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Patent # Description
US-9,982,301 Urine mRNA profile and acute dysfunction of kidney allograft
Non-invasive methods for detecting, predicting, and/or monitoring differential diagnosis of kidney transplant dysfunction in kidney transplant patients are...
US-9,982,300 Size-based genomic analysis
Systems, methods, and apparatuses for performing a prenatal diagnosis of a sequence imbalance are provided. A shift (e.g. to a smaller size distribution) can...
US-9,982,299 Markers for brain damage
Methods to identify markers for brain damage using fresh brain tissue and methods and compositions for detecting these markers are disclosed.
US-9,982,298 Process and kit for determining in vitro the immune status of an individual
The present invention relates to a process for determining in vitro the immune status of an individual according to which: (a) a blood sample from the...
US-9,982,296 Polony sequencing methods
We describe ultra-high throughput polony genome sequencing that can permit, for example, generating raw data to re-sequencing the human genome in about one week...
US-9,982,295 Non-invasive prenatal diagnosis of fetal genetic condition using cellular DNA and cell free DNA
Disclosed are methods for determining at least one sequence of interest of a fetus of a pregnant mother. In various embodiments, the method can determine one or...
US-9,982,294 Sequencing by orthogonal synthesis
A method for sequencing includes steps of (a) providing first and second nucleic acid templates, wherein the two templates have different sequences; (b)...
US-9,982,293 Amplification and analysis of selected targets on solid supports
Methods are provided for multiplexed amplification of selected targets and analysis of the amplified targets. In preferred aspects the amplification and...
US-9,982,292 Detecting chemical and biological agents using textile-based sensors
Methods and systems for detecting chemical and biological agents using oligonucleotide aptamers. A sensor includes a detection aptamer that has a binding domain...
US-9,982,291 Probes for improved melt discrimination and multiplexing in nucleic acid assays
Methods and compositions for the detection and quantification of nucleic acids are provided. In certain embodiments, methods involve the use of cleavable probes...
US-9,982,290 Methods and systems for using encapsulated microbubbles to process biological samples
Methods and systems for using encapsulated microbubbles to process biological samples are disclosed. According to one aspect, a method for using encapsulated...
US-9,982,289 Size self-limiting compositions and test devices for measuring analytes in biological fluids
A test strip or electrochemical sensor for measuring the amount of an analyte in a biological fluid, e.g. the glucose content of whole blood, includes a size...
US-9,982,288 Mucopolysaccharidosis IVA/VII screening and treatment method
Provided is a rapid screening method for detecting mucopolysaccharidosis IVA and mucopolysaccharidosis VII. Biological samples containing glycosaminoglycans are...
US-9,982,287 Enterokinase cleavable polypeptides
The present invention relates to Enterokinase-cleavable polypeptides comprising an Enterokinase cleavage site connected to a polypeptide and their use for...
US-9,982,286 Medium for the protein-free and serum-free cultivation of cells
A medium is described for the protein-free and serum-free cultivation of cells, especially mammalian cells, whereby the medium contains a proportion of soy...
US-9,982,285 Polypeptides having cellulolytic enhancing activity and polynucleotides encoding same
The present invention relates to polypeptides having cellulolytic enhancing activity, catalytic domains, and carbohydrate binding domains, and polynucleotides...
US-9,982,284 Enzymatic hydrolysis of disaccharides and oligosaccharides using alpha-glucosidase enzymes
A method is disclosed for hydrolyzing an alpha-1,5 glucosyl-fructose linkage in a saccharide (disaccharide or oligosaccharide) such as leucrose. This method...
US-9,982,283 Saccharide solution production system, saccharide solution production method using biomass raw material, and...
Provided is a biomass hydrothermal decomposition system which includes: a biomass supply unit that supplies a biomass raw material; hydrothermally decomposing...
US-9,982,282 Process for preparation of sugars and syrups
The present invention relates to a process for producing a syrup comprising liquefying an aqueous granular starch slurry with an alpha-amylase variant...
US-9,982,281 Microorganisms for producing 1,3-butanediol and methods related thereto
Provided herein is a non-naturally occurring microbial organism having a 1,3-butanediol (1,3-BDO) pathway and comprising at least one exogenous nucleic acid...
US-9,982,280 Process for enzymatic hydrolysis of lignocellulosic material and fermentation of sugars
The invention relates to a process for the preparation of a fermentation product from ligno-cellulosic material, comprising the following steps: a) optionally...
US-9,982,279 Nucleic acid-guided nucleases
Disclosed herein are nucleic acid-guided nucleases, guide nucleic acids, and targetable nuclease systems, and methods of use. Disclosed herein are engineered...
US-9,982,278 CRISPR enabled multiplexed genome engineering
Described herein are methods and vectors for rational, multiplexed manipulation of chromosomes within open reading frames (e.g., in protein libraries) or any...
US-9,982,277 Methods and compositions for target DNA modification
The disclosure provides compositions and methods for increasing efficiency of Cas9-mediated target DNA modification. Specifically, the disclosure provides...
US-9,982,276 Penton-mutated, integrin-retargeted adenovirus vectors with reduced toxicity and their use
The present invention describes generation and the use of adenovirus variants (Ad) possessing modified capsid penton base protein where mutations in the penton...
