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Patent # Description
US-1,001,7555 Long-acting blood sugar decreasing fusion protein
The present invention provides an anthropogenic glucagon-like peptide-1 (GLP-1) recombinant protein molecule fused with an anthropogenic immunoglobulin subtype...
US-1,001,7554 Neuropeptide Y-derived peptides
The present invention discloses peptide fragments derived from neuropeptide Y (NPY), which are capable of selective binding to the neural cell adhesion molecule...
US-1,001,7553 Splice variants of GDNF and uses thereof
The present invention relates to Glial Cell Line-Derived Neurotrophic Factor (GDNF) protein and gene and is, in particular, directed to a novel splice variant...
US-1,001,7552 Methods of using a composition comprising leukolectin for cosmetic skin treatment
The present invention relates to cosmetic compositions comprising polypeptides obtained or obtainable from Salmonidae hatching fluid, methods of producing said...
US-1,001,7551 Peptides having reduced toxicity that stimulate cholesterol efflux
The present invention provides a family of non-naturally occurring polypeptides having cholesterol efflux activity that parallels that of full-length...
US-1,001,7550 Mycobacterium tuberculosis porins and toxins and related methods
Provided herein are isolated polypeptides comprising the amino-terminal domain of Mycobacterium tuberculosis porin A (MtpA), wherein the polypeptide is a porin...
US-1,001,7549 Hemipteran and coleopteran active toxin proteins from Bacillus thuringiensis
A novel Bacillus thuringiensis crystal protein exhibiting insect inhibitory activity is disclosed. Growth of Lygus insects is significantly inhibited by...
US-1,001,7548 Modified biotin-binding protein, fusion proteins thereof and applications
The disclosure provides modified biotin-binding proteins which can be expressed in soluble form in high yield in bacteria. Also provided are fusion proteins...
US-1,001,7547 Adhesin as immunogen against enterotoxigenic Escherichia coli
The inventive subject matter relates to the methods for the induction of immunity and prevention of diarrhea resulting from Escherichia coli. The inventive...
US-1,001,7546 Monomeric avidin-like proteins with stable biotin binding ability
Disclosed are monomeric avidin-like proteins with a strong and stable biotin-binding ability, protein conjugates containing two or more of the monomeric...
US-1,001,7545 Compositions and vaccines comprising vesicles and methods of using the same
The disclosure relates to compositions, pharmaceutical compositions, vaccines, and methods of making and using the same. The compositions of the disclosure are...
US-1,001,7544 Computationally optimized broadly reactive antigens for H1N1 influenza
Generation of optimized H1N1 influenza HA polypeptides for eliciting a broadly reactive immune response to H1N1 influenza virus isolates are described. The...
US-1,001,7543 Prefusion RSV F proteins and their use
Disclosed are Respiratory Syncytial Virus (RSV) antigens including a recombinant RSV F protein stabilized in a prefusion conformation. Also disclosed are...
US-1,001,7542 Antimicrobial peptides and methods of use thereof
Aspects of the present invention relate to peptides having antimicrobial activity. In certain aspects, the invention relates to peptides having potent...
US-1,001,7541 Cyclosporin a form 2 and method of making same
Disclosed herein are methods of making cyclosporin A Form 2.
US-1,001,7540 Cyclic peptide binder against oncogenic K-Ras
Cyclic peptides represented by (Formula 1) ##STR00001## selectively bind the oncoprotein K-Ras G12D in vitro and in cellulo, where Z1 and Z2 are each...
US-1,001,7539 Melanocortin-1 receptor-specific cyclic hexapeptides
Melanocortin receptor-specific cyclic hexapeptides of the formula ##STR00001## where R.sub.1, R.sub.2, R.sub.3, R.sub.4, R.sub.5, R.sub.6, R.sub.7, R.sub.8 and...
US-1,001,7538 Bioactive peptides having insecticide activity
Disclosed are novel bioactive peptides derived as antagonists to a fire ant receptor for a pheromone biosynthesis-activating neuropeptide/pyrokinin...
US-1,001,7537 Peptide selectively binding to graphitic materials and volatile organic compounds
Provided is a peptide including X.sub.2SX.sub.1AAX.sub.2X.sub.3P (SEQ ID NO. 1), X.sub.2X.sub.2PX.sub.3X.sub.2AX.sub.3P (SEQ ID NO. 2), ...
US-1,001,7536 Synthetic peptide amides and dimers thereof
The invention relates to synthetic peptide amide ligands of the kappa opioid receptor and particularly to agonists of the kappa opioid receptor that exhibit low...
US-1,001,7535 Amphiphilic compounds with neuroprotective properties
Amphiphilic compounds with tetradecahydrophenanthrene skeleton and their enantiomers, exhibiting neuroprotective effects, their use in methods of treatment of...
US-1,001,7534 Method for producing Tebbe complex
The present invention relates to a method for producing a Tebbe complex having high purity and high activity and having excellent storage stability in a high...
US-1,001,7533 Cytotoxic titanium and vanadium complexes
The present application provides a family of highly resistant and water-stable Titanium and Vanadium complexes, which may be administered directly without a...
US-1,001,7532 Platinum (IV) complex with increased anti-tumor efficacy
The invention relates to a new platinum (IV) complex with substantially increased antitumor efficacy. The invention further discloses a process for preparing of...
US-1,001,7531 Lipid-based platinum-N-heterocyclic carbene compounds and nanoparticles
The present disclosure is in relation to the field of nanotechnology and cancer therapeutics. In particular, the present disclosure relates to carbene...
