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Patent # Description
US-9,981,943 Antifungal compound process
The present invention relates to a process for preparing compound 1 that is useful as an antifungal agent. In particular, the invention seeks to provide new...
US-9,981,942 Piperidine derivatives having multimodal activity against pain
The present invention relates to compounds having dual pharmacological activity towards both the sigma (.sigma.) receptor, and the .mu.-opiod receptor and more...
US-9,981,941 Process for preparing 3-[(4S)-8-bromo-1-methyl-6-(2-pyridinyl)-4H-imidazo[1,2-a][1,4]benzodiaze- ...
A process for preparing 3-[(4S)-8-bromo-1-methyl-6-(2-pyridinyl)-4H-imidazo[1,2-a][1,4]-benzodiaz- epin-4-yl]propionic acid methyl ester benzenesulfonate by...
US-9,981,940 Aryl sulfide derivatives and aryl sulfoxide derivatives as acaricides and insecticides
The present invention relates to aryl sulphide and aryl sulphoxide derivatives, to the use thereof as acaricides and insecticides for controlling animal pests...
US-9,981,939 Compounds and uses thereof for the modulation of hemoglobin
Provide herein are compounds and pharmaceutical compositions suitable as modulators of hemoglobin, methods and intermediates for their preparation, and methods...
US-9,981,938 Quaternary ammonium alkyl esters as stable prodrugs
Disclosed herein are compounds according to Formulas 1-12, compositions comprising these compounds, and methods of lowering intraocular pressure (IOP) or...
US-9,981,937 Orthoformic acid esters as pro-fragrances
The disclosure relates to special orthoformic acid esters of formula (I), as defined herein, which can be used as thermally labile and acid-labile fragrance...
US-9,981,936 Isoflavonoid compositions and methods for the treatment of cancer
Provided herein is a pharmaceutical composition comprising an isoflavonoid derivative and a cyclodextrin. Also provided herein are methods of treating cancer,...
US-9,981,935 Formation of chiral 4-chromanones using chiral pyrrolidines in the presence of acids
The present invention relates to a synthesis of chromanones or chromanes in a stereospecific matter in view of the 2-position in the chromanone or chromane...
US-9,981,934 Enzyme-specific fluorescent compound capable of being retained in cells
Provided is an enzyme-specific fluorescent compound capable of being retained in cells, which can emit fluorescence specifically in a target cell, particularly...
US-9,981,933 Detergent compositions
A surfactant component comprising a compound of formula (I): (I) wherein R.sup.1 is a C.sub.5 to C.sub.39 alkyl or alkenyl group and R.sup.2 is a group of...
US-9,981,932 Bioderived based plasticizers
A bioderived based plasticizer is produced by reacting a bioderived diol (and/or a bioderived alcohol) and a bioderived carboxylic acid in the presence of...
US-9,981,931 Process for the preparation of substituted oxiranes and triazoles
The present invention relates to a process for the preparation of the compounds II ##STR00001## from the respective oxo compounds. Furthermore, he invention...
US-9,981,930 MAGL inhibitors
Provided herein are piperazine carbamates and pharmaceutical compositions comprising said compounds. The subject compounds and compositions are useful as...
US-9,981,929 Method for prevention of premature polymerization
The present invention relates to a method for prevention of premature polymerization during the preparation, purification, transportation and storage of a...
US-9,981,928 Aryl sulfide derivatives and aryl sulfoxide derivatives as acaricides and insecticides
The present invention relates to aryl sulfoxide derivatives, to the use thereof as acaricides and insecticides for controlling animal pests and to processes and...
US-9,981,927 Process for preparation of polymorphic form of Mirabegron
The present invention is directed to process for preparation of .alpha.-form crystal of Mirabegron, ...
US-9,981,926 Heteroaryl butanoic acid derivatives
The present invention describes novel heteroaryl butanoic acid derivatives that are good drug candidates especially with regard to leukotriene A4 hydrolase...
US-9,981,925 Substituted benzo[d][1,2,3]triazines as p70S6K inhibitors
Novel azaquinazoline carboxamide derivatives of formula (I) ##STR00001## wherein W.sup.1, W.sup.2, W.sup.3, W.sup.4, R.sup.1, R.sup.2, R.sup.3 and m which are...
US-9,981,924 Integrated production of urea and melamine
Disclosed is a process for the integrated production of urea and melamine. A urea production zone produces a urea synthesis stream comprising urea, water and...
US-9,981,923 1,2,3 Triazole antifungal agents and preparation thereof
The present application relates to 1,4-disubstituted 1,2,3-Triazole antifungal agents of the formula (I) wherein, R1 is halogens such as fluorine, chlorine or...
US-9,981,922 KDM1A inhibitors for the treatment of disease
Disclosed herein are new compounds and compositions and their application as pharmaceuticals for the treatment of diseases. Methods of inhibition of KDM1A,...
US-9,981,921 Solid forms of substituted 5,6-dihydro-6-phenylbenzo[F]isoquinolin-2-amine compounds
The present application provides solid forms of (R)-6-(2-fluorophenyl)-N-(3-(2-(2-methoxyethylamino)ethyl)phenyl)-5,6-dih- ydrobenzo[h]quinazolin-2-amine...
US-9,981,920 Inhibitors of histone deacetylase
This invention provides compounds that are inhibitors of HDAC2. The compounds (e.g., compounds according to Formula (I), (II), (IIa), (III), (IV), (V), or (VI))...
US-9,981,919 HIV replication inhibiting pyrimidines
This invention concerns HIV replication inhibitors of formula ##STR00001## the N-oxides, the pharmaceutically acceptable addition salts, the quaternary amines...