US-9,982,275 Promoters, expression cassettes, vectors, kits, and methods for the treatment of achromatopsia and other diseases
The present invention provides isolated promoters, transgene expression cassettes, vectors, kits, and methods for treatment of genetic diseases that affect the...
US-9,982,274 AXMI115 variant insecticidal gene and methods for its use
Compositions and methods for conferring pesticidal activity to bacteria, plants, plant cells, tissues and seeds are provided. The toxin coding sequences can be...
US-9,982,273 Yield and stress tolerance in transgenic plants IV
Polynucleotides and polypeptides incorporated into expression vectors have been introduced into plants and were ectopically expressed. The polypeptides of the...
US-9,982,272 Algal mutants having a locked-in high light acclimated phenotype
Mutant photosynthetic microorganisms having reduced chlorophyll and increased photosynthetic efficiency are provided. The mutants have a locked in high...
US-9,982,271 Controlling gene expression in plants using fusion protein containing LexA binding domain and DREB...
The present invention relates to the regulation of transgene expression in plants through a transactivation system which comprises the following: (1) a promoter...
US-9,982,270 Organic compounds
Method for heterologous protein production in plant cell plastids comprising introducing into plant cells nucleic acid components that encode heterologous...
US-9,982,269 Mortierella alpine uracil auxotroph with URA5 gene knocked out through homologous recombination, and...
It relates to a Mortierella alpine ATCC32222 uracil auxotroph strain and a construction method thereof. In the present invention, Mortierella alpine ATCC32222...
US-9,982,268 Vectors for cloning
A vector for transformation into a host cell is described comprising a toxic gene encoding a product that is lethal to the host cell, wherein the toxic gene...
US-9,982,267 Rationally-designed synthetic peptide shuttle agents for delivering polypeptide cargos from an extracellular...
The present description relates to methods for delivering polypeptide cargos from an extracellular space to the cytosol and/or nucleus of a target eukaryotic...
US-9,982,266 Methods and pharmaceutical compositions for treatment of cystic fibrosis
The present invention relates to a method and compositions for the treatment of cystic fibrosis.
US-9,982,265 Inhibition of Bruton's tyrosine kinase (Btk) in the lung to treat severe lung inflammation and lung injury
Bruton's tyrosine kinase (Btk) plays an important role in the pathophysiology of local inflammation in acute lung injury (ALI)/acute respiratory distress...
US-9,982,264 Antisense compositions and methods of making and using same
The present invention provides pharmaceutical formulations for oral administration of antisense oligonucleotides, such as antisense oligonucleotides against...
US-9,982,263 Conserved HBV and HCV sequences useful for gene silencing
Conserved consensus sequences from known hepatitis B virus strains and known hepatitis C virus strains, which are useful in inhibiting the expression of the...
US-9,982,262 Neutral nucleic acid ligands
The invention generally relates to isolated nucleic acid ligands that are neutral under physiological conditions.
US-9,982,261 Antisense antiviral compounds and methods for treating a filovirus infection
The present invention provides antisense antiviral compounds, compositions, and methods of their use and production, mainly for inhibiting the replication of...
US-9,982,260 Identification of structurally similar small molecules that enhance therapeutic exon skipping
This invention relates, e.g., to a method for enhancing exon skipping in a pre-mRNA of interest, comprising contacting the pre-mRNA with an effective amount of...
US-9,982,259 Transthyretin allele selective UNA oligomers for gene silencing
This invention provides UNA oligomers for selectively inhibiting V30M TTR expression, which can be used in treating amyloidosis. The UNA oligomers can have a...
US-9,982,258 Methods for controlling pests using RNAi
The present invention relates to methods for controlling pest infestation using double stranded RNA molecules. The invention provides methods for producing...
US-9,982,257 Chiral control
The present invention relates to chirally controlled oligonucleotides, chirally controlled oligonucleotide compositions, and the method of making and using the...
US-9,982,256 Random RNAi libraries, methods of generating same, and screening methods utilizing same
This invention provides expression vectors for a ribonucleic acid (RNA) molecule comprising a double-stranded region of random sequence, sets and libraries of...
US-9,982,255 Capture methodologies for circulating cell free DNA
A nucleic acid patch method for amplifying target nucleic acid sequences in circulating free DNA or residual DNA samples where the defining ends of the target...
US-9,982,254 Ligand having three finger structure and a method for detecting a molecule by using thereof
The present invention improves in vitro virus synthesis efficiency and stability of mRNA derived from screened cDNA in a cDNA display method to improve the...
US-9,982,253 Stabilized fibronectin domain compositions, methods and uses
A protein scaffold based on a consensus sequence of fibronectin type III (FN3) proteins, such as the tenth FN3 repeat from human fibronectin (human Tenascin),...
US-9,982,252 Mirac proteins
This disclosure relates to a method of generating conditionally active biologic proteins from wild type proteins, in particular therapeutic proteins, which are...
US-9,982,251 Large volume ex vivo electroporation method
An object of the invention is to provide an electroporation method for treating vesicles with exogenous material for insertion of the exogenous material into...
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