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Patent # Description
US-1,001,1658 Constructs targeting AFP peptide/MHC complexes and uses thereof
The present application provides constructs comprising an antibody moiety that specifically binds to a complex comprising an AFP peptide and an MHC class I...
US-1,001,1657 Anti-CS1 antibodies and antibody drug conjugates
The present disclosure provides antibodies and antibody drug conjugates that bind human CS1 and their uses to treat subjects diagnosed with a plasma cell...
US-1,001,1656 Human anti-PD-1, PD-L1, and PD-L2 antibodies and uses therefor
The present invention is based, in part, on the identification of novel human anti-PD-1, PD-L1, and PD-L2 antibodies. Accordingly, the invention relates to...
US-1,001,1655 Compositions and methods for the identification and isolation of cell-membrane protein specific binding moieties
Disclosed are methods of identifying binding moieties that recognize antigens displayed on cells, such as membrane proteins or recombinant proteins that display...
US-1,001,1654 Antibodies directed to IL-17A/IL-17F heterodimers
The present invention is directed to a novel naturally occurring human cytokine that is comprised of a heterodimer of interleukin-17 and interleukin-17F...
US-1,001,1653 Antibodies to tau and methods of treatment therewith
Monoclonal antibodies to human tau aggregate, compositions comprising such tau antibodies, and methods of using such tau antibodies for the treatment of...
US-1,001,1652 Immunoglobulin-like molecules directed against fibronectin-EDA
The present invention is concerned with immunoglobulin (Ig)-like molecules or fragments thereof for use in treatment, prevention, or prevention of progression...
US-1,001,1651 Methods and compositions for increasing iduronate 2-sulfatase activity in the CNS
Provided herein are methods and compositions for treating a subject suffering from a deficiency in iduronate 2-sulfatase in the CNS. The methods include...
US-1,001,1650 Compositions and methods for the therapy and diagnosis of inflammatory bowel disease
Compositions and methods for the therapy and diagnosis of Inflammatory Bowel Disease (IBD), including Crohn's Disease and Ulcerative Colitis, are disclosed....
US-1,001,1649 High affinity synbodies for influenza
Composition of synbodies that bind influenza. The synbodies are composed of two peptides joined on a scaffold.
US-1,001,1648 Human monoclonal antibody against the VP1 protein of JC virus
A human neutralizing monoclonal antibody is directed against the VP1 protein of JC virus. The JC virus is responsible for progressive multifocal...
US-1,001,1647 IL-33 antagonists and uses thereof
The present invention provides interleukin-33 (IL-33) antagonists comprising one or more IL-33-binding domains and one or more multimerizing domains and methods...
US-1,001,1646 Recombinant decoy receptor 3 for treating spinal cord injury
Disclosed herein are methods for treating spinal cord injury using recombinant decoy receptor 3 (DcR3) polypeptide. Also disclosed herein are methods for...
US-1,001,1645 Peptides and combination of peptides for use in immunotherapy against esophageal cancer and other cancers
The present invention relates to peptides, proteins, nucleic acids and cells for use in immunotherapeutic methods. In particular, the present invention relates...
US-1,001,1644 Method for producing soluble FcR as Fc-fusion with inert immunoglobulin Fc-region and uses thereof
Herein is a fusion polypeptide with the formula R1-FC-R2, wherein R1 denotes a first Fc-receptor, R2 denotes a second Fc-receptor, and FC denotes a heavy chain...
US-1,001,1643 Freeze-dried preparation containing high-purity PTH and method for producing same
[Problem] Provided is a freeze-dried preparation containing high-purity PTH peptide and a method for the production thereof. Also provided is a test method for...
US-1,001,1642 Methods of treating of diabetes and obesity using FGF21 mutants
The invention provides methods of treating diabetes, reducing triglyceride levels, and treating obesity by administering to a subject in need there a fusion...
US-1,001,1641 ABD binding polypeptide
The disclosure provides an ABD binding polypeptide comprising an ABD binding motif BM, which motif consists of an amino acid sequence selected from...
US-1,001,1640 Capsid-modified rAAV vector compositions and methods therefor
Disclosed are capsid-modified rAAV expression vectors, as well as infectious virions, compositions, and pharmaceutical formulations containing them. Also...
US-1,001,1639 Peptidomimetic compounds
The present invention relates to inhibitors of protein-protein interactions (PPI). Specifically, the present invention relates to a structural informatics...
US-1,001,1638 PTEN antagonist peptides and methods of using the same
The presently disclosed subject matter relates to antagonists of PTEN and methods of using the same. In particular, the presently disclosed subject matter...
US-1,001,1637 Ultra-pure agonists of guanylate cyclase C, method of making and using same
The invention provides processes of purifying a peptide including a GCC agonist sequence selected from the group consisting of SEQ ID NOs: 1-251 described...
US-1,001,1636 Inhibitors of metastasis
The present invention relates to methods and compounds for treating or preventing cancer. Methods and compositions provided include including inhibiting or...
US-1,001,1635 Cyclic peptide conjugates and methods of use
The present invention concerns cyclic compounds, compositions comprising the cyclic compounds, linkers, a method of preparing a carrying agent:cyclic compound...
US-1,001,1634 Inhibitors of beta integrin-G protein alpha subunit binding interactions
Provided herein are compounds that inhibit a binding interaction between a .beta. integrin and a G protein subunit, as well as compositions, e.g., ...
