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Patent # Description
US-1,001,1636 Inhibitors of metastasis
The present invention relates to methods and compounds for treating or preventing cancer. Methods and compositions provided include including inhibiting or...
US-1,001,1635 Cyclic peptide conjugates and methods of use
The present invention concerns cyclic compounds, compositions comprising the cyclic compounds, linkers, a method of preparing a carrying agent:cyclic compound...
US-1,001,1634 Inhibitors of beta integrin-G protein alpha subunit binding interactions
Provided herein are compounds that inhibit a binding interaction between a .beta. integrin and a G protein subunit, as well as compositions, e.g., ...
US-1,001,1633 IBAT inhibitors for the treatment of liver diseases
The present invention regards specific IBAT inhibitors useful in the prophylaxis and/or treatment of a liver disease. It also relates to compositions comprising...
US-1,001,1632 PSMA imaging agents
Compounds for targeting and agents for imaging, Prostate-specific membrane antigen (PSMA) are disclosed. Methods of synthesizing compounds and imaging agents,...
US-1,001,1631 Stapled helical peptides and methods of synthesis
The present disclosure relates to the design and generation of stapled helical peptides that perturb protein-protein interactions (PPIs). The methods disclosed...
US-1,001,1630 Cyclic dinucleotides for cytokine induction
A cyclic dinucleotide compound of Formula (I): ##STR00001## wherein X.sub.1 is H or F; X.sub.2 is H or F; at least one among X.sub.1 and X.sub.2 is a fluorine...
US-1,001,1629 Nucleoside analogs for treatment of the flaviviridae family of viruses and cancer
The present invention is directed to compounds, compositions and methods for treating or preventing Flaviviridae family of viruses (including HCV, Yellow fever,...
US-1,001,1628 Multivalent sialic acid derivatives
Disclosed is tri- or tetravalent sialic acid derivatives comprising a core moiety to which 3 or 4 sialic acid residues are connected via a linker. Such...
US-1,001,1627 C-aryl glucoside derivative, preparation methods thereof, and medical applications thereof
C-aryl glucoside derivatives, preparation methods thereof, and medical applications thereof are described. Specifically, compounds represented by formula I,...
US-1,001,1626 Method for the purification of decitabine
A method of preparing purified decitabine comprises mixing crude decitabine with solvent, such as dimethylacetamide, to form a solution or suspension and...
US-1,001,1625 Processing facility
Biomass feedstocks (e.g., plant biomass, animal biomass, and municipal waste biomass) are processed to produce useful products, such as fuels. For example,...
US-1,001,1624 Transition metal compound having heteroatom, catalyst composition including the same and preparation method of...
The present invention discloses a transition metal compound including a heteroatom and having a novel structure, a catalyst composition including the same, and...
US-1,001,1623 Alkoxide compound, thin film-forming starting material, and thin film formation method
The alkoxide compound of the present invention is characteristically represented by the following general formula (I): ##STR00001##
US-1,001,1622 Compounds, compositions, and methods for the treatment of cancers
The present teachings relate to compounds and compositions for treatment of cancers. In some embodiments, the composition comprises a platinum (IV) complex...
US-1,001,1621 Method for producing silica gel-immobolized phosphonium salt catalysts
Disclosed herein is a method for producing silica gel-immobilized phosphonium salt catalysts including the steps of (a) reacting a silane compound with a silica...
US-1,001,1620 Lipophenol compounds and uses thereof
The present invention relates to a compound of formula (I) wherein: i is 0 or 1; j is 0 or 1; k is 0 or 1; R.sub.1 and R.sub.2 are in particular H,...
US-1,001,1619 Process for reducing the chlorine content of organotetraphosphites
Universally usable process for reducing the chlorine content of organotetraphosphites.
US-1,001,1617 Isocyanate derived organosilanes
The invention relates to isocyanate derived organosilanes and the use thereof. The isocyanate derived organosilanes can be reacted with inorganic substrates,...
US-1,001,1616 Boron-containing small molecules as antiprotozoal1 agents
This invention provides, among other things, novel compounds useful for treating protozoal infections, pharmaceutical compositions containing such compounds, as...
US-1,001,1615 Heterobicyclo-substituted [1,2,4]triazolo[1,5-c]quinazolin-5-amine compounds with A2A anatagonist properties
Disclosed are compounds of Formula G1: ##STR00001## where "R.sup.G3". "R.sup.d1" to "R.sup.d4", "n", "m", "p", "W", "X", "Y", and "Z" are defined herein,...
US-1,001,1614 Bis-.beta.-carboline compound and preparation method, pharmaceutical composition and use thereof
Disclosed in the present invention are a bis-.beta.-carboline compound and a preparation method, a pharmaceutical composition and the use thereof. In...
US-1,001,1613 Polycyclic pyridone derivative having integrase inhibitory activity
The present invention relates to a novel compound having an antiviral effect, more specifically, a pyridone derivative having HIV integrase inhibitory activity,...
US-1,001,1612 Aryl, heteroaryl, and heterocyclic compounds for treatment of medical disorders
Compounds, methods of use, and processes for making inhibitors of complement Factor D comprising Formula I, or a pharmaceutically acceptable salt or composition...
US-1,001,1611 Histone deacetylase inhibitors and methods for use thereof
The present invention relates to methods of modulating (for example inhibiting) activity of histone deacetylases (HDACs) and/or treating HDACs-associated...
US-1,001,1610 Selective BACE1 inhibitors
The present invention provides a compound of Formula I: ##STR00001## or a pharmaceutically acceptable salt thereof.
