences and polypeptides encoded thereby useful for modifying plant characteristics
Isolated polynucleotides and polypeptides encoded thereby are described, together with the use of those products for making transgenic plants with increased...
US-9,957,520 Methods of increasing resistance of crop plants to heat stress and selecting crop plants with increased...
Methods of increasing the resistance of a crop plant to heat stress and in particular methods of improving the grain yield and quality of crop plants grown...
US-9,957,519 Acyltransferase polynucleotides, polypeptides and methods of use
The invention provides a novel DGAT1 protein with improved properties over known DGAT proteins, particularly known DGAT1 proteins from plants. The novel DGAT1...
US-9,957,518 Methods and compositions for modulating gene expression in plants
The present invention provides methods and compositions for regulation of gene expression in plants. In particular, the invention provides nucleic acids that...
US-9,957,517 RNA interference mediated inhibition of gene expression using chemically modified short interfering nucleic...
The present invention concerns methods and reagents useful in modulating gene expression in a variety of applications, including use in therapeutic, diagnostic,...
US-9,957,516 Method for modulating expression of specific protein using specific transcription factor, isoprenoid-producing...
The present invention provides methods for enhancing the polyisoprenoid biosynthesis pathway. The present invention further provides isoprenoid-producing plants...
US-9,957,515 Methods and compositions for targeted gene modification
Provided herein include methods and compositions for effecting a targeted genetic change in DNA in a cell. Certain aspects and embodiments relate to improving...
US-9,957,514 Transformation of duckweed and uses thereof
The present disclosure provides methods and compositions for genetic transformation of Lemnaceae species.
US-9,957,513 Engineering of hydrocarbon metabolism in yeast
The present invention relates to the development of genetically engineered yeasts that can produce hydrocarbons in a controllable and economic fashion. More...
US-9,957,512 Biological methods for preparing a fatty dicarboxylic acid
The technology relates in part to biological methods for producing a fatty dicarboxylic acid and engineered microorganisms capable of such production.
US-9,957,511 Functionalization of endogenous bacteria
Various aspects and embodiments of the present disclosure are directed to methods and compositions for functionalizing endogenous bacteria in vivo. The methods...
US-9,957,510 Transcriptional control in Alicyclobacillus acidocaldarius and associated genes, proteins, and methods
Isolated and/or purified polypeptides and nucleic acid sequences encoding polypeptides from Alicyclobacillus acidocaldarius are provided. Further provided are...
US-9,957,509 Synthetic gene clusters
Methods for making synthetic gene clusters are described.
US-9,957,508 Modulation of KCNH2 isoform expression by oligonucleotides as a therapeutic approach for long QT syndrome
Oligonucleotides with activity in preventing poly(A) adenylation at intron 9 of the KCNH2 gene, as well as pharmaceutical compositions comprising the...
US-9,957,507 Compositions and methods for inhibiting expression of mutant EGFR gene
The invention relates to a double-stranded ribonucleic acid (dsRNA) targeting a mutant Epidermal Growth Factor Receptor (EGFR), and methods of using the dsRNA...
US-9,957,506 Compounds for inducing anti-tumor immunity and methods thereof
Described herein is a previously unknown function of XBP1 in controlling anti-tumor immunity. It is shown that inhibiting XBP1 in tumor-associated dendritic...
US-9,957,505 Polynucleotides for multivalent RNA interference, compositions and methods of use thereof
The present invention includes bivalent or multivalent nucleic acid molecules or complexes of nucleic acid molecules having two or more target-specific regions,...
US-9,957,504 Compositions and methods for modulating apolipoprotein (a) expression
Provided herein are oligomeric compounds with conjugate groups targeting apoplipoprotein (a) [apo(a)]. In certain embodiments, the apo(a) targeting oligomeric...
US-9,957,503 Treatment of LCAT gene related diseases by inhibition of a natural antisense transcript to LCAT
The present invention relates to antisense oligonucleotides that modulate the expression of and/or function of a Lipid transport and metabolism gene, in...
