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Patent # Description
US-9,988,421 Dipeptides as inhibitors of human immunoproteasomes
The compounds of the present invention are represented by the following compounds having Formula (I) where the substituents R.sup.1-R.sup.10, X, Y, k, m, n, q,...
US-9,988,420 Cytotoxic peptides and conjugates thereof
Disclosed herein are novel cytotoxic peptides of formula (I) as described herein: ##STR00001## and the use of such peptides in making immunoconjugates (i.e...
US-9,988,419 Protein purification methods
A method for the purification of a desired protein from a protein preparation includes conditioning the protein preparation by treatment with soluble organic...
US-9,988,418 Methods for reducing aggregate levels in protein preparations by treatment with thio-heterocyclic cations
A method of reducing the aggregate content in a protein preparation having a target protein includes contacting the protein preparation with a thio-heterocyclic...
US-9,988,417 Process for the preparation of estetrol
The invention relates to a process for obtaining Estetrol or a salt or solvate thereof, the process comprising: a) reacting a compound of formula (IV) or a salt...
US-9,988,416 Alkynyl nucleoside analogs as inhibitors of human rhinovirus
The present invention provides a compound of Formula (I) or a salt thereof; ##STR00001## and therapeutic uses of these compounds. The invention further...
US-9,988,415 Glycoside compound, method for producing thioether, ether, method for producing ether, method for producing...
The invention provides a glucoside compound, which is capable of providing a phosphoramidite, which can be produced at low cost and can produce a nucleic acid...
US-9,988,414 Non-caloric sweetener
Disclosed is a steviol glycoside referred to as rebaudioside D3. Rebaudioside D3 has five .beta.-D-glucosyl units connected to the aglycone steviol. Also...
US-9,988,413 Process for conversion of hemicellulose into C5 sugars using ionic liquids
The present invention discloses one pot process for the conversion of hemicellulose into C5 sugars using ionic liquids in water media.
US-9,988,412 Methods for preparing thermally stable lignin fractions
The present invention relates to fractions of high purity lignin which are thermally stable, and to methods of producing said fractions from lignocellulosic...
US-9,988,411 Thin-film-forming material including a molybdenum imide compound
In the method of the present invention for producing a thin film, including introducing, onto a substrate, a vapor that has been obtained by vaporizing a...
US-9,988,410 Substituted bis indenyl metallocene catalyst compounds comprising-Si--Si-bridge
This invention relates to novel bridged bis indenyl metallocene catalyst compounds where the bridge is --((R.sup.15*).sub.2Si--Si(R.sup.15).sub.2)-- wherein,...
US-9,988,409 Multi-dimensional networks
Described herein are multi-dimensional networks that can include a recurring unit of Formula (I) and a recurring unit of Formula (II), and methods of...
US-9,988,408 Cytotoxic agents for conjugation to a cell binding molecule
The present invention is related to novel cytotoxic agents, pyrrolo[2,1-c][1,4]benzodiazepine (PBD) derivatives, their conjugates with a cell-binding agent, the...
US-9,988,407 Prodrugs of prostate specific membrane antigen (PSMA) inhibitor
Methods and compounds are disclosed for treating a disease or condition by inhibiting PSMA (Prostate Specific Membrane Antigen) using prodrugs of 2-PMPA.
US-9,988,406 Forms of R)-3-(4-(2-(2-methyltetrazol-5-yl)pyridin-5-yl)-3-fluorophenyl)-5- -hydroxymethyl oxazolidin-2-one...
A crystalline form of crystalline (R)-3-(4-(2-(2-methyltetrazol-5-yl)-pyridin-5-yl)-3-fluorophenyl)-5-hydro- xymethyl oxazolidin-2-one dihydrogen phosphate,...
US-9,988,405 O-phenyl chalcone compounds and uses thereof
Disclosed are an o-phenyl chalcone compounds and preparation methods and uses thereof. The o-phenyl chalcone compounds are capable of inhibiting the aggregation...