US-1,001,1609 Heterocyclic compounds
The present invention relates to novel GPR 40 agonists of the general formula (I), their tautomeric forms, their stereoisomers, their pharmaceutically...
US-1,001,1608 Compound for organic electronic element, organic electronic element using the same, and an electronic device...
Provided are a compound of Formula 1 and an organic electric element including a first electrode, a second electrode, and an organic material layer between the...
US-1,001,1607 Ethynyl derivatives
The present invention relates to compounds of formula I ##STR00001## wherein R.sup.1 is hydrogen, F or Cl; L is a bond or lower alkylene; R.sup.2 is...
US-1,001,1606 Imidazopyrazinones as PDE1 inhibitors
The present invention provides imidazopyrazinones as PDE1 inhibitors and their use as a medicament, in particular for the treatment of neurodegenerative...
US-1,001,1605 Process for the preparation of triazolo[4,5-D] pyrimidine cyclopentane compounds
The present invention relates to a process for preparation of triazolo[4,5-d] pyrimidine cyclopentane compounds of formula (I), and pharmaceutically acceptable...
US-1,001,1604 Method of treatment using substituted imidazo[1,2b]pyridazine compounds
Methods for treating a disease or disorder selected from pain, cancer, inflammation, neurodegenerative disease, Typanosoma cruzi infection and osteolytic...
US-1,001,1603 Process for preparing a carbapenem antibiotic
A process for the preparation of a carbapenem, includes the step of treating a solution of a protected carbapenem with hydrogen gas in the presence of a...
US-1,001,1602 Immunological reagents and uses therefor
The present invention provides a ligand which binds to MR1 wherein said binding results in binding of the MR1 to MAIT cells.
US-1,001,1601 Substituted spirocyclic inhibitors of autotaxin
The present invention relates to compounds according to Formula 1 and pharmaceutically acceptable salts, synthesis, intermediates, formulations, and methods of...
US-1,001,1600 Methods and compositions for inhibition of Ras
Inhibitors of Ras protein, methods to modulate the activity of Ras protein, and methods of treatment of disorders mediated by Ras protein are provided. A method...
US-1,001,1599 Compounds and compositions as inhibitors of MEK
The present invention relates to compounds of formula I: ##STR00001## in which n, R.sub.1, R.sub.2, R.sub.3a, R.sub.4 and R.sub.5 are defined in the Summary of...
US-1,001,1598 Small molecules targeting repeat r(CGG) sequences
The invention provides a series of bioactive small molecules that target expanded r(CGG) repeats, termed r(CGG).sup.exp, that causes Fragile X-associated Tremor...
US-1,001,1597 Derivatives of 2-(1,2,4-triazol-3-ylsulfanyl)-N-1,3,4-thiadiazol-2-yl acetamide which are useful for the...
Disclosed are compounds, pharmaceutical compositions and methods for modulating aquaporin 9.
US-1,001,1596 2-amino-3-fluoro-3-(fluoromethyl)-6-methyl-6-phenyl-3,4,5,6-tetrahydropyri- dines as BACE1 inhibitors
The present invention provides compounds of Formula I ##STR00001## for the treatment of neurodegenerative or cognitive diseases. The method further provides...
US-1,001,1595 Ethyldiamine orexin receptor antagonists
The present invention is directed to ethyldiamne compounds which are antagonists of orexin receptors. Such compounds are of the general structural formula I: ...
US-1,001,1594 4-hydroxy-3-(heteroaryl)pyridine-2-one APJ agonists
The present invention provides compounds of Formula (I): ##STR00001## wherein all variables are as defined in the specification, and compositions comprising...
US-1,001,1593 Heterocycle-substituted pyridyl benzothiophenes as kinase inhibitors
This invention is directed to a compound of Formula I ##STR00001## or a pharmaceutically acceptable salt thereof, wherein R.sup.1, R.sup.2, R.sup.3, R.sup.4...
US-1,001,1592 Polycyclic inhibitor of anaplastic lymphoma kinase
Disclosed is a polycyclic inhibitor of anaplastic lymphoma kinase as represented by Formula (I), or a pharmaceutically acceptable salt or stereoisomer thereof....
US-1,001,1591 Crystalline form of afatinib dimaleate
The present invention provides a crystalline Form I of afatinib dimaleate, its process for preparation and pharmaceutical composition thereof, and its use in...
US-1,001,1590 Crystalline forms of vilazodone hydrochloride and vilazodone free base
The present application relates to crystalline and amorphous Vilazodone hydrochloride. The present application further relates to amorphous solid dispersions of...
US-1,001,1589 Treatments for gastrointestinal conditions
Compounds for the treatment of bacterial and parasitic infections which are hybrid compounds of compounds having antibacterial or antiparasitic activity and...
US-1,001,1588 1,2-substituted cyclopentanes as orexin receptor antagonists
The present invention provides compounds of formula (I) and pharmaceutically acceptable salts thereof, (I) wherein L, X, R.sup.a, R.sup.b, R.sup.1, R.sup.2 and...
US-1,001,1587 Multivalent ligands targeting VEGFR
Compounds that target vascular endothelial growth factor receptors for therapy and imaging are disclosed. Methods for making the compounds and detecting or...
US-1,001,1586 Heterocyclic compound, method for preparing the same, and pharmaceutical composition comprising the same
The present invention relates to a heterocyclic compound having a novel structure that can be used in the prevention or treatment of diseases caused by...
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