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Patent # Description
US-9,970,058 Digital amplification
The identification of pre-defined mutations expected to be present in a minor fraction of a cell population is important for a variety of basic research and...
US-9,970,057 Human invasion signature for prognosis of metastatic risk
Methods and products are provided for determining if a subject having a tumor is (i) at risk of metastasis of the tumor, or (ii) at risk of recurrence of the...
US-9,970,056 Methods and kits for diagnosing, prognosing and monitoring parkinson's disease
Network-based meta-analysis of four independent microarray studies identified the hepatocyte nuclear factor (HNF4A), a transcription factor associated with...
US-9,970,055 Method of nucleotide detection
The invention relates to an additive which can be added to buffers used in nucleotide detection processes and improved methods of nucleic acid sequencing using...
US-9,970,054 Method for accurate sequencing of DNA
DNA is sequenced by (a) independently sequencing first and second strands of a dsDNA to obtain corresponding first and second sequences; and (b) combining the...
US-9,970,053 Washing-free template-ready PCR detection method for RNA
Provided in the present invention is a washing-free template-ready PCR detection method for RNA. On the basis of retaining the advantages of the original...
US-9,970,052 Digital assays with a generic reporter
Digital assay system, including methods, apparatus, and compositions, for assay of one or more targets in a set of partitions containing a generic reporter of...
US-9,970,051 System for diagnosing Avellino corneal dystrophy
The present invention relates to a system for diagnosing Avellino corneal dystrophy, and more particularly to a system for diagnosing Avellino corneal...
US-9,970,050 Hydrolysis probes
Methods and compositions for the detection and quantification of nucleic acids are provided. In one embodiment, a sample is contacted with a primer...
US-9,970,049 Use of modular nucleic acid scaffolds to create nanoscale energy harvesting and focusing arrays
The invention relates to a nanoscale antenna including a nucleic acid scaffold having a structure selected from the group consisting of a Holliday junction, a...
US-9,970,048 Oligonucleotides and methods for the preparation of RNA libraries
Disclosed are compositions and methods for the preparation of RNA libraries for sequencing, gene expression profiling, microarray and other uses and for...
US-9,970,047 Quantitative assessment for cap efficiency of messenger RNA
The present invention provides, among other things, methods of quantitating mRNA capping efficiency, particularly for mRNA synthesized in vitro. In some...
US-9,970,046 Method of measuring blood coagulation time to detect lupus anticoagulants
Provided is a method of measuring blood coagulation time, the method being capable of LA detection easily and with high sensitivity as compared with the method...
US-9,970,045 Cellular analysis of body fluids
Herein is provided a simple, reliable and accurate method for cellular analysis on hematology analyzers. In various aspects, the methods provide separation...
US-9,970,044 Method for improving measurement accuracy and devices and systems related thereto
The present disclosure relates to methods and devices for providing accurate measurement of a property of a sample. The method comprises obtaining a plurality...
US-9,970,043 Process for producing optically active 2-alkyl-1,1,3-trialkoxycarbonylpropane
A process for producing an optically active 2-alkyl-1,1,3-trialkoxycarbonylpropane (2), comprising a step of asymmetric hydrolysis of...
US-9,970,042 Enzymatic process for the preparation of testosterone and esters thereof
The present invention relates to a new process for the preparation of testosterone by means of enzymatic hydrolysis of testosterone esters.
US-9,970,041 Procedure for the production of tiacumicin B
The present invention relates to a procedure for the production of tiacumicin B comprising fermentation of a micro-organism capable of producing tiacumicin B,...
US-9,970,040 Engineering DNA assembly in vivo and methods of making and using the reverse transcriptase technology
Cells that can synthesize oligonucleotides in vivo to produce a nucleic acid nanostructure are described. Methods for producing oligonucleotide nanostructures...
US-9,970,039 Processing biomass
Biomass (e.g., plant biomass, animal biomass, microbial, and municipal waste biomass) is processed to produce useful products, such as food products and amino...
US-9,970,038 Process for the production of carbohydrate cleavage products from a lingnocellulosic material
A process for the production of carbohydrate cleavage products, characterized by a combination of the measures that a lignocellulosic material is treated with...
US-9,970,037 Methods and materials for making simvastatin and related compounds
The invention disclosed herein relates to methods and materials for producing simvastatin and related compounds such as huvastatin.
US-9,970,036 Generation of acyl amino acids
Engineered polypeptides useful in synthesizing acyl amino acids are provided. Also provided are methods of making acyl amino acids using engineered polypeptides.
US-9,970,035 Methods for producing biodiesel by recombinant lipase
A method for producing biodiesel is provided, which includes providing a recombinant Candida rugosa lipase; reacting the recombinant C. rugosa lipase and a...
US-9,970,034 Use of marine algae for co-producing alkenones, alkenone derivatives, and co-products
A method comprising a series of selective extraction techniques for the parallel production of biodiesel and isolation of several valuable co-products including...
US-9,970,033 Synthesis of long-chain polyunsaturated fatty acids by recombinant cell
The present invention relates to methods of synthesizing long-chain polyunsaturated fatty acids, especially eicosapentaenoic acid, docosapentaenoic acid and...
US-9,970,032 Biorefinery system, methods and compositions thereof
The present disclosure relates to bioengineering approaches for producing biofuel and, in particular, to the use of a C.sub.1 metabolizing microorganism reactor...
US-9,970,031 Method for producing dicarboxylic acid
A method for producing a dicarboxylic acid is provided. A dicarboxylic acid is produced by culturing a bacterium having a dicarboxylic acid-producing ability,...
US-9,970,030 Methods for increasing CAS9-mediated engineering efficiency
Methods for use with Type II CRISPR-Cas9 systems for increasing Cas9-mediated genome engineering efficiency are disclosed. The methods can be used to decrease...
US-9,970,029 Engineered nucleic acid-targeting nucleic acids
The present disclosure provides engineered polynucleotide sequences that form scaffolds and nucleoprotein complexes comprising such engineered polynucleotide...
US-9,970,028 Targeted genomic modification with partially single-stranded donor molecules
Disclosed herein are donor molecules comprising single-stranded complementary regions flanking one or more sequences of interest. The donor molecules and/or...
US-9,970,027 Compositions and methods of engineered CRISPR-CAS9 systems using split-nexus CAS9-associated polynucleotides
The present specification discloses engineered Type II CRISPR-Cas9 systems comprising split-nexus Cas9-associated polynucleotides (sn-casPNs), including systems...
US-9,970,026 Compositions and methods of engineered CRISPR-Cas9 systems using split-nexus Cas9-associated polynucleotides
The present specification discloses engineered Type II CRISPR-Cas9 systems comprising split-nexus Cas9-associated polynucleotides (sn-casPNs), including systems...
US-9,970,024 RNA-guided human genome engineering
A method of altering a eukaryotic cell is provided including transfecting the eukaryotic cell with a nucleic acid encoding RNA complementary to genomic DNA of...
US-9,970,023 Plants of the genus Diplotaxis having cytoplasmic male sterility
The present invention concerns plants, seeds and cells of the genus Diplotaxis having cytoplasmic male sterility, and more particularly plants, seeds and cells...
US-9,970,022 Gall wasp control agents
The present invention relates to the field of RNA-mediated gene silencing in insect species. The present invention is based, in part, on the inventors'...
US-9,970,021 HPPD-inhibitor herbicide tolerance
This invention relates generally to the detection of genetic differences among soybeans. More particularly, the invention relates to soybean quantitative trait...
US-9,970,020 Plant with reduced protein productivity in seeds and method for producing same
According to the present invention, a gene having a novel function that can cause an increase or decrease in seed protein content is searched for. A chimeric...
US-9,970,019 Regulatory nucleic acid molecules for enhancing seed-specific and/or seed-preferential gene expression in plants
The present invention is in the field of plant molecular biology and provides methods for production of high expressing seed-specific and/or seed-preferential...
US-9,970,018 Biosynthesis of human milk oligosaccharides in engineered bacteria
The invention provides compositions and methods for engineering bacteria to produce fucosylated oligosaccharides, and the use thereof in the prevention or...
US-9,970,017 Regulation of inducible promoters
The present invention relates to the production of heterologous polypeptides in a recombinant bacterial host cell, wherein the bacterial host cell is rendered...
US-9,970,016 Genetic engineered bacteria and methods for promoting production of succinic acid or lactic acid
A genetic engineered bacteria without or comprising a plurality of important metabolic enzyme related genes is provided. When the by-product or waste of fruit...
US-9,970,015 Aspergillus fumigatus cellulolytic enzyme compositions and uses thereof
The present invention relates to recombinant Trichoderma host cells producing Aspergillus fumigatus cellulolytic enzyme compositions and methods of producing...
US-9,970,014 Factor V/Va-targeting aptamer compositions and methods of using the same
Provided herein are Factor V/Factor Va-targeting aptamer compositions and antidote compositions targeting such aptamer compositions. Methods for preventing...
US-9,970,013 Rapid in situ testing for environmental contamination
The present invention provides synthetic RNA aptamers that bind RDX. In various embodiments, the synthetic RNA aptamers may include one or more aptamers...
US-9,970,012 Replication factor C-40 (RFC40/RFC2) as a prognostic marker and target in estrogen positive and negative and...
The present disclosure relates generally to cancer and particularly to breast cancer including estrogen sensitive, estrogen resistant and triple negative breast...
US-9,970,011 Methods for treatment of alport syndrome
Provided herein are methods for the treatment of Alport Syndrome, using modified oligonucleotides targeted to miR-21. In certain embodiments, a modified...
US-9,970,010 Oligomers
Molecules are provided for inducing or facilitating exon skipping in forming spliced mRNA products from pre-mRNA molecules in cells. The molecules may be...
US-9,970,009 MicroRNA compounds and methods for modulating miR-21 activity
Described herein are compositions and methods for the inhibition of miR-21 activity. The compositions have certain nucleoside modification patterns that yield...
US-9,970,008 Treatment of atonal homolog 1 (ATOH1) related diseases by inhibition of natural antisense transcript to ATOH1
The present invention relates to antisense oligonucleotides that modulate the expression of and/or function of Atonal homolog 1 (ATOH1), in particular, by...
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