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Patent # Description
US-1,001,6440 Methods of enhancing antibody-dependent cellular cytotoxicity
The application relates to method of increasing antibody-dependent cellular cytotoxicity in a subject receiving therapeutic monoclonal antibody treatment. In...
US-1,001,6439 Fused imidazole compounds
The present invention provides compounds represented by formula (I), pharmaceutically acceptable salts thereof, N-oxides thereof, solvates thereof or prodrugs...
US-1,001,6438 Bicyclic heterocycles as FGFR4 inhibitors
The present disclosure relates to bicyclic heterocycles, and pharmaceutical compositions of the same, that are inhibitors of the FGFR4 enzyme and are useful in...
US-1,001,6437 Drug combinations and uses in treating a coughing condition
The present specification discloses compositions comprising a plurality of therapeutic compound having antitussive activity and methods and uses for treating a...
US-1,001,6436 Animal and human anti-malarial agents
Provided herein are Purine Comounds of Formula (I) ##STR00001## or pharmaceutically acceptable salts, tautomers, isotopologues, or stereoisomers thereof,...
US-1,001,6435 Use of inhibitors of Bruton's tyrosine kinase (Btk)
Disclosed herein are methods for treating a cancer comprising: a. administering a Btk inhibitor to a subject sufficient to result in an increase or appearance...
US-1,001,6434 Methods for the treatment of HER2 amplified cancer
Described herein are methods and compositions for treating HER2-amplified cancer. The methods include administering to an individual in need thereof ibrutinib.
US-1,001,6433 Salt of fused heterocyclic derivative and crystal thereof
The present invention provides 3-[2-fluoro-5-(2,3-difluoro-6-methoxybenzyl-oxy)-4-methoxyphenyl]-2,4-dio- ...
US-1,001,6432 Methanocarba derivatives of pseudoribose that inhibit adenosine kinase
Adenosine kinase inhibitors, including pharmaceutical compositions containing the adenosine kinase inhibitors, and their use for preventing epilepsy and its...
US-1,001,6431 Solid pharmaceutical compositions comprising biopterin derivatives and uses of suchcompositions
The present invention relates to a method of treating a disease in a subject, comprising administering to a subject in need thereof a solid pharmaceutical...
US-1,001,6430 1-[2-(aminomethyl)benzyl]-2-thioxo-1,2,3,5-tetrahydro-4H-pyrrolo[3,2-d]pyr- imidin-4-ones as inhibitors of...
There are disclosed certain 1-[2-(aminomethyl)benzyl]-2-thioxo-1,2,3,5-tetrahydro-4H-pyrrolo[3,2-d]py- rimidin-4-one compounds of formula (I), ##STR00001## ...
US-1,001,6429 Salts of the janus kinase inhibitor (R)-3-(4-(7H-pyrrolo[2,3-D]pyrimidin-4-yl)-1H-pyrazol-1-yl)-3-cyclopentyl- ...
The present invention provides salt forms of (R)-3-(4-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-1H-pyrazol-1-yl)-3-cyclopentyl- propanenitrile that are useful in the...
US-1,001,6428 Pharmaceutical composition of sildenafil citrate in the form of a suspension for oral use
The present invention refers to a pharmaceutical composition of sildenafil citrate in the form of a suspension for administration orally that comprises water as...
US-1,001,6427 Hydrochloride salt of((1S,2S,4R)-4-{4-[(1S)-2,3-dihydro-1H-inden-1-ylamino]-7H-pyrrolo[2,3-D- ...
Disclosed is a compound of formula (I): ##STR00001## crystalline forms thereof, and solvates thereof; pharmaceutical compositions comprising a ...
US-1,001,6425 Anti-ulcerative colitis compound
Anti-ulcerative colitis compounds include quinazoline derivatives having the following structural formula: ##STR00001## wherein R is H, OH, or OCH.sub.3,...
US-1,001,6424 Method and pharmaceutical composition for use in the treatment of epilepsy
The present invention relates to a compound which is an antagonist of the GluK2/GluK5 receptor or an inhibitor of the GluK2/GluK5 receptor expression for use in...
US-1,001,6423 Solid forms of nilotinib hydrochloride
A solid form of Nilotinib hydrochloride, which exists as a co-crystal of nilotinib hydrochloride and levulinic acid having a molar ratio of nilotinib...
US-1,001,6422 Nanocarrier drug delivery platform
Disclosed herein are embodiments of a composition comprising a drug in a polymer nanoparticle. The nanoparticles may have a size and/or a surface potential...
US-1,001,6421 Histone deacetylase 6 inhibition for enhancing T-cell function during anti-tumor response and tumor-peptide...
Disclosed are methods whereby an effective amount of a HDAC6 inhibitor is used to activate a subjects T-cell response to tumor or tumor vaccine. Methods of...
US-1,001,6420 Substituted pyridazines for the treatment of pain
The invention provides compounds of formula I, ##STR00001## wherein: R.sup.1 represents a cyclic group selected from phenyl, heteroaryl.sup.1, ...
US-1,001,6418 Compounds useful as modulators of TRPM8
The present invention includes compounds useful as modulators of TRPM8, such as compounds of Formula (I) and the subgenus and species thereof; personal products...
US-1,001,6417 Extended release formulation of a direct thrombin inhibitor
Extended release formulations of 3-fluoro-2-pyridylmethyl-3-(2,2-difluoro-2-(2-pyridyl)ethylamino)-6-chlor- opyrazin-2-one-1-acetamide (DPOC-4088) that provide...
US-1,001,6416 Composition for reducing nervous system injury and method of making and use thereof
This application discloses a composition comprising an amiloride and/or an amiloride analog which can be used for reducing nerve injury or nervous system injury...
