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Patent # Description
US-1,001,7504 Piperidine isoxazole and isothiazole orexin receptor antagonists
The present invention is directed to piperidine isoxazole and isothiazole orexin compounds which are antagonists of orexin receptors. Such compounds are of the...
US-1,001,7503 Compounds, compositions, and methods for increasing CFTR activity
The disclosure encompasses compounds having e.g., Formula (Ia) or (Ib), compositions thereof, and methods of modulating CFTR activity. The disclosure also...
US-1,001,7502 Benzoxazinone amides as mineralocorticoid receptor modulators
Disclosed are certain derivatives of benzoxazinone amides of formula (I), or pharmaceutically acceptable salts thereof, (Formula (I)) that act as ...
US-1,001,7501 Benzimidazole derivatives as bromodomain inhibitors
This application relates to chemical compounds which may act as inhibitors of, or which may otherwise modulate the activity of, a bromodomain-containing...
US-1,001,7500 1,3-benzodioxole derivative
The present invention provides a compound having a particular chemical structure or a pharmacologically acceptable salt thereof which has an excellent...
US-1,001,7499 Benzimidazole derivatives
The present invention discloses compounds of Formula (I), or pharmaceutically acceptable salts, esters, or prodrugs thereof: ##STR00001## which inhibit...
US-1,001,7498 Compounds useful for treating AIDS
A compound having the following formula or a pharmaceutically acceptable salt thereof: ##STR00001## where: R independently represents a hydrogen atom, a...
US-1,001,7497 Pyrrolidine GPR40 modulators for the treatment of diseases such as diabetes
The present invention provides compounds of Formula (I) or a stereoisomer, a tautomer, a pharmaceutically acceptable salt, or a solvate thereof, wherein all of...
US-1,001,7496 Uracil derivatives as AXL and c-MET kinase inhibitors
The present invention provides compounds of Formula I ##STR00001## or pharmaceutically acceptable salt forms thereof, wherein R.sub.a, R.sub.b, R.sub.c,...
US-1,001,7495 Therapeutically active compounds and their methods of use
Provided are compounds useful for treating cancer and methods of treating cancer comprising administering to a subject in need thereof a compound described herein.
US-1,001,7494 Antifungal compound process
The present invention relates to a process for preparing compound 1 that is useful as an antifungal agent. In particular, the invention seeks to provide new...
US-1,001,7493 2-(2,4,5-substituted-anilino)pyrimidine compounds
The present invention relates to certain 2-(2,4,5-substituted-anilino)pyrimidine compounds and pharmaceutically acceptable salts thereof which may be useful in...
US-1,001,7492 Isoindoline derivative, intermediate, preparation method, pharmaceutical composition and use thereof
Provided are an isoindoline derivative, intermediate, preparation method, pharmaceutical composition and use thereof. The isoindoline derivative and the...
US-1,001,7491 Compounds and uses thereof for the modulation of hemoglobin
Provide herein are compounds and pharmaceutical compositions suitable as modulators of hemoglobin, methods and intermediates for their preparation, and methods...
US-1,001,7490 Endoparasite control agent and method for using the same
An object of the present invention is to provide a novel endoparasite control agent as a parasiticide, an antiprotozoal or the like. Provided is an endoparasite...
US-1,001,7489 Method for preparing benzopyran compound and application thereof in treating pulmonary fibrosis
The present invention opens to the public a method to prepare a benzopyran compound and its use for treating pulmonary fibrosis. A benzopyran compound has a...
US-1,001,7488 3-substituted carbonyl-naphtho[2,3-B]furane derivative or pharmaceutically acceptable salt thereof
The present invention provides a compound of the following Formula (1) or a pharmaceutically acceptable salt thereof: ##STR00001## wherein X is an oxygen atom...
US-1,001,7487 Fused heterocyclic compound
The present invention relates to a condensed heterocyclic compound that has an enteropeptidase inhibitory effect, and use of the compound as a medicament for...
US-1,001,7486 Conversion of fructose-containing feedstocks to HMF-containing product
The present invention relates generally to processes for converting fructose-containing feedstocks to a product comprising 5-(hydroxymethyl)furfural (HMF) and...
US-1,001,7485 Manufacturing method for compound having N,N-bis(2-hydroxy-3-chloropropyl)amino group
A method efficiently and safely manufactures, on an industrial scale, a compound having an N,N-bis(2-hydroxy-3-chloropropyl)amino group. (1) an amine compound...
US-1,001,7484 Catalysts containing specific titanium polymorphic forms
A catalyst composition which comprises titanium, wherein part of the titanium is present as a titanium dioxide phase and at least some of the titanium dioxide...
US-1,001,7483 Epoxidation using peroxygenase
The invention relates to enzymatic methods for epoxidation of a non-cyclic aliphatic alkene, or a terpene.
US-1,001,7482 Mitotic kinesin inhibitors and methods of use thereof
This invention relates to inhibitors of mitotic kinesins, particularly KSP, and methods for producing these inhibitors. ##STR00001##
US-1,001,7481 Conformationally constrained, fully synthetic macrocyclic compounds
The conformationally restricted, spatially defined macrocyclic ring system of formula (I) is constituted by three distinct molecular parts: Template A,...
US-1,001,7480 Compounds having a selective PDE4D inhibiting activity
Compounds of formula (I), wherein Z=cyclopentyl. cyclopropylmethyl, --CH.sub.3; R'.dbd.--CH.sub.3, CHF.sub.2, X=formula (II) (III) (IV) (V) Y=--CO;...
US-1,001,7479 Process to make non nucleosidal reverse transcriptase inhibitors (NNRTI) for the treatment of HIV
A chemical process that can form pharmaceutically acceptable medicaments NNRTI's for the treatment of HIV starting from thiotriazole compounds. The chemical...