US-9,988,404 Ester-modified organosilicon-based surfactants, methods of making same and applications containing the same
There is provided herein a polyalkylene-oxide-free surfactant composition comprising an ester-modified organosilicon having the general formula (I) ...
US-9,988,403 Compositions and methods for treating cancer with aberrant lipogenic signaling
The technology described herein relates to dimethyl boronate esters of the following formula for the treatment of cancers expressing abnormally high levels of...
US-9,988,402 Amine-boranes bearing borane-intolerant functionalities
Disclosed herein is the preparation of functional group containing amine-boranes from the corresponding amines. The mild reaction conditions allow for the...
US-9,988,401 Crystalline forms of a PI3K inhibitor
The present invention is related to crystalline forms of (S)-7-(1-(9H-purin-6-ylamino) ethyl)-6-(3-fluorophenyl)-3-methyl-5H-thiazolo[3,2-a]pyrimidin-5-one ...
US-9,988,400 Thiazolopyrimidinones and methods of use thereof
The present invention relates to certain thiazolopyrimidinone compounds, pharmaceutical compositions comprising such compounds, and methods of treatment using...
US-9,988,399 Bicyclic compounds as ACC inhibitors and uses thereof
The present invention provides compounds useful as inhibitors of Acetyl CoA Carboxylase (ACC), compositions thereof, and methods of using the same.
US-9,988,398 Crystalline form of rifaximin and process for its preparation
A novel crystalline form of rifaximin and process for its preparation are described. A pharmaceutical composition comprising crystalline rifaximin is also...
US-9,988,397 ERK inhibitors
The present invention provides a compound of Formula (I) or the pharmaceutically acceptable salts, esters, and prodrugs thereof, which are ERK2 inhibitors. The...
US-9,988,396 Oxaziridine compound and production method thereof
Provided are an oxaziridine compound showing an antifungal activity and cytotoxicity and expected as a new antifungal agent or anticancer agent, and a...
US-9,988,395 Antiparasitic compositions and methods utilizing substituted ...
The present disclosure relates generally to systems, methods, and compounds for therapeutic use against parasitic infections. More particularly, the disclosure...
US-9,988,394 Oxabicycloheptane prodrugs
The present invention provides a compound having the structure: ##STR00001##
US-9,988,393 Isosorbide-based polymethacrylates
A monomer comprises the structure ##STR00001## wherein R.sup.1 comprises H or a substituted hydrocarbyl or unsubstituted hydrocarbyl, and wherein R.sup.2...
US-9,988,392 7-beta-alkyl analogs of orvinols
The application is directed to compounds of Formula (I) and pharmaceutically acceptable salts and solvates thereof, wherein R.sup.1, R.sup.1a, R.sup.1b,...
US-9,988,391 TBK/IKK inhibitor compounds and uses thereof
The present invention relates to compounds of Formula I and pharmaceutically acceptable compositions thereof, useful as TBK/IKK.epsilon. inhibitors.
US-9,988,390 Pyrimidone derivatives and their use in the treatment, amelioration or prevention of a viral disease
The present invention relates to compounds having the general formula (Ia) or (Ib), optionally in the form of a pharmaceutically acceptable salt, solvate,...
US-9,988,389 Processes for making ponatinib and intermediates thereof
Methods are disclosed for making 3-(imidazo[1,2-b]pyridazin-3-ylethynyl)-4-methyl-N-[4-[(4-methylpiperazin- -1-yl)methyl]-3-(trifluoromethyl)phenyl]benzamide,...
US-9,988,388 Synthesis of imidazo[1,2-a]pyrazin-4-ium salts for the synthesis of 1,4,7-triazacyclononane (tacn) and N-...
A compound with formula (V') ##STR00001## the synthesis method for compound (V'), and its use for the preparation of 1,4,7-triazacyclononane (tacn) and N-...