US-1,001,6415 Aripiprazole prodrug compositions
Described is a composition comprising (a) a population of particles of an aripiprazole prodrug having a volume based particle size (Dv50) of less than 1000 nm...
US-1,001,6414 Modulation of ubiquitination of synaptic proteins for the treatment of neurodegenerative and psychiatric disorders
The instant invention is based, at least in part, on a newly-identified proteasome-independent signaling function of ubiquitinated PSD-95. Mdm2 inhibitors, Mdm4...
US-1,001,6413 Combination dopamine antagonist and opiate receptor antagonist treatment of addictive behavior
The present invention is directed to a method of treating or preventing an addictive behavior in a subject, said method comprising administering to said subject...
US-1,001,6412 TLR-agonist-conjugated antibody recruiting molecules (TLR-ARMs)
The present invention relates to chimeric chemical compounds which are used to recruit antibodies to cancer cells, in particular, prostate cancer cells or...
US-1,001,6411 Slow-release conjugates of SN-38
Conjugates of SN-38 that provide optimal drug release rates and minimize the formation of the corresponding glucuronate are described. The conjugates release...
US-1,001,6410 Tetrahydroisoquinolin-1-one derivative or salt thereof
To provide a pharmaceutical, in particular a compound which can be used as a therapeutic agent for irritable bowel syndrome (IBS). It was found that a...
US-1,001,6409 Method for improving interstitial flow
Provided is a prophylactic and/or therapeutic drug for mild cognitive impairment, which can improve interstitial flow in cerebral blood vessel and the like to...
US-1,001,6408 Chemokine CXCR4 receptor modulators and uses related thereto
The disclosure relates to chemokine CXCR4 receptor modulators and uses related thereto. In certain embodiments, the disclosure relates to pharmaceutical...
US-1,001,6407 Pharmaceutical compositions and methods of using the same
Novel pharmaceutical compositions including cocaine hydrochloride and methods of treating patients using those pharmaceutical compositions are described.
US-1,001,6406 Indazole inhibitors of the WNT signal pathway and therapeutic uses thereof
Indazole compounds for treating various diseases and pathologies are disclosed. More particularly, the present invention concerns the use of an indazole...
US-1,001,6405 Modulators of methyl modifying enzymes, compositions and uses thereof
Agents for modulating methyl modifying enzymes, compositions and uses thereof are provided herein.
US-1,001,6404 Methods for treating disorders or diseases associated with hyperlipidemia and hypercholesterolemia while...
The present invention provides methods and compositions for treating hyperlipidemia and/or hypercholesterolemia comprising administering to the subject an...
US-1,001,6403 Sublingual fentanyl spray
The present invention is directed to sublingual formulations containing fentanyl, a pharmaceutically acceptable salt thereof, or derivative thereof, suitable...
US-1,001,6402 Methods for treatment of melanoma
Embodiments of the present invention are directed to methods for treatment of melanoma using an inhibitor of dihydroorotate dehydrogenase (DHODH) and to...
US-1,001,6401 Histone demethylase inhibitors
The present invention relates generally to compositions and methods for treating cancer and neoplastic disease. Provided herein are substituted pyrrolopyridine...
US-1,001,6400 Composition including rapamycin as active ingredient for preventing or treating hearing loss
A pharmaceutical or health food includes rapamycin as an active ingredient, the pharmaceutical or health food being applied for prevention, improvement, and...
US-1,001,6399 Compositions and methods of treating cardiac fibrosis with ifetroban
The present invention is directed to methods of treating, preventing, and/or ameliorating fibrosis syndrome, and in particular cardiac fibrosis, by...
US-1,001,6398 Antimitotic amides for the treatment of cancer and proliferative disorders
Novel, antimitotic heteroaryl amides and pharmaceutically acceptable salts of Formula I where Ar, R.sup.5, R.sup.6, R.sup.8, R.sup.9, R.sup.11, X.sup.1, and...
US-1,001,6397 Selective AT2 receptor agonists for use in treatment of cachexia
The present invention is directed to selective AT2 receptor agonist or a pharmaceutically acceptable salt thereof for use in treatment of cachexia, preferably...
US-1,001,6396 Dexmedetomidine premix formulation
The presently disclosed subject matter relates to pharmaceutical compositions comprising dexmedetomidine or a pharmaceutically acceptable salt thereof wherein...
US-1,001,6395 Therapeutic agent for keratoconjunctive disorders
The present invention addresses the problem of providing a novel therapeutic agent for keratoconjunctive disorders. As a means for solving the problem, a...
US-1,001,6394 PPARG modulators for treatment of osteoporosis
The invention provides methods of treatment of a progressive bone disease, such as osteoporosis, Paget's Disease, multiple myeloma, or hyperparathyroidism,...
US-1,001,6393 Stabilized pharmaceutical dosage forms comprising atrasentan
The present disclosure relates to: (a) methods of using stabilized pharmaceutical dosage forms comprising atrasentan, or a pharmaceutically acceptable salt...
US-1,001,6392 Method of treating cancer with combinations of histone deacetylase inhibitors (HDAC1) substances
A method for treating cancer is described using combination therapies comprising the use of hyperbaric oxygen with histone deacetylase inhibitors, with and...
US-1,001,6391 Duloxetine sprinkles
The present invention relates in part a to multiparticulate sprinkle dosage form comprising duloxetine or a pharmaceutically acceptable salt thereof, having...
US-1,001,6390 Uses of duloxetine HCL medicament in preparing pharmaceutical treatment of cancer
Provided in the present invention are uses of duloxetine hydrochloride in preparing a pharmaceutical composition for treatment of cancer.
US-1,001,6389 Method of making liposomes, liposome compositions made by the methods, and methods of using the same
A method of preparing liposomes, liposome compositions formed by the process, and methods of using the liposome composition are provided herein.
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