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Patent # Description
US-9,988,674 Full interrogation of nuclease DSBs and sequencing (find-seq)
Sensitive, unbiased methods for genome-wide detection of potential off-target nuclease cleavage sites in DNA, e.g., in cell type-specific genomic DNA samples.
US-9,988,673 Nucleic acid production and sequence analysis
A method for producing a nucleic acid molecule from a template nucleic acid sequence and a linking unit attached to a primer, which method comprises a step of...
US-9,988,672 Methylcytosine detection method
To provide a method for selectively detecting the methylation of particular cytosines in genomic DNA using a methylcytosine detection method using an...
US-9,988,671 Diagnostic probe detection system
The invention provides methods for detecting target nucleic acid sequences with diagnostic probes including first and second probe regions that are...
US-9,988,670 Methods and compositions for detecting antibiotic resistant bacteria
Primers and probes specific to genes encoding carbapenem-resistant Enterobacteriaceae (CREs) that include KPC (Klebsiella pneumoniae carbapenemase), NDM-1 (New...
US-9,988,669 Medium used for blood sample collection and transport
The present invention provides materials and methods for the stable transport of aqueous biological samples without refrigeration. Samples stabilized and...
US-9,988,668 Apparatus for amplification of nucleic acids
Described herein is a chip-based apparatus for amplifying nucleic acids, a cartridge housing the apparatus, and methods of using the apparatus for amplification...
US-9,988,667 Device and methods for epigenetic analysis
Provided herein are methods and devices for single object detection. The methods and devices can be used to identify a plurality of epigenetic markers on a...
US-9,988,666 Resonance energy transfer assay with cleavage sequence and spacer
Methods for the identification of inhibitors of botulinum neurotoxins are described. Cells are provided that are genetically engineered to express peptides that...
US-9,988,665 Methods for determining protein binding specificity using peptide libraries
A method for determining protein binding specificity using a screen of a peptide library is provided. The method can be used to determine binding specificity...
US-9,988,664 Fiber sampler for recovery of bioaerosols and particles
A bioparticle collection device and an aerosol collection system. The bioparticle collection device includes a collection medium including a plurality of fibers...
US-9,988,663 Method for collecting biological material and device for collecting biological material
Provided is a device for collecting biological material from a microbe, the device including: a collection container that is used to collect a microbe from a...
US-9,988,662 Use of low temperature and/or low pH in cell culture
The present disclosure provides a method of reducing protein misfolding and aggregation in the cell culture by growing the cell culture at a reduced temperature...
US-9,988,661 Process for the modification of a glycoprotein using a glycosyltransferase that is or is derived from A ...
The present invention relates to a process for the enzymatic modification of a glycoprotein. The process comprises the step of contacting a glycoprotein...
US-9,988,660 Compositions and methods for cDNA synthesis
Methods for making eDNA molecules, for amplification of RNA by PCR and for preparation of cDNA libraries are provided. Kits for making eDNA molecules also are...
US-9,988,659 In vivo conversion of nucleosides in plasmid DNA
The instant invention provides for the assembly of large DNA oligonucleotide constructs by the self-assembly of multiple oligonucleotide fragments, wherein the...
US-9,988,658 Process for the hydrolysis of biomass
The present invention is directed to a process for the hydrolysis of biomass as well as the saccharide-containing permeate product and the protein-containing...
US-9,988,657 Enzymatic hydrolysis of disaccharides and oligosaccharides using alpha-glucosidase enzymes
A method is disclosed for hydrolyzing an alpha-1,3 or alpha-1,6 glucosyl-glucose linkage in a saccharide (disaccharide or oligosaccharide). This method...
US-9,988,656 Microorganisms and methods for the coproduction 1,4-butanediol and gamma-butyrolactone
The invention provides non-naturally occurring microbial organisms comprising 1,4-butanediol (14-BDO) and gamma-butyrolactone (GBL) pathways comprising at least...
US-9,988,655 Use of inducible promoters in the production of methionine
The present invention relates to use of inducible promoters in the production of methionine by fermentation. The present invention concerns a method for the...
US-9,988,654 Methods, reagents and cells for biosynthesizing compounds
This document describes biochemical pathways for producing 2,3-dehydroadipyl-CoA methyl ester from precursors such as 2-oxoglutarate using one or more of a...
US-9,988,653 Method and apparatus for CO.sub.2 sequestration
Processes, methods, and apparatus for carbon sequestration utilizing catalysis schemes configured to provide high concentrations of hydrated CO.sub.2 in...
US-9,988,652 Yeast expressing cellulases for simultaneous saccharification and fermentation using cellulose
The present invention is directed to cellulytic host cells. The host cells of the invention expressing heterologous cellulases and are able to produce ethanol...
US-9,988,651 Processes for increasing bioalcohol yield from biomass
A process for increasing alcohol yield from biomass (the form or agro- or forest residue, grains, hops, etc.), involving multiple hydrodynamic cavitation...
US-9,988,650 Electron consuming ethanol production pathway to displace glycerol formation in S. cerevisiae
The present invention provides for a mechanism to completely replace the electron accepting function of glycerol formation with an alternative pathway to...
