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Patent # Description
US-1,000,5841 Method of treating a solid tumor with IL1RAP antibodies
The present invention provides agents comprising or consisting of a binding moiety with specificity for interleukin-1 receptor accessory protein (IL1RAP) for...
US-1,000,5840 Method for treatment of osteoarthritis with C-Fms antagonists
The present invention relates generally to a method for the treatment and/or prophylaxis of osteoarthritis (OA) and/or pain. In accordance with the present...
US-1,000,5839 Antagonist of the BTLA/HVEM interaction for use in therapy
Antagonist of the BTLA/HVEM interaction for use in therapy The present invention relates to an antagonist of the BTLA/HVEM interaction for use in therapy,...
US-1,000,5838 Milk fat globule epidermal growth factor 8 regulates fatty acid uptake
Methods and compositions for regulating fatty acid uptake and/or decreasing gastric motility in an animal are provided. The method comprises administering an...
US-1,000,5837 B7 family member zB7H6 and related compositions and methods
Disclosed is a newly identified B7 family member, zB7H6, which functions as a counter-receptor for the NK cell triggering receptor, NKp30. Methods and...
US-1,000,5836 Antibody drug conjugates
This application discloses anti-P-cadherin antibodies, antigen binding fragments thereof, and antibody drug conjugates of said antibodies or antigen binding...
US-1,000,5835 Anti-IL-4/anti-IL-13 bispecific antibody formulations
The present invention provides stable pharmaceutical antibody formulations, including lyophilized formulations, comprising an anti-IL-4/anti-IL-13 bispecific...
US-1,000,5834 Biomarkers related to interleukin-33 (IL-33)-mediated diseases and uses thereof
The present invention relates to the identification of certain biomarkers for use in identifying patients who have, or are likely to develop an IL-33 mediated...
US-1,000,5833 Methods of treating inflammation associated airway diseases and viral infections
The present disclosure provides methods of treating a pathogen-induced lung inflammation in a subject are provided in which an anti-S100A9 antibody is...
US-1,000,5832 Method for treating a disease originated from receptor activation by EREG and TGF.alpha.
The present inventors identified inhibition of a combination of EGFR ligands that serve as targets for inhibition of cancer cell proliferation. More...
US-1,000,5831 Human binding molecules capable of neutralizing influenza virus H5N1 and uses thereof
Described are binding molecules such as human monoclonal antibodies that bind to influenza virus H5N1 and have neutralizing activity against influenza virus...
US-1,000,5830 Antigen binding dimer-complexes, methods of making/avoiding and uses thereof
In a broad aspect the present invention generally relates to novel dimer-complexes (herein called "non-fused-dimers" or NFDs) comprising single variable...
US-1,000,5829 Synthetic linear apelin mimetics for the treatment of heart failure
The invention relates to novel compositions comprising modified apelin-13 peptide sequences designed to treat cardiovascular disease in subjects to whom they...
US-1,000,5828 Peptides and combination of peptides for use in immunotherapy against various tumors
The present invention relates to peptides, proteins, nucleic acids and cells for use in immunotherapeutic methods. In particular, the present invention relates...
US-1,000,5827 Double-acylated GLP-1 derivatives
The invention relates to a derivative of a GLP-1 analog, which analog comprises a first K residue at a position corresponding to position 27 of GLP-1(7-37) (SEQ...
US-1,000,5826 Compounds that bind to the erythropoietin receptor
The present invention provides mimetics of erythropoietin that bind to the erythropoietin receptor and that are suitable for use in pharmaceutical compositions....
US-1,000,5825 Compositions and methods related to diseases associated with deposits of amyloid, tau, and alpha-synuclein
Disclosed are compositions, comprising one or more immunogens, wherein each immunogen comprises at least two regions, wherein one region comprises at least one...
US-1,000,5824 Selective PYY compounds and uses thereof
The invention relates to PYY compounds with the amino acid modifications 7Lys, 30Trp, and 31Leu, and in addition to these, 22Ile and/or 28Tyr, and derivatives...
US-1,000,5823 Peptides having effects on promoting wound healing, collagen production, angiogenesis, activation of...
The present invention provides 11 peptides represented as SEQ ID NO: 1-11. The peptides have the ability of anti-virus and bacteria, and can reduce infections,...
US-1,000,5822 Treatment of ischemia
A system, including methods and compositions, for treatment of ischemia.
US-1,000,5821 Modifications of cupredoxin derived peptides and methods of use thereof
The present invention provides modified cupredoxin derived peptides with pharmacologic activity that have improved pharmacokinetic properties, and methods to...
US-1,000,5820 Therapeutic compositions and methods for antibody and Fc-containing targeting molecule-based targeted delivery...
The present application relates to the use of bacterial minicells as targeted delivery agents in vivo and in vitro. Described herein are genetically engineered...
US-1,000,5819 Method of purifying authentic trimeric HIV-1 GP140 envelope glycoproteins comprising a long linker and tag
An approach of producing recombinant trimers that mimic native HIV-1 envelope trimers is developed. A recombinant protein forming the recombinant trimers...
US-1,000,5818 Derivative peptide compounds and methods of use
The present invention provides synthetic peptide compounds and uses thereof for therapy and diagnostics of complement-mediated diseases, such as inflammatory...
US-1,000,5817 Peptide pharmaceuticals
Described herein are methods of syntheses and therapeutic uses of covalently modified peptides and/or proteins. The covalently modified peptides and/or proteins...
US-1,000,5816 Peptides and their use in food and beverage
Described herein is a peptide with an amino acid sequence comprising a Leu-Leu moiety. Also described is a composition having a mixture of such peptides, and...
