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Patent # Description
US-1,000,0537 Polypeptides with permease activity
The invention relates to a polypeptide having one or more substitution at a position corresponding to position 339 or 376 of SEQ ID NO: 59, wherein the...
US-1,000,0536 Method for coating substrates with at least one monolayer of self-assembling proteins
The invention relates to methods for coating a substrate with at least one monolayer of self-assembling proteins, using stabilized aqueous solutions with...
US-1,000,0535 Template-fixed peptidomimetics
Template-fixed .beta.-hairpin peptidomimetics of the general formula ##STR00001## wherein Z is a template-fixed chain of 4 .alpha.-amino acid residues which,...
US-1,000,0534 Peptide having osteoblast proliferation activity and periodontal ligament fibroblast proliferation activity,...
A peptide comprising an amino acid sequence of SEQ ID NO: 1 or SEQ ID NO: 2, according to the present invention, shows proliferation and differentiation...
US-1,000,0533 Immunotherapy against several tumors of the blood, in particular chronic lymphoid leukemia (CLL)
The present invention relates to peptides, nucleic acids and cells for use in immunotherapeutic methods. In particular, the present invention relates to the...
US-1,000,0532 Bone delivery conjugates and method of using same to target proteins to bone
A bone delivery conjugate having a structure selected from the group consisting of: A) X-D.sub.n-Y-protein-Z; and B) Z-protein-Y-D.sub.n-X, wherein X is absent...
US-1,000,0531 Gamma-AA-peptide STAT3/DNA inhibitors and methods of use
STAT3 hyperphosphorylation, dimerization and DNA binding are required for its ability to contribute to malignant transformation. As such, STAT3 has been...
US-1,000,0529 Synthesis of boronic ester and acid compounds
The invention relates to the synthesis of boronic ester and acid compounds. More particularly, the invention provides improved synthetic processes for the...
US-1,000,0528 IBAT inhibitors for the treatment of liver diseases
The present invention regards specific IBAT inhibitors useful in the prophylaxis and/or treatment of a liver disease. It also relates to compositions comprising...
US-1,000,0527 11-substituted bile acid derivatives, process for the preparation thereof and use of these compounds as medicaments
The present invention discloses a novel bile acid derivatives having substituted nitrogen functionality at C-11 and process for synthesis thereof. These C-11...
US-1,000,0526 Optimized synthesis of pure, non-polymorphic, crystalline bile acids with defined particle size
The present invention relates to a pure polymorph of Nor-UDCA or Bis-nor-UDCA, or of a pharmaceutically acceptable salt thereof. The invention further provides...
US-1,000,0525 Non-hormonal steroid modulators of NF-.kappa.B for treatment of disease
The present invention relates to compounds and methods which may be useful as treatments of neuromuscular diseases such as muscular dystrophy, and as inhibitors...
US-1,000,0524 Synthesis of estetrol via estrone derived steroids
A process is provided for the making of estetrol starting from a 3-A-oxy-estra-1,3,5(10),15-tetraen-17-one, wherein A is an C.sub.1-C.sub.5 alkyl group,...
US-1,000,0523 .beta.-D-2'-deoxy-2'-.alpha.-fluoro-2'-.beta.-C-substituted-2-modified-N.s- up.6-substituted purine nucleotides...
A compound of the structure: ##STR00001## or a pharmaceutically acceptable salt or composition thereof for the treatment of a host infected with or exposed to...
US-1,000,0522 Derivatives of uridine 5'-cyclophosphate useful to treat hepatitis C viral infections
Some embodiments of the present invention include nucleoside 5'-monophosphate derivative compounds, their preparation and their uses. In some embodiments, such...
US-1,000,0521 Substituted gemcitabine bicyclic amide analogs and treatment methods using same
In one aspect, the invention relates to substituted gemcitabine aryl amide analogs, derivatives thereof, and related compounds; synthesis methods for making the...
