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Patent # Description
US-9,981,993 Manufacturing method of carbon-silicon composite
Disclosed herein are a manufacturing method of a carbon-silicon composite, including: (a) preparing a slurry solution including silicon (Si)-block copolymer...
US-9,981,992 Compositions and methods for reduction of ketones, aldehydes and iminiums, and products produced thereby
A method of producing an alcohol, comprises reducing an aldehyde or a ketone with a hydridosilatrane. The reducing is carried out with an activator.
US-9,981,991 Synthesis and isolation of crystalline alkali metal arene radical anions
Certain embodiments are directed to a composition comprising a complex of the general formula [M(crown ether)(solvent).sub.n][arene.sup.- ], wherein M is an...
US-9,981,990 Melampomagnolide B dimers
The present disclosure provides dimers of melampomagnolide B (MMB), including carbamate, carbonate, succinic amide, ester and carboxamide dimers of MMB. These...
US-9,981,989 Ataxia telengiectasia and Rad3-related (ATR) protein kinase inhibitors
Macrocyclic compounds having the structure of Formula (A), or pharmaceutically acceptable salts thereof, are provided, ##STR00001## wherein R.sup.1, R.sup.2,...
US-9,981,988 Polymorphic forms and co-crystals of a c-Met inhibitor
Provided herein are novel polymorphic forms and co-crystals of a compound useful in the treatment, prevention, or amelioration of cancer. In particular, the...
US-9,981,987 Tricyclic heterocyclic compounds as phosphoinositide 3-kinase inhibitors
A compound of formula I: ##STR00001## or a pharmaceutically acceptable salt thereof, wherein: W is O, N--H, N--(C.sub.1-C.sub.10 alkyl) or S; each X is...
US-9,981,986 Antimicrobial compounds
The present invention relates to certain tetramic acid derivatives and, in particular, bicyclic tetramic acid derivatives that are suitable for use in the...
US-9,981,985 Pharmaceutical formulations containing 3-(4-cinnamyl-l-piperazinyl) amino derivatives of 3-formylrifamycin SV...
The present invention related to a process of preparation of pharmaceutically acceptable formulations containing as active substance ...
US-9,981,984 Method for producing cis-5-hydroxy-2-piperidinecarboxylic acid derivative, and method for purifying...
The present invention aims to provide a method for purifying cis-5-hydroxy-2-piperidinecarboxylic acid with high purity, and a method for producing its...
US-9,981,983 Thienopyranones as kinase inhibitors
The invention relates to compounds of formula I (or pharmaceutically acceptable salts thereof) as defined herein, pharmaceutical compositions thereof, and their...
US-9,981,982 Superoleophobic and/or superhydrophobic material, process for preparing same and applications thereof
The invention relates to a multilayer superoleophobic and/or superhydrophobic material comprising: on the one hand, a first constituent that is a conductive...
US-9,981,981 Tricyclic proteasome activity enhancing compounds
Proteinopathies result from the proteasome not acting efficiently enough to eliminate harmful proteins and prevent the formation of the pathogenic aggregates....
US-9,981,980 1,5-Disubstituted 1,2,3-triazoles are inhibitors of Rac/Cdc42 GTPases
Compounds are disclosed that inhibit RhoGTPases that are useful for inhibiting hyperprofilerative and neoplastic diseases. Specifically, the compounds inhibit...
US-9,981,979 Process for the formation of hydrocodone bitatrate
There is provided a novel process for the preparation of a hydrocodone salt. In particular, there is provided a novel process for the preparation of a...
US-9,981,978 Preparation of saturated ketone morphinan compounds by catalytic isomerisation
There is provided a novel process for the preparation of a compound of formula I, wherein R.sup.1, R.sup.2 and R.sup.3 are as described in the description, by...
US-9,981,977 Asymmetric electrophilic fluorination using an anionic chiral phase-transfer catalyst
The discovery of distinct modes of asymmetric catalysis has the potential to rapidly advance chemists' ability to build enantioenriched molecules. As an...
