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Patent # Description
US-9,957,329 Factor XII inhibitors for the treatment of neurological inflammatory disorders
This application relates to neurological inflammatory diseases, such as multiple sclerosis, and to methods of administering a Factor XII inhibitor to prevent,...
US-9,957,328 Bacterial host strain expressing recombinant DSBC
The present invention provides a recombinant gram-negative bacterial cell comprising an expression vector comprising a recombinant polynucleotide encoding DsbC...
US-9,957,327 Antibodies that bind colony stimulating factor 1 receptor (CSF1R)
Antibodies that bind CSF1R are provided. Antibody heavy chains and light chains that are capable of forming antibodies that bind CSF1R are also provided....
US-9,957,326 Antigen binding molecules that bind EGFR, vectors encoding same, and uses thereof
The present invention relates to antigen binding molecules (ABMs). In particular embodiments, the present invention relates to recombinant monoclonal...
US-9,957,325 Synthetic antibody mimic peptides
The present disclosure relates to compositions and methods comprising peptide molecules that mimic the binding and functional properties of native antibodies...
US-9,957,324 Anti-FLT-1 antibodies in treating duchenne muscular dystrophy
The present invention provides, among other things, methods and compositions for treating muscular dystrophy, in particular, Duchenne muscular dystrophy (DMD)....
US-9,957,323 Anti-ICOS antibodies
Antibodies that bind ICOS (Inducible T cell Co-Stimulator). Therapeutic use of anti-ICOS antibodies for modulating the ratio between regulatory T cells and...
US-9,957,322 Antagonists of IL-6 to raise albumin and/or lower CRP
The present invention is directed to therapeutic methods using IL-6 antagonists such as antibodies and fragments thereof having binding specificity for IL-6 to...
US-9,957,321 Anti-IL-6 antibodies for the treatment of oral mucositis
The present invention is directed to therapeutic methods using IL-6 antagonists such as anti-IL-6 antibodies and fragments thereof having binding specificity...
US-9,957,320 Isolated DNA sequences encoding, and methods for making, antibody molecules having binding specificity for...
The invention relates to antibody molecules having specificity for antigenic determinants of human IL-13, therapeutic uses of the antibody molecules and methods...
US-9,957,319 Method of isolating human antibodies
Provided is a novel method of isolating and producing human antibodies with desired specificity from human B cells. In particular, a method of isolating human...
US-9,957,318 Protein purification methods to reduce acidic species
The instant invention relates to the field of protein production and purification, and in particular to compositions and processes for controlling the amount of...
US-9,957,317 Humanized anti-tau antibodies
Provided herein is an isolated antibody or antigen-binding fragment that specifically binds tau, the antibody or fragment comprising a heavy chain variable (VH)...
US-9,957,316 Weight loss by inhibition of gastrokine
Gastrokine-1 (Gkn-1) is a stomach protein that protects the gastrointestinal (GI) tract and has properties to manipulate smooth muscle contraction, prevent...
US-9,957,315 Purification of cell culture derived alpha1 protease inhibitor
Described herein are methods for purifying recombinant, cell culture derived alpha.sub.1-protease inhibitor and removing a colored species that co-purifies with...
US-9,957,314 Regeneration and repair of mesenchymal tissue using amelogenin
A method of treating an injury to hyaline cartilage in a subject in need thereof. The method comprises administering to the subject a therapeutically effective...
US-9,957,313 FGFR-FC fusion proteins and the use thereof
The present invention belongs to the field of biotechnology and relates to the treatment of diseases, especially the treatment of FGF overexpression-related...
US-9,957,312 B7-H4 fusion proteins and methods of use thereof
Fusion proteins containing B7-H4 polypeptides are disclosed. The B7-H4 fusion proteins can include full-length B7-H4 polypeptides, or can contain a fragment of...
US-9,957,311 Surface-binding peptide
Surface-binding peptides have the capability of binding to surfaces of biocompatible materials and can thereby be used to immobilize various heterologous...
US-9,957,310 Fibroblast growth factor mutants having improved functional half-life and methods of their use
Mutant fibroblast growth factor (FGF) proteins having a polypeptide sequence with a high sequence identity to proteins encoded by members of the Fgf-1 subfamily...
US-9,957,309 Follistatin in treating duchenne muscular dystrophy
The present invention provides, among other things, methods and compositions for treating muscular dystrophy, in particular, Duchenne muscular dystrophy (DMD)....
US-9,957,308 Method for detecting bilirubin using a fluorescent protein
In order to provide a novel fluorescent protein and use thereof, the polypeptide according to the present invention has fluorescent properties in the presence...
US-9,957,307 Expression vectors for cell-surface expression of polypeptides comprising a transmembrane domain of glycophorin A
The present invention provides expression vectors for cell-surface expression of polypeptides comprising a transmembrane domain of glycophorin A.
US-9,957,306 Hypoallergenic variants of mal d 1, the major allergen from malus domestica
Disclosed are hypoallergenic variants of Mal d 1, the major allergen from Malus domestica, and the uses thereof in the treatment of allergic diseases.
US-9,957,305 Anti-C. difficile toxin antibodies and associated methods
Embodiments of the invention are directed to a composition comprising a recombinant protein in soluble form wherein said recombinant protein comprises a portion...