US-1,001,7530 Fluorination method for phosphonitrilic chloride trimer and its derivatives
The present invention relates to a fluorination method for phosphonitrilic chloride trimer and its derivatives including using phosphonitrilicchloride or...
US-1,001,7529 Metformin derivatives
The present invention relates to novel biguanide derivatives including their pharmaceutically acceptable salts. The invention also relates processes for the...
US-1,001,7528 Controlled synthesis of polymeric perylene diimide and applications thereof
Perylene diimide phosphoramidite derivatives and methods for polymerization of perylene diimide phosphoramidite derivatives and applications thereof are...
US-1,001,7527 KLK4 inhibitors
The present invention relates to novel compounds and probes which have a common chemical structure necessary to obtain potent inhibitory activity against KLK4...
US-1,001,7526 Method for producing siloxanes from alkali salts of silanols
Cyclic siloxanes are prepared economically by reaction of an alkali metal siliconate having a mol ratio of alkali metal cation to silicon of less than one or...
US-1,001,7525 Multi-sensor array compound and methods of use thereof
The present invention is directed to a multi-sensor array compound including at least three chromophores, at least one receptor and an anchor. Contacting the...
US-1,001,7524 Compound and pharmaceutical composition for neuropsychological disorder or malignant tumor
The present invention provides a compound and a pharmaceutical composition for neuropsychological disorders or malignant tumors, the use of the compound and the...
US-1,001,7523 NAMPT inhibitors and methods
The invention features compounds of Formula (I), Formula (I)-A and Formula (I)-B as disclosed herein, as well as methods of synthesis, therapy, diagnostics, and...
US-1,001,7522 Alpha helix mimetics and methods relating thereto
Alpha-helix mimetic structures and compounds represented by the formula (I) wherein the general formula and the definition of each symbol are as defined in the...
US-1,001,7521 Chromone oxime derivative and its use as allosteric modulator of metabotropic glutamate receptors
The present invention provides a novel chromone oxime derivative of formula (I), which is a modulator of nervous system receptors sensitive to glutamate and,...
US-1,001,7520 Myc modulators and uses thereof
The present disclosure provides compounds of Formula (I-a), Formula (I), and Formula (II). The compounds described herein may be Myc modulators (e.g., Myc...
US-1,001,7519 Alpha-hydroxy carboxylic acid and derivatives and other GRAS based prodrugs of oxycodone and uses thereof
The invention describes pharmaceutical compounds and compositions comprised of a ligand attached to the opioid oxycodone, in a manner that substantially...
US-1,001,7517 Processes for the preparation of (3S,4R)-3-ethyl-4-(3H-imidazo[1,2-.alpha.]pyrrolo[2,3-e]-pyrazin-8-yl)-N-- ...
The present disclosure relates to processes for preparing (3S,4R)-3-ethyl-4-(3H-imidazo[1,2-a]pyrrolo[2,3-e]pyrazin-8-yl)-N-(2,2,2-- ...
US-1,001,7516 BMP inhibitors and methods of use thereof
The present invention provides small molecule inhibitors of BMP signaling. These compounds may be used to modulate cell growth, differentiation, proliferation,...
US-1,001,7515 Stable amorphous ticagrelor and a process for its preparation
The present invention relates to a stable amorphous ticagrelor and a process for its preparation.
US-1,001,7514 6,7-dihydropyrazolo[1,5-.alpha.]pyrazin-4(5H)-one compounds and their use as negative allosteric modulators of...
The present invention relates to novel 6,7-dihydropyrazolo[1,5-a]pyrazin-4(5H)-one derivatives as negative allosteric modulators (NAMs) of the metabotropic...
US-1,001,7513 Crystalline forms of sodium 4-{[9-chloro-7-(2-fluoro-6-methoxyphenyl)-5H-pyrimido ...
The present invention is directed to a compound of formula (I): ##STR00001## or a crystalline form thereof, or a solvate thereof; to a solid pharmaceutical...
US-1,001,7512 Compounds and compositions useful for treating disorders related to NTRK
This disclosure relates to inhibitors of NTRK that are active against wild-type NTRK and its resistant mutants, such as compounds of Formula (I): ##STR00001##
US-1,001,7511 Pyrazolopyrimidinones for the treatment of impotence and process for the preparation thereof
The present invention relates to Pyrazolopyrimidinone compounds as PDE5 inhibitors with better IC.sub.50 value, good in vivo efficacy and PK profile and a...
US-1,001,7510 Thiol-X click foldamers for polymer affinity and catalysis libraries
Click thiol-X monomers and polymers containing such monomers are disclosed. The clickable sequence controllable monomers include an optionally protected thiol...
US-1,001,7509 Macrocylic pyrimidine derivatives
The present invention relates to substituted macrocylic pyrimidine derivatives of Formula (I) ##STR00001## wherein the variables have the meaning defined in...
US-1,001,7508 Nitrogenated heterocyclic compound
The present invention provides a compound having a PDE2A selective inhibitory action, which is useful as an agent for the prophylaxis or treatment of...
US-1,001,7507 Diaza-benzofluoranthrene compounds
Disclosed are a series of diaza-benzofluoranthrene compounds. The present invention particularly relates to a compound represented by formula (I), ...
US-1,001,7506 ATX modulating agents
Disclosed are bicyclic aryl compounds of formula (I), that can modulate the activity of the autotaxin (ATX) enzyme. This invention further relates to compounds...
US-1,001,7505 Crystalline forms of a BACE inhibitor, compositions, and their use
The present invention provides four crystalline forms of verubecestat, as well as pharmaceutically acceptable compositions thereof, each of which may be useful...
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