US-1,000,0520 B-vitamin and amino acid conjugates ofnicotinoyl ribosides and reduced nicotinoyl ribosides, derivatives...
The present disclosure provides nicotinate/nicotinamide riboside compounds or derivatives of formula (I): ##STR00001## wherein X.sup.-, Z.sup.1, Z.sup.2, n,...
US-1,000,0519 Methods of preparing nicotinamide riboside and derivatives thereof
The invention relates to methods of preparing nicotinamide riboside and derivatives thereof. In an aspect, the invention relates to a method of preparing a...
US-1,000,0518 Stabilisation of radiopharmaceutical precursors
The present invention relates to a method for improving stability of non fluoridated sugar derivatives, and in particular glucose derivatives such as...
US-1,000,0517 Organic electroluminescent materials and devices
Phosphorescent metal complexes comprising a pendant redox-active metallocene are disclosed. These complexes are useful as emitters for phosphorescent OLEDs.
US-1,000,0516 Phosphonate compounds for treatment of medical disorders
Compounds, methods of use, and processes for making inhibitors of complement Factor D comprising Formula I, or a pharmaceutically acceptable salt or composition...
US-1,000,0515 Hydrosilylation reaction catalyst
A hydrosilylation reaction catalyst prepared from: a catalyst precursor comprising a transition metal compound, excluding platinum, belonging to group 8-10 of...
US-1,000,0514 Method for producing tetraalkoxysilane
An object of the present invention is to provide a method for producing tetraalkoxysilane while saving energy at a high yield. Tetraalkoxysilane can be produced...
US-1,000,0513 Thienothiophene--boron (donor-acceptor) based materials for organic light emitting diodes
The present invention discloses new molecules having defined structures of a series of thienothiophene (TT) and boron derivatives, light emitting devices of...
US-1,000,0512 Compounds for the treatment of infectious diseases
The present invention relates to compounds of formula (I), ##STR00001## wherein R.sup.1, R.sup.2, R.sup.3, R.sup.4, R.sup.5 and R.sup.6 are as described...
US-1,000,0511 Small molecules for the modulation of MCL-1 and methods of modulating cell death, cell division, cell...
This invention relates to compounds which selectively bind to the survival protein MCL-1 with high affinity and selectivity, pharmaceutical compositions...
US-1,000,0510 Salt forms of ceftolozane
This disclosure relates to salt forms of ceftolozane, processes for making these salt forms, and compositions comprising the same. Also disclosed are stabilized...
US-1,000,0509 Broad spectrum beta-lactamase inhibitors
Broad spectrum beta-lactamase inhibitors. Certain inhibitors also exhibit potent antibiotic activity in addition to beta-lactamase inhibition. Compounds of the...
US-1,000,0508 Crystalline dimethyl 3-(benzyloxy)-1-(2,2-dimethoxyethyl)-4-oxo-1,4-dihydropyridine-2,5-dicarb- oxylate
A crystalline dimethyl 2-(benzyloxy)-1-(2,2-diethoxy-ethyl)-4-oxo-1,4-dihydropyridine-2,5-dicarb- oxylate of the formula (U1): ##STR00001##
US-1,000,0507 Furo- and thieno-pyridine carboxamide compounds useful as pim kinase inhibitors
The present disclosure describes furo- and thieno-pyridine carboxamide compounds, as well as their compositions and methods of use. The compounds inhibit the...
US-1,000,0506 Optically active 2-hydroxy tetrahydrothienopyridine derivatives, preparation method and use in manufacture of...
Optically active 2-hydroxytetrahydrothienopyridine derivatives represented by Formula I and pharmaceutically acceptable salts, preparation method and use in the...
US-1,000,0505 Anti-cancer agents and preparation thereof
Embodiments of the present invention provide, among other compounds, a family of spliceosome-inhibiting compounds that can be used as therapeutic anti-cancer...
