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Patent # Description
US-9,982,045 Anti-CDH6 antibody drug conjugates
The present invention relates to anti-CDH6 antibodies, antibody fragments, antibody drug conjugates, and their uses for the treatment of cancer.
US-9,982,044 Method of treating pruritus with IL-31 monoclonal antibody formulations
The invention provides humanized mouse anti-human IL-31 antibodies and antibody fragments that are capable of binding IL-31 and thereby neutralizing,...
US-9,982,043 Use of IL-20 antagonists for treating pancreatic cancer
Methods for treating pancreatic cancer using an IL-20 antagonist, which can be an antibody that binds IL-20 or an IL-20 receptor, thereby blocking the signaling...
US-9,982,042 Therapeutic combination and methods of treatment with a DLL4 antagonist and an anti-hypertensive agent
Methods for treating cancer comprising administering a DLL4 antagonist and one or more anti-hypertensive agents are described. Also described are pharmaceutical...
US-9,982,041 Compositions and methods for treatment and detection of cancers
Pharmaceutical composition comprising antibodies or antigen binding fragments thereof that bind to SSEA-4 are disclosed herein, as well as methods of use...
US-9,982,040 Anti-ricin antibodies and uses thereof
The present invention relates to anti-ricin antibodies and uses thereof. More specifically, the invention relates to anti-ricin antibodies and fragments thereof...
US-9,982,039 Mycobacterial antigen composition
There is provided an antigenic composition comprising (a) a first mycobacterial antigenic polypeptide or a first mycobacterial polynucleotide; and (b) a second...
US-9,982,038 Antibodies against F glycoprotein of Hendra and Nipah viruses
The present invention relates to antibodies or antibody fragments that bind, neutralize, and/or inhibit Hendra or Nipah virus. The invention provides antibodies...
US-9,982,037 Agents for influenza neutralization
The present invention provides antibodies (e.g., monoclonal antibodies, human antibodies, humanized antibodies, etc.), which bind to multiple influenza strains....
US-9,982,036 Dual FC antigen binding proteins
The present invention relates to antigen binding proteins comprising two Fc parts, methods for their production, pharmaceutical compositions containing said...
US-9,982,035 Modified serpins for the treatment of bleeding disorders
This invention relates pro-coagulant serpin molecules engineered by modification of the P4, P2, P1 and/or P1' residues within the reactive center loop (RCL) to...
US-9,982,034 Platelet targeted treatment
The present disclosure relates to compositions and methods for targeting expression of exogenous genes to platelets. In particular, the present disclosure...
US-9,982,033 Factor VIII polypeptide titers in cell cultures
The invention relates to a method for the production of a Factor VIII polypeptide, the method comprising the steps of a) culturing a mammalian cell expressing a...
US-9,982,032 Stable liquid formulation of fusion protein with IgG Fc domain
A stable liquid formulation includes a fusion protein having an Fc domain of a human immunoglobulin G (IgG), in particular, a protein in which an Fc domain of a...
US-9,982,031 Peptides and combination of peptides for use in immunotherapy against various tumors
The present invention relates to peptides, proteins, nucleic acids and cells for use in immunotherapeutic methods. In particular, the present invention relates...
US-9,982,030 Peptides and combination of peptides for use in immunotherapy against various tumors
The present invention relates to peptides, proteins, nucleic acids and cells for use in immunotherapeutic methods. In particular, the present invention relates...
US-9,982,029 Exendin-4 derivatives as selective peptidic dual GLP-1/glucagon receptor agonists
The present invention relates to dual GLP-1/glucagon receptor agonists and their medical use, for example in the treatment of disorders of the metabolic...
US-9,982,028 Recombinant human interferon-like proteins
This application relates to recombinant human interferon-like proteins. In one embodiment a recombinant protein created by gene shuffling technology in...
US-9,982,027 Control of rheological properties of mixed hyaluronate/lubricin solutions
Disclosed are mixed solutions of PRG4 and hyaluronic acids having controlled, enhanced rheological properties adapted for various particular medical and...
US-9,982,026 Compositions and methods for assessing and treating adrenal diseases and disorders
The present invention relates to the discovery that mutations in KCNJ5 are associated with adrenal diseases and disorders. The invention includes compositions...
US-9,982,025 Monomeric griffithsin tandemers
The invention provides a construct containing two or more monomeric griffithsin molecules, optionally joined by a linker, as well as conjugate comprising the...
US-9,982,024 CyaA-based chimeric proteins comprising a heterologous polypeptide and their uses in the induction of immune...
The invention relates to a chimeric protein comprising or consisting of, from N-terminal to C-terminal, (a) a N-terminal part of a Bordetella CyaA protein (b) a...
US-9,982,023 Compositions and methods for treating autoimmune and inflammatory disorders
Ligand-specific HVEM variants, compositions comprising such variants, and methods of treating inflammatory diseases comprising administering such variants, are...
US-9,982,022 Binding polypeptides having a mutated scaffold
The present disclosure relates to a class of engineered polypeptides and provides a polypeptide comprising the sequence ...
US-9,982,021 Composition for dissolving thrombi, and a pharmaceutical composition for treating stenotic or occlusive...
The present invention relates to: a composition for dissolving thrombi comprising a peptide comprising the Arg-Gly-Asp motif; a pharmaceutical composition for...