US-9,981,976 Piperidine substituted pyrazolo[1,5-A]pyrimidine derivatives with inhibitory activity on the replication of the...
The invention concerns novel substituted bicyclic pyrazolo pyrimidine compounds of formula (I) having antiviral activity, in particular, having an inhibitory...
US-9,981,975 Pyrrolotriazine compounds as tam inhibitors
This application relates to compounds of Formula I: ##STR00001## or pharmaceutically acceptable salts thereof, which are inhibitors of TAM kinases which are...
US-9,981,974 Small molecules targeting androgen receptor nuclear localization and/or level in prostate cancer
A method for treating prostate cancer in a subject, comprising administering a therapeutically effective amount of at least one agent to the subject, wherein...
US-9,981,973 Tricyclic compounds as inhibitors of immunosuppression mediated by tryptophan metabolization
Presently provided are inhibitors of IDO and TDO and pharmaceutical compositions thereof, useful for modulating an activity of indoleamine 2,3-dioxygenase and...
US-9,981,972 N-hydroxy bicyclic hydantoin carbamates as tools for identification of serine hydrolase targets
Provided herein are N-hydroxy bicyclic hydantoin carbamates and pharmaceutical compositions comprising said compounds. The subject compounds and compositions...
US-9,981,971 Solid forms of 1-ethyl-7-(2-methyl-6-(1H-1,2,4-triazol-3-yl)pyridin-3-yl)-3,4-dihydropyr- ...
Provided herein are formulations, processes, solid forms and methods of use relating to the Compound for formula 1: ##STR00001## having the name...
US-9,981,970 Bicyclic ureas and thiadiazolidine-1, 1-dioxides as CETP inhibitors
Compounds having the structure of Formula I, including pharmaceutically acceptable salts of the compounds, wherein X is --C(.dbd.O) or --S(O).sub.2--, are CETP...
US-9,981,969 Imidazole derivatives and methods of use thereof for improving the pharmacokinetics of a drug
The present invention relates to Imidazole Derivatives of Formula (I), and pharmaceutically acceptable salts thereof, wherein A, B, Y, R.sup.1 and R.sup.2 are...
US-9,981,968 Substituted pyrrolo[2,3-d]pyrimidines for the treatment of cancer and proliferative disorders
Disclosed are substituted pyrrolo[2,3-d]pyrimidine compounds. The disclosed compounds are shown to be useful in inhibiting the growth of cancer cell lines and...
US-9,981,967 Synthesis of imidazo[1,2-a]pyrazin-4-ium salts for the synthesis of 1,4,7-triazacyclononane (tacn) and N-...
The present invention embodiments relate to a compound with formula (V') ##STR00001## The invention also relates in certain embodiments to the synthesis method...
US-9,981,966 Purinone derivative hydrochloride
The purinone derivative 6-amino-9-[(3R)-1-(2-butynoyl)-3-pyrrolidinyl]-7-(4-phenoxyphenyl)-7,9-di- hydro-8H-purin-8-one hydrochloride has Btk-selective...
US-9,981,965 Process for preparing idelalisib
The present invention relates to an improved process for preparing Idelalisib (1). In this process, acid addition salts of idelalisamine (2) are useful...
US-9,981,964 Maleimide derivatives as modulators of wnt pathway
The present invention relates to compounds of formula (I), combinations and uses thereof for disease therapy, or a pharmaceutically acceptable salt, solvate or...
US-9,981,963 3-(1H-pyrazol-4-yl)-1H-pyrrolo[2,3-c]pyridine derivatives as NIK inhibitors
The present invention relates to pharmaceutical agents useful for therapy and/or prophylaxis in a mammal, and in particular to inhibitors of ...
US-9,981,962 Pyrazole derivatives as NIK inhibitors
The present invention relates to pharmaceutical agents useful for therapy and/or prophylaxis in a mammal, and in particular to inhibitors of ...
US-9,981,961 Deoxycytidine kinase inhibitors
Provided herein are compounds that bind to dCK and methods for treating cancer.
