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Patent # Description
US-1,001,0546 Treatment of ophthalmic conditions by selectively removing senescent cells from the eye
Methods are provided herein for selectively killing senescent cells and for treating senescence-associated diseases and disorders by administering a senolytic...
US-1,001,0545 Antibiotic compositions and methods of use
Embodiments of the present disclosure provide for compositions including an antibiotic containing a N-thiolated beta-lactam moiety, pharmaceutical compositions...
US-1,001,0544 METAP2 inhibitors and methods of treating obesity
The present invention relates to modified or polymer conjugated MetAP2 inhibitors. The present invention also relates to methods of preventing, inducing,...
US-1,001,0543 Transdermal dosage form
The disclosure generally relates to tamper-resistant transdermal dosage forms. The dosage forms can comprise an active agent and more than one antagonist...
US-1,001,0542 PFKFB3 inhibit and methods of use as an anti-cancer therapeutic
A novel compound, (E)-1-(pyridyn-4-yl)-3-(7-(trifluoromethyl)quinolin-2-yl)-prop-2-en-1-one- , is provided herein. ...
US-1,001,0541 Modulation of tissue transglutaminase activation in disease
Compositions and methods are provided for modulating the physiological activation of tissue transglutaminase (TG2); which methods can include inhibiting the...
US-1,001,0540 Aurora A kinase inhibitor
The present invention provides an aminopyridine compound, or a pharmaceutically acceptable salt thereof, that inhibits Aurora A and, therefore may be useful in...
US-1,001,0539 Pyrazole, triazole and tetrazole orexin receptor antagonists
The present invention is directed to pyrazole, triazole and tetrazole compounds which are antagonists of orexin receptors. Such compounds are of the general...
US-1,001,0538 Use of anthelmintic agents against Dirofilaria immitis
This invention is directed to compounds and salts that are generally useful as agents to treat an infection with Dirofilaria immitis. This invention also is...
US-1,001,0537 Clevidipine emulsion formulations containing antimicrobial agents
Pharmaceutical formulations comprising clevidipine and an antimicrobial agent exhibit a reduced propensity for microbial growth and provide increased...
US-1,001,0536 Method of modulating stress-activated protein kinase system
Disclosed are methods of modulating a stress activated protein kinase (SAPK) system with an active compound, wherein the active compound exhibits low potency...
US-1,001,0535 Desferrithiocin analogs and uses thereof
Iron overload is associated with pathological conditions such as oxidative stress, transfusional iron overload, thalassemia, primary hemochromatosis, secondary...
US-1,001,0534 Intravenous formulation and LC/MS/MS analysis method for GMC1
Certain embodiments are directed to a GMC1 co-solvent formulation. The GMC1 co-solvent formulation described herein can be used for the treatment of prostate...
US-1,001,0533 Formulations of bendamustine
Long term storage stable bendamustine-containing compositions are disclosed. The compositions can include bendamustine or a pharmaceutically acceptable salt...
US-1,001,0532 Combination therapy with nitrated lipids and inhibitors of the renin-angiotensin-aldosterone system
The present technology provides compositions and methods for treating chronic kidney disease, end-stage renal disease, or diabetic nephropathy. The compositions...
US-1,001,0531 Methods and compositions for treating clostridium difficile associated disease
The present invention provides methods for treating and preventing the reoccurrence of C. diff infection by administering an immunoglobulin concentrate in...
US-1,001,0530 Carboxamide derivative and its diastereomers in stable crystalline form
The present disclosure relates to solid crystalline forms of N--((S)-1-(3-(3-chloro-4-cyanophenyl)-1H-pyrazol-1-yl)-propan-2-yl)-5-(1-- ...
US-1,001,0529 Extended release pharmaceutical formulations with controlled impurity levels
The present invention provides extended release pharmaceutical formulations of valsartan with controlled impurity levels. Particularly, the present invention...
US-1,001,0527 Active metabolite of 1-[(2-bromophenyl)sulfonyl]-5-methoxy-3-[(4-methyl-1-piperazinyl)methyl]-- 1H-indole...
The present invention is directed to active metabolite of 1-[(2-bromophenyl)sulfonyl]-5-methoxy-3-[(4-methyl-1-piperazinyl)methyl]-- 1H-indole dimesylate...
US-1,001,0526 Heterocyclic flavone derivatives, compositions, and methods related thereto
In certain embodiments, the disclosure relates to heterocyclic flavone derivatives, such as those described by formula provided herein, pharmaceutical...
US-1,001,0525 Methods of inducing anesthesia
The present invention provides methods for determining the selectivity of an anesthetic for an anesthetic-sensitive receptor by determining the molar water...
US-1,001,0524 Short acting phenylalkylamine calcium channel blockers and uses thereof
The present invention relates to the use of a pharmaceutically effective amount of an short-acting calcium channel blocking compound to treat ischemic heart...
US-1,001,0523 Short acting phenylalkylamine calcium channel blockers and uses thereof
The present invention relates to the use of a pharmaceutically effective amount of an short-acting calcium channel blocking compound to treat ischemic heart...
US-1,001,0522 Short acting phenylalkylamine calcium channel blockers and uses thereof
The present invention relates to the use of a pharmaceutically effective amount of an short-acting calcium channel blocking compound to treat ischemic heart...