US-9,957,304 Compositions and methods for treating conditions related to ephrin signaling with cupredoxins
The present invention relates to compositions and methods of use of cupredoxins, and variants, derivatives and structural equivalents of cupredoxins that...
US-9,957,303 Selective recovery
Provided herein are methods of selective screening. In addition, various targeting proteins and sequences, as well as methods of their use, are also provided.
US-9,957,302 Treating cancer with viral nucleic acid
This document provides methods and materials related to the use of nucleic acid coding for viruses to reduce the number of viable cancer cells within a mammal....
US-9,957,301 Therapy of cancer based on targeting adaptive, innate and/or regulatory component of the immune response
The invention relates to a kit of parts, suitable for use in a therapy of cancer, wherein said kit comprises: (i) a recombinant protein comprising one or...
US-9,957,300 Virus-like particles, methods of preparation, and immunogenic compositions
Briefly described, virus-like particles, methods of preparing virus-like particles, immunogenic compositions that include virus-like particles, and methods of...
US-9,957,299 Peptidomimetic macrocycles
The present invention provides novel peptidomimetic macrocycles and methods of using such macrocycles for the treatment of disease.
US-9,957,298 Peptides as oxytocin agonists
The present compounds compounds are oxytocin receptor agonists for the treatment of autism, stress, including post traumatic stress disorder, anxiety, including...
US-9,957,297 Template-fixed peptidomimetics as inhibitors of FPR1
Novel template-fixed .beta.-hairpin peptidomimetics of the general formula (I): cyclo[P.sup.1-P.sup.2-P.sup.3-P.sup.4-P.sup.5-P.sup.6-P.sup.7-P.sup.8-P.s- ...
US-9,957,296 Triazole macrocycle systems
The present invention provides novel peptidomimetic macrocycles and methods for their preparation and use, as well as amino acid analogs and macrocycle-forming...
US-9,957,295 Peptides inhibiting cold-inducible RNA binding protein activity
Disclosed are pharmaceutical compositions comprising a CIRP inhibitor. Methods of treating a subject suffering from an inflammatory condition comprising...
US-9,957,294 Compositions and methods for analyzing histidine phosphorylation
A peptide is disclosed of the general structure: Z--W--Y, wherein Z and Y are independently a one to eight amino acid sequence wherein the amino acids are...
US-9,957,293 Conjugates of RGD peptides and porphyrin or (bacterio)chlorophyll photosynthesizers and their uses
Conjugates of porphyrin, chlorophyll and bacteriochlorophyll photosensitizers with RGD-containing peptides or RGD peptidomimetics are provided that are useful...
US-9,957,292 Compositions and methods for modulating angiopoietin-like 3 expression
Provided herein are methods, compounds, and compositions for reducing expression of an ANGPTL3 mRNA and protein in an animal. Also provided herein are methods,...
US-9,957,291 Protected fluorescent reagent compounds
Protected fluorescent reagent compounds and their methods of synthesis are provided. The compounds are useful in various fluorescence-based analytical methods,...
US-9,957,290 Derivatives of amphotericin B
Disclosed are derivatives of amphotericin B (AmB) characterized by improved therapeutic index compared to AmB. The AmB derivatives include C16 ureas,...
US-9,957,289 Compounds and methods for treating bacterial infections
The present invention encompasses compounds and methods for treating and preventing bacterial infections specifically urinary tract infections and those caused...
US-9,957,288 Pyrabactin analogues to modulate plant development
The present invention relates to compounds which can be used to control plant development. Indeed, the present invention discloses a new class of pyrabactin...
US-9,957,287 Methods and compositions to treat type-1 and type-2 diabetes
The present disclosure is directed to novel methods of treating type-1 or type-2 diabetes by inactivating TLR2 and TLR4 genes together in cells capable of...
US-9,957,286 Method for the synthesis of solid heterogeneous chiral catalysts and their use in stereoselective reactions
This invention describes the methodology to produce solid heterogeneous chiral organocatalysts that can be used in condensation reactions. The catalysts can be...
US-9,957,285 Metal complex, adsorbent, separating material, and 1, 3-butadiene separation method
A separating material superior to conventional separating materials, and a separation method are provided, with which 1,3-butadiene is selectively separated and...
US-9,957,284 Method of increasing mass transfer rate of acid gas scrubbing solvents
A method and catalysts for increasing the overall mass transfer rate of acid gas scrubbing solids is disclosed. Various catalyst compounds for that purpose are...
US-9,957,283 Processes for making alkylated arylpiperazine and alkylated arylpiperidine compounds including novel intermediates
Novel processes, and intermediates, for making alkylated arylpiperazine and alkylated arylpiperidine compounds of the general formulas (I) and (VII),...
US-9,957,282 Crystalline forms of quinolone analogs and their salts
The present invention includes crystalline forms of 2-(4-Methyl-[1,4]diazepan-1-yl)-5-oxo-5H-7-thia-1,11b-diaza-benzo[c]fluor- ene-6-carboxylic acid...
US-9,957,281 Benzodiazepine derivatives as RSV inhibitors
The present invention discloses compounds of Formula (I), or pharmaceutically acceptable salts, esters, or prodrugs thereof: ##STR00001## which inhibit...
US-9,957,280 Luminescent compound and electroluminescent device exhibiting thermally activated delayed fluorescence
A chemical compound is provided having a structure that includes at least one donor moiety covalently bonded to at least one acceptor moiety. For example, the...
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