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Patent # Description
US-9,988,473 Polyethylene composition and articles made therefrom
A polyethylene composition comprising at least 95 percent by weight of the units derived from ethylene; less than 5 percent by weight of units derived from one...
US-9,988,472 Composition, electronic device, and thin film transistor
A composition includes a product of a condensation reaction between a thermal cross-linking agent and a product of hydrolysis and condensation polymerization of...
US-9,988,471 Catalysts for producing polymers with enhanced properties
Disclosed are novel hafnium-based metallocene catalyst compounds with the following characteristics: 1) 4,5-dialkyl substitutions on a fluorenyl ligand, and...
US-9,988,470 Boron-Bridged metallocene catalyst systems and polymers produced therefrom
Disclosed herein are catalyst compositions containing boron bridged, cyclopentadienyl-indenyl metallocene compounds with an alkenyl substituent. These catalyst...
US-9,988,469 Method for preparing polyolefin and polyolefin prepared thereby
The present invention relates to a method for preparing polyolefin that can easily and effectively prepare polyolefin having high molecular weight and various...
US-9,988,468 Methods of preparing a catalyst
A method of preparing a catalyst comprising a) contacting (i) a silica-support, (ii) an oxotitanium compound, (iii) a chromium-containing compound, and (iv) an...
US-9,988,467 Polymerization process for the production of high density polyethylene
The invention relates to a polymerization process for the production of high density polyethylene by polymerization of ethylene in the presence of a catalyst...
US-9,988,466 Benzocrown ether graft polymer with lithium isotopic separation effect and preparation method thereof
Disclosed in the present invention is a benzocrown ether graft polymer with a lithium isotopic separation effect and a preparation method thereof. The polymer...
US-9,988,465 Metallocene catalyst supported by hybrid supporting means, process for producing same, polymerization process...
The present invention describes a metallocene catalyst based on a transition metal of group 4 or 5 of the periodic table, supported on a hybrid catalytic...
US-9,988,463 Thrombin-binding antibody molecules and uses thereof
This invention relates to isolated antibodies which recognise the exosite 1 epitope of thrombin and selectively inhibit thrombin without promoting bleeding....
US-9,988,462 Material and methods for treating or preventing HER-3 associated diseases
Described herein are materials and methods for treating subjects having a HER-3 associated disease, by administering a first agent that binds to HER-3, in...
US-9,988,461 Thrombin-binding antibody molecules and uses thereof
This invention relates to isolated antibodies which recognise the exosite 1 epitope of thrombin and selectively inhibit thrombin without promoting bleeding....
US-9,988,460 Crystal structures of heterodimeric Fc domains
Disclosed are the atomic coordinates of compositions comprising Fc heterodimer proteins in crystalline form derived from high resolution x-ray diffraction....
US-9,988,459 Anti-IFNAR1 antibodies with reduced Fc ligand affinity
The invention provides anti-IFNAR1 antibodies with reduced affinity for Fc receptors and/or ligands and methods of making and using such antibodies.
US-9,988,458 Antibodies against human CSF-1R and uses thereof
The present invention relates to antibodies against human CSF-1R (CSF-1R antibody), methods for their production, pharmaceutical compositions containing said...
US-9,988,457 Human C-FMS antigen binding proteins
Antigen binding proteins that bind to human c-fms protein are provided. Nucleic acids encoding the antigen binding protein, vectors, and cells encoding the same...
US-9,988,456 Fusion immunomodulatory proteins and methods for making same
The present invention relates generally to the field of generating recombinant chimeric fusion proteins to be used in the cancer therapy, and more specifically,...
US-9,988,455 Methods of treating cardiovascular disorders with lectin-like oxidized LDL receptor 1 antibodies
The present invention relates to monoclonal antibodies binding to human lectin-like oxidized LDL (low density lipoprotein) receptor 1 (hereinafter, sometimes...
US-9,988,454 Peptide core-based multi-arm linkers for treating central nervous system diseases
The present disclosure provides various molecular constructs having a targeting element and an effector element. Methods for treating various diseases using...
US-9,988,453 Human monoclonal antibodies to O8E
The present disclosure provides isolated monoclonal antibodies, particularly human monoclonal antibodies that specifically bind to O8E with high affinity....
US-9,988,452 Antibody molecules to PD-L1 and uses thereof
Antibody molecules that specifically bind to PD-L1 are disclosed. Combination therapies comprising the anti-PD-L1 antibody molecules are also disclosed. The...
US-9,988,451 HIV-1 vaccine
A method for inducing an immune response against HIV in a subject includes the step of preparing an HIV-1 gp120 envelope protein coding sequence particle having...
US-9,988,450 Anti-PD1 antibodies and their use as therapeutics and diagnostics
Provided are antibodies that specifically bind to Programmed Death-1 (PD1, Pdcd-1, or CD279) and inhibit PD1-mediated cellular signaling and activities in...
US-9,988,449 Plexin D1 as a target for tumor diagnosis and therapy
The present invention relates to plexin D1 for use as a targetable protein in the treatment or diagnosis of disorders that involve expression of plexin D1....
US-9,988,448 DC-STAMP antibodies
Provided herein are antibodies that specifically bind an epitope of DC-STAMP. Specifically, provided herein are monoclonal antibodies that bind an epitope of...