US-1,000,0504 Pseudopolymorphic forms of a HIV protease inhibitor
New pseudopolymorphic forms of (3R,3aS,6aR)-hexahydrofuro [2,3-b] furan-3-yl (1S,2R)-3-[[(4-aminophenyl) sulfonyl] (isobutyl) ...
US-1,000,0503 Power supply system and connector
A power supply system and a connector, which can suppress occurrence of crosstalk between a power supply wire, and a control wire and an earth wire in a...
US-1,000,0502 Substituted thiohydantoin derivatives as androgen receptor antagonists
Disclosed are compounds, compositions and methods for treating of disorders that are affected by the antagonism of one or more androgen receptor types. Such...
US-1,000,0501 Inhibitors of HIF prolyl hydroxylase
The present invention concerns a compound of formula I or a pharmaceutically acceptable salt thereof, which inhibit HIF prolyl hydroxylase, their use for...
US-1,000,0499 Methyl diazepane orexin receptor antagonists
The present invention is directed to methyl diazepane compounds which are antagonists of orexin receptors. The present invention is also directed to uses of the...
US-1,000,0498 Selective proton coupled folate transporter and folate receptor, and GARFTase inhibitor compounds and methods...
Fused cyclic pyrimidine compounds, including tautomers thereof, and pharmaceutically acceptable salts, prodrugs, solvates and hydrates thereof, are disclosed...
US-1,000,0497 Fused bicyclic heteroaromatic derivatives as kinase inhibitors
A series of fused bicyclic heteroaromatic derivatives of formula (I), as defined herein, being selective inhibitors of phosphatidylinositol-4-kinase III.beta....
US-1,000,0496 Compositions useful for treating disorders related to kit and PDGFR
Compounds and compositions useful for treating disorders related to KIT and PDGFR are described herein.
US-1,000,0494 Small-molecule Hsp90 inhibitors
Purine scaffold Hsp90 inhibitors are useful in therapeutic applications and as radioimaging ligands.
US-1,000,0493 Process and intermediates for the synthesis of ...
This application discloses a process to synthesize 8-({1-(3,5-Bis-(trifluoromethyl)phenyl)-ethoxy)-methyl]-8-pheny-1,7-diaza- spiro[4.5]decan-2-one comprising...
US-1,000,0492 Process for producing diazabicyclooctane derivative
A process for producing a compound represented by a Formula (III), including reacting a compound of the following formula ##STR00001## with a compound selected...
US-1,000,0491 Process for producing diazabicyclooctane derivative and intermediate thereof
A process for producing a diazabicyclooctane derivative represented by Formula (IV) and intermediates thereof by carrying out the following steps: ##STR00001##...
US-1,000,0490 Inhibitors of the fibroblast growth factor receptor
Described herein are inhibitors of FGFR-4, pharmaceutical compositions including such compounds, and methods of using such compounds and compositions to inhibit...
US-1,000,0489 Compounds .alpha..sub.v.beta..sub.6 integrin antagonists
A compound of formula (I): ##STR00001## wherein R is H or F; or a salt thereof.
US-1,000,0488 Heterocyclic compound
The problem of the present invention is to provide a compound having a superior ROR.gamma.t inhibitory action, and useful as a prophylactic or therapeutic agent...
US-1,000,0487 Heterocyclic compounds that inhibit the kinase activity of Mnk useful for treating various cancers
The present invention provides synthesis, pharmaceutically acceptable formulations and uses of compounds in accordance with Formula IA or Formula IB, as well as...
US-1,000,0486 Antiviral drugs for treatment of arenavirus infection
Compounds, methods and pharmaceutical compositions for treating viral infections, by administering certain compounds in therapeutically effective amounts are...
US-1,000,0484 Inhibitors of the renal outer medullary potassim channel
The present invention provides compounds of Formula (I) (Formula (I)) including pharmaceutically acceptable salts thereof, which are inhibitors of the ROMK...
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