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Patent # Description
US-9,987,308 Method and compositions for cellular immunotherapy
The present invention provides methods and compositions to confer and/or augment immune responses mediated by cellular immunotherapy, such as by adoptively...
US-9,987,307 Tolerogenic dendritic cells, methods of producing the same, and uses thereof
Described herein are methods for the preparation of stable semi-mature tolerogenic dendritic cells and compositions comprising such stable semi-mature...
US-9,987,306 Materials and methods for prevention and treatment of diarrhea and inflammation in the gastrointestinal tract
The present invention pertains to the use of the calcium-sensing receptor (CaSR)-activating nutrients (designated as "CaSR-based nutrients") for the prevention...
US-9,987,305 Antimicrobial skin cream
Some embodiments of the present disclosure include a cream for treating the skin. The cream may include gray clay kaolin; sodium lauryl ether sulfate; blue...
US-9,987,304 Method and topical composition for the treatment of Rosacea and skin erythema using selenium sulfide
A method for the treatment of facial Rosacea and skin erythema using selenium sulfide as the sole active ingredient in a topically applied administration to a...
US-9,987,302 Methods of treating DNA damage
The present invention relates to methods and compositions of treating patients suffering from, or at risk for, DNA damage and to increase life span, i.e.,...
US-9,987,301 Heparin-based compositions and methods for the inhibition of metastasis
The invention provides the use in combination of a heparin containing composition that has anticoagulant activity when used alone, such as an unfractionated...
US-9,987,300 Polyinosinic-polycytidylic acid (poly (I:C)) formulations for the treatment of upper respiratory tract infections
The present invention concerns a composition comprising micro particles of polyinosinic-polycytidylic acid (Poly (I:C)) and a carrier polymer selected from...
US-9,987,299 Methods of improving RNAi in well-differentiated airway epithelia
The present invention relates to methods of reducing a level of a target mRNA in a well-differentiated airway epithelial cell by contacting the cell with a...
US-9,987,298 Aptamer for FGF2 and use thereof
Provided by the present invention are an aptamer having an inhibitory activity on FGF2; a complex containing an aptamer having a binding activity or an...
US-9,987,297 Polymeric fibers having tissue reactive members
A method for bonding a polymeric fiber to tissue is provided which includes providing a polymeric fiber having a plurality of tissue reactive members linked to...
US-9,987,296 Compositions including anthocyanin or anthocyanidin for the prevention or treatment of Articular...
Methods of treating an arthritic joint of a subject, including administering a pharmaceutical composition by injection into the arthritic joint, wherein the...
US-9,987,295 Compounds for the treatment of addiction
Disclosed are novel compounds having the structure of Formula (I): ##STR00001## which are useful for treating mammals for dependence upon substances of...
US-9,987,294 Mitochondria-targeted anti-tumor agents
Described are mitochondria-targeted anti-tumor agents, and methods of making and using the same for the treatment of disorders associated with unwanted cell...
US-9,987,293 Method for treating chronic lymphocytic leukemia
The present disclosure provides methods for treating chronic lymphocytic leukemia (CLL) with medicaments useful for same. The medicaments can be pharmaceutical...
US-9,987,292 Method for treatment of diseases
The invention provides a method of inhibiting vascular hyperpermeability in an animal in need thereof. The method comprises administering a ...
US-9,987,291 Synthetic bile acid compositions and methods
Bile acids and related compositions and methods of synthesis and use. More specifically, deoxycholic acid and related compositions, said compositions being free...
US-9,987,290 Methods for the separation and detection of an oxysterol
Assay methods for determining purity of a sample of a sterol are provided. These methods include providing an HPLC eluent including a sterol, other compounds...
US-9,987,289 Slow release oxysterols and methods of use
Provided is a slow release composition to promote bone growth, the slow release composition comprising: an oxysterol encapsulated in a biodegradable polymer to...
US-9,987,288 Methods and materials for reducing supression of immune function
This document provides methods and materials involved in reducing suppression of immune function in mammals. For example, methods and materials for (a)...
US-9,987,287 Orally disintegrating solid dosage unit containing an estetrol component
The present invention provides an orally disintegrating solid pharmaceutical dosage unit having a weight of 50-1,000 mg and containing at least 0.1 mg of an...
US-9,987,286 Compositions and methods for the treatment of addiction, psychiatric disorders, and neurodegenerative disease
The present invention features, inter alia, pharmaceutically acceptable compositions that include metyrapol as the sole pharmaceutically active agent;...
US-9,987,285 High dosage strength tablets of rucaparib
A tablet including high dosage of 8-fluoro-2-{4-[(methylamino)methyl]phenyl}-1,3,4,5-tetrahydro-6H-azepino[- 5,4,3-cd]indol-6-one camsylate salt has been disclosed.
US-9,987,284 Substituted benzooxadiazole DNA-PK inhibitors
Provided are compounds of Formula (I): ##STR00001## wherein R.sup.1, R.sup.2, X, Ring A, Ring B, and Ring C are as defined herein. Compounds of Formula (I)...
US-9,987,283 Tricyclic compounds having antimitotic and/or antitumor activity and methods of use thereof
The present invention provides tricyclic compounds, pharmaceutically acceptable salts, solvates, or hydrates thereof, having antimitotic activity,...
US-9,987,282 Small molecule inhibitors of influenza A RNA-dependent RNA polymerase
Antiviral compositions and methods are contemplated that are especially effective in the treatment and prevention of influenza A viruses. Also presented are...