US-9,981,918 Kynurenine-3-monooxygenase inhibitors, pharmaceutical compositions, and methods of use thereof
Certain chemical entities are provided herein. Also provided are pharmaceutical compositions comprising at least one chemical entity and one or more...
US-9,981,917 Preparation method for revaprazan hydrochloride
Provided is a preparation method for revaprazan hydrochloride, the method comprising: (1) the preparation of ...
US-9,981,916 Pyridazine derivatives as RORc modulators
Compounds of the formula I: ##STR00001## or a pharmaceutical salt thereof, wherein X, Ar.sup.1, R1, R.sup.2, R.sup.3, R.sup.4, R.sup.5, R.sup.6 and R.sup.7...
US-9,981,915 Compounds for treatment of cancer
The present invention relates to colchicine-binding site compounds having anti-cancer activity, compositions comprising the same, and their use for treating...
US-9,981,914 Hydrogen barrier agent, hydrogen barrier film forming composition, hydrogen barrier film, method for producing...
To provide a hydrogen barrier agent capable of imparting hydrogen barrier performance to various materials; a hydrogen barrier film forming composition...
US-9,981,913 Liver X receptor (LXR) modulators
Described herein are liver X receptor (LXR) modulators and methods of utilizing LXR modulators in the treatment of dermal diseases, disorders or conditions....
US-9,981,912 Cocrystal of lorcaserin, preparation methods, pharmaceutical compositions and uses thereof
The present invention relates to a new type of eutectic crystal of lorcaserin hydrochloride and benzoic acid, when compared with the prior art, the eutectic...
US-9,981,911 Process for the preparation of 4-amino-5-fluoro-3-chloro-6-(substituted)picolinates
4-Amino-5-fluoro-3-chloro-6-(substituted)picolinates are prepared from trifluoroacetic acid, p-methoxyaniline, a 3,3-dialkoxyprop-1-yne and a substituted...
US-9,981,910 Substituted pyrrolidines and methods of use
The invention discloses compounds of Formula (I) ##STR00001## wherein R.sup.1, R.sup.2, R.sup.2A, R.sup.3, R.sup.3A, R.sup.4, R.sup.4A, and R.sup.5 are as...
US-9,981,909 Serotonin receptor modulators
Certain biphenyic compounds are serotonin modulators useful in the treatment of serotonin-mediated diseases.
US-9,981,907 Low molecular weight cationic lipids for oligonucleotide delivery
The instant invention provides for novel cationic lipids that can be used in combination with other lipid components such as cholesterol and PEG-lipids to form...
US-9,981,906 Trans-clomiphene metabolites and uses thereof
The present invention relates to substantially pure metabolites of irara-clomiphene. The invention is also directed to pharmaceutical compositions comprising...
US-9,981,905 Aromatic diamine, an intermediate therefor, a method for producing the aromatic diamine, and a method for...
An asymmetric diamine suitable for preparing a soluble polyimide and a method for preparing the same, including a compound represented by the following formula...
US-9,981,904 Process for preparing primary amines using an unsupported cobalt catalyst
The invention relates to a process for preparing primary amines, which comprises hydrogenating at least one nitrile in an apparatus (V1) in the presence of an...
US-9,981,903 Method for preparing di- or tricarboxylic esters by alkoxycarbonylation of dienes having conjugated double bonds
The invention relates to a method for preparing di- or tricarboxylic esters by alkoxycarbonylation of dienes having conjugated double bonds. The method includes...
US-9,981,902 Process for production of an ester and diol from reclaimed carpet material
The current invention pertains to a process for producing a terephthalate ester comprising: providing reclaimed carpet material comprising a polyester...
US-9,981,901 IRE-1.alpha. inhibitors
Compounds which directly inhibit IRE-1.alpha. activity in vitro, prodrugs, and pharmaceutically acceptable salts thereof. Such compounds and prodrugs are useful...
US-9,981,900 Methods of metal oxide nanocrystals preparation
Embodiments relate to methods of metal oxide nanocrystals preparation. In embodiments, a metal-organic precursor may be economically synthesized by reacting a...
US-9,981,899 Composition containing reduced coenzyme Q.sub.10 and production method thereof
The present invention provides a particulate composition wherein an oil component containing reduced coenzyme Q.sub.10 is polydispersed forming a domain in a...
US-9,981,898 Process for oxidation of fatty alkenols to alkenal pheromone products
The present invention relates, in part, to an improved process for oxidation of alcohols containing oxidatively sensitive functional groups, using inexpensive...
US-9,981,897 Ethers of bis(hydroxymethyl)cyclohexanes
The present invention relates to ethers of 1,2-, 1,3- and 1,4-bis(hydroxymethyl)cyclohexanes, to the preparation of such ethers and also to the use of such...
US-9,981,896 Conversion of methane to dimethyl ether
Herein disclosed is a method of producing dimethyl ether (DME) comprising introducing one or more feed streams comprising methane and carbon dioxide into a...
US-9,981,895 Compositions and methods of synthesizing arachidin-3 from resveratrol
Composition, methods of synthesizing trans-arachidin-3; and, methods of use as a dietary supplement, food additive, pharmaceutical, nutraceutical,...
US-9,981,894 Intermediate compounds for producing perfuming ingredients
The present invention relates to the field of chemical processes and, more particularly, it concerns valuable new chemical intermediates of formula (IV) for...
US-9,981,893 Method to synthesize lanthanide fluoride materials from lanthanide fluorinated alkoxides
Lanthanide fluorinated alkoxide derivatives can be synthesized from the alcoholysis reaction of the lanthanide bis-trimethylsilyl amide and an excess amount of...
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