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Patent # Description
US-9,994,587 HIV protease inhibitors
The present invention is directed to 2,6-morpholine derivatives of Formula (I): and pharmaceutically acceptable salts thereof, wherein Z.sup.1, Z.sup.2,...
US-9,994,586 Monocyclic, thieno, pyrido, and pyrrolo pyrimidine compounds and methods of use and manufacture of the same
The present invention provides a compound of Formula XXVIII: ##STR00001## werein R.sub.1is H or CH.sub.3, and optionally including a salt or a hydrate of...
US-9,994,585 Transplantation therapies
Embodiments of the present invention are directed to methods and dosage forms for treating inflammation and rejection in transplantation injuries with...
US-9,994,584 Process of synthesizing 3-(4-methylpiperazine-1-carbonyl)-7-oxabicyclo[2.2.1] heptane-2-carboxylic acid
The present invention provides a process for producing the compound having the structure: ##STR00001## comprising (a) reacting a compound having the...
US-9,994,583 Method for preparing curable bicyclic compound derived from biomass
The present invention relates to a method for preparing a curable bicyclic compound derived from biomass. The method includes preparing starting materials furan...
US-9,994,582 Cortistatin analogues and syntheses and uses thereof
Provided herein are compounds of Formula (A), (B), (C), (D) and (E), pharmaceutically acceptable salts, quaternary amine salts, and N-oxides thereof, and...
US-9,994,581 Bromodomain inhibitors
The present invention provides for compounds of formula (I) wherein R.sup.x, X, Y, Y.sup.1, L.sup.1, A.sup.1, A.sup.2, A.sup.3, A.sup.4, A.sup.5, A.sup.6,...
US-9,994,580 Phthalocyanine compound and method of preparing the same, color filter containing phthalocyanine compound, and...
Provided is a phthalocyanine compound which has a green hue without having a halogen atom, and exhibits high luminance and an excellent coloring force at the...
US-9,994,579 Salt of pyrrolo[2,3-D]pyrimidine compound and novel polymorph of salt
The present invention relates to novel crystalline forms of 7-cyclopentyl-2-(5-piperazin-1-yl-pyridin-2-ylamino)-7H-pyrrolo[2,3-d]pyr- imidine-6-car boxylic acid...
US-9,994,578 Benzodiazepine derivative and use thereof
The present invention relates to a new benzodiazepine derivative, pharmaceutically acceptable salt thereof, preparation method therefor, and use thereof. The...
US-9,994,577 Azepanyl-derivatives and pharmaceutical compositions comprising the same with antiparasitic activity
The present invention provides compounds of Formula (i). Furthermore, pharmaceutical compositions are provided comprising at least one compound of Formula (i),...
US-9,994,576 Substituted pyrazolo[3,4-d]pyrimidines as kinase inhibitors
The present disclosure provides compounds of Formula (II) ##STR00001## as disclosed herein, and/or pharmaceutically acceptable salts thereof that are tyrosine...
US-9,994,575 Compositions useful for treating disorders related to kit
Compounds and compositions useful for treating disorders related to mutant KIT are described herein.
US-9,994,574 Salt and polymorphic forms of (3R,4S)-L-((4-amino-5H-pyrrolo[3,2,-d]pyrimidin-7-yl)methyl)-4(methylthio- ...
The invention relates to salt forms of (3R,4S)-1-((4-amino-5H-pyrrolo[3,2-d]pyrimidin-7-yl)methyl)-4-(methyl-thi- omethyl)pyrrolidin-3-ol, as well as polymorphic...
US-9,994,573 Methods and reagents for radiolabeling
The present invention provides methods for radiolabeling compounds useful as Hsp90 inhibitors. The present invention also provides intermediates useful in such...
US-9,994,572 Therapeutic compounds for pain and synthesis thereof
The invention provides compounds of Formula 1: ##STR00001## and stereoisomers, pharmaceutically acceptable salts and derivatives thereof; and methods of...
US-9,994,571 10-substituted morphinan hydantoins
The application is directed to compounds of Formula (I) and pharmaceutically acceptable salts and solvates thereof, wherein R.sup.1-R.sup.9, Y, Z are defined as...
US-9,994,570 Bridged diazepane orexin receptor antagonists
The present invention is directed to bridged diazepane compounds which are antagonists of orexin receptors. The present invention is also directed to uses of...
US-9,994,569 Chromophores for the detection of volatile organic compounds
Aromatic diimide chromophores and methods for using the chromophores for the detection of volatile organic compounds are described. The chromophores are able to...
US-9,994,568 Tricyclic quinoline and quinoxaline derivatives
The present invention relates to tricyclic quinoline and quinoxaline derivatives, to a pharmaceutical composition containing such compounds, to their use as...
US-9,994,567 Synthesis of heterocyclic compounds
Provided herein are intermediates and processes useful for facile synthesis of compounds of formula (I): ##STR00001## or a pharmaceutically acceptable salt, a...
US-9,994,566 Compound of 5-hydroxyl-1,7-naphthyridine substituted by aryl or heteroaryl, preparation method thereof and...
Disclosed are a compound of the following formula (I) or a pharmaceutically acceptable salt thereof, a preparation method thereof, pharmaceutical compositions...
US-9,994,565 Kinase inhibitors
Compounds of formula (I) defined herein are p38 MAPK inhibitors and are useful as anti-inflammatory agents in the treatment of, inter alia, diseases of the...
US-9,994,564 Myosin II ATPase inhibitor compounds
The present invention relates to Myosin II ATPase inhibitor compounds, including substituted 3a-hydroxy-1,2,3,3a-tetrahydro-4H-pyrrolo [2,3b] quinolin-4-one...