US-9,981,960 Pyrrolidine compound and application as melanocortin receptor agonist
The present invention relates to a novel pyrrolidine compound having melanocortin receptor agonist activity or a pharmaceutically acceptable salt thereof, and...
US-9,981,959 Thiazolyl and oxazolyl urea, thiourea, guanidine and cyanoguanidine compounds as TrkA kinase inhibitors
Compounds of Formula (I) or stereoisomers, tautomers, or pharmaceutically acceptable salts, solvates or prodrugs thereof, wherein Ring A, Ring C and X are as...
US-9,981,958 Oxazolidines derived from polyalkyl or polyalkenyl n-hydroxyalkyl succinimides, obtainment process and use
Oxazolidines, a process for producing the oxazolidines, and use as additives for fuels to prevent and control deposits in internal combustion engines are...
US-9,981,957 Synthetic process
The present invention relates to a process for preparing substituted piperidine compounds and especially chiral substituted piperidine compounds. The process...
US-9,981,956 Small molecule inhibitors of fibrosis
Described herein are compounds and compositions for the treatment of a fibrotic disease.
US-9,981,955 Antiviral compounds
The invention is related to anti-viral compounds, compositions containing such compounds, and therapeutic methods that include the administration of such...
US-9,981,954 2-(pyrazin-2-ylcarbonylaminomethyl) benzimidazolium compounds as epithelial sodium channel inhibitors
The present invention relates to compounds of formula (I) or the tautomers or pharmacologically acceptable acid addition salts thereof, characterized by a...
US-9,981,953 Contrast agent precursor and method for preparing the same
A contrast agent precursor is revealed. The contrast agent precursor includes a 1,4,7-Tris(carbonylmethyl)-1,4,7,10-tetraazacyclododecane that forms complexes...
US-9,981,952 Oxazetidine derivatives, process for preparing them and use in human medicine and in cosmetics
Compounds that are agonists of the MCIR receptor and that exhibit reduced toxicity relative to other compounds of the same class are described. These compounds...
US-9,981,951 Crystalline and amorphous forms of Olaparib
Disclosed are a novel crystalline form and an amorphous form of Olaparib, and the process for their preparation.
US-9,981,950 Triazoles as NR2B receptor inhibitors
Provided here in are compounds of Formula I having the structure: Also provided herein are compositions comprising compounds of Formula I and methods of using...
US-9,981,949 Synthesis and novel salt forms of (R)-5-((E)-2-pyrrolidin-3-ylvinyl)pyrimidine
The present invention relates to the stereospecific synthesis of (R)-5-((E)-2-pyrrolidin-3-ylvinyl)pyrimidine, its salt forms, and novel polymorphic forms of...
US-9,981,948 Crystalline salts of (S)-6-((1-acetylpiperidin-4-yl)amino)-N-(3-(3,4-dihydroisoquinolin-2(1H)-- ...
Disclosed are novel crystalline salts of (S)-6-((1-acetylpiperidin-4-yl)amino)-N-(3-(3,4-dihydroisoquinolin-2(1H)-- yl)-2-hydroxypropyl)pyrimidine-4-carboxamide...
US-9,981,947 Polymorphic forms of nilotinib hydrochloride
Crystalline Forms R5, R5a, R5b and R6 of nilotinib hydrochloride and processes for their preparation.
US-9,981,946 Pyridine-substituted 2-aminopyridine protein kinase inhibitors
The present invention discloses pharmaceutically acceptable acid salts of pyridine-substituted 2-aminopyridine derivatives as protein kinase inhibitors,...
US-9,981,945 Pyrimidine derivatives as CFTR modulators
A compound having the structure of Formula II, or a stereoisomer, tautomer, or a pharmaceutically acceptable salt thereof: ##STR00001## The compound is useful...
US-9,981,944 GDF-8 inhibitors
Disclosed are 2,2'-bipyridyl compounds, as well as pharmaceutical compositions and methods of use thereof. One embodiment is a compound having the structure ...
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