US-9,988,387 Imidazo[1,2-B][1,2,4]triazines as c-Met inhibitors
The present invention relates to imidazo[1,2-b][1,2,4]triazines that are inhibitors of c-Met and are useful in the treatment of c-Met associated diseases...
US-9,988,386 Compounds for treatment of diseases of abnormal angiogenesis or aberrant growth factors and uses thereof
The present invention provides novel compounds of any one of Formulae (I)-(IV), and pharmaceutical compositions thereof. Also provided are particles (e.g.,...
US-9,988,385 Strongly fluorescent heterocycles and a method for their synthesis
This invention provides 1,4-dihydropyrrolo[3,2-b]pyrrole derivatives which can be used as strongly fluorescent compounds and a one-stage method for their...
US-9,988,384 Aurora kinase inhibitors for inhibiting mitotic progression
The present invention relates to compounds and methods for the treatment of cancer. In particular, the invention provides potent inhibitors of Aurora A kinase,...
US-9,988,383 Purine derivatives as modulators of TNF activity
A series of substituted purine derivatives, being potent modulators of human TNF.alpha. activity, are accordingly of benefit in the treatment and/or prevention...
US-9,988,382 [9,10-dimethoxy-3-(2-methylpropyl)-1H,2H,3H,4H,6H,7H,11bH-pyrido-[2,1-A]is- oquinolin-2-yl]methanol and...
Compounds having a structure of formula (I), including stereoisomers and pharmaceutically acceptable salts and solvates thereof: ##STR00001## wherein R.sub.1...
US-9,988,381 Five-member-heterocycle fused pyridine compounds, method of producing the same, and use thereof
This invention provides a class of five-member-heterocycle fused pyridine compounds as shown below in Formula (X), pharmaceutically acceptable salts or...
US-9,988,380 Quorum sensing inhibitors
The invention relates to compounds for use as quorum sensing inhibitors, and in particular, to quorum sensing inhibitors of Pseudomonas aeruginosa.
US-9,988,379 GPR40 receptor agonist, methods of preparing the same, and pharmaceutical compositions containing the same as...
The present invention relates to a novel compound having GPR40 receptor agonist activity that promotes insulin secretion and inhibits blood sugar rise after...
US-9,988,377 Small molecule inducers of GDNF as potential new therapeutics for neuropsychiatric disorders
This invention provides a compound having the structure ##STR00001## wherein A is a ring structure, with or without substitution; Z is present or absent and...
US-9,988,376 Benzothiophene derivatives as estrogen receptor inhibitors
A compound of formula (I): ##STR00001## or a pharmaceutically acceptable salt thereof, compositions, combinations and medicaments containing said compounds...
US-9,988,375 Inhibitors of lysine gingipain
The present invention relates generally to therapeutics targeting the bacterium Porphyromonas gingivalis, including its protease Lysine gingipain (Kgp), and...
US-9,988,374 Cytochrome P450 inhibitors and uses thereof
The present invention provides compounds having the general structural formula (I) (I) and pharmaceutically acceptable derivatives thereof, as described...
US-9,988,373 Nitrogen-containing six-membered cyclic derivatives and pharmaceutical composition comprising the same
A compound represented by formula (I): ##STR00001## wherein Z.sub.1 is C(R.sup.2) or N; Z.sub.3 is CH or N; Z.sub.2 is C(R.sup.3) or N; provided that...
US-9,988,372 Crystalline form of 5-chloro-N-({(5S)-2-oxo-3-[4-(5,6-dihydro-4H-[1,2,4]triazin-1-yl)phenyl]-- ...
The present invention relates to a novel crystalline form of 5-chloro-N-({(5S)-2-oxo-3-[4-(5,6-dihydro-4H-[1,2,4]triazin-1-yl)phenyl]-- ...
US-9,988,371 Benzimidazole analogues and related methods
The invention relates to compounds of the formula (VIII) wherein the moieties R.sub.1, R.sub.2, R.sub.3, R.sub.4, and R.sub.5 are as defined in the...
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