US-9,987,281 Solid state forms of a quinazoline derivative and its use as a BRAF inhibitor
This application relates to various salts and solid state forms of Compound (I). This application also relates to pharmaceutical compositions and therapeutic...
US-9,987,280 SIRT1 inhibitors and stem cell rejuvenation
Provided herein are, inter alia, methods and compositions for treating or preventing diseases using SIRT1 inhibitors. The methods provided herein are...
US-9,987,279 Pharmaceutical composition for prevention and/or treatment of urinary incontinence
The problem to be solved by the present invention is to provide a novel pharmaceutical composition for prevention and/or treatment of urinary incontinence,...
US-9,987,278 Pharmaceutical composition for treating FLT3 mutation-positive cancer, mutant FLT3 inhibitor and uses thereof
Provided are a pharmaceutical composition for treating an FLT3 mutation-positive cancer; a mutant FLT3 inhibitor; and uses thereof. Disclosed are a...
US-9,987,277 Carboxamide 4-[(4-pyridyl)amino] pryimidines for the treatment of hepatitis C
The present invention relates to the use of carboxamide 4-[(4-pyridyl)amino]-pyrimidines as inhibitors of HCV replication as well as their use in pharmaceutical...
US-9,987,276 Substituted 2,4-diaminopyrimidines as kinase inhibitors
The present invention provides 2,4-diaminopyrimidines, and/or pharmaceutically acceptable compositions thereof, as kinase inhibitors.
US-9,987,275 Targeting PARP1 for treatment of TSC and cancers
The present invention relates to methods of treating a condition associated with mTORC1 hyperactivation or TSC2-deficient cancer, the method comprising...
US-9,987,274 N-acyl-(3-substituted)-(8-substituted)-5,6-dihydro-[1,2,4]triazolo[4,3-a]p- yrazines as selective NK-3 receptor...
A method for treating and/or preventing hot flashes, by administering, to a patient in need thereof, of a pharmaceutically effective amount of a compound of...
US-9,987,272 Compound useful for the treatement of degenerative and inflammatory diseases
A pyrazolopyridine compound according to Formula I, able to inhibit JAK is disclosed, as well as pharmaceutically acceptable salts, a solvate thereof, solvates...
US-9,987,271 Method of treating nasopharyngeal carcinoma using perillyl alcohol derivative
A method of treating nasopharyngeal carcinoma in a mammal includes delivering to the mammal a therapeutically effective amount of a perillyl alcohol (POH)...
US-9,987,270 Treatment of gliomas using organonitro compound combination therapy
The invention provides therapeutic methods and kits for treating a glioma using a particular dosing regimen of the organonitro compound ABDNAZ, radiation...
US-9,987,269 Alpha-hydroxy carboxylic acid and derivatives and other GRAS-based prodrugs of oxymorphone and uses thereof
The invention describes pharmaceutical compounds and compositions comprised of a ligand attached to the opioid oxymorphone, in a manner that substantially...
US-9,987,268 Method of restoring the incretin effect
The present invention relates to methods of treating metabolic syndrome Type 2 diabetes mellitus atherogenic dyslipidemia and/or obesity. The present invention...
US-9,987,267 Transdermal formulations of pergolide and uses thereof
This invention provides transdermal non-patch pergolide formulations useful for the treatment of disease in an equine. The invention also provides methods for...
US-9,987,266 Alkyl-amide-substituted pyridyl compounds useful as modulators of IL-12, IL-23 and/or IFN.alpha. responses
Compounds having the following formula I: ##STR00001## or a stereoisomer or a pharmaceutically-acceptable salt thereof, wherein R.sup.1, R.sup.2, R.sup.3,...
US-9,987,265 Methods for treating post traumatic stress disorder
Compounds and compositions are described herein for treating post traumatic stress disorder.
US-9,987,264 Method and composition for treating a serotonin receptor-mediated condition
A method and composition for treating serotonin receptor-mediated conditions.
US-9,987,263 Methods for treatment of Fabry disease
Provided are in vitro and in vivo methods for determining whether a patient with Fabry disease will respond to treatment with a specific pharmacological chaperone.
US-9,987,262 Solid forms of {[5-(3-chlorophenyl)-3-hydroxypyridine-2-carbonyl]amino}acetic acid, compositions, and uses...
Provided herein are solid forms comprising {[5-(3-chlorophenyl)-3-hydroxypyridine-2-carbonyl]amino}acetic acid, compositions comprising the solid forms, methods...
US-9,987,261 Substituted diazaspiroalkanes as androgen receptor modulators
Described herein, inter alia, are compounds useful for the prevention or treatment of hyperproliferative diseases or disorders.
US-9,987,260 Tiotropium inhalation solution for nebulization
The present invention relates to a sterile pharmaceutical composition comprising tiotropium or a pharmaceutically acceptable salt thereof, for inhalation via...
US-9,987,259 Pharmaceutical composition comprising pyridone derivatives
A pyridone derivative compound and a pharmaceutically acceptable salt, isomer, solvate or hydrate thereof, and a preventive or therapeutic pharmaceutical...
US-9,987,258 Histone deacetylase as a modulator of PDL1 expression and activity
Disclosed herein is a method for modulating Program Death Receptor Ligand 1 (PDL1) in a cancer cell, comprising contacting the cell with a composition...
US-9,987,257 Pediatric oral suspension formulations of amoxicillin and clavulanate potassium and method for using same
The invention is directed to a pediatric oral suspension composition containing amoxicillin and clavulanate potassium where the clavulanate potassium is present...
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