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Patent # Description
US-9,957,279 Process for the preparation of intermediates useful in the preparation of Hepatitis C virus (HCV) inhibitors
The present invention generally relates to a process for preparation of 9-halo-3-(2-haloacetyl)-10,11-dihydro-5H-dibenzo[c,g]chromen-8(9H)-one of Formula I,...
US-9,957,278 Furopyridine compounds for the treatment of hepatitis C
Compounds of formula I, including their salts, as well as compositions and methods of using the compounds are set forth. The compounds have activity against...
US-9,957,277 eIF4A-inhibiting compounds and methods related thereto
The present invention provides synthesis, pharmaceutically acceptable formulations and uses of compounds in accordance with Formula I, or a stereoisomer,...
US-9,957,276 CDK inhibitors
Compounds of formulae I, II or III, and pharmaceutically acceptable salts thereof, are useful as CDK inhibitors.
US-9,957,275 Pyrazolo[1,5-A]pyrimidines for antiviral treatment
The invention provides compounds of Formula I or Formula II: ##STR00001## or a pharmaceutically acceptable salt or ester, thereof, as described herein. The...
US-9,957,274 Indane inhibitors of EED and methods of their use
Compounds having a structure of Formula (I): ##STR00001## or a stereoisomer, tautomer or pharmaceutically acceptable salt thereof, wherein A.sup.1, A.sup.2,...
US-9,957,273 5-substituted 7- [4-(2-pyridyl)phenylmethylamino] -3-isopropylpyrazolo4,3-D]pyrimidine derivatives, use thereof...
5-substituted-7-[4-(2-pyridyl)phenylmethylamino]-3-isopropylpyrazolo[4,3-- d]pyrimidines are potent inhibitors of protein kinases, especially cyclin-dependent...
US-9,957,272 3-hydroxypyrrolidine inhibitors of 5'-methylthioadenosine phosphorylase and nucleosidase
The present invention relates to 3-hydroxypyrrolidine compounds of the general formula (1) which are inhibitors of 5'-methylthioadenosine phosphorylase or...
US-9,957,271 Substituted bicyclic aza-heterocycles and analogues as sirtuin modulators
Provided herein are novel substituted bicyclic aza-heterocycle sirtuin-modulating compounds and methods of use thereof. The sirtuin-modulating compounds may be...
US-9,957,269 S-imino-S-oxo iminothiazine compounds as bace inhibitors, compositions, and their use
In its many embodiments, the present invention provides certain C-6 spirocarbocyclic iminothiadiazine compounds, including compounds Formula (I): or a tautomer...
US-9,957,268 1H-pyrrolo[2,3,c]pyridin-7(6H)-ones and pyrazolo[3,4-c]pyridin-7(6H)-ones as inhibitors of BET proteins
The present invention relates to substituted pyrrolopyridinones and substituted pyrazolopyridinones which are inhibitors of BET proteins such as BRD2, BRD3,...
US-9,957,267 Somatostatin modulators and uses thereof
Described herein are compounds that are somatostatin modulators, methods of making such compounds, pharmaceutical compositions and medicaments comprising such...
US-9,957,266 Imidazo[1,2-a]pyridin-7-amine
The present invention relates to compounds that may be used for binding and imaging tau aggregates and related beta-sheet aggregates including, for example,...
US-9,957,265 N-(2-cyano heterocyclyl) pyrazolo pyridones as janus kinase inhibitors
Provided are compounds of Formula I, a JAK inhibitor, and use thereof for the treatment of JAK-mediated diseases by the application. ##STR00001##
US-9,957,264 Geminally substituted cyanoethylpyrazolo pyridones as Janus kinase inhibitors
The instant invention provides compounds of Formula (I) which are JAK inhibitors, and as such are useful for the treatment of JAK-mediated diseases such as...
US-9,957,263 Bromodomain inhibitors
Compounds of formula (I) and pharmaceutically acceptable salts thereof are provided. The compounds are useful as agents in the treatment of diseases and...