US-9,988,649 Yeast strains engineered to produce ethanol from acetic acid and glycerol
The present invention relates to processes for producing ethanol from lignocellulosic hydrolysates comprising hexoses, pentoses and acetic acid, whereby...
US-9,988,648 Microorganisms and methods for producing alkenes
The invention provides non-naturally occurring microbial organisms containing an alkene pathway having at least one exogenous nucleic acid encoding an alkene...
US-9,988,647 Methods of anaerobic digestion of biomass to produce biogas
Improved methods for anaerobic digestion of organic matter to produce biogas. Among the improvements given are including ferric iron in a hydrolysis reactor to...
US-9,988,646 Methods of anaerobic digestion of biomass to produce biogas
Improved methods for anaerobic digestion of organic matter to produce biogas. Among the improvements given are including ferric iron in a hydrolysis reactor to...
US-9,988,645 Vectors with modified initiation codon for the translation of AAV-REP78 useful for production of AAV
The present invention relates nucleic acid constructs for the production of recombinant parvoviral (e.g. adeno-associated viral) vectors in insect cells, to...
US-9,988,644 Compounds for improved viral transduction
The present invention provides methods and compositions for improving the efficacy of viral transduction of cells. More particularly, the present invention...
US-9,988,643 Chimeric nucleic acid molecules with non-AUG translation initiation sequences and uses thereof
The present disclosure relates to nucleic acid vaccine compositions and methods for preventing or treating pathological conditions, such as cancer or infectious...
US-9,988,642 Identification and use of target genes for control of plant parasitic nematodes
The invention relates to identifying and evaluating target coding sequences for control of plant parasitic nematodes by inhibiting one or more biological...
US-9,988,641 Compositions and methods for producing starch with novel functionality
This invention disclosure relates to novel maize starch. The starch can be made from the newly developed waxy sugary-2 double-mutant maize that has low activity...
US-9,988,640 Nucleic acid sequences encoding transcription factors regulating alkaloid biosynthesis and their use in...
Plant metabolism and alkaloid levels can be regulated by transcription factors that regulate the nicotinic alkaloid biosynthetic pathway. In one embodiment, the...
US-9,988,639 Method for breeding Brassica rapa plant having self-compatibility
The problem of providing a technology that converts a Brassica rapa plant having self-incompatibility to having self-compatibility is addressed. The problem is...
US-9,988,638 Synthetic bi-directional plant promoter
This disclosure concerns compositions and methods for promoting transcription of a nucleotide sequence in a plant or plant cell, employing a minimal core...
US-9,988,637 Cas9 plasmid, genome editing system and method of Escherichia coli
A Cas9 expression plasmid, a genome editing system and a genome editing method for Escherichia coli are provided. The Cas9 expression plasmid includes a...
US-9,988,636 SDF-1 binding nucleic acids and the use thereof
The present invention is related to a nucleic acid molecule binding to SDF-1, whereby the nucleic acid molecule influences migration of cells.
US-9,988,635 Modulation of growth hormone receptor expression and insulin-like growth factor expression
Compounds, compositions and methods are provided for modulating the expression of growth hormone receptor and/or insulin like growth factor-I (IGF-I). The...
US-9,988,634 Polynucleotide molecules for gene regulation in plants
This invention provides polynucleotide molecules and methods for regulating genes in plants, e. g., by providing RNA for systemic regulation of genes. Various...
US-9,988,633 Compositions and methods to promote erythropoiesis
Described herein are compositions and methods for enhancing erythropoiesis in an individual in need thereof. Specifically agents that decrease the expression of...
US-9,988,632 Composition including pint gene expression inhibitor or pint activity inhibitor and use thereof
Provided are a composition for stimulating DNA damage in cells, the composition including a p53 induced non-coding transcript (PINT) gene expression inhibitor...
US-9,988,631 Pharmaceutical composition comprising Nanog shRNA, and method of using Nanog shRNA to treat cancer
The present description relates to an inhibitory RNA molecule, comprising an oligonucleotide that selectively knocks down expression a Nanog pseudogene...
US-9,988,630 Methods and compositions for the specific inhibition of gene expression by double-stranded RNA
The invention provides compositions and methods for selectively reducing the expression of a gene product from a desired target gene, as well as treating...
US-9,988,629 Antisense nucleic acids
Provided is a drug that allows highly-efficient skipping of exon 51 in the human dystrophin gene. The present invention provides an antisense oligomer which...
US-9,988,628 Agents useful in treating facioscapulohumeral muscular dystrophy
The invention teaches antisense agents and RNA interference agents useful for treating diseases and conditions the treatment of which can benefit from reducing...
US-9,988,627 Formats for organic compounds for use in RNA interference
The disclosure relates to compositions comprising a RNAi agent having a novel format including a spacer subunit. The disclosure relates to compositions...
US-9,988,626 Neurocalcin delta inhibitors and therapeutic and non-therapeutic uses thereof
The present invention relates to an inhibitor of neurocalcin delta (NCALD) for use in a method for the treatment or prevention of a patient suffering from a...
US-9,988,625 Templates, libraries, kits and methods for generating molecules
The present invention is directed to collections of templates for molecules such as RNA, as well as templates, devices, kits and methods for generating...
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