US-1,001,7478 Inhibitors of ACK1/TNK2 tyrosine kinase
Described are cancer therapies and anti-cancer compounds. In particular, disclosed are inhibitors of Ack1 tyrosine kinase and their use in the treatment of...
US-1,001,7477 Janus kinase inhibitors and uses thereof
The present invention provides kinase inhibitors, such as compounds of Formula (I) and Formula (II). The compounds may covalently or non-covalently bind a...
US-1,001,7476 1,4-bis(3-aminopropyl)piperazine derivative and its use
The present invention relates to the compound having Formula (I) or pharmaceutically acceptable salts or solvates thereof, and its use in treating and/or...
US-1,001,7475 Anti-vasculature and anti-tubulin combretastatin analogs for treatment of cancer
Combretastatins analog compounds and their pharmaceutically acceptable salts are presented, as well as pharmaceutical compositions comprising the combretastatin...
US-1,001,7474 Method of synthesizing (E)-1,2-di(pyridin-2-yl) ethene-1,2-diol
The method of synthesizing (E)-1,2-di(pyridine-2-yl)ethene-1,2-diol involves dimerization of 2-pyridinecarboxaldehyde (also referred to herein as...
US-1,001,7473 Method for preparing pentachloropyridine by utilizing DCTF rectifying short steaming residues
A method for preparing pentachloropyridine by utilizing DCTF rectifying short steaming residues, comprising the following steps: converting polymers in the...
US-1,001,7472 Hydrate of 2-isopropoxy-5-methyl-4-(piperidin-4-yl) aniline dihydrochloride, preparation method and use of the same
The present invention relates to 2-isopropoxy-5-methyl-4-(piperidin-4-yl) aniline dihydrochloride monohydrate and a preparation method of the same. The...
US-1,001,7471 Selective androgen receptor degrader (SARD) ligands and methods of use thereof
This invention provides novel indole, indazole, benzimidazole, indoline, quinolone, isoquinoline, and carbazole selective androgen receptor degrader (SARD)...
US-1,001,7470 Treatment for lipodystrophy
The present invention provides a therapeutic compound of formula (I) and their pharmaceutically acceptable salts for the prevention and treatment of...
US-1,001,7469 Stabilized compositions and methods of manufacture
A method for stabilization of potent alkanone-heterocyclic flavorants in dry powder form is provided. Coordination of alkanone-heterocyclic flavorants to...
US-1,001,7468 Substituted pyrrolidines as G-protein coupled receptor 43 agonists
The present invention is directed to a process for the preparation of aryl-pyrrolidine carboxylic acid derivative compounds which are useful in treating...
US-1,001,7467 Alkylbenzene hydroperoxide production using dispersed bubbles of oxygen containing gas
An apparatus for oxidation of a C.sub.8-C.sub.12alkylbenzene reactant to a C.sub.8-C.sub.12 alkylbenzene hydroperoxide product, the re-actor can comprise: a...
US-1,001,7466 Process for purifying astaxanthin and canthaxanthin
The present invention relates to a process for purifying the xanthophylls astaxanthin and canthaxanthin. The process comprises suspending the xanthophyll in an...
US-1,001,7465 Method for producing astaxanthin from astacin
The invention relates to a method for the non-stereoselective and also for the stereoselective synthesis of astaxanthin from astacin. For this purpose, a...
US-1,001,7464 Process for preparing cyclic alpha-keto alcohols from cyclic alpha-keto enols
The invention relates to a method for preparing a cyclic .alpha.-ketoalcohol, particularly a 6-hydroxycyclohexenone from a cyclic .alpha.-ketoenol, particularly...
US-1,001,7463 Inhibitors of deubiquitinating proteases
Disclosed are small molecule inhibitors of deubiquitinating enzymes (DUBs), and methods of using them. Certain compounds are selective for particular...
US-1,001,7462 Antimicrobial poly(guanylurea)s
A poly(guanylurea) (PGU), comprising the structure where a multiplicity of repeating units are connected by guanylurea groups. The repeating units comprise:...
US-1,001,7461 Method of making ligand functionalized substrates
Ligand functionalized substrates, methods of making ligand functionalized substrates, and methods of using functionalized substrates are disclosed.
US-1,001,7460 Compounds for promoting liposomal and cellular adhesion and compositions and methods of use thereof
The present application describes amphiphatic compounds like compound IIa below, compositions and methods for incorporating chemoselective and bio-orthogonal...
US-1,001,7459 .beta.-substituted .beta.-amino acids and analogs as chemotherapeutic agents and uses thereof
.beta.-Substituted .beta.-amino acids, .beta.-substituted .beta.-amino acid derivatives, and .beta.-substituted .beta.-amino acid analogs and (bio)isosteres and...
US-1,001,7458 Therapeutic tetrahydronaphthalene compounds
The invention relates to protein binding interacting/binding compounds and methods of identifying and using them. The invention further relates to...
US-1,001,7457 Continuous synthesis of isooctyl nitrate in a flow reactor
A process for synthesizing isooctyl nitrate in a continuous flow reactor comprises flowing a H2SO4-HNO3 mixture within a flow reactor, flowing isooctyl alcohol...
US-1,001,7456 Monomer and polymer and compensation film and optical film and display device
A monomer is represented by Chemical Formula 1: ##STR00001## wherein in Chemical Formula 1, X.sup.1 and X.sup.2 are independently O, C(.dbd.O), or...
US-1,001,7455 Enhanced production of fatty acid derivatives
Genetically engineered cells and microorganisms are provided that produce fatty alcohols from the fatty acid biosynthetic pathway, as well as methods of their use.
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