US-9,994,563 Indazole inhibitors of the wnt signal pathway and therapeutic uses thereof
Indazole compounds for treating various diseases and pathologies are disclosed. More particularly, the present invention concerns the use of an indazole...
US-9,994,562 Histone demethylase inhibitors
The present invention relates generally to compositions and methods for treating cancer and neoplastic disease. Provided herein are substituted ...
US-9,994,561 Histone demethylase inhibitors
The present disclosure relates generally to compositions and methods for treating cancer and neoplastic disease. Provided herein are substituted pyridine...
US-9,994,560 HPTP-.beta. inhibitors
Disclosed herein are compounds effective for activation of Tie-2 and inhibition of HPTP-beta. The compounds can provide effective therapy for conditions...
US-9,994,559 Bicycloheteroaryl-heteroaryl-benzoic acid compounds as retinoic acid receptor beta (RAR.beta.) agonists
The present invention pertains generally to the field of therapeutic compounds, and more specifically to certain bicycloheteroaryl-heteroaryl-benzoic acid...
US-9,994,558 Multicyclic compounds and methods of using same
The invention generally relates to compounds represented by Structural Formula I: or a pharmaceutically acceptable salt thereof, wherein the variables are as...
US-9,994,557 Strigolactone formulations and uses thereof
Disclosed herein plant propagation materials, methods of manufacturing, formulations and uses thereof. The plant propagation materials disclosed herein may...
US-9,994,556 Triazole modified coumarin and biphenyl amide-based HSP90 inhibitors
Provided herein are compounds of the formulas: which are 90-kDa heat shock protein inhibitors. Pharmaceutical compositions of the compounds are also provided....
US-9,994,555 Chromenone inhibitors of monocarboxylate transporters
The invention provides compounds effective as inhibitors of monocarboxylate transporters such as MCT1 and MCT4, which can be used for treatment of medical...
US-9,994,554 Barbiturate and thiobarbiturate compounds for use in cancer therapy
Provided are methods and compositions for use in therapy, and in particular for treating cancer, preferably drug-resistant cancer, and/or radiation resistant...
US-9,994,553 Process for the purification of the Axl tyrosine receptor kinase inhibitor "R428"
A process for purifying 1-(6,7-dihydro-5H-benzo[6,7]cyclohepta[1,2-c]pyridazine-3-yl)-N.sup.3-(7-- ...
US-9,994,552 Compositions useful for treating disorders related to kit
Compounds and compositions useful for treating disorders related to Kit are described herein.
US-9,994,551 Pyridazine derivatives as RORc modulators
Compounds of formula I: ##STR00001## or pharmaceutical salts thereof, wherein R.sup.1, R.sup.2, R.sup.3 and R.sup.4 are as defined herein. Also disclosed are...
US-9,994,550 Heterocyclic modulators of lipid synthesis for use against cancer and viral infections
Heterocyclic modulators of lipid synthesis are provided as well as pharmaceutically acceptable salts thereof; pharmaceutical compositions comprising such...
US-9,994,549 Quinoline derivative
A compound represented by general formula (I) has a strong Axl inhibitory activity by introducing a distinctive bicyclic structure in which a saturated carbon...
US-9,994,548 Phenyl-substituted nicotinic ligands, and methods of use thereof
Disclosed are compounds and methods of using them to treat a disorder selected from the group consisting of addiction, pain, obesity, schizophrenia, epilepsy,...
US-9,994,547 Heteroarylamide inhibitors of TBK1
Disclosed are compounds of formula 1: ##STR00001## which are useful as inhibitors of TBK1. Also disclosed are pharmaceutical compositions which contain the...
US-9,994,546 Cyclopropylamines as LSD1 inhibitors
The present invention is directed to cyclopropylamine derivatives which are LSD1 inhibitors useful in the treatment of diseases such as cancer.
US-9,994,545 Crystalline forms of an androgen receptor modulator
Described herein are amorphous and crystalline forms of the androgen receptor modulator ...
US-9,994,544 Method for preparing trioxane
The present invention concerns a method for preparing 1,3,5-trioxane by trimerization of formaldehyde in the presence of methanesulfonic acid. The invention...
US-9,994,543 Processes and intermediates for the preparations of isomer free prostaglandins
Novel processes for the preparation of a compound of Formula I-2 substantially free of the 5,6-trans isomer: ##STR00001## wherein ##STR00002## R.sub.2,...
US-9,994,542 Prodrugs of urolithins and uses thereof
The invention provides compounds of formula (I) or salts thereof: ##STR00001## wherein: A, B, C, D, W, X, Y and Z are as defined in the specification, and at...
US-9,994,541 Nitroalkene trolox derivatives and methods of use thereof in the treatment and prevention of inflammation...
The present invention is directed to a class of anti-inflammatory, antioxidant nitroalkene compounds used in biological or biochemical applications to reduce...
US-9,994,539 Formation of 2,5-furan dicarboxylic acid from aldaric acids
The disclosure relates to a method for forming 2,5-furan dicarboxylic acid (FDCA) from aldaric acids. The aldaric acids are dehydrating and cyclizing via acid...
US-9,994,538 Latent acids and their use
Compounds of the formula (I) and (IA) wherein X is --O(CO)--; R.sub.1 is C.sub.1-C.sub.12haloalkyl or C.sub.6-C.sub.10haloaryl; R.sub.2 is located in position 7...
US-9,994,537 Piperazine carbamates and methods of making and using same
Provided herein are piperazine carbamates and pharmaceutical compositions comprising said compounds. The subject compounds and compositions are useful as...
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