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Patent # Description
US-1,000,4756 Compositions for oral administration of zoledronic acid or related compounds for treating complex regional pain...
Oral dosage forms of osteoclast inhibitors, such as zoledronic acid, in an acid or a salt form can be used to treat or alleviate pain or related conditions,...
US-1,000,4755 Therapeutic uses of selected pyrrolopyrimidine compounds with anti-mer tyrosine kinase activity
Uses of pyrrolopyrimidines with anti-Mer tyrosine kinase activity as anti-infective agents, immunostimulatory and immunomodulatory agents, anti-cancer agents...
US-1,000,4754 ANP fragment adjuvant therapy to standard of care (SOC) diuretic treatment
A therapeutic method for treating and/or preventing diseases and medical conditions typically treated by administering diuretic agents (eg congestive heart...
US-1,000,4753 Methods for treating tauopathy
The present disclosure provides methods of reducing the level of acetylated Tau in a neuron or a glial cell in an individual, the methods involving...
US-1,000,4752 Adapter for acetabular component positioning
An adapter for a tripodal stereotactic reference frame for use in arthroplastic surgery mounts a third leg of the frame at an angle with respect to the other...
US-1,000,4751 Compositions and methods for treating Dengue virus infection
The present disclosure provides methods of treating a flavivirus infection, and compositions for use in the methods.
US-1,000,4750 Salt of cephalosporin derivative, its crystalline solid and a method of manufacturing thereof
The present invention provides an acid addition salt or a sodium salt of a compound represented by the formula (IA): ##STR00001## or their hydrate or a stable...
US-1,000,4749 Composition comprising a therapeutic agent and a respiratory stimulant and methods for the use thereof
The present disclosure provides a safe method for anesthesia or the treatment of pain by safely administering an amount of active agent to a patient while...
US-1,000,4748 Methods of treating PR-positive, luminal A breast cancer with PI3K inhibitor, pictilisib
Methods and compositions are provided for treating breast cancer in patients with a PI3K inhibitor, GDC-0941 in combination with an endocrine therapy agent. ...
US-1,000,4747 Combination therapy
The present invention relates to methods for treating and/or preventing metabolic diseases comprising the combined administration of a GLP-1 receptor agonist...
US-1,000,4746 Use of inhibitors of Bruton's tyrosine kinase (Btk)
Disclosed herein are methods for treating a cancer comprising: a. administering a Btk inhibitor to a subject sufficient to result in an increase or appearance...
US-1,000,4745 Use of inhibitors of Bruton'S tyrosine kinase (Btk)
Disclosed herein are methods for treating a cancer comprising: a. administering a Btk inhibitor to a subject sufficient to result in an increase or appearance...
US-1,000,4744 Therapeutic approaches for treating Parkinson's disease
The present invention relates to compositions and methods for the treatment of Parkinson's disease and related disorders. More specifically, the present...
US-1,000,4743 Process for drying of BIBW2992, of its salts and of solid pharmaceutical formulations comprising this active...
The present invention relates to a drying process of BIBW 2992 or the salts thereof, preferably the dimaleate salt, as well as of solid pharmaceutical...
US-1,000,4742 Method of treating cancer
Methods are provided of treating a human for cancer comprising administering at least one dose of lapatinib, or a pharmaceutically acceptable salt or...
US-1,000,4741 Solid forms of an epidermal growth factor receptor kinase inhibitor
The present invention provides a solid form and composites thereof, which are useful as an inhibitor of EGFR kinases and which exhibit desirable characteristics...
US-1,000,4740 Prodrugs of HIV reverse transcriptase inhibitors
Compounds of Formula I are described: wherein R.sup.1 and R.sup.2 are defined herein. The compounds of Formula I are useful in the inhibition of HIV reverse...
US-1,000,4739 Methods for treating cancer by inhibiting FGFR3/TACC3 fusion protein
The present invention aims to elucidate a polynucleotide as a novel responsible gene for cancer and aims to thus provide a method for detecting the...
US-1,000,4738 Combination treatment comprising administration of 2-amino-3,5,5-trifluoro-3,4,5,6-tetrahydropyridines
The present invention is directed to the combined use of BACE1 inhibitor of Formula I ##STR00001## and a compound useful in active or passive Tau...
US-1,000,4737 Fused imidazole and pyrazole derivatives as modulators of TNF activity
A series of substituted benzimidazole, imidazo[1,2-.alpha.]pyridine and pyrazolo[1,5-.alpha.]pyridine derivatives, and analogs thereof, being potent modulators...
US-1,000,4736 Method of preventing or treating skin necroptosis disease comprising RIP3-MLKL pathway blocker
The present invention relates to methods of preventing or treating skin necroptosis diseases, including administering to subjects receptor-interacting protein...
US-1,000,4735 Methods for treating cancer using TOR kinase inhibitor combination therapy comprising administering substituted...
Provided herein are methods for treating or preventing a cancer, comprising administering an effective amount of a TOR kinase inhibitor and an effective amount...
US-1,000,4734 Compositions and methods for treating rebound erythema associated with topical alpha-adrenergic agonists
The present disclosure provides methods and compositions for treating or preventing erythema, including rebound erythema associated with the use of topical...
US-1,000,4733 Substituted pyrido[2,3-b]pyrazines as FGFR kinase inhibitors
The invention relates to new pyridopyrazine derivative compounds of formula (I-A) or formula (I-B): ##STR00001## to pharmaceutical compositions comprising...
US-1,000,4732 Amino pyrazine derivatives as phosphatidylinositol 3-kinase inhibitors
The present invention provides compounds of formula (I) which inhibit the activity of PI 3-kinase gamma isoform, which are useful for the treatment of diseases...