US-9,982,020 Antiviral compounds and methods for treating infections caused by double-stranded DNA viruses
The present invention relates to polyamide compounds and their use in pharmaceutical compositions and in medical applications for the treatment of human...
US-9,982,019 Glycopeptide compound or pharmaceutical salt thereof and method for preparing same, and pharmaceutical...
The present invention provides a glycopeptide compound or pharmaceutically acceptable salt thereof as shown in Formula (I) or (II), and a method for preparing...
US-9,982,018 Amatoxin derivatives
The invention relates to tumor therapy. In one aspect, the present invention relates to conjugates of an amatoxin and a target-binding moiety, e.g. an antibody,...
US-9,982,017 Synthetic apelin mimetics for the treatment of heart failure
The invention provides a synthetic polypeptide of Formula I': ##STR00001## or an amide, an ester or a salt thereof, wherein X1, X2, X3, X4, X5, X6, X7, X8,...
US-9,982,016 NPR-B agonists
Disclosed are novel compounds having NPR-B agonistic activity. Preferred compounds are linear peptides containing 8-13 conventional or non-conventional L- or...
US-9,982,015 Cyclin based inhibitors of CDK2 and CDK4
Structural and functional analysis of peptide inhibitor binding to the cyclin D and cyclin A groove has been investigated and used to design peptides that...
US-9,982,014 Tetrapeptide compound and method for producing same
The present invention is to provide a method for the efficient production on an industrial scale of SS-31 (D-Arg-Dmt-Lys-Phe-NH.sub.2), which is an SS peptide....
US-9,982,013 Readily isolated bispecific antibodies with native immunoglobulin format
A bispecific antibody format providing ease of isolation is provided, comprising immunoglobulin heavy chain variable domains that are differentially modified in...
US-9,982,012 Refolding of granulocyte colony stimulating factor
Provided is a method of refolding of recombinant GCSF that minimizes the generation of oxidized forms of GCSF by optimizing the refolding of inclusion bodies...
US-9,982,011 Legumain activated doxorubicin derivative as well as preparation method and application thereof
The present invention discloses doxorubicin derivatives for targeted activation by Legumain, its preparation method and use. The doxorubicin derivatives are...
US-9,982,010 7-dehydrocholesterol derivatives and methods using same
The present invention provides, in certain aspects, novel 7-dehydrocholesterol (7DHC) derivatives that are useful in treating or preventing cancer, as well as...
US-9,982,009 Methods for treating polycystic kidney disease and polycystic liver disease
The present invention provides compounds of Formula (I) or (II), which are thought to be able to inhibit mTOR (mammalian target of rapamycin) signaling pathway,...
US-9,982,008 Preparation and uses of obeticholic acid
The present invention relates to obeticholic acid: ##STR00001## or a pharmaceutically acceptable salt, solvate or amino acid conjugate thereof. Obeticholic...
US-9,982,007 Cocrystals of progesterone
The present invention relates to a cocrystal of progesterone and a coformer selected from the group consisting of vanillic acid, benzoic acid, salicylic acid,...
US-9,982,006 2'-chloro aminopyrimidinone and pyrimidine dione nucleosides
Provided herein are formulations, methods and substituted 2'-chloro aminopyrimidinone and pyrimidine dione compounds of Formula (I) for treating Pneumovirinae...
US-9,982,005 Macrolides and methods of their preparation and use
Provided herein are methods of preparing macrolides by the coupling of an eastern and western half, followed by macrocyclization, to provide macrolides,...
US-9,982,004 Method for recovering low molecular weight lignin from a filtrate
The invention relates to a method for recovering low molecular weight lignin from a filtrate, wherein the low molecular weight lignin includes lignin molecules...
US-9,982,002 Sulfoxidation catalysts and methods for their preparation and use
Methods and compositions of catalysts for sulfoxidation reaction processes are disclosed. The sulfoxidation reaction process can be performed in an aqueous...
US-9,982,001 Bisphosphites having an unsymmetric central biaryl unit
Bisphosphites having an unsymmetric central biaryl unit.
US-9,982,000 Pyrazole compounds and method for making and using the compounds
Disclosed embodiments concern novel interleukin receptor associated kinases (IRAK) inhibitors and compositions comprising such inhibitors. Also disclosed are...
US-9,981,999 Neprilysin inhibitors
In one aspect, the invention relates to compounds having the formula X: ##STR00001## where R.sup.a, R.sup.b, R.sup.2, R.sup.7, and X are as defined in the...
US-9,981,998 Water-soluble acetaminophen analogs
The present invention provides water-soluble acetaminophen prodrugs and formulations which may be suitable for parenteral administration. Methods of treating a...
US-9,981,997 Chemical reagents for attaching affinity molecules on surfaces
Chemical linkage reagents, methods of making and method of using the same are provided. Chemical linkage reagents according to at least some of the embodiments...
US-9,981,995 Azocarbonyl-functionalized silanes
Azocarbonyl-functionalized silanes of formula I (R.sup.1).sub.3-a(R.sup.2).sub.aSi--R.sup.1--NH--C(O)--N.dbd.N--R.sup.4 (I) and methods for their production are...
US-9,981,994 Pyrazole compounds, compositions and methods for treatment of degenerative diseases and disorders
Provided herein are compounds of the formula (I): ##STR00001## as well as pharmaceutically acceptable salts thereof, wherein the substituents are as those...
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