US-1,000,5815 Biologically cleavable tetrapeptide linking agents
Tetrapeptide linkers for reversibly linking a first compound to a amine-containing second compound are described. Compounds containing the tetrapeptide linkers...
US-1,000,5814 Ligand functionalized polymers
Ligand functionalized substrates, methods of making ligand functionalized substrates, and methods of using functionalized substrates are disclosed.
US-1,000,5813 Methods for the purification of deoxycholic acid
Synthetic methods for preparing deoxycholic acid and intermediates thereof, high purity synthetic deoxycholic acid, compositions and methods of use are...
US-1,000,5812 Transition metal molybdotungsten oxy-hydroxide
A hydroprocessing catalyst has been developed. The catalyst is a unique transition metal molybdotungsten oxy-hydroxide material. The hydroprocessing using the...
US-1,000,5811 .beta.-D-2'-deoxy-2'-.alpha.-fluoro-2'.beta.-C-substituted-2-modified-N.su- p.6-substituted purine nucleotides...
A compound of the structure: ##STR00001## or a pharmaceutically acceptable salt or composition thereof for the treatment of a host infected with or exposed to...
US-1,000,5810 Process for preparing nucleoside prodrugs
Provided are phosphoramidate nucleoside compounds of Formula (I), or pharmaceutically acceptable salts or esters or solvates thereof, useful in the treatment of...
US-1,000,5809 Bio-active antioxidants from plant foods for nutraceutical product development
The present invention relates to 5-O-[6''-(3-hydroxy-3-methyl glutarate).beta.-D-glucoside as a new antioxidant.
US-1,000,5808 Crystal of alkali metal N-acetylneuraminate anhydrate, and process for producing same
According to the present invention, a crystal of an alkali metal N-acetylneuraminate anhydrate, and a process for producing a crystal of an alkali metal...
US-1,000,5807 Synthesis of sialylated/fucosylated human milk oligosaccharides
An achemo-enzymatic synthesis of oligosaccharides of formula 1 is presented wherein R is selected from --OH, --N 3 and --OR 6 wherein R 6 is selected from allyl...
US-1,000,5806 Metalporphyrin complex, preparation method therefor and method for preparing polycarbonate
The present invention provides a metalporphyrin complex having structure represented by formula (I), wherein R.sub.1, R.sub.2, R.sub.3, R.sub.4, R.sub.5,...
US-1,000,5804 TC-PTP inhibitors as APC activators for immunotherapy
The invention encompasses the novel class of compounds represented by the Formula (I) below, which are inhibitors of the TC-PTP enzyme. The invention also...
US-1,000,5803 Crystalline forms of fosnetupitant
The present invention provides crystalline forms of the chloride monohydrochloride salt of fosnetupitant, methods of making the crystalline forms, and...
US-1,000,5802 Amide compounds for treatment of complement mediated disorders
Compounds, methods of use, and processes for making inhibitors of complement factor D comprising Formula I, or a pharmaceutically acceptable salt or composition...
US-1,000,5801 Compounds for pH-controlled release of hydrogen sulfide
The embodiments herein generally relates to compounds and methods for releasing H.sub.2S in a pH dependent manner. In particular, the invention provides...
US-1,000,5800 Mixed metal halide perovskite compound and semiconductor device including the same
Provided are a mixed metal halide perovskite compound, and an electronic device including the same, wherein the mixed metal halide perovskite compound includes...
US-1,000,5799 Bis (alkoxysilyl-vinylene) group-containing silicon compound and production method of same
Provided is an organic silicon compound represented by the following general formula (1) ##STR00001## (wherein R.sup.1 represents either an alkyl group that...
US-1,000,5798 Plasma-assisted organofunctionalization of silicon tetrahalides or organohalosilanes
The invention relates to a method for the plasma-assisted synthesis of organohalosilanes in which organohalosilanes of the general empirical formula...
US-1,000,5797 Hydrosilylation reaction catalyst
A hydrosilylation reaction catalyst prepared from: a catalyst precursor comprising a transition metal compound, excluding platinum, belonging to group 8-10 of...
US-1,000,5796 Substituted angular bistetracenes and substituted angular bisoligoacenes and electronic devices made with same
We report the synthesis and characterization of novel bistetracenes, an unconventional, linearly extended conjugated core with eight fused rings. Also described...
US-1,000,5795 Group 4 metal element-containing compound, method of preparing the same, precursor composition including the...
The present disclosure provides a Group 4 metal element-containing novel compound, a method of preparing the Group 4 metal element-containing compound, a...
US-1,000,5794 Production method for 2-fluoro-4-borono-L-phenylalanine, and precursor of 2-fluoro-4-borono-L-phenylalanine
The present invention involves preparing compounds represented by the formula. (In the formula: R.sup.1 represents a Br group, an iodine group, a Cl group, an...
US-1,000,5793 Bodipy dyes for biological imaging
This invention relates to water-soluble mono-alkoxy and mono-alkyne BODIPY derivatives, including methods for making the same. For examples, provided herein are...
US-1,000,5792 Aminoindane-, aminotetrahydronaphthalene- and aminobenzocyclobutane-derived PRMT5-inhibitors
A compound of formula (1a), (1b) or (1c) wherein: n is 1 or 2; R.sup.N is H or Me; R.sup.1 is optionally one or more halo or methyl groups; R.sup.2a and...
US-1,000,5791 O-demethylating process of methoxy substituted morphinan-6-one derivatives
The present invention relates to an improved process for O-demethylating methoxy substituted morphinan-6-one derivatives using AlCl3 as a demethylating agent in...
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