US-1,000,4731 Flibanserin for the treatment of urinary incontinence and related diseases
The invention relates to the use of Flibanserin for the treatment or prevention of urinary incontinence and related diseases. In a further embodiment, the...
US-1,000,4730 Small molecules targeting androgen receptor nuclear localization and/or level in prostate cancer
A method for treating prostate cancer in a subject, comprising administering a therapeutically effective amount of at least one agent to the subject, wherein...
US-1,000,4729 Tamper-resistant pharmaceutical compositions of opioids and other drugs
Tamper-resistant pharmaceutical compositions have been developed to reduce the likelihood of improper administration of drugs, especially drugs such as opioids....
US-1,000,4728 Compounds having muscarinic receptor antagonist and BETA2 adrenergic receptor agonist activity
Compounds of formula I, defined herein, act both as muscarinic receptor antagonists and beta2 adrenergic receptor agonists and are useful for treating...
US-1,000,4727 Composition for preventing, alleviating or treating metabolic diseases, containing amodiaquine as active ingredient
The present invention relates to a novel use of a composition containing, as an active ingredient, an amodiaquine compound or a pharmaceutically acceptable salt...
US-1,000,4726 Polymorphs of cocrystals of P-coumaric acid:nicotinamide
Polymorphs, Forms II and III, of cocrystals of p-coumaric acid and nicotinamide in a 1:1 molar ratio. Pharmaceutical compositions containing Forms II or III,...
US-1,000,4725 Methods of treatment
This disclosure relates to use of certain aldehyde compounds for treating pulmonary fibrosis, hypoxia, and connective tissue and autoimmune disease such as...
US-1,000,4724 Compounds alpha v beta 6 integrin antagonists
A compound according to formula (I) ##STR00001## wherein R.sub.1 is hydrogen, cyclopropyl, or pyrazolyl, wherein said pyrazolyl is optionally substituted by...
US-1,000,4723 Aromatase inhibitor-releasing intravaginal device
An intravaginal device that provides biologically active circulating concentrations of an aromatase inhibitor for at least about of 4 days. Liposome-based and a...
US-1,000,4722 Method for treating hepatic encephalopathy or a disease associated with free radical mediate stress and...
Pharmaceutical compositions of the invention include novel functionalized 1,3-benzenediols having a disease-modifying action in the treatment of hepatic...
US-1,000,4721 Pharmaceutical antiretroviral composition
A pharmaceutical composition comprises at least one integrase inhibitor or its salt, solvate, complex, hydrate, isomer, ester, tautomer, anhydrate, enantiomer,...
US-1,000,4720 Agent for preventing and/or treating ophthalmologic diseases
It is an object of the present invention to provide a novel medicament for preventing and/or treating ophthalmologic diseases caused by ocular angiogenesis....
US-1,000,4719 Solid dispersion formulation
A spray-dried solid dispersion containing a pharmaceutical compound of formula (I) shown below and a pharmaceutically acceptable polymer, ##STR00001## in...
US-1,000,4718 Erythropoietin expression promoter
The present invention provides an erythropoietin expression-enhancing agent that can cancel the suppression of erythropoietin production or promote...
US-1,000,4717 Glycopyrrolate salts
Salts of glycopyrrolate, including solid forms and formulations such as topicals thereof, are disclosed. Methods of making glycopyrrolate salts, including...
US-1,000,4716 Therapeutic/ preventive agent containing coumarin derivative as active ingredient
A method for prophylactically or therapeutically treating an inflammatory disease and/or degenerative intervertebral disk disease in a subject is disclosed. The...
US-1,000,4715 Entacapone for prevention and treatment of atherosclerosis
Obesity is inhibited by administering to a person in need thereof an effective amount of entacapone ...
US-1,000,4714 Compositions, methods and/or devices for prevention and/or treatment of dry eye disorders
The present disclosure relates to compositions, methods and devices for treating, reducing or preventing one or more eye disorders, particularly dry eye...
US-1,000,4713 Uses of chlorogenic acid in the preparation of medicaments for treatment of oligodendroglioma
The present invention provides uses of chlorogenic acid in the preparation of medicaments for treatment of oligodendroglioma. Chlorogenic acid according to the...
US-1,000,4712 Condom
There is provided a condom having a coating or deposit of a composition which includes a physiologically-active agent such as glyceryl trinitrate, wherein the...
US-1,000,4711 Methods and compositions comprising 10-hydroxy-2-decenoic acid
Disclosed herein are compositions for use in treating anxiety, inflammatory conditions, fertility-related disorders, for increasing cognitive performance and...
US-1,000,4710 Medicament for therapeutic treatment of neuropathic disease
A medicament to be applied as an external preparation for therapeutic treatment of a local symptom of a neuropathic disease, which contains gabapentin or...
US-1,000,4709 Receptor subtype and function selective retinoid and rexinoid compounds in combination with immune modulators...
Disclosed herein are methods for treating cancer comprising administering at least one immune checkpoint inhibitor and at least one Retinoic Acid Receptor or...
US-1,000,4708 Receptor subtype and function selective retinoid and rexinoid compounds in combination with immune modulators...
Disclosed herein are methods for treating cancer comprising administering at least one immune checkpoint inhibitor and at least one Retinoic Acid Receptor or...
US-1,000,4707 Method for treating cancer with low molecular weight components of aurin tricarboxylic acid complex
A method of preventing and/or treating cancer in a subject is provided. The method includes administering to the subject a composition comprising an effective...
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