US-1,001,1633 IBAT inhibitors for the treatment of liver diseases
The present invention regards specific IBAT inhibitors useful in the prophylaxis and/or treatment of a liver disease. It also relates to compositions comprising...
US-1,001,1632 PSMA imaging agents
Compounds for targeting and agents for imaging, Prostate-specific membrane antigen (PSMA) are disclosed. Methods of synthesizing compounds and imaging agents,...
US-1,001,1631 Stapled helical peptides and methods of synthesis
The present disclosure relates to the design and generation of stapled helical peptides that perturb protein-protein interactions (PPIs). The methods disclosed...
US-1,001,1630 Cyclic dinucleotides for cytokine induction
A cyclic dinucleotide compound of Formula (I): ##STR00001## wherein X.sub.1 is H or F; X.sub.2 is H or F; at least one among X.sub.1 and X.sub.2 is a fluorine...
US-1,001,1629 Nucleoside analogs for treatment of the flaviviridae family of viruses and cancer
The present invention is directed to compounds, compositions and methods for treating or preventing Flaviviridae family of viruses (including HCV, Yellow fever,...
US-1,001,1628 Multivalent sialic acid derivatives
Disclosed is tri- or tetravalent sialic acid derivatives comprising a core moiety to which 3 or 4 sialic acid residues are connected via a linker. Such...
US-1,001,1627 C-aryl glucoside derivative, preparation methods thereof, and medical applications thereof
C-aryl glucoside derivatives, preparation methods thereof, and medical applications thereof are described. Specifically, compounds represented by formula I,...
US-1,001,1626 Method for the purification of decitabine
A method of preparing purified decitabine comprises mixing crude decitabine with solvent, such as dimethylacetamide, to form a solution or suspension and...
US-1,001,1625 Processing facility
Biomass feedstocks (e.g., plant biomass, animal biomass, and municipal waste biomass) are processed to produce useful products, such as fuels. For example,...
US-1,001,1624 Transition metal compound having heteroatom, catalyst composition including the same and preparation method of...
The present invention discloses a transition metal compound including a heteroatom and having a novel structure, a catalyst composition including the same, and...
US-1,001,1623 Alkoxide compound, thin film-forming starting material, and thin film formation method
The alkoxide compound of the present invention is characteristically represented by the following general formula (I): ##STR00001##
US-1,001,1622 Compounds, compositions, and methods for the treatment of cancers
The present teachings relate to compounds and compositions for treatment of cancers. In some embodiments, the composition comprises a platinum (IV) complex...
US-1,001,1621 Method for producing silica gel-immobolized phosphonium salt catalysts
Disclosed herein is a method for producing silica gel-immobilized phosphonium salt catalysts including the steps of (a) reacting a silane compound with a silica...
US-1,001,1620 Lipophenol compounds and uses thereof
The present invention relates to a compound of formula (I) wherein: i is 0 or 1; j is 0 or 1; k is 0 or 1; R.sub.1 and R.sub.2 are in particular H,...
US-1,001,1619 Process for reducing the chlorine content of organotetraphosphites
Universally usable process for reducing the chlorine content of organotetraphosphites.
US-1,001,1617 Isocyanate derived organosilanes
The invention relates to isocyanate derived organosilanes and the use thereof. The isocyanate derived organosilanes can be reacted with inorganic substrates,...
US-1,001,1616 Boron-containing small molecules as antiprotozoal1 agents
This invention provides, among other things, novel compounds useful for treating protozoal infections, pharmaceutical compositions containing such compounds, as...
US-1,001,1615 Heterobicyclo-substituted [1,2,4]triazolo[1,5-c]quinazolin-5-amine compounds with A2A anatagonist properties
Disclosed are compounds of Formula G1: ##STR00001## where "R.sup.G3". "R.sup.d1" to "R.sup.d4", "n", "m", "p", "W", "X", "Y", and "Z" are defined herein,...
US-1,001,1614 Bis-.beta.-carboline compound and preparation method, pharmaceutical composition and use thereof
Disclosed in the present invention are a bis-.beta.-carboline compound and a preparation method, a pharmaceutical composition and the use thereof. In...
US-1,001,1613 Polycyclic pyridone derivative having integrase inhibitory activity
The present invention relates to a novel compound having an antiviral effect, more specifically, a pyridone derivative having HIV integrase inhibitory activity,...
US-1,001,1612 Aryl, heteroaryl, and heterocyclic compounds for treatment of medical disorders
Compounds, methods of use, and processes for making inhibitors of complement Factor D comprising Formula I, or a pharmaceutically acceptable salt or composition...
US-1,001,1611 Histone deacetylase inhibitors and methods for use thereof
The present invention relates to methods of modulating (for example inhibiting) activity of histone deacetylases (HDACs) and/or treating HDACs-associated...
US-1,001,1610 Selective BACE1 inhibitors
The present invention provides a compound of Formula I: ##STR00001## or a pharmaceutically acceptable salt thereof.
US-1,001,1609 Heterocyclic compounds
The present invention relates to novel GPR 40 agonists of the general formula (I), their tautomeric forms, their stereoisomers, their pharmaceutically...
US-1,001,1608 Compound for organic electronic element, organic electronic element using the same, and an electronic device...
Provided are a compound of Formula 1 and an organic electric element including a first electrode, a second electrode, and an organic material layer between the...
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