US-1,001,0521 SARMs and method of use thereof
This invention is directed to substituted acylanilide compounds and uses thereof in improving or preserving lung function and cardiac function in a subject...
US-1,001,0520 Combined application of isothiocyanate compound and anti-cancer medicine
The present invention relates to a combined application of isothiocyanate compounds and anti-cancer drugs, in particular to a composition, comprising: (A) a...
US-1,001,0519 Compositions and methods of use of phorbol esters for the treatment of stroke
Methods and compositions containing a phorbol ester or a derivative of a phorbol ester are provided for the treatment and prevention of stroke and the sequelae...
US-1,001,0518 Prostacyclin compounds, compositions and methods of use thereof
Prostacyclin compounds and compositions comprising the same are provided herein. Specifically, prostacyclin compounds comprising treprostinil covalently linked...
US-1,001,0517 Stable pharmaceutical composition and methods of using same
The present invention relates to, inter alia, pharmaceutical compositions comprising a polyunsaturated fatty acid and to methods of using the same to treat or...
US-1,001,0516 Method for regulating retinal endothelial cell viability
Here provided is a method for regulating retinal endothelial cell viability in a mammal by administering to the mammal a therapeutically effective amount of a...
US-1,001,0515 Therapeutic approaches for treating Parkinson's disease
The present invention relates to compositions and methods for the treatment of Parkinson's disease and related disorders. More specifically, the present...
US-1,001,0514 Pharmaceutical formulation for reducing frequency of urination and method of use thereof
Methods and compositions for reducing frequency of urination are disclosed. The methods comprise administering to a subject having a condition that resulting in...
US-1,001,0513 Aqueous pharmaceutical composition containing a biologic therapeutic agent and guanidine or a guanidine...
The present invention is directed to an aqueous pharmaceutical composition, particularly an aqueous ophthalmic composition, suitable as an injection,...
US-1,001,0512 Methods of treating diseases associated with high-fat diet and vitamin A deficiency using retinoic acid...
This invention relates to pharmaceutical composition and methods of using vitamin A and/or RAR.beta. agonist for the treatment or prevention of diseases or...
US-1,001,0511 Transdermal drug delivery system
A transdermal drug delivery system is provided that includes a drug-in-adhesive matrix layer and a backing layer. The matrix layer includes an active...
US-1,001,0510 Oral pharmaceutical formulation
Described herein are oral pharmaceutical formulations comprising a core component and a coating composition applied on the core component. Also described is a...
US-1,001,0509 Apparatus and method for producing controlled dosage of bioactive agent
An apparatus for producing a controlled dosage of bioactive agent is disclosed. The apparatus includes: a print device to eject a drop of a mixture onto an...
US-1,001,0508 MTAB-TA-Coated gold nanorods and method of fabrication
11-mercaptoundecyl trimethylammonium bromide gold nanorod (MTAB-GNR) coated with tannic acid (TA), useful for biological cellular imaging. A method of...
US-1,001,0507 Pharmaceutical formulations of a bruton's tyrosine kinase inhibitor
Described herein are pharmaceutical formulations of Bruton's tyrosine kinase (Btk) inhibitor ...
US-1,001,0506 Matrix and layer compositions for protection of bioactives
The invention relates to matrix and layer compositions comprising a first polymer. The matrix and layer compositions are useful in the delivery of bioactives....
US-1,001,0505 Liposomes active in-vivo on neurodegenerative diseases
New liposomes are described, comprising: (i) phosphatidic acid and/or cardiolipin; (ii) apolipoprotein E (ApoE) or derivatives thereof. The so modified...
US-1,001,0504 Compositions and methods including celecoxib and plumbagin relating to treatment of cancer
The present invention relates to compositions and methods for treatment of proliferative disease. In specific aspects, the present invention relates to...
US-1,001,0503 Methods and compositions for oral administration
This invention provides compositions comprising a protein, an absorption enhancer, a protease inhibitor, method for treating diabetes mellitus, comprising...
US-1,001,0502 Device that delivers a sustained low-dose of a myopia-suppressing drug, while preserving pupillary function and...
A non-degradable topical ocular drug delivery device includes about 0.001% to about 10% w/w of at least one myopia-suppressing agent complexed with an immobile...
US-1,001,0501 Process for making controlled release medical implant products
A method (and the resulting product) of making a medical implant device for releasing self-contained drugs on a controlled basis wherein the method utilizes, at...
US-1,001,0500 Ceramic implants affording controlled release of active materials
Implantable compositions providing release of bioactive agents according to a predetermined release profile and methods for their use. Such compositions include...
US-1,001,0499 Methods of using microneedle vaccine formulations to elicit in animals protective immunity against rabies virus
The present invention relates to microneedle vaccine formulations, as well as methods of use thereof to provide animals, including canines, protective immunity...
US-1,001,0498 Methods for treatment of amyotrophic lateral sclerosis with follistatin fusion proteins
The disclosure provides, in part, follistatin polypeptides that are suitable for use in local administration and methods for use.
US-1,001,0497 Cosmetic preparation containing crosslinkable silicone rubber emulsion and its production method
A cosmetic preparation containing a crosslinkable silicone rubber emulsion comprising (A) 100 parts by weight of a straight chain or branched organopolysiloxane...
US-1,001,0496 Topical sanitizing formulations and uses thereof
Several embodiments disclosed herein relate to formulations having antimicrobial and/or sanitizing effects, and uses of the same. In particular, the...
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