US-9,957,262 Opioid analgesic
Provided are a compound represented by formula (I) or (II), a salt thereof, or solvates of the compound and salt, having an analgesic effect and high metabolic...
US-9,957,261 6-amino-5,6,7,8-tetrahydronaphthalen-2-yl or 3-aminochroman-7-yl derivatives
The present invention relates to compounds TAAR receptor antagonists of formula I wherein X, R, L, Ar and R.sup.1 are as described herein, compositions...
US-9,957,260 Organic metal complex, light emitting material, delayed fluorescent material, and organic light emitting device
An organic metal complex represented by the following general formula is useful as a light emitting material for an organic electroluminescent device and...
US-9,957,259 Selective HDAC1 and HDAC2 inhibitors
Provided herein are compounds, pharmaceutical compositions comprising such compounds and methods of using such compounds to treat or prevent diseases or...
US-9,957,258 Oxime ester photoinitiators
Disclosed are oxime ester compounds which have specific benzo (unsaturated 5-membered ring)-carbonyl group and their use as photoinitiators in...
US-9,957,257 Amide compounds as 5-HT4 receptor agonists
The present invention relates to compounds of formula (I), including their stereoisomers and pharmaceutically acceptable salts. This invention also relates to...
US-9,957,256 Process for the preparation of 5-fluoro-1H-pyrazoles starting from hexafluoropropene
A new process for the preparation of 5-fluoro-1H-pyrazoles of the general formula (I) as described herein and further reactions with this compound.
US-9,957,255 Benzotriazole derivatives as modulators of TNF activity
A series of substituted benzotriazole derivatives, being potent modulators of various human ailments, including autoimmune and inflammatory disorders;...
US-9,957,254 Cyclohexen-1-yl-pyridin-2-yl-1h-pyrazole-4-carboxylic acid derivatives and the use thereof as soluble guanylate...
The present invention provides a compound of formula (I) or a pharmaceutically acceptable salt thereof; a method for manufacturing the compounds of the...
US-9,957,253 Triaminopyrimidine compounds useful for preventing or treating malaria
The present invention relates to triaminopyrimidines and to pharmaceutically acceptable salts thereof, to their use in the treatment and/or prevention of...
US-9,957,252 Metalloenzyme inhibitor compounds as fungicides
The instant invention describes compounds of Formula I having metalloenzyme modulating activity, and methods of treating diseases, disorders or symptoms thereof...
US-9,957,251 Heterocyclic compound
The present invention provides a heterocyclic compound having a CDK8 and/or CDK19 inhibitory effect. The present invention provides a compound represented by...
US-9,957,250 Compounds and uses thereof for the modulation of hemoglobin
Provide herein are compounds and pharmaceutical compositions suitable as modulators of hemoglobin, methods and intermediates for their preparation, and methods...
US-9,957,249 Saturated nitrogen and N-acylated heterocycles potentiating the activity of an active antibiotic against...
The present invention concerns a compound of general formula (I): ##STR00001## in which n=0 or 1, R1 represents an optionally substituted alkyl chain, in...
US-9,957,248 Substituted 5-hydroxy-2-heteroaryl-3-phenylpentanonitrile derivatives, processes for their preparation and...
Primarily, the present invention relates to compounds of the formula (I) defined below and to their use as herbicides, in particular for controlling...
US-9,957,247 SecA inhibitors and methods of making and using thereof
Inhibitors of SecA, and methods of making and using thereof, are described herein. The compounds described herein can be used to treat or prevent microbial...
US-9,957,246 Prodrugs of tetrahydrocannabinol, compositions comprising prodrugs of tetrahydrocannabinol and methods of using...
Described herein are .DELTA..sup.9-THC prodrugs, methods of making .DELTA..sup.9-THC prodrugs, formulations comprising .DELTA..sup.9-THC prodrugs and methods of...
US-9,957,245 Catalyst for synthesizing theaflavins and method for synthesizing theaflavins
The objective/problem addressed by the present invention is to provide a novel technique pertaining to theaflavins synthesis. The present invention pertains to:...
US-9,957,244 Catalyst and process for producing 2,5-furandicarboxylic acid from hydroxymethylfurfural in water
A process is described for converting hydroxymethylfurfural to furanic products inclusive of 2,5-furandicarboxylic acid, comprising combining a quantity of...
US-9,957,243 Vinyl-containing compounds and processes for making the same
The present invention provides a process for forming vinyl-containing compounds including the steps of: a) reacting in a nitrogen atmosphere a dicarboxylic acid...
US-9,957,242 Carbamate compounds and methods of making and using same
This disclosure provides compounds and compositions which may be modulators of MAGL and/or ABHD6 and their use as medicinal agents, processes for their...
US-9,957,241 Aromatic diamine, an intermediate therefor, a method for producing the aromatic diamine, and a method for...
A novel asymmetric diamine, diamino-2-(benzothiazole-2-yl)diphenyl ether, derivatives therefor, and an intermediate for the compound such as ...
US-9,957,240 Crystalline forms of trisodium supramolecular complex comprising valsartan and AHU-377 and methods thereof
Novel crystalline Forms of trisodium [3-((1S,3R)-1-biphenyl-4-ylmethyl-3-ethoxycarbonyl-1-butyl carbamoyl) ...
US-9,957,239 Process and plant for the synthesis of urea and melamine
An integrated process for the synthesis of urea and melamine, wherein: urea is synthesized with a stripping process in a high-pressure synthesis loop comprising...
US-9,957,238 Arylalkyl-and aryloxyalkyl-substituted epithelial sodium channel blocking compounds
The present invention relates to the compound of the formula: ##STR00001## or pharmaceutically acceptable salts thereof, as well as compositions containing the...
US-9,957,237 Crystal form of neptinib di-p-methylbenzenesulfonate, preparation method thereof, and pharmaceutical...
Provided is a composition of N-[4-[(3-chloro-4-fluorophenyl)amino]-7-[3-(ethoxy)-6-quinazolinyl]-4-(di- methylamino)-2-butenamide p-toluene sulfonate 1.5...
US-9,957,236 Selective inhibitors interfering with fibroblast growth factor receptor and FRS2 interaction for the prevention...
The present technology relates to medicine and includes the use of inhibitors which selectively interfere with the interaction between a fibroblast growth...
US-9,957,235 Benzimidazol-2-amines as mIDH1 inhibitors
The present invention relates to benzimidazol-2-amines of general formula (I), in which R.sup.1, R.sup.2, R.sup.3, R.sup.4, R.sup.5, R.sup.6, R.sup.7, R.sup.8,...
US-9,957,234 Polymorphs of Ivacaftor, process for its preparation and pharmaceutical composition thereof
The present invention relates to novel polymorphic forms of ivacaftor, process for its preparation and pharmaceutical compositions comprising the same.
US-9,957,233 Process for preparing substituted quinolin-4-ol compounds
The invention relates to a process for preparing substituted quinolin-4-ol compounds useful for preparing protein tyrosine kinase (PTK) inhibitors which are...
US-9,957,232 4-[4-({[4-chloro-3-(trifluoromethyl)phenyl]carbamoyl}amino)-3-fluorophenox- y]-N-methylpyridine-2-carboxamide...
The present invention relates to 4-[4-({[4-chloro-3-(trifluoromethyl)phenyl]carbamoyl}amino)-3-fluoropheno- xy]-N-methylpyridine-2-carboxamide monohydrate, to...
US-9,957,231 Iodine(II)-mediated radiofluorination
A process for fluorination of aromatic compounds employing iodonium ylides and applicable to radiofluorination using .sup.18F is described. Processes,...
US-9,957,230 Synergistic compositions
The present invention describes a synergistic composition comprising of one or more statins, or one or more dipeptidyl peptidase IV (DPP IV) inhibitor or one or...
US-9,957,229 Amido compounds and their use as pharmaceuticals
The present invention relates to inhibitors of 11-.beta. hydroxyl steroid dehydrogenase type 1, antagonists of the mineralocorticoid receptor (MR), and...
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