US-9,988,447 Treatment of diabetes
Glycated hemoglobin (HbA1c) levels and other characteristics of diabetes are reduced by administering to a human subject a pharmaceutical composition that...
US-9,988,446 Methods of treatment using antibodies which bind IL-17A and IL-17F
The invention relates to antibody molecules having specificity for antigenic determinants of both IL-17A and IL-17F, therapeutic uses of the antibody molecules...
US-9,988,445 Method of treatment of pain by administration of a CCL17 specific antibody
A protocol for pain management includes a pharmaceutical composition and its use in ameliorating the sensation of pain. The protocol includes the use of a CCL17...
US-9,988,444 Polypeptides comprising a modified bacteriophage g3p amino acid sequence with reduced immunogenicity
The invention relates to polypeptides that comprise a portion of filamentous bacteriophage gene 3 protein (g3p) sufficient to bind to and/or disaggregate...
US-9,988,442 MFAP4 binding antibodies blocking the interaction between MFAP4 and integrin receptors
Microfibrillar-associated protein 4 (MFAP4) binding antibodies are provided to prevent or to inhibit the proliferation of vascular smooth muscle cells and...
US-9,988,441 Methods of treating hemolytic disorders comprising administering anti-Bb antibodies
A method of treating a hemolytic disorder in a subject in need thereof includes administering to the subject a therapeutically effective amount of an antibody...
US-9,988,440 Compositions comprising antibodies targeting factor P
The present invention relates to antibodies or antigen binding fragments thereof that bind to complement Factor P and used thereof as well as combinations of...
US-9,988,439 Immunoglobulins and variants directed against pathogenic microbes
Anti-SpA murine, chimeric and humanized monoclonal antibodies, and variant antibodies having a heavy chain with at least one amino acid substitution are...
US-9,988,438 Anti-HIV dual specificity antibodies and methods of HIV treatment
Dual variable domain immunoglobulins (DVD Igs) are provided capable of tetravalent binding to bispecific sites of the human immunodeficiency virus (HIV). The...
US-9,988,437 Anti-human Respiratory Syncytial Virus (RSV) antibodies and methods of use
Provided herein are antibodies or antigen-binding fragments thereof that immunospecifically bind to the fusion (F) protein of Respiratory Syncytial Virus (RSV)....
US-9,988,436 Composite comprising antibody capable of binding to intranuclear protein of influenza virus
The present invention provides a composite comprising a novel antibody and at least one selected from the group consisting of a solid phase support and a...
US-9,988,435 Composite comprising antibody capable of binding to intranuclear protein of influenza virus
The present invention provides a composite comprising a novel antibody and at least one selected from the group consisting of a solid phase support and a...
US-9,988,434 Optimal interstrand bridge for collagen mimics
Novel collagen-mimetic peptides are disclosed comprising the formula (Xaa-Yaa-Gly).sub.n, where the amino acid at one of the Xaa positions is substituted with a...
US-9,988,433 Covalent modification of biological macromolecules
The present disclosure provides a method of covalently modifying a biological macromolecule, the method comprising subjecting a reaction mixture comprising: (a)...
US-9,988,432 Peptides and combination of peptides for use in immunotherapy against various tumors
The present invention relates to peptides, proteins, nucleic acids and cells for use in immunotherapeutic methods. In particular, the present invention relates...
US-9,988,431 Dendritic cell marker and uses thereof
The present invention relates to the identification of proteins located on the cell surface of dendritic cells or precursors thereof, particularly antigen...
US-9,988,430 Stable GLP-1 based GLP-1/glucagon receptor co-agonists
New GLP-1 derivatives, compositions thereof and their use in medicine.
US-9,988,429 Glucagon analogues
The invention provides materials and methods for the treatment of obesity and excess weight, diabetes, and other associated metabolic disorders. In particular,...
US-9,988,428 Pegylated bioactive peptides and uses thereof
Described herein are bioactive peptides that are modified at one or more positions with a PEG moiety. An example of such a PEGylated bioactive peptide is a GHRH...
US-9,988,427 Erythropoietin variants
The present invention relates to novel endogenous variants of erythropoietin (EPO) and their use for treatment or prevention of a condition associated with...
US-9,988,426 Broad spectrum conjugate vaccine to prevent Klebsiella pneumoniae and Pseudomonas aeruginosa infections
The present invention is drawn to conjugates and vaccine compositions comprising a Pseudomonas flagellin or an antigenic fragment or derivative thereof linked...
US-9,988,425 Immunogens for HIV vaccination
The present invention relates to novel immunogens based on overlapping peptides (OLPs) and peptides derived therefrom useful for the prevention and treatment of...
US-9,988,424 Immunogens comprising human immunodeficiency virus V1/V2 polypeptides
The invention is generally directed to V1V2 immunogens.
US-9,988,423 Organogels and emulsions for biological and non-biological applications
The present invention relates to organogels and emulsions based on ultrasmall self-assembling peptides. It further relates to methods for producing such...
US-9,988,422 Aromatic-cationic peptides and methods for using same
The present disclosure provides methods of preventing or treating renal ischemia-reperfusion injury in a mammalian subject and methods for chronic treatment of...
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