US-9,957,502 Nucleic acid synthesis methods
The present invention relates to a single-stranded nucleic acid molecule for use in a method for the production of a nucleic acid, whereby the nucleic acid...
US-9,957,501 Nuclease-mediated regulation of gene expression
The present disclosure is in the field of genome engineering, particularly targeted modification of the genome of a hematopoietic cell.
US-9,957,500 Continuous flow nucleic acid extraction apparatus and method of use thereof
A continuous flow nucleic acid extraction apparatus comprising a piston column apparatus for the extraction of nucleic acids from a nucleic acid sample. The...
US-9,957,499 Methods for purification of messenger RNA
The present invention provides, among other things, methods of purifying messenger RNA (mRNA) including the steps of subjecting an impure preparation comprising...
US-9,957,498 Photoremovable protecting groups and uses thereof
The invention relates to a method for photoreleasing a moiety G from a compound of the formula A-G. The methods of the present invention comprise irradiating a...
US-9,957,497 Hydrocarbon synthase gene and use thereof
A hydrocarbon synthase gene encoding protein having excellent capacity to synthesize a hydrocarbon such as alkane and novel functions is provided. The gene...
US-9,957,496 Method for regulating acid resistance of microbes
Provided are a method for regulating acid resistance of a microorganism by suppressing the expression of the fadD gene therein and a screening method for a...
US-9,957,495 Means and methods for generating improved proteins
The disclosure provides a general method for the production of protein variants with a reduced aggregation propensity without affecting the thermodynamic...
US-9,957,494 Crystal structure of human four-phosphate adaptor protein 2 glycolipid transfer protein like domain
In some embodiments, the present invention provides method of identifying compounds that bind to phosphoinositol 4-phosphate adaptor protein-2 (FAPP2),...
US-9,957,493 Polypeptides having cellobiohydrolase activity and polynucleotides encoding same
The present invention relates to isolated polypeptides having cellobiohydrolase activity and isolated polynucleotides encoding the polypeptides. The invention...
US-9,957,492 Polypeptides having cellulolytic enhancing activity and polynucleotides encoding same
Provided are isolated polypeptides having cellulolytic enhancing activity and polynucleotides encoding the polypeptides, catalytic domains or carbohydrate...
US-9,957,491 Polypeptides having cellulolytic enhancing activity and polynucleotides encoding same
The present invention relates to isolated polypeptides having cellulolytic enhancing activity and isolated polynucleotides encoding the polypeptides. The...
US-9,957,490 Cells comprising engineered nucleic-acid targeting nucleic acids
The present disclosure provides engineered cross-type-nucleic-acid targeting nucleic acids and compositions thereof. Nucleic acid sequences encoding the...
US-9,957,489 Production and purification of recombinant arylsulfatase A
The present invention pertains to a process for production of recombinant arylsulfatase A in a cell culture system, the process comprising culturing a mammalian...
US-9,957,488 Pharmaceutical compositions and dermatogic compositions synthesized from catalytic domains producing highly...
The invention relates to an isolated polypeptide with an glycosyl transferase enzymatic activity for producing dextrans with .alpha.(1.fwdarw.2) sidechains,...
US-9,957,487 Mutated genes for the catalytic protein of Oplophorus luciferase and use thereof
Luciferases which are different from those known heretofore have been desired. A luciferase mutant comprising an amino acid sequence in which at least one amino...
US-9,957,486 Attenuation of human respiratory syncytial virus by genome scale codon-pair deoptimization
Described herein are RSV polynucleotide sequences that make use of multiple codons that are containing silent nucleotide substitutions engineered in multiple...
US-9,957,485 Systems and methods for virus propagation in cell cultures for vaccine manufacture
The present invention provides a closed system to propagate virus-infected cells without the effect of shear force, while providing quicker access to nutrients...
US-9,957,484 Methods for promoting cell reprogramming
The present invention is based on the seminal discovery that several kinases play important roles in barrier pathways in somatic cell reprogramming. The present...
US-9,957,483 Multiloop engineered heart muscle tissue
The invention is directed to a method for the preparation of a multiring engineered heart tissue construct suitable for use in cardiac tissue augmentation...
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