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Patent # Description
US-9,980,978 Compositions and methods for the treatment of neurodegenerative and other diseases
In one embodiment, the present application discloses methods of treating diseases and disorders with sulfasalazine and pharmaceutical formulations of...
US-9,980,977 Modified hyaluronic acid polymer compositions and related methods
The present application provides compositions comprising hyaluronic acid having low levels of functional group modification, mixtures formed by controlled...
US-9,980,976 Use of REDD1 inhibitors to dissociate therapeutic and adverse atrophogenic effects of glucocorticoid receptor...
Disclosed are methods and pharmaceutical compositions for treating diseases, disorders, and conditions associated with glucocorticoid receptor (GR) expression...
US-9,980,975 Dosage forms containing fluticasone propionate for the treatment of inflammatory conditions of the esophagus
The present invention describes novel and improved dosage forms containing fluticasone propionate for the treatment of conditions associated with inflammation...
US-9,980,974 Prostamide-containing intraocular implants and methods of use thereof
Prostamide-containing intraocular implants that biodegrade in the eye and that are effective for reducing intraocular pressure in an eye for a sustained period....
US-9,980,973 Bicyclic heterocycle compounds and their uses in therapy
The invention relates to new bicyclic heterocycle compounds, to pharmaceutical compositions comprising the compounds and to the use of the compounds in the...
US-9,980,972 Rho kinase inhibitors for use in treating familial amyotrophic lateral sclerosis
The invention relates to a new use of a known Rho kinase inhibitor, fasudil or a fasudil derivative selected from hydroy-fasudil or dimethylfasudil, in the...
US-9,980,971 Methods of synthesis and/or purification of diaminophenothiazinium compounds
Disclosed are methods of synthesis and/or purification of certain 3,7-diamino-phenothiazin-5-ium compounds ("diaminophenothiazinium compounds") including...
US-9,980,970 Use of PAR-1 antagonists for preventing and/or treating pelvi-perineal functional pathological conditions
The present invention relates to the use of PAR1 antagonists, in particular of vorapaxar, of atopaxar and of ...
US-9,980,969 Treatment of neurodegenerative diseases, causation of memory enhancement, and assay for screening compounds for...
The invention provides methods of enhancing memory and/or learning and prevent neurodegeneration, comprising administering therapeutically effective amounts of...
US-9,980,968 Compounds and compositions for treating chemical warfare agent-induced injuries
Compounds and compositions for treating injuries caused by exposure to chemical warfare agents are described herein.
US-9,980,967 Method for overcoming drug resistance of EGFR mutation and cancerous stemness of human non-small cell lung...
EGFR mutation (T790M) and cancerous stemness have shown drug resistances in human non-small-cell lung cancer (NSCLC), thus development of novel drugs in...
US-9,980,966 Combinations of cancer therapeutics
The invention relates to combinations of 4-[(S)-2-Azetidin-1-yl-1-(4-chloro-3-trifluoromethyl-phenyl)-ethylamino]-- quinazoline-8-carboxylic acid amide and/or...
US-9,980,965 Treatment of autoimmune disease
Provided herein are compositions and methods for the treatment of autoimmune diseases, including lupus, uveitis and encephalitis. Said compositions useful for...
US-9,980,964 ERK inhibitors and uses thereof
The present invention provides compounds, compositions thereof, and methods of using the same.
US-9,980,963 Treatment of cancer with dihydropyrazino-pyrazines
Provided herein are methods for treating or preventing chronic lymphocytic leukemia, comprising administering an effective amount of a Dihydropyrazino-Pyrazine...
US-9,980,962 Use of sulfonamide inhibitors of Bcl-2 to treat senescence-associated lung conditions such as pulmonary...
Methods are provided herein for selectively killing senescent cells and for treating senescence-associated diseases and disorders by administering a senolytic...
US-9,980,961 Pyruvate kinase activators for use in therapy
Described herein are methods for using compounds that activate pyruvate kinase.
US-9,980,960 Methods for determining the risk of cardiovascular disease in a subject having a chronic viral infection
A method for determining the risk of cardiovascular disease in a subject having a chronic viral infection includes determining a level of ectonucleotide...
US-9,980,959 Method and composition for treating rhinitis
There is provided pharmaceutical compositions for the treatment of rhinitis by, for example, nasal or ocular administration comprising zwitterionic cetirizine,...
US-9,980,958 Polymorphic forms of naltrexone
This invention relates to the discovery of novel polymorphic forms of naltrexone, including solvates, hydrates, anhydrous and other crystalline forms and...
US-9,980,957 Histone deacetylase (HDAC) inhibitors for the treatment of cancer
The present invention relates generally to methods for treating cancer. In one respect, the present invention relates to a method of treating a hematological...
US-9,980,956 Methods and therapeutic combinations for treating tumors
Methods and therapeutic combinations useful for increasing cell-mediated anti-tumor responses are described. The methods include administering to a subject a...
US-9,980,955 Lower dosage strength imiquimod formulations and short dosing regimens for treating genital and perianal warts
Pharmaceutical formulations and methods for the topical or transdermal delivery of 1isobutyl-1H-imidazo[4,5-c]-quinolin-4-amine or ...
US-9,980,954 Quinoline derivatives for inhibiting histone methyltransferases and use thereof
The present disclosure relates to a quinoline derivative which inhibits the activity of histone methyltransferases (ESET/SETDB1) specific for the histone...
US-9,980,953 Combined composition for preventing or treating cancer comprising a benzophenone thiazole derivatives as a VDA...
The present invention relates to a pharmaceutical combined composition for preventing or treating cancer comprising a compound of formula 1 or a ...
US-9,980,952 Modulators of methyl modifying enzymes, compositions and uses thereof
Agents for modulating methyl modifying enzymes, compositions and uses thereof are provided herein.
US-9,980,951 Image guided therapy for cancer
The invention provides a method to treat cancer in an animal comprising administering a tetra-arylethylene cation to the animal.
US-9,980,950 Maternal vitamin B6 administration for the prevention of increased adiposity, overweight or obesity in the...
The present invention generally relates to the early prevention of overweight, obesity, excessive fat accumulation and/or associated metabolic disorders in...
US-9,980,949 SNS-595 and methods of using the same
The present invention relates to SNS-595 and methods of treating cancer using the same.
US-9,980,948 Azaindole derivative having AMPK-activating activity
Disclosed is a compound which is useful as an AMPK activator. A compound represented by formula: ##STR00001## or its pharmaceutically acceptable salt, wherein...
US-9,980,947 Tetrahydro-pyrido[3,4-b]indole estrogen receptor modulators and uses thereof
Described herein are tetrahydro-pyrido[3,4-b]indol-1-yl compounds with estrogen receptor modulation activity or function having the Formula I structure: ...
US-9,980,946 Extended release methazolamide formulation
A once-a-day controlled release oral dosage form of methazolamide is provided. The dosage form comprises a therapeutically effective amount of methazolamide and...
US-9,980,945 Benzoisoxazole-substituted compounds as MGLUR4 allosteric potentiators, compositions, and methods of treating...
Compounds which are useful as allosteric potentiators/positive allosteric modulators of the metabotropic glutamate receptor subtype 4 (mGluR4); synthetic...
US-9,980,944 Preparation of and formulation comprising a MEK inhibitor
The present invention relates to processes for preparing 6-(4-bromo-2-fluorophenylamino)-7-fluoro-3-methyl-3H-benzoimidazole-5-car- boxylic acid...
US-9,980,943 Methods of treating muscular dystrophy
Disclosed herein are .alpha.7.beta.1 integrin modulatory agents and methods of using such to treat conditions associated with decreased .alpha.7.beta.1 integrin...
US-9,980,942 Rejuvenation of precursor cells
The present invention relates generally to methods and pharmaceutical compositions for rejuvenating hematopoietic stem cells and progenitor cells from blood,...
US-9,980,941 Quaternary ammonium anti-cholinergic muscarinic receptor antagonists
A method administers quaternary ammonium anti-cholinergic muscarinic receptor antagonists in combination with acetyl-cholinesterase inhibitors to treat either...
US-9,980,940 Composition for the treatment of neuropathies and/or neuropathic pain
A pharmaceutical composition or dietary supplement is described that is effective in the treatment of neuropathies and/or neuropathic pain, comprising, as the...
US-9,980,939 Composition for enhancing newborn infant cognitive, brain and/or CNS development and method of using same
Disclosed are nutritional compositions generally, and infant formulas specifically, that include a combination of RRR-alpha tocopherol, fat, and protein. The...
US-9,980,938 Method for treatment of diarrhea-predominant irritable bowel syndrome
The present invention provides methods for treating diarrhea-predominant irritable bowel syndrome comprising administering to a patient in need thereof, an...
US-9,980,937 Therapeutic agent for Alzheimer's disease
The present invention aims to provide a pharmaceutical agent for the prophylaxis and/or treatment of Alzheimer's disease, which has a novel action mechanism and...
US-9,980,936 BH4 antagonists and methods related thereto
The disclosure relates to BH4 inhibitors and therapeutic uses relates thereto. In certain embodiments, the disclosure relates to methods of treating or...
US-9,980,935 Method of treating hyperglycemia
Disclosed herein are methods for treating conditions and/or disorders related to hyperglycemia. Such conditions and/or disorders related to hyperglycemia...
US-9,980,934 Monoacylglycerols for use in conjunction with a lipase inhibitor and/or diets low in fat and/or calories
In an embodiment, compositions comprising monoacylglycerols (MAG), such as sn-1(3) MAG, are administered with a lipase inhibitor, such as tetrahydrolipstatin,...
US-9,980,933 Thyroid hormone analogs and methods of use
Disclosed are methods of treating subjects having conditions related to angiogenesis including administering an effective amount of a polymeric form of thyroid...
US-9,980,932 Valaciclovir and meloxicam combination therapy for functional somatic syndromes
The present invention relates to pharmaceutical compositions comprising a combination of a therapeutically-effective amount of the antiviral compound...
US-9,980,931 Use of glycyl glutamine against depression
A prophylactic or therapeutic agent is provided for depression (including each subtype according to DSM-IV of depression) or anxiety by increasing the levels of...
US-9,980,930 Imaging composition and uses thereof
The invention discussed in this application relates to hydroxamic acid-based compounds that are useful as imaging agents when bound to an appropriate metal...
US-9,980,929 Trifluoromethylpropanamide derivatives
The invention provides novel compounds having the general formula (I) ##STR00001## wherein R.sup.1, R.sup.2, R.sup.3, R.sup.4, R.sup.5, R.sup.6 and R.sup.7 are...
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