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Patent # Description
US-9,970,007 Targeting microRNAs for the treatment of fibrosis
Provided herein are compositions and methods for the modulation of miR-214 for the treatment and/or prevention of fibrosis and fibroproliferative conditions.
US-9,970,006 Compositions and methods for inhibition of expression of apolipoprotein C-III (APOC3) genes
The invention relates to double-stranded ribonucleic acid (dsRNA) targeting an APOC3 gene, and methods of using the dsRNA to inhibit expression of APOC3.
US-9,970,005 RNA interference mediated inhibition of gene expression using short interfering nucleic acids (siNA)
The present invention relates to compounds, compositions, and methods for the study, diagnosis, and treatment of traits, diseases and conditions that respond to...
US-9,970,004 Nucleic acid molecule, expression cassette, expression vector, eukaryotic host cell, induction method of RNA...
Subjects of the invention are: nucleic acid molecule, expression cassette, expression vector, eukaryotic host cell, induction method of RNA interference in...
US-9,970,003 Method of treating pain with an antibody against netrin-4, Unc5B or neogenin
The present invention provides a screening method for pain suppressors, which method is characterized by using netrin-4 and/or a netrin-4 receptor to select a...
US-9,970,002 Compositions and methods for functional nucleic acid delivery
Provided are derivatized therapeutic, prophylactic, or diagnostic agents, such as nucleic acids, that can be effectively delivered to cells and tissues. Also...
US-9,970,001 Methods and compositions for nuclease design
Methods and compositions for genetic alteration of cells are provided.
US-9,970,000 Cell-based composite materials with programmed structures and functions
The present invention is directed to the use of silicic acid to transform biological materials, including cellular architecture into inorganic materials to...
US-9,969,999 Method for producing alpha-santalene
The present invention provides a method of producing .alpha.-santalene by contacting at least one polypeptide with farnesyl phyrophosphate (fpp). In particular,...
US-9,969,998 Compositions of adenosine deaminase-2 (ADA2), variants thereof and methods of using same
Provided are variant adenosine deaminase 2 (ADA2) proteins, conjugates thereof and compositions containing the proteins and/or conjugates. Also provided are...
US-9,969,997 Compositions and methods for inhibition of MMP8:MMP8-substrate interactions
The present invention provides compounds for disrupting the binding of a matrix metalloprotease (MMP) protein to a substrate protein at an interaction site...
US-9,969,996 Method for making mutated pullulanase enzyme, mutated pullulanase enzyme, and microorganism expressing the same
A method for making a mutated pullulanase enzyme that hydrolyzes an .alpha.-1,6-glycosidic linkage is provided. The method includes obtaining the amino acid...
US-9,969,995 Methods for recombinant expression of beta-glucosidase gene
Provided is a method for recombinant expression of .beta.-glucosidase gene. Also provided is a recombinant expression vector comprising: (a) a coding sequence...
US-9,969,994 Hybrid polypeptides having cellobiohydrolase activity and polynucleotides encoding same
The present invention relates to hybrid polypeptides having cellobiohydrolase activity. The present invention also relates to polynucleotides encoding the...
US-9,969,993 Filamentous fungal host cells and methods of recombinantly producing proteins
The present invention relates to cellulolytic compositions for degrading or converting cellulose-containing material and methods of producing and using the...
US-9,969,992 Phytases, nucleic acids encoding them and methods for making and using them
This invention relates to phytases, polynucleotides encoding them, uses of the polynucleotides and polypeptides of the invention, as well as the production and...
US-9,969,991 Internal protein tags
Provided herein are substantially non-luminescent peptide/polypeptide tags that are inserted internally within a protein of interest or between N-terminal and...
US-9,969,990 Ketoacyl ACP synthase genes and uses thereof
The present invention relates to beta-ketoacyl ACP synthase genes of the KASI/KASIV type and proteins encoded by these genes. The genes can be included in...
US-9,969,989 Carotenoid dioxygenase and methods for the biotechnological production in microorganisms and plants of...
The present invention relates to a new carotenoid dioxygenase and methods for the biological production in microorganisms and plants of compounds with high...
US-9,969,988 Pipecolinic acid 4-hydroxylase and method for producing 4-hydroxy amino acid using same
The present invention provides a pipecolic acid 4-hydroxylase protein exemplified by the following (A), (B), and (C), having activity to react with L-pipecolic...
US-9,969,987 Split peroxidases and methods of use
An imaging method utilizing a split peroxidase is described herein. Imaging methods involve contacting a cell with a split peroxidase and a substrate thereof to...
US-9,969,986 Virus like particle comprising modified envelope protein E3
A virus like particle comprising a viral structural protein which comprises modified envelope protein E3. The viral structural protein may be that derived from...
US-9,969,985 Modified human rotaviruses and uses therefor
The present disclosure relates generally to the field of viral vaccines. Particularly, the present disclosure provides a modified Vero-adapted human rotavirus...
US-9,969,984 Storage stable recombinant lentiviral vector preparation
Herein is provided a recombinant lentiviral vector preparation, in which the preparation comprises: a) an effective dose of the recombinant lentiviral vector;...
US-9,969,983 Methods and products for transfection
The present invention relates in part to methods for producing tissue-specific cells from patient samples, and to tissue-specific cells produced using these...
US-9,969,982 Differentiation of human embryonic stem cells
The present invention provides methods to promote the differentiation of pluripotent stem cells and the products related to or resulting from such methods. In...
US-9,969,981 Methods for purifying cells derived from pluripotent stem cells
The present invention is directed to methods to differentiate pluripotent stem cells. In particular, the present invention provides methods of characterization...
US-9,969,980 Cell populations which co-express CD49c and CD90
Substantially homogenous cells populations which co-express CD49c, CD90 and telomerase are made. In one embodiment, humans suffering from a degenerative,...
US-9,969,979 Methods for producing cells having a phenotype of a primary human hepatocytes and compositions
The present disclosure provides methods and compositions relating to in vitro cultures of human hepatocyte cell lines which exhibit a primary human hepatocyte...
US-9,969,978 Method for producing cardiomyocytes from human or mouse embryonic stem cells in a medium consisting of a...
The present invention relates to a method for producing embryonic stem cell-derived cardiomyocytes, cardiomyocytes produced by the method, a method for...
US-9,969,977 Cell populations which co-express CD49c and CD90
Substantially homogenous cells populations which co-express CD49c, CD90 and telomerase are made. In one embodiment, humans suffering from a degenerative,...
US-9,969,976 Cell populations having immunoregulatory activity, methods for the preparation and uses thereof
A method for the preparation and/or generation of immunomodulatory cells which comprises contacting a mesenchymal stem cell (MSC) and/or fibroblast cell...
US-9,969,975 Genetically-modified cells comprising a modified human T cell receptor alpha constant region gene
Disclosed herein is a genetically-modified cell comprising in its genome a modified human T cell receptor alpha constant region gene, wherein the cell has...
US-9,969,974 Differntiation method for production of glial cell population
The present invention provides methods for generating oligodendrocyte progenitor cells from pluripotent cells, as well as methods for sustaining these...
US-9,969,973 Methods and compositions for cell attachment and cultivation on planar substrates
The present invention is directed to methods for the growth, expansion and differentiation of pluripotent stem cells on planar substrates lacking an adlayer and...
US-9,969,972 Pluripotent stem cell culture on micro-carriers
The present invention is directed to methods for the growth, expansion and differentiation of pluripotent stem cells on micro-carriers.
US-9,969,971 Calcium-containing structures and methods of making and using the same
The present invention generally relates to calcium-containing structures and methods of making and using the structures. In one aspect, hollow calcium...
US-9,969,970 DNA-cell conjugates
The present invention provides conjugates of DNA and cells by linking the DNA to a native functional group on the cell surface. The cells can be without cell...
US-9,969,969 Fed-batch fermentation process and culture medium for the production of plasmid DNA in E. coli on a...
A process for producing plasmid DNA E. coli cells comprises a pre-culture and fed-batch process. The culture media of the batch phase and the culture medium...
US-9,969,968 Hydrodynamic separation (HDS) for removing protist predators from algal crops
A method and system removes biological contaminants from an algal crop. A flow of an algal crop containing biological contaminants is provided to a hydrodynamic...
US-9,969,967 Subject moving device
A subject moving device includes: a base; a head section provided with vertically movable rods and moving along a prescribed movement path above the base; a...
US-9,969,966 Bioreactor system for continuous cell cultivation
A cell culture system for fermentation or cultivation of at least one of cells, tissues or tissue-like cell cultures, organs or organ-like cell cultures and...
US-9,969,965 Linearly scalable single use bioreactor system
Disclosed is a single-use bioreactor bag design providing substantially equivalent maximum shear rate at the impeller tip and average or bulk shear rate over a...
US-9,969,964 Disease-on-a-chip
The invention generally relates to a cell culture system for coculturing non-neoplastic and neoplastic cells on a planar member which more faithfully mimics the...
US-9,969,963 Methods and apparatus for cell culture array
Methods and systems are described for improved handling and/or culturing and/or assaying of cells, chemically active beads, or similar materials in microfluidic...
US-9,969,962 Modular stand for home beer brewing
A modular home beer brewing stand includes: a base having a center post and three or more adjustable legs, a first leg fixedly attached to the center post with...
US-9,969,961 Benefit agent containing delivery particle
The present invention relates to benefit agent containing delivery particles, compositions comprising said particles, and processes for making and using the...
US-9,969,960 Aqueous liquid composition
An aqueous liquid composition, which may be used as a light duty hand dishwashing composition, comprising (i) at least one surfactant, (ii) at least one...
US-9,969,959 Detergent composition that performs both a cleaning and rinsing function
Industrial 2-in-1 cleaning compositions providing both detergency and rinseability in a single cleaning composition are disclosed. Alkali metal carbonate-based...
US-9,969,958 Concentrated detergent composition for the improved removal of starch in warewashing applications
The invention provides a concentrated detergent composition comprising alkali metal carbonate, alkali metal percarbonate, and a peroxidation catalyst according...
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