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Patent # Description
US-9,968,691 PSMA-targeted NIR dyes and their uses
The present disclosure relates to prostate specific membrane antigen (PSMA) targeted compounds conjugated to near-infra red (NIR) dyes and methods for their...
US-9,968,690 Norbornene modified peptides and their labelling with tetrazine compounds
The invention relates to a polypeptide comprising an amino acid having a norbornene group. Suitably said norbornene group is present as an amino acid residue of...
US-9,968,689 AAV-mediated subcellular targeting of heterologous rhodopsins in retinal ganglion cells
Microbial type rhodopsins, such as the light-gated cation-selective membrane channel, channelrhodopsin-2 (Chop2/ChR2) or the ion pump halorhodopsin (HaloR) are...
US-9,968,688 Shielded targeting agents, methods, and in vivo diagnostic system
A system is provided which includes nanoparticle conjugates configured to bind with a tumor cell, the nanoparticle conjugate comprising a nanoparticle, at least...
US-9,968,687 Anti-DLL3 antibody drug conjugates
Provided are novel antibody drug conjugates (ADCs), and methods of using such ADCs to treat proliferative disorders.
US-9,968,686 Antisense oligonucleotides with improved pharmacokinetic properties
The invention relates to an antisense or siRNA oligonucleotide or conjugate with improved pharmacokinetic properties, methods of producing the same as well as...
US-9,968,685 Methods to treat cancer with cupredoxins
The present invention discloses methods and materials for killing and/or inhibiting the growth of a cancer cell via preferential entry of a cytotoxic compound....
US-9,968,684 Polymer-NSAID conjugate
The invention relates to polymer-drug conjugate for delivering a substituted alkanoic acid non-steroidal anti-inflammatory drug (NSAID). The invention also...
US-9,968,683 Method for conjugating molecules
Methods of conjugating two molecules are disclosed herein in which a non-polymeric aliphatic dialdehyde or non-polymeric aromatic dialdehyde is reacted with a...
US-9,968,682 Polypeptide hydrogel and method for producing same
A polypeptide hydrogel of the present invention is a hydrogel of a polypeptide derived from spider silk proteins, and has a moisture content of 85.0 to 99.9...
US-9,968,681 Silylated biomolecule-based hydrogel for culturing cardiomyocytes and stem cells, and use of the hydrogel...
The present invention relates to the use of an hydrogel comprising silylated biomolecule for the three-dimensional culture of cardiomyocytes or stem cells which...
US-9,968,680 Topical bioadhesive formulations
The present invention relates to topical bioadhesive formulations comprising low viscosity, non-liquid crystalline, mixtures of: a) at least one neutral diacyl...
US-9,968,679 Clear aqueous solution
The present invention provides a stable and clear aqueous liquid preparation containing ...
US-9,968,678 Liquid pharmaceutical composition for the delivery of active ingredients
The invention provides novel pharmaceutical compositions based on semifluorinated alkanes which are useful as carriers for a broad range of active ingredients....
US-9,968,677 Stabilized protein-containing formulations
A method for maintaining the biological activity in a protein formulation without adding an antioxidant and for inhibiting the formation of insoluble particles,...
US-9,968,676 Subcutaneous anti-HER2 antibody formulations and uses thereof
The present invention relates to a highly concentrated, stable pharmaceutical formulation of a pharmaceutically active anti-HER2 antibody, such as e.g....
US-9,968,675 Methods for treating and/or limiting development of diabetes in subjects with amyotrophic lateral sclerosis
Methods for treating and/or limiting development of diabetes in a subject with amyotrophic lateral sclerosis (ALS) by inhibiting IgG-mediated activation of...
US-9,968,674 Methods and compositions comprising a combination of a VEGF Trap and an anti-CTLA-4 antibody
The present invention provides pharmaceutical compositions comprising a VEGF antagonist and an anti-CTLA-4 antibody, and methods of use thereof. The...
US-9,968,673 Immunogenic composition in emulsion form comprising two dispersed phases, one comprising an antigen and the...
The application relates to an immunogenic composition comprising a continuous aqueous phase and at least two dispersed phases 1 and 2 as droplets, wherein the...
US-9,968,672 IDNA vaccines and methods for using the same
Described herein are iDNA vectors and vaccines and methods for using the same. The iDNA generates live attenuated vaccines in eukaryotic cells in vitro or in...
US-9,968,671 Avian reovirus vaccines
The present invention relates to novel strains of avian reovirus that were isolated from clinical cases of viral arthritis/tenosynovitis in chickens in the...
US-9,968,670 Influenza virus vaccines and uses thereof
Provided herein are chimeric influenza hemagglutinin (HA) polypeptides, compositions comprising the same, vaccines comprising the same, and methods of their use.
US-9,968,669 Gene optimized hantaan virus M segment DNA vaccine for hemorrhagic fever with renal syndrome
A synthetic, codon-optimized Hantaan virus (HTNV) full-length M gene open reading frame that consists of a unique nucleotide sequence encoding HTNV proteins....
US-9,968,668 Staphylococcal coagulase antigens and methods of their use
The present invention concerns methods and compositions for treating or preventing a bacterial infection, particularly infection by a Staphylococcus bacterium....
US-9,968,667 Targets and compositions for use in decontamination, immunoprophylaxis, and post-exposure therapy against anthrax
The present invention relates to the decontamination of anthrax spores, prophylaxis and treatment of anthrax infections and, more particularly, to compounds...
US-9,968,666 Methods and compositions for promoting a cell-mediated immune response
The present invention is directed to a method for promoting or stimulating a cell-mediated immune response to an antigen, by administering a target antigen...
US-9,968,665 Anti-malaria compositions and methods
Described herein are multilayer films that include modified polypeptide epitopes from Plasmodium falciparum, specifically a modified T* epitope. The multilayer...
US-9,968,664 Fusion molecule based on novel TAA variant
This invention provides novel carbonic anhydrase (CAIX) nucleic acid and peptide sequences, as well as related methods and compositions, including anti-cancer...
US-9,968,663 Erythrocytes containing arginine deiminase
Use of erythrocytes containing arginine deirainase for the preparation of a medicinal product for lowering the plasma concentration of arginine in vivo. The use...
US-9,968,662 Factor VII composition
A stable pharmaceutical composition in liquid form or in solid form, containing factor VII. The composition is free of mannitol, sucrose, and any antioxidant.
US-9,968,661 Bone regeneration agent including gelatin
It is an object of the present invention to provide a bone regeneration agent and a bone supplementation formulation, in which a supplementation material itself...
US-9,968,660 Method of bone regeneration or bone augmentation
The present invention provides a means effective for bone regeneration or bone augmentation. Provided is a method of bone regeneration or bone augmentation,...
US-9,968,659 Liraglutide in cardiovascular conditions
The present invention relates to the GLP-1 receptor agonist liraglutide for use in medicine.
US-9,968,658 Treatment of short bowel syndrome patients with colon-in-continuity
Intestinal absorption is enhanced in short bowel syndrome patients presenting with colon-in-continuity by treatment with a GLP-2 receptor agonist, such as...
US-9,968,657 Treatment of short bowel syndrome patients with colon-in-continuity
Intestinal absorption is enhanced in short bowel syndrome patients presenting with colon-in-continuity by treatment with a GLP-2 receptor agonist, such as...
US-9,968,656 Treatment of short bowel syndrome patients with colon-in-continuity
Intestinal absorption is enhanced in short bowel syndrome patients presenting with colon-in-continuity by treatment with a GLP-2 receptor agonist, such as...
US-9,968,655 Treatment of short bowel syndrome patients with colon-in-continuity
Intestinal absorption is enhanced in short bowel syndrome patients presenting with colon-in-continuity by treatment with a GLP-2 receptor agonist, such as...
US-9,968,654 Method of treatment dermatitis with c-type natriuretic peptide derivatives
The problem to be solved by the present invention is to provide a safe and efficacious therapeutic agent for dermatitis which is not only safe and efficacious...
US-9,968,653 Angiopoietin-based interventions for treating cerebral malaria
The present invention provides methods for treating, preventing or reducing the severity of cerebral malaria. The methods of the present invention comprise...
US-9,968,652 Optically-controlled CNS dysfunction
Provided herein are animals expressing light-responsive opsin proteins in the basal lateral amygdala of the brain and methods for producing the same wherein...
US-9,968,651 Nerve regenerating or nerve growth-promoting pharmaceutical composition containing Vax protein as active ingredient
The present invention relates to a pharmaceutical composition for the regeneration of nerves comprising Vax protein as an active ingredient. Vax1 is secreted in...
US-9,968,650 Modified viral structural protein with antiviral activity
This disclosure provides a novel strategy to cope with chronic virus infection by introducing a dominant negative viral structural protein to disturb effective...
US-9,968,649 Vasopressin formulations for use in treatment of hypotension
Provided herein are peptide formulations comprising polymers as stabilizing agents. The peptide formulations can be more stable for prolonged periods of time at...
US-9,968,648 Peptide or protein stabilizing formulation
The invention relates to the use of a mixture of tetraethyleneglycol and amino sugars such as glucosamine or galactosamine to protect peptides and proteins and...
US-9,968,647 Small molecule conjugates for intracellular delivery of biologically active compounds
The invention provides novel compounds and conjugates of these compounds useful for the delivery of biologically active substances. Further novel design...
US-9,968,646 Method for treatment of prostatic hyperplasia and/or ameliorating urinary disturbance with banana flower extract
The present invention provides a method for treatment of prostatic hyperplasia with banana flower extract. Such banana flower extract can suppress the...
US-9,968,645 Method for enhanced production of morinda metabolites
This invention concerns a genetic transformation method to induce hairy root culture of Morinda species, such as Morinda officinalis How, to increase production...
US-9,968,644 Traditional chinese medicine composition for sober-up and hepatic protection and a process for preparing the same
The present invention relates to traditional Chinese medicine, particularly to a traditional Chinese medicine composition for sober-up and hepatic protection...
US-9,968,643 Selection and use of lactic acid bacteria preventing bone loss in mammals
The present invention comprises a method for selecting lactic acid bacterial strains effective for preventing bone loss in humans and strains that have been...
US-9,968,642 Compositions and methods for treatment of pain
The present invention provides compositions and methods for treatment or prevention of pain resulting from infection, infection related